A minimally invasive, translational biomarker of ketamine-induced neuronal death in rats: microPET imaging using 18F-annexin V

Toxicological Sciences

Volumn 111, Issue 2, 2009, Pages 355-361

  Zhang, Xuan ^a   Paule, Merle G ^a   Newport, Glenn D ^a   Zou, Xiaoju ^a   Sadovova, Natalya ^b   Berridge, Marc S ^c   Apana, Scott M ^c   Hanig, Joseph P ^d   Slikker Jr , William ^a   Wang, Cheng ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b Toxicologic Pathology Associates   (United States)

^c 3D Imaging LLC   (United States)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Apoptosis; Ketamine; microPET

Indexed keywords

BIOLOGICAL MARKER; FLUORODEOXYGLUCOSE F 18; KETAMINE; LIPOCORTIN 5 F 18; PROTEIN BAX; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN METABOLISM; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DRUG UPTAKE; IMAGE QUALITY; MICROPOSITRON EMISSION TOMOGRAPHY; MINIMALLY INVASIVE PROCEDURE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTEIN EXPRESSION; RAT;

ANESTHETICS, DISSOCIATIVE; ANIMALS; ANNEXIN A5; APOPTOSIS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; FEMALE; FLUORINE RADIOISOTOPES; KETAMINE; MALE; NEURONS; POSITRON-EMISSION TOMOGRAPHY; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; RATTUS;

EID: 70349267971     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp167     Document Type: Article

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