MicroPET imaging of ketamine-induced neuronal apoptosis with radiolabeled DFNSH

Journal of Neural Transmission

Volumn 118, Issue 2, 2011, Pages 203-211

  Zhang, X ^a   Paule, M G ^a   Newport, G D ^a   Sadovova, N ^b   Berridge, M S ^c   Apana, S M ^c   Kabalka, G ^d   Miao, W ^d   Slikker Jr , W ^a   Wang, Cheng ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b Toxicologic Pathology Associates   (United States)

^c 3D Imaging LLC   (United States)

^d UNIVERSITY OF TENNESSEE   (United States)

Author keywords

Apoptosis; DFNSH; Ketamine; MicroPET

Indexed keywords

5 (DIMETHYLAMINO) N' (4 FLUOROBENZYLIDENE NAPHTHALENE 1 SULFONOHYDRAZIDE; FLUORINE 18; HYDRAZIDE; KETAMINE; LIPOCORTIN 5; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN CORTEX; CELL MEMBRANE; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FRONTAL CORTEX; MALE; NEUROTOXICITY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT;

ANESTHETICS, DISSOCIATIVE; ANIMALS; APOPTOSIS; BENZALDEHYDES; BRAIN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORINE RADIOISOTOPES; IMAGE PROCESSING, COMPUTER-ASSISTED; KETAMINE; MALE; NEURONS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 79955934517     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-010-0499-z     Document Type: Article

References (46)

1. Aloya R, Shirvan A, Grimberg H, Reshef A, Levin G, Kidron D, Cohen A, Ziv I (2006) Molecular imaging of cell death in vivo by a novel small molecule probe. Apoptosis 11:2089-2101 (Pubitemid 44885386)
2. Berridge MS, Apana S, Hersh JM (2009) Teflon radiolysis as the major source of carrier in fluorine-18. J Labelled Comp Radiopharm 52:543-548
3. Bianchi SL, Tran T, Liu C, Lin S, Li Y, Keller JM, Eckenhoff RG, Eckenhoff MF (2008) Brain and behavior changes in 12-month-old Tg2576 and nontransgenic mice exposed to anesthetics. Neurobiol Aging 29:1002-1010 (Pubitemid 351711665)
4. Chen YY, Chien C, Lee TW, Fu YK, Kuo TS, Jaw FS (2004) Dynamic evaluation of [18F]-FDG uptake in the rat brain by microPET imaging. Conf Proc IEEE Eng Med Biol Soc 6:4461-4464
5. Chen X, Shu S, Bayliss DA (2009a) HCN1 channel subunits are a molecular substrate for hypnotic actions of ketamine. J Neurosci 29:600-609
6. Chen YY, Shih YY, Chien CN, Chou TW, Lee TW, Jaw FS (2009b) MicroPET study of brain neuronal metabolism under electrical and mechanical stimulation of the rat tail. Nucl Med Commun 30:188-193
7. Clements JA, Nimmo WS (1981) Pharmacokinetics and analgesic effect of ketamine in man. Br J Anaesth 53:27-30 (Pubitemid 11210925)
8. Cohen A, Ziv I, Aloya T, Levin G, Kidron D, Grimberg H, Reshef A, Shirvan A (2007) Monitoring of chemotherapy-induced cell death in melanoma tumors by N, N'-Didansyl-L-cystine. Technol Cancer Res Treat 6:221-234
9. Cohen A, Shirvan A, Levin G, Grimberg H, Reshef A, Ziv I (2009) From the Gla domain to a novel small-molecule detector of apoptosis. Cell Res 19:625-637
10. Damianovich M, Ziv I, Heyman SN, Rosen S, Shina A, Kidron D, Aloya T, Grimberg H, Levin G, Reshef A, Bentolila A, Cohen A, Shirvan A (2006) ApoSense: a novel technology for functional molecular imaging of cell death in models of acute renal tubular necrosis. Eur J Nucl Med Mol Imaging 33:281-291
11. DiMaggio C, Sun LS, Kakavouli A, Byrne MW, Li G (2009) A retrospective cohort study of the association of anesthesia and hernia repair surgery with behavioral and developmental disorders in young children. J Neurosurg Anesthesiol 21:286-291
12. Grant IS, Nimmo WS, Clements JA (1981) Lack of effect of ketamine analgesia on gastric emptying in man. Br J Anaesth 53:1321-1323 (Pubitemid 12248934)
13. Grierson JR, Yagle KJ, Eary JF, Tait JF, Gibson DF, Lewellen B, Link JM, Krohn KA (2004) Production of [F-18] fluoroannexin for imaging apoptosis with PET. Bioconjugate Chem 15:373-379 (Pubitemid 38365198)
14. Grimberg H, Levin G, Shirvan A, Cohen A, Yogev-Falach M, Reshef A, Ziv I (2009) Monitoring of tumor response to chemotherapy in vivo by a novel small-molecule detector of apoptosis. Apoptosis 14:257-267
15. Haka MS, Kilbourn M, Watkins GL, Toorongian SA (1988) Aryltrimethylammonium trifluoromethanesulfonates as precursors to aryl [F-18]fluorides: Improved synthesis of [F-18]GBR- 13119. J Labelled Comp Radiopharm 27:823-833 (Pubitemid 19159742)
16. Hayashi H, Dikkes P, Soriano SG (2002) Repeated administration of ketamine may lead to neuronal degeneration in the developing rat brain. Paediatr Anaesth 12:770-774 (Pubitemid 36051344)
17. Hosoi R, Matsumura A, Mizokawa S, Tanaka M, Nakamura F, Kobayashi K, Watanabe Y, Inoue O (2005) MicroPET detection of enhanced 18F-FDG utilization by PKA inhibitor in awake rat brain. Brain Res 1039:199-202 (Pubitemid 40386843)
18. Ikonomidou C, Bosch F, Miksa M, Bittigau P, Vockler J, Dikranian K, Tenkova TI, Stefovska V, Turski L, Olney JW (1999) Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 283:70-74 (Pubitemid 29044848)
19. Istaphanous GK, Loepke AW (2009) General anesthetics and the developing brain. Curr Opin Anaesthesiol 22:368-373
20. Jevtovic-Todorovic V, Hartman RE, Izumi Y, Benshoff ND, Dikranian K, Zorumski CF, Olney JW, Wozniak DF (2003) Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci 23:876-882 (Pubitemid 36206178)
21. Kilbourn MR, Hockley B, Lee L, Sherman P, Quesada C, Frey KA, Koeppe RA (2009) Positron emission tomography imaging of (2R, 3R)-5-[(18)F] fluoroethoxybenzovesamicol in rat and monkey brain: a radioligand for the vesicular acetylcholine transporter. Nucl Med Biol 36:489-493
22. Kim K, Lee M, Park H, Kim JH, Kim S, Chung H, Choi K, Kim IS, Seong BL, Kwon IC (2006) Cell-permeable and biocompatible polymeric nanoparticles for apoptosis imaging. J Am Chem Soc 128:3490-3491
23. Kornblum HI, Araujo DM, Annala AJ, Tatsukawa KJ, Phelps ME, Cherry SR (2000) In vivo imaging of neuronal activation and plasticity in the rat brain by high resolution positron emission tomography (microPET). Nat Biotechnol 18:655-660
24. Lahorte CM, Vanderheyden JL, Steinmetz N, Van de Wiele C, Dierckx RA, Slegers G (2004) Apoptosis-detecting radioligands: current state of the art and future perspectives. Eur J Nucl Med Mol Imaging 31:887-919 (Pubitemid 38765126)
25. Lorberboym M, Blankenberg FG, Sadeh M, Lampl Y (2006) In vivo imaging of apoptosis in patients with acute stroke: correlation with blood-brain barrier permeability. Brain Res 1103:13-19
26. Olney JW, Wozniak DF, Jevtovic-Todorovic V, Farber NB, Bittigau P, Ikonomidou C (2002) Drug-induced apoptotic neurodegeneration in the developing brain. Brain Pathol 12:488-498 (Pubitemid 35154937)
27. Reshef A, Shirvan A, Grimberg H, Levin G, Cohen A, Mayk A, Kidron D, Djaldetti R, Melamed E, Ziv I (2007) Novel molecular imaging of cell death in experimental cerebral stroke. Brain Res 1144:156-164 (Pubitemid 46440847)
28. Reshef A, Shirvan A, Shohami E, Grimberg H, Levin G, Cohen A, Trembovler V, Ziv I (2008a) Targeting cell death in vivo in experimental traumatic brain injury by a novel molecular probe. J Neurotrauma 25:569-580 (Pubitemid 351918433)
29. Reshef A, Shirvan A, Waterhouse RN, Grimberg H, Levin G, Cohen A, Ulysse LG, Friedman G, Antoni G, Ziv I (2008b) Molecular imaging of neurovascular cell death in experimental cerebral stroke by PET. J Nucl Med 49:1520-1528
30. Reshef A, Shirvan A, Akselrod-Ballin A, Wall A, Ziv I (2010) Small-molecule biomarkers for clinical PET imaging of apoptosis. J Nucl Med 51:837-840
31. Scallet AC, Schmued LC, Slikker W Jr, Grunberg N, Faustino PJ, Davis H, Lester D, Pine PS, Sistare F, Hanig JP (2004) Developmental neurotoxicity of ketamine: morphometric confirmation, exposure parameters, and multiple fluorescent labeling of apoptotic neurons. Toxicol Sci 81:364-370 (Pubitemid 39377966)
32. Slikker W Jr, Paule MG, Wright LK, Patterson TA, Wang C (2007a) Systems biology approaches for toxicology. J Appl Toxicol 27:201-217 (Pubitemid 46663415)
33. Slikker W Jr, Zou X, Hotchkiss CE, Divine RL, Sadovova N, Twaddle NC, Doerge DR, Scallet AC, Patterson TA, Hanig JP, Paule MG, Wang C (2007b) Ketamine-induced neuronal cell death in the perinatal rhesus monkey. Toxicol Sci 98:145-158 (Pubitemid 47073827)
34. Strauss HW, Blankenberg F, Vanderheyden JL, Tait J (2008) Translational imaging: imaging of apoptosis. Handb Exp Pharmacol 185:259-275
35. Tait JF (2008) Imaging of apoptosis. J Nucl Med 49:1573-1576
36. Toretsky J, Levenson A, Weinberg IN, Tait JF, Uren A, Mease RC (2004) Preparation of F-18 labeled annexin V: a potential PET radiopharmaceutical for imaging cell death. Nucl Med Biol 31:747-752 (Pubitemid 38887756)
37. Wang C, Slikker W Jr (2008) Strategies and experimental models for evaluating anesthetics: effects on the developing nervous system. Anesth Analg 106:1643-1658
38. Wang C, Sadovova N, Fu X, Schmued L, Scallet A, Hanig J, Slikker W (2005) The role of the N-methyl-D-aspartate receptor in ketamine-induced apoptosis in rat forebrain culture. Neuroscience 132:967-977 (Pubitemid 40602532)
39. Wilder RT, Flick RP, Sprung J, Katusic SK, Barbaresi WJ, Mickelson C, Gleich SJ, Schroeder DR, Weaver AL, Warner DO (2009) Early exposure to anesthesia and learning disabilities in a population-based birth cohort. Anesthesiology 110:796-804
40. Wolters SL, Corsten MF, Reutelingsperger CP, Narula J, Hofstra L (2007) Cardiovascular molecular imaging of apoptosis. Eur J Nucl Med Mol Imaging 34(Suppl 1):86-98
41. Xie Z, Dong Y, Maeda U, Moir RD, Xia W, Culley DJ, Crosby G, Tanzi RE (2007) The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation. J Neurosci 27:1247-1254
42. Zeng W, Yao ML, Townsend D, Kabalka G, Wall J, Le Puil M, Biggerstaff J, Miao W (2008) Synthesis, biological evaluation and radiochemical labeling of a dansylhydrazone derivative as a potential imaging agent for apoptosis. Bioorg Med Chem Lett 18:3573-3577 (Pubitemid 351787557)
43. Zhang X, Paule MG, Newport GD, Zou X, Sadovova N, Berridge MS, Apana SM, Hanig JP, Slikker W Jr, Wang C (2009) A minimally invasive, translational biomarker of ketamine-induced neuronal death in rats: microPET Imaging using 18F-annexin V. Toxicol Sci 111:355-361
44. Zijlstra S, Gunawan J, Burchert W (2003) Synthesis and evaluation of a 18F-labelled recombinant annexin-V derivative, for identification and quantification of apoptotic cells with PET. Appl Radiat Isot 58:201-207 (Pubitemid 36172511)
45. Zou X, Patterson TA, Divine RL, Sadovova N, Zhang X, Hanig JP, Paule MG, Slikker W Jr, Wang C (2009a) Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain. Int J Dev Neurosci 27:727-731
46. Zou X, Patterson TA, Sadovova N, Twaddle NC, Doerge DR, Zhang X, Fu X, Hanig JP, Paule MG, Slikker W, Wang C (2009b) Potential neurotoxicity of ketamine in the developing rat brain. Toxicol Sci 108:149-158