Positron emission tomography imaging of (2R,3R)-5-[18F]fluoroethoxybenzovesamicol in rat and monkey brain: a radioligand for the vesicular acetylcholine transporter

Nuclear Medicine and Biology

Volumn 36, Issue 5, 2009, Pages 489-493

  Kilbourn, Michael R ^a   Hockley, Brian ^a   Lee, Lihsueh ^a   Sherman, Phillip ^a   Quesada, Carole ^a   Frey, Kirk A ^a   Koeppe, Robert A ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

PET; Vesamicol; Vesicular transporter

Indexed keywords

5 FLUOROETHOXYBENZOVESAMICOL F 18; FLUORINE 18; UNCLASSIFIED DRUG; VESICULAR ACETYLCHOLINE TRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CEREBELLUM; CHOLINERGIC NERVE; CONTROLLED STUDY; CORPUS STRIATUM; MALE; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIATION DOSE DISTRIBUTION; RADIOACTIVITY; RAT; RHESUS MONKEY; THALAMUS;

ANIMALS; BRAIN; HUMANS; LIGANDS; MACACA MULATTA; MALE; MICE; PIPERIDINES; POSITRON-EMISSION TOMOGRAPHY; RATS; TIME FACTORS; TISSUE DISTRIBUTION; VESICULAR ACETYLCHOLINE TRANSPORT PROTEINS;

EID: 67349275045     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2009.02.007     Document Type: Article

References (14)

1. Parsons S.M., Prior C., and Marshall I.G. Acetylcholine transport, storage and release. Int Rev Neurobiol 35 (1993) 279-390
2. Frey K.A., Wieland D.M., and Kilbourn M.R. Imaging of monoaminergic and cholinergic vesicular transporters in the brain. In: Goldstein D., Eisenhofer G., and McCarty R. (Eds). Catecholamines: Bridging Basic Science with Clinical Medicine (1997), Academic Press, San Diego 269-272
3. Efange S.M. In vivo imaging of the vesicular acetylcholine transporter and the vesicular monoamine transporter. FASEB J 14 (2000) 2401-2413
4. Kuhl D.E., Minoshima S., Fessler J.A., Frey K.A., Foster N.L., Ficaro E.P., Wieland D.M., and Koeppe R.A. In vivo mapping of cholinergic terminals in normal aging, Alzheimer's disease, and Parkinson's disease. Ann Neurol 40 (1996) 399-410
5. 123I]iodobenzovesamicol binding in idiopathic cervical dystonia. Ann Neurol 53 (2003) 528-532
6. Gilman S., Chervin R.D., Koeppe R.A., Consens F.B., Little R., An H., Junck L., and Heumann M. Obstructive sleep apnea is related to a thalamic cholinergic deficit in MSA. Neurology 61 (2003) 35-39
7. 123I)]-IBVM in early Alzheimer's disease. NeuroImage 40 (2008) 280-288
8. Kilbourn M.R., Jung Y.W., Haka M.S., Gildersleeve D.L., Kuhl D.E., and Wieland D.M. Mouse brain distribution of a carbon-11 labeled vesamicol derivative: presynaptic marker of cholinergic neurons. Life Sciences 47 (1990) 1955-1963
9. Widén L., Eriksson L., Ingvar M., Parsons S.M., Rogers G.A., and Stone-Elander S. Positron emission tomographic studies of central cholinergic nerve terminals. Neurosci Lett 136 (1992) 1-4
10. 18F]-fluoroethoxy- and fluoropropoxy-benzovesamicol, as PET radioligands for the vesicular acetylcholine transporter. Synapse 61 (2007) 962-970
11. 11C]methylvesamicol for diagnosing cholinergic deficit dementia. Synapse 63 (2009) 167-171
12. 18F]fluoroethoxy-benzovesamicol, a radiotracer for cholinergic neurons. J Labelled Compds Radiopharm 33 (1993) 583-591
13. 18F]Fluoroethoxy-benzovesamicol, a PET radiotracer for the vesicular acetylcholine transporter and cholinergic synapses. Synapse 30 (1998) 263-274
14. 18F]fluoroethoxy-benzovesamical and microPET. J Cer Blood Flow Metab 27 Suppl 1 (2007) PP03--07M