메뉴 건너뛰기




Volumn 203, Issue 3, 2011, Pages 258-264

Epigallocatechin-3-gallate does not affect the activity of enzymes involved in metabolic activation and cellular excretion of benzo[a]pyrene in human colon carcinoma cells

Author keywords

Aryl hydrocarbon receptor; Benzo a pyrene; Caco 2; Chemoprevention; Epigallocatechin 3 gallate

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; BENZO[A]PYRENE; CYTOCHROME P450; CYTOCHROME P450 1A1; EPIGALLOCATECHIN GALLATE; FISETIN; FLAVONOID; GLUCURONOSYLTRANSFERASE;

EID: 79955960722     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.03.026     Document Type: Article
Times cited : (7)

References (51)
  • 1
    • 78649339242 scopus 로고    scopus 로고
    • An introduction to the molecular basics of aryl hydrocarbon receptor biology
    • Abel J., Haarmann-Stemmann T. An introduction to the molecular basics of aryl hydrocarbon receptor biology. Biol. Chem. 2010, 391:1235-1248.
    • (2010) Biol. Chem. , vol.391 , pp. 1235-1248
    • Abel, J.1    Haarmann-Stemmann, T.2
  • 2
    • 0031413702 scopus 로고    scopus 로고
    • Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond
    • Artursson P., Borchardt R.T. Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond. Pharm. Res. 1997, 14:1655-1658.
    • (1997) Pharm. Res. , vol.14 , pp. 1655-1658
    • Artursson, P.1    Borchardt, R.T.2
  • 3
    • 4644356710 scopus 로고    scopus 로고
    • Regulation of aryl hydrocarbon receptor signal transduction by protein tyrosine kinases
    • Backlund M., Ingelman-Sundberg M. Regulation of aryl hydrocarbon receptor signal transduction by protein tyrosine kinases. Cell Signal. 2005, 17:39-48.
    • (2005) Cell Signal. , vol.17 , pp. 39-48
    • Backlund, M.1    Ingelman-Sundberg, M.2
  • 5
    • 0037420963 scopus 로고    scopus 로고
    • Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolites
    • Buesen R., Mock M., Nau H., Seidel A., Jacob J., Lampen A. Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolites. Chem. Biol. Interact. 2003, 142:201-221.
    • (2003) Chem. Biol. Interact. , vol.142 , pp. 201-221
    • Buesen, R.1    Mock, M.2    Nau, H.3    Seidel, A.4    Jacob, J.5    Lampen, A.6
  • 7
    • 0031725843 scopus 로고    scopus 로고
    • Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells
    • Ciolino H.P., Daschner P.J., Wang T.T., Yeh G.C. Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells. Biochem. Pharmacol. 1998, 56:197-206.
    • (1998) Biochem. Pharmacol. , vol.56 , pp. 197-206
    • Ciolino, H.P.1    Daschner, P.J.2    Wang, T.T.3    Yeh, G.C.4
  • 8
    • 68149124472 scopus 로고    scopus 로고
    • Dietary phenolics: chemistry, bioavailability and effects on health
    • Crozier A., Jaganath I., Clifford M. Dietary phenolics: chemistry, bioavailability and effects on health. Nat. Prod. Rep. 2009, 26:1001-1043.
    • (2009) Nat. Prod. Rep. , vol.26 , pp. 1001-1043
    • Crozier, A.1    Jaganath, I.2    Clifford, M.3
  • 9
    • 27144483358 scopus 로고    scopus 로고
    • Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists
    • Ebert B., Seidel A., Lampen A. Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists. Carcinogenesis 2005, 26:1754-1763.
    • (2005) Carcinogenesis , vol.26 , pp. 1754-1763
    • Ebert, B.1    Seidel, A.2    Lampen, A.3
  • 10
    • 33947233105 scopus 로고    scopus 로고
    • Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate
    • Ebert B., Seidel A., Lampen A. Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. Toxicol. Sci. 2007, 96:227-236.
    • (2007) Toxicol. Sci. , vol.96 , pp. 227-236
    • Ebert, B.1    Seidel, A.2    Lampen, A.3
  • 11
    • 76749101143 scopus 로고    scopus 로고
    • (-)-Epigallocatechin-3-gallate downregulates Pg-P and BCRP in a tamoxifen resistant MCF-7 cell line
    • Farabegoli F., Papi A., Bartolini G., Ostan R., Orlandi M. (-)-Epigallocatechin-3-gallate downregulates Pg-P and BCRP in a tamoxifen resistant MCF-7 cell line. Phytomedicine 2010, 17:356-362.
    • (2010) Phytomedicine , vol.17 , pp. 356-362
    • Farabegoli, F.1    Papi, A.2    Bartolini, G.3    Ostan, R.4    Orlandi, M.5
  • 12
    • 0037184717 scopus 로고    scopus 로고
    • Natural and human-made mutagens and carcinogens in the human diet
    • Ferguson L.R. Natural and human-made mutagens and carcinogens in the human diet. Toxicology 2002, 181-182:79-82.
    • (2002) Toxicology , pp. 79-82
    • Ferguson, L.R.1
  • 13
    • 1942532874 scopus 로고    scopus 로고
    • Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappa B and induction of apoptosis
    • Gupta S., Hastak K., Afaq F., Ahmad N., Mukhtar H. Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappa B and induction of apoptosis. Oncogene 2004, 23:2507-2522.
    • (2004) Oncogene , vol.23 , pp. 2507-2522
    • Gupta, S.1    Hastak, K.2    Afaq, F.3    Ahmad, N.4    Mukhtar, H.5
  • 15
    • 0141849078 scopus 로고    scopus 로고
    • Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites
    • Hong J., Lambert J.D., Lee S.H., Sinko P.J., Yang C.S. Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites. Biochem. Biophys. Res. Commun. 2003, 310:222-227.
    • (2003) Biochem. Biophys. Res. Commun. , vol.310 , pp. 222-227
    • Hong, J.1    Lambert, J.D.2    Lee, S.H.3    Sinko, P.J.4    Yang, C.S.5
  • 16
    • 10844224317 scopus 로고    scopus 로고
    • Cytochromes P450 in the bioactivation of chemicals
    • Ioannides C., Lewis D.F. Cytochromes P450 in the bioactivation of chemicals. Curr. Top. Med. Chem. 2004, 4:1767-1788.
    • (2004) Curr. Top. Med. Chem. , vol.4 , pp. 1767-1788
    • Ioannides, C.1    Lewis, D.F.2
  • 17
    • 19444383488 scopus 로고    scopus 로고
    • Genotoxicity of heat-processed foods
    • Jagerstad M., Skog K. Genotoxicity of heat-processed foods. Mutat. Res. 2005, 574:156-172.
    • (2005) Mutat. Res. , vol.574 , pp. 156-172
    • Jagerstad, M.1    Skog, K.2
  • 18
    • 0035451344 scopus 로고    scopus 로고
    • Protective effect of green tea against benzo[a]pyrene-induced mutations in the liver of Big Blue transgenic mice
    • Jiang T., Glickman B.W., de Boer J.G. Protective effect of green tea against benzo[a]pyrene-induced mutations in the liver of Big Blue transgenic mice. Mutat. Res. 2001, 480-481:147-151.
    • (2001) Mutat. Res. , pp. 147-151
    • Jiang, T.1    Glickman, B.W.2    de Boer, J.G.3
  • 19
    • 0035937335 scopus 로고    scopus 로고
    • EGCG, a major component of green tea, inhibits tumour growth by inhibiting VEGF induction in human colon carcinoma cells
    • Jung Y.D., Kim M.S., Shin B.A., Chay K.O., Ahn B.W., Liu W., Bucana C.D., Gallick G.E., Ellis L.M. EGCG, a major component of green tea, inhibits tumour growth by inhibiting VEGF induction in human colon carcinoma cells. Br. J. Cancer 2001, 84:844-850.
    • (2001) Br. J. Cancer , vol.84 , pp. 844-850
    • Jung, Y.D.1    Kim, M.S.2    Shin, B.A.3    Chay, K.O.4    Ahn, B.W.5    Liu, W.6    Bucana, C.D.7    Gallick, G.E.8    Ellis, L.M.9
  • 20
    • 44349166921 scopus 로고    scopus 로고
    • Blockade of the dioxin pathway by herbal medicine Formula Bupleuri Minor: identification of active entities for suppression of AhR activation
    • Kasai A., Hiramatsu N., Hayakawa K., Yao J., Kitamura M. Blockade of the dioxin pathway by herbal medicine Formula Bupleuri Minor: identification of active entities for suppression of AhR activation. Biol. Pharm. Bull. 2008, 31:838-846.
    • (2008) Biol. Pharm. Bull. , vol.31 , pp. 838-846
    • Kasai, A.1    Hiramatsu, N.2    Hayakawa, K.3    Yao, J.4    Kitamura, M.5
  • 21
    • 75649112306 scopus 로고    scopus 로고
    • The inhibitory mechanisms of the tyrosine kinase inhibitors herbimycin a, genistein, and tyrphostin B48 with regard to the function of the aryl hydrocarbon receptor in Caco-2 cells
    • Kasai S., Kikuchi H. The inhibitory mechanisms of the tyrosine kinase inhibitors herbimycin a, genistein, and tyrphostin B48 with regard to the function of the aryl hydrocarbon receptor in Caco-2 cells. Biosci. Biotechnol. Biochem. 2010, 74:36-43.
    • (2010) Biosci. Biotechnol. Biochem. , vol.74 , pp. 36-43
    • Kasai, S.1    Kikuchi, H.2
  • 22
    • 28744436977 scopus 로고    scopus 로고
    • Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells
    • Kitagawa S., Nabekura T., Takahashi T., Nakamura Y., Sakamoto H., Tano H., Hirai M., Tsukahara G. Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells. Biol. Pharm. Bull. 2005, 28:2274-2278.
    • (2005) Biol. Pharm. Bull. , vol.28 , pp. 2274-2278
    • Kitagawa, S.1    Nabekura, T.2    Takahashi, T.3    Nakamura, Y.4    Sakamoto, H.5    Tano, H.6    Hirai, M.7    Tsukahara, G.8
  • 24
    • 24044496560 scopus 로고    scopus 로고
    • The role of protein kinase C in regulation of TCDD-mediated CYP1A1 gene expression
    • Machemer D.E., Tukey R.H. The role of protein kinase C in regulation of TCDD-mediated CYP1A1 gene expression. Toxicol. Sci. 2005, 87:27-37.
    • (2005) Toxicol. Sci. , vol.87 , pp. 27-37
    • Machemer, D.E.1    Tukey, R.H.2
  • 25
    • 77956575028 scopus 로고    scopus 로고
    • Inhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity
    • Mohamed M.E., Tseng T., Frye R.F. Inhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity. Xenobiotica 2010, 40:663-669.
    • (2010) Xenobiotica , vol.40 , pp. 663-669
    • Mohamed, M.E.1    Tseng, T.2    Frye, R.F.3
  • 26
    • 0035828180 scopus 로고    scopus 로고
    • Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450
    • Muto S., Fujita K., Yamazaki Y., Kamataki T. Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450. Mutat. Res. 2001, 479:197-206.
    • (2001) Mutat. Res. , vol.479 , pp. 197-206
    • Muto, S.1    Fujita, K.2    Yamazaki, Y.3    Kamataki, T.4
  • 27
    • 0033065391 scopus 로고    scopus 로고
    • Inhibition of benzo[a]pyrene-induced mutagenesis by (-)-epigallocatechin gallate in the lung of rpsL transgenic mice
    • Muto S., Yokoi T., Gondo Y., Katsuki M., Shioyama Y., Fujita K., Kamataki T. Inhibition of benzo[a]pyrene-induced mutagenesis by (-)-epigallocatechin gallate in the lung of rpsL transgenic mice. Carcinogenesis 1999, 20:421-424.
    • (1999) Carcinogenesis , vol.20 , pp. 421-424
    • Muto, S.1    Yokoi, T.2    Gondo, Y.3    Katsuki, M.4    Shioyama, Y.5    Fujita, K.6    Kamataki, T.7
  • 28
    • 33747877987 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate (EGCG): chemical and biomedical perspectives
    • Nagle D.G., Ferreira D., Zhou Y.D. Epigallocatechin-3-gallate (EGCG): chemical and biomedical perspectives. Phytochemistry 2006, 67:1849-1855.
    • (2006) Phytochemistry , vol.67 , pp. 1849-1855
    • Nagle, D.G.1    Ferreira, D.2    Zhou, Y.D.3
  • 29
    • 0031310905 scopus 로고    scopus 로고
    • Dose-dependent incorporation of tea catechins, (-)-epigallocatechin-3-gallate and (-)-epigallocatechin, into human plasma
    • Nakagawa K., Okuda S., Miyazawa T. Dose-dependent incorporation of tea catechins, (-)-epigallocatechin-3-gallate and (-)-epigallocatechin, into human plasma. Biosci. Biotechnol. Biochem. 1997, 61:1981-1985.
    • (1997) Biosci. Biotechnol. Biochem. , vol.61 , pp. 1981-1985
    • Nakagawa, K.1    Okuda, S.2    Miyazawa, T.3
  • 30
    • 4344685858 scopus 로고    scopus 로고
    • Dibenzo[A,L]pyrene-induced genotoxic and carcinogenic responses are dramatically suppressed in aryl hydrocarbon receptor-deficient mice
    • Nakatsuru Y., Wakabayashi K., Fujii-Kuriyama Y., Ishikawa T., Kusama K., Ide F. Dibenzo[A,L]pyrene-induced genotoxic and carcinogenic responses are dramatically suppressed in aryl hydrocarbon receptor-deficient mice. Int. J. Cancer 2004, 112:179-183.
    • (2004) Int. J. Cancer , vol.112 , pp. 179-183
    • Nakatsuru, Y.1    Wakabayashi, K.2    Fujii-Kuriyama, Y.3    Ishikawa, T.4    Kusama, K.5    Ide, F.6
  • 32
    • 16344364163 scopus 로고    scopus 로고
    • Epigallocatechin gallate inhibits aryl hydrocarbon receptor gene transcription through an indirect mechanism involving binding to a 90 kDa heat shock protein
    • Palermo C.M., Westlake C.A., Gasiewicz T.A. Epigallocatechin gallate inhibits aryl hydrocarbon receptor gene transcription through an indirect mechanism involving binding to a 90 kDa heat shock protein. Biochemistry 2005, 44:5041-5052.
    • (2005) Biochemistry , vol.44 , pp. 5041-5052
    • Palermo, C.M.1    Westlake, C.A.2    Gasiewicz, T.A.3
  • 33
    • 34047191433 scopus 로고    scopus 로고
    • Identification of kaempferol as an inhibitor of cigarette smoke-induced activation of the aryl hydrocarbon receptor and cell transformation
    • Puppala D., Gairola C.G., Swanson H.I. Identification of kaempferol as an inhibitor of cigarette smoke-induced activation of the aryl hydrocarbon receptor and cell transformation. Carcinogenesis 2006, 28:639-647.
    • (2006) Carcinogenesis , vol.28 , pp. 639-647
    • Puppala, D.1    Gairola, C.G.2    Swanson, H.I.3
  • 34
    • 22744444072 scopus 로고    scopus 로고
    • EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells
    • Shimizu M., Deguchi A., Hara Y., Moriwaki H., Weinstein I.B. EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells. Biochem. Biophys. Res. Commun. 2005, 334:947-953.
    • (2005) Biochem. Biophys. Res. Commun. , vol.334 , pp. 947-953
    • Shimizu, M.1    Deguchi, A.2    Hara, Y.3    Moriwaki, H.4    Weinstein, I.B.5
  • 35
    • 17644401337 scopus 로고    scopus 로고
    • (-)-Epigallocatechin gallate and polyphenon e inhibit growth and activation of the epidermal growth factor receptor and human epidermal growth factor receptor-2 signaling pathways in human colon cancer cells
    • Shimizu M., Deguchi A., Lim J.T.E., Moriwaki H., Kopelovich L., Weinstein I.B. (-)-Epigallocatechin gallate and polyphenon e inhibit growth and activation of the epidermal growth factor receptor and human epidermal growth factor receptor-2 signaling pathways in human colon cancer cells. Clin. Cancer Res. 2005, 11:2735-2746.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 2735-2746
    • Shimizu, M.1    Deguchi, A.2    Lim, J.T.E.3    Moriwaki, H.4    Kopelovich, L.5    Weinstein, I.B.6
  • 37
    • 33745634380 scopus 로고    scopus 로고
    • Green tea, black tea and colorectal cancer risk: a meta-analysis of epidemiologic studies
    • Sun C.L., Yuan J.M., Koh W.P., Yu M.C. Green tea, black tea and colorectal cancer risk: a meta-analysis of epidemiologic studies. Carcinogenesis 2006, 27:1301-1309.
    • (2006) Carcinogenesis , vol.27 , pp. 1301-1309
    • Sun, C.L.1    Yuan, J.M.2    Koh, W.P.3    Yu, M.C.4
  • 38
    • 56249106571 scopus 로고    scopus 로고
    • Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals
    • Surh Y.J., Kundu J.K., Na H.K. Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. Planta Med. 2008, 74:1526-1539.
    • (2008) Planta Med. , vol.74 , pp. 1526-1539
    • Surh, Y.J.1    Kundu, J.K.2    Na, H.K.3
  • 39
    • 25444461706 scopus 로고    scopus 로고
    • Green tea and the risk of colorectal cancer: pooled analysis of two prospective studies in Japan
    • Suzuki Y., Tsubono Y., Nakaya N., Koizumi Y., Suzuki Y., Shibuya D., Tsuji I. Green tea and the risk of colorectal cancer: pooled analysis of two prospective studies in Japan. J. Epidemiol. 2005, 15:118-124.
    • (2005) J. Epidemiol. , vol.15 , pp. 118-124
    • Suzuki, Y.1    Tsubono, Y.2    Nakaya, N.3    Koizumi, Y.4    Suzuki, Y.5    Shibuya, D.6    Tsuji, I.7
  • 42
    • 0036282695 scopus 로고    scopus 로고
    • Mechanisms of chronic disease causation by nutritional factors and tobacco products and their prevention by tea polyphenols
    • Weisburger J.H., Chung F.L. Mechanisms of chronic disease causation by nutritional factors and tobacco products and their prevention by tea polyphenols. Food Chem. Toxicol. 2002, 40:1145-1154.
    • (2002) Food Chem. Toxicol. , vol.40 , pp. 1145-1154
    • Weisburger, J.H.1    Chung, F.L.2
  • 46
    • 59849112850 scopus 로고    scopus 로고
    • (-)-Epigallocatechin-3-gallate is a novel Hsp90 inhibitor
    • Yin Z., Henry E.C., Gasiewicz T.A. (-)-Epigallocatechin-3-gallate is a novel Hsp90 inhibitor. Biochemistry 2009, 48:336-345.
    • (2009) Biochemistry , vol.48 , pp. 336-345
    • Yin, Z.1    Henry, E.C.2    Gasiewicz, T.A.3
  • 47
    • 69249215244 scopus 로고    scopus 로고
    • Inhibitory effect of flavonoids on the efflux of N-acetyl 5-aminosalicylic acid intracellularly formed in Caco-2 cells
    • Yoshimura S., Kawano K., Matsumura R., Sugihara N., Furuno K. Inhibitory effect of flavonoids on the efflux of N-acetyl 5-aminosalicylic acid intracellularly formed in Caco-2 cells. J. Biomed. Biotechnol. 2009, 2009:467489.
    • (2009) J. Biomed. Biotechnol. , vol.2009 , pp. 467489
    • Yoshimura, S.1    Kawano, K.2    Matsumura, R.3    Sugihara, N.4    Furuno, K.5
  • 48
    • 0038236664 scopus 로고    scopus 로고
    • Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1
    • Yueh M.F., Huang Y.H., Hiller A., Chen S., Nguyen N., Tukey R.H. Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1. J. Biol. Chem. 2003, 278:15001-15006.
    • (2003) J. Biol. Chem. , vol.278 , pp. 15001-15006
    • Yueh, M.F.1    Huang, Y.H.2    Hiller, A.3    Chen, S.4    Nguyen, N.5    Tukey, R.H.6
  • 49
    • 0346121452 scopus 로고    scopus 로고
    • Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context
    • Zhang S., Qin C., Safe S.H. Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context. Environ. Health Perspect. 2003, 111:1877-1882.
    • (2003) Environ. Health Perspect. , vol.111 , pp. 1877-1882
    • Zhang, S.1    Qin, C.2    Safe, S.H.3
  • 50
    • 2142711101 scopus 로고    scopus 로고
    • Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport
    • Zhang S., Yang X., Morris M.E. Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport. Mol. Pharmacol. 2004, 65:1208-1216.
    • (2004) Mol. Pharmacol. , vol.65 , pp. 1208-1216
    • Zhang, S.1    Yang, X.2    Morris, M.E.3
  • 51
    • 0037381945 scopus 로고    scopus 로고
    • Species-specific transcriptional activity of synthetic flavonoids in guinea pig and mouse cells as a result of differential activation of the aryl hydrocarbon receptor to interact with dioxin-responsive elements
    • Zhou J.G., Henry E.C., Palermo C.M., Dertinger S.D., Gasiewicz T.A. Species-specific transcriptional activity of synthetic flavonoids in guinea pig and mouse cells as a result of differential activation of the aryl hydrocarbon receptor to interact with dioxin-responsive elements. Mol. Pharmacol. 2003, 63:915-924.
    • (2003) Mol. Pharmacol. , vol.63 , pp. 915-924
    • Zhou, J.G.1    Henry, E.C.2    Palermo, C.M.3    Dertinger, S.D.4    Gasiewicz, T.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.