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Volumn 15, Issue 1-4, 2005, Pages 99-108

VEGF production by primary human renal proximal tubular cells: Requirement of HIF-1, PI3-kinase and MAPKK-1 signaling

Author keywords

Erk1 2 (p42 44 mitogen activated protein kinase); Hypoxia inducible factor 1; Interleukin 1; Phosphatidylinositol 3 kinase; Renal tubules; Vascular endothelial growth factor

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; VASCULOTROPIN;

EID: 12444324520     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000083642     Document Type: Article
Times cited : (17)

References (40)
  • 1
    • 0031039243 scopus 로고    scopus 로고
    • The biology of vascular endothelial growth factor
    • Ferrara N, Davis-Smyth T: The biology of vascular endothelial growth factor. Endocr Rev 1997;18:4-25.
    • (1997) Endocr Rev , vol.18 , pp. 4-25
    • Ferrara, N.1    Davis-Smyth, T.2
  • 2
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
    • Shweiki D, Itin A, Soffer D, Keshet E: Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992;359:843-845.
    • (1992) Nature , vol.359 , pp. 843-845
    • Shweiki, D.1    Itin, A.2    Soffer, D.3    Keshet, E.4
  • 3
    • 2542450917 scopus 로고    scopus 로고
    • HIF hydroxylation and cellular oxygen sensing
    • Metzen E, Ratcliffe PJ: HIF hydroxylation and cellular oxygen sensing. Biol Chem 2004;385:223-230.
    • (2004) Biol Chem , vol.385 , pp. 223-230
    • Metzen, E.1    Ratcliffe, P.J.2
  • 4
    • 0033181324 scopus 로고    scopus 로고
    • Interleukin-1β and tumor necrosis factor-a stimulate DNA binding of hypoxia-inducible factor-1
    • Hellwig-Burgel T., Rutkowski K, Metzen E, Fandrey J, Jelkmann W: Interleukin-1β and tumor necrosis factor-a stimulate DNA binding of hypoxia-inducible factor-1. Blood 1999;94:1561-1567.
    • (1999) Blood , vol.94 , pp. 1561-1567
    • Hellwig-Burgel, T.1    Rutkowski, K.2    Metzen, E.3    Fandrey, J.4    Jelkmann, W.5
  • 5
    • 0032169214 scopus 로고    scopus 로고
    • Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1a/ARNT
    • Zelzer E, Levy Y, Kahana C, Shilo BZ, Rubinstein M, Cohen B: Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1a/ARNT. EMBO J 1998;17:5085-5094.
    • (1998) EMBO J , vol.17 , pp. 5085-5094
    • Zelzer, E.1    Levy, Y.2    Kahana, C.3    Shilo, B.Z.4    Rubinstein, M.5    Cohen, B.6
  • 6
    • 0034282388 scopus 로고    scopus 로고
    • Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1a in vascular smooth muscle cells
    • Richard DE, Berra E, Pouyssegur J: Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1a in vascular smooth muscle cells. J Biol Chem 2000;275:26765-26771.
    • (2000) J Biol Chem , vol.275 , pp. 26765-26771
    • Richard, D.E.1    Berra, E.2    Pouyssegur, J.3
  • 8
    • 0038308573 scopus 로고    scopus 로고
    • Tumor necrosis factor-α causes accumulation of a ubiquitinated form of hypoxia inducible factor-1α through a nuclear factor-κB- dependent pathway
    • Zhou J, Schmid T, Brüne B: Tumor necrosis factor-α causes accumulation of a ubiquitinated form of hypoxia inducible factor-1α through a nuclear factor-κB-dependent pathway. Mol Biol Cell 2003;14:2216-2225.
    • (2003) Mol Biol Cell , vol.14 , pp. 2216-2225
    • Zhou, J.1    Schmid, T.2    Brüne, B.3
  • 9
    • 0030869787 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-rastransformed cells through a hypoxia inducible factor-1 transcriptional element
    • Mazure NM, Chen EY, Laderoute KR, Giaccia AJ: Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-rastransformed cells through a hypoxia inducible factor-1 transcriptional element. Blood 1997;90:3322-3331.
    • (1997) Blood , vol.90 , pp. 3322-3331
    • Mazure, N.M.1    Chen, E.Y.2    Laderoute, K.R.3    Giaccia, A.J.4
  • 10
    • 0035933726 scopus 로고    scopus 로고
    • Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: Protective role in apoptosis
    • Alvarez-Tejado M, Naranjo-Suarez S, Jimenez C, Carrera AC, Landazuri MO, del Peso L: Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. J Biol Chem 2001;276:22368-22374.
    • (2001) J Biol Chem , vol.276 , pp. 22368-22374
    • Alvarez-Tejado, M.1    Naranjo-Suarez, S.2    Jimenez, C.3    Carrera, A.C.4    Landazuri, M.O.5    Del Peso, L.6
  • 11
    • 0035866784 scopus 로고    scopus 로고
    • Hypoxia activates a platelet-derived growth factor receptor/ phosphatidylinositol 3-kinase/Akt pathway that results in glycogen synthase kinase-3 inactivation
    • Chen EY, Mazure NM, Cooper JA, Giaccia AJ: Hypoxia activates a platelet-derived growth factor receptor/ phosphatidylinositol 3-kinase/Akt pathway that results in glycogen synthase kinase-3 inactivation. Cancer Res 2001;61:2429-2433.
    • (2001) Cancer Res , vol.61 , pp. 2429-2433
    • Chen, E.Y.1    Mazure, N.M.2    Cooper, J.A.3    Giaccia, A.J.4
  • 12
    • 0034652392 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
    • Jiang BH, Zheng JZ, Aoki M, Vogt PK: Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc Natl Acad Sci U S A 2000;97:1749-1753.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 1749-1753
    • Jiang, B.H.1    Zheng, J.Z.2    Aoki, M.3    Vogt, P.K.4
  • 13
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1? expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, Simons JW, Semenza GL: Modulation of hypoxia-inducible factor 1? expression by the epidermal growth factor/ phosphatidylinositol 3-kinase/PTEN/ AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 2000;60:1541-1545.
    • (2000) Cancer Res , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.M.6    Simons, J.W.7    Semenza, G.L.8
  • 14
    • 0037070223 scopus 로고    scopus 로고
    • Normoxic induction of the hypoxia-inducible factor-1α??by insulin and interleukin-1β?involves the phosphatidylinositol 3-kinase pathway
    • Stiehl DP, Jelkmann W, Wenger RH, Hellwig-Bürgel T: Normoxic induction of the hypoxia-inducible factor-1α??by insulin and interleukin-1β?involves the phosphatidylinositol 3-kinase pathway. FEBS Letters 2002;512:157-162.
    • (2002) FEBS Letters , vol.512 , pp. 157-162
    • Stiehl, D.P.1    Jelkmann, W.2    Wenger, R.H.3    Hellwig-Bürgel, T.4
  • 15
    • 0037134442 scopus 로고    scopus 로고
    • Lack of evidence for the involvement of the phoshoinositide 3-kinase/akt pathway in the activation of hypoxia-inducible factors by low oxygen tension
    • Alvarez-Tejado M, Alfranca A, Aragonés J, Vara A, Landazuri MO, del Peso L: Lack of evidence for the involvement of the phoshoinositide 3-kinase/akt pathway in the activation of hypoxia-inducible factors by low oxygen tension. J Biol Chem 2002;277:13508-13517.
    • (2002) J Biol Chem , vol.277 , pp. 13508-13517
    • Alvarez-Tejado, M.1    Alfranca, A.2    Aragonés, J.3    Vara, A.4    Landazuri, M.O.5    Del Peso, L.6
  • 16
    • 0037177867 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription
    • Arsham AM, Plas DR, Thompson CB, Simon MC: Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription. J Biol Chem 2002;277:15162-15170.
    • (2002) J Biol Chem , vol.277 , pp. 15162-15170
    • Arsham, A.M.1    Plas, D.R.2    Thompson, C.B.3    Simon, M.C.4
  • 17
    • 0034647770 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways
    • Miele C, Rochford JJ, Filippa N, Giorgetti-Peraldi S, Van Obberghen E: Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways. J Biol Chem 2000;275:21695-21702.
    • (2000) J Biol Chem , vol.275 , pp. 21695-21702
    • Miele, C.1    Rochford, J.J.2    Filippa, N.3    Giorgetti-Peraldi, S.4    Van Obberghen, E.5
  • 18
    • 0032541029 scopus 로고    scopus 로고
    • P42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts
    • Milanini J, Vinals F, Pouyssegur J, Pages G: p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts. J Biol Chem 1998;273:18165-18172.
    • (1998) J Biol Chem , vol.273 , pp. 18165-18172
    • Milanini, J.1    Vinals, F.2    Pouyssegur, J.3    Pages, G.4
  • 19
    • 0032725554 scopus 로고    scopus 로고
    • P42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1
    • Richard DE, Berra E, Gothie E, Roux D, Pouyssegur J: p42/p44 mitogen-activated protein kinases phosphorylate hypoxia inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1. J Biol Chem 1999;274:32631-32637.
    • (1999) J Biol Chem , vol.274 , pp. 32631-32637
    • Richard, D.E.1    Berra, E.2    Gothie, E.3    Roux, D.4    Pouyssegur, J.5
  • 20
    • 0034282553 scopus 로고    scopus 로고
    • The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha
    • Sodhi A, Montaner S, Patel V, Zohar M, Bais C, Mesri EA, Gutkind JS: The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha. Cancer Res 2000;60:4873-4880.
    • (2000) Cancer Res , vol.60 , pp. 4873-4880
    • Sodhi, A.1    Montaner, S.2    Patel, V.3    Zohar, M.4    Bais, C.5    Mesri, E.A.6    Gutkind, J.S.7
  • 22
    • 0033623788 scopus 로고    scopus 로고
    • Hypoxia and interleukin-1β stimulate vascular endothelial growth factor production in human proximal tubular cells
    • El Awad B, Kreft B, Wolber E-M, Hellwig-Burgel T, Metzen E, Fandrey J, Jelkmann W: Hypoxia and interleukin-1β stimulate vascular endothelial growth factor production in human proximal tubular cells. Kidney Int 2000;58:43-50.
    • (2000) Kidney Int , vol.58 , pp. 43-50
    • El Awad, B.1    Kreft, B.2    Wolber, E.-M.3    Hellwig-Burgel, T.4    Metzen, E.5    Fandrey, J.6    Jelkmann, W.7
  • 23
    • 0027410240 scopus 로고
    • Effects of chemotherapeutic and immunosuppressive drugs on the production of erythropoietin in human hepatoma cultures
    • Wolff M, Jelkmann W: Effects of chemotherapeutic and immunosuppressive drugs on the production of erythropoietin in human hepatoma cultures. Ann Hematol 1993;66:27-31.
    • (1993) Ann Hematol , vol.66 , pp. 27-31
    • Wolff, M.1    Jelkmann, W.2
  • 24
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction
    • Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal Biochem 1987;162:156-159.
    • (1987) Anal Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 25
    • 0037446983 scopus 로고    scopus 로고
    • Effect of ascorbate on the activity of hypoxia inducible factor (HIF) in cancer cells
    • Knowles HJ, Raval RR, Harris AL, Ratcliffe PJ: Effect of ascorbate on the activity of hypoxia inducible factor (HIF) in cancer cells. Cancer Res 2003;63:1764-1768.
    • (2003) Cancer Res , vol.63 , pp. 1764-1768
    • Knowles, H.J.1    Raval, R.R.2    Harris, A.L.3    Ratcliffe, P.J.4
  • 26
    • 0034925041 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1
    • Jiang BH, Jiang G, Zheng JZ, Lu Z, Hunter T, Vogt PK: Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ 2001;12:363-369.
    • (2001) Cell Growth Differ , vol.12 , pp. 363-369
    • Jiang, B.H.1    Jiang, G.2    Zheng, J.Z.3    Lu, Z.4    Hunter, T.5    Vogt, P.K.6
  • 27
    • 0035037527 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase kinase inhibitor PD98059 blocks the trans-activation but not the stabilization or DNA binding ability of hypoxia-inducible factor-1α
    • Hur E, Chang KY, Lee E, Lee S-K, Park H: Mitogen-activated protein kinase kinase inhibitor PD98059 blocks the trans-activation but not the stabilization or DNA binding ability of hypoxia-inducible factor-1α. Mol Pharmacol 2001;59:1216-1224.
    • (2001) Mol Pharmacol , vol.59 , pp. 1216-1224
    • Hur, E.1    Chang, K.Y.2    Lee, E.3    Lee, S.-K.4    Park, H.5
  • 28
    • 0037515549 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase (MAPK) signaling up-regulates the activity of hypoxia inducible factors by its effects on p300
    • Sang N, Stiehl DP, Bohensky J, Leshchinsky I, Srinivas V, Caro J: Mitogen-activated protein kinase (MAPK) signaling up-regulates the activity of hypoxia inducible factors by its effects on p300. J Biol Chem 2003;278:14013-14019.
    • (2003) J Biol Chem , vol.278 , pp. 14013-14019
    • Sang, N.1    Stiehl, D.P.2    Bohensky, J.3    Leshchinsky, I.4    Srinivas, V.5    Caro, J.6
  • 29
    • 0035864361 scopus 로고    scopus 로고
    • Accumulation of HIF-1α under the influence of nitric oxide
    • Sandau K, Fandrey J, Brüne, B.: Accumulation of HIF-1α under the influence of nitric oxide. Blood 2001;97:1009-1015.
    • (2001) Blood , vol.97 , pp. 1009-1015
    • Sandau, K.1    Fandrey, J.2    Brüne, B.3
  • 30
    • 0035910429 scopus 로고    scopus 로고
    • Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide
    • Kimura H, Weisz A, Ogura T, Hitomi Y, Kurashima Y, Hashimoto K, D'Acquisto F, Makuuchi M, Esumi H: Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide. J Biol Chem 2001;276:2292-2298.
    • (2001) J Biol Chem , vol.276 , pp. 2292-2298
    • Kimura, H.1    Weisz, A.2    Ogura, T.3    Hitomi, Y.4    Kurashima, Y.5    Hashimoto, K.6    D'Acquisto, F.7    Makuuchi, M.8    Esumi, H.9
  • 31
    • 0034638623 scopus 로고    scopus 로고
    • Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI 3K pathway
    • Sandau KB, Faus HG, Brune B: Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI 3K pathway. Biochem Biophys Res Commun 2000;278:263-267.
    • (2000) Biochem Biophys Res Commun , vol.278 , pp. 263-267
    • Sandau, K.B.1    Faus, H.G.2    Brune, B.3
  • 32
    • 0035955663 scopus 로고    scopus 로고
    • Regulation of the hypoxia-inducible factor 1α by the inflammatory mediators nitric oxide and tumor necrosis factor-a in contrast to desferroxamine and phenylarsine oxide
    • Sandau KB, Zhou J, Kietzmann T, Brune B: Regulation of the hypoxia-inducible factor 1a by the inflammatory mediators nitric oxide and tumor necrosis factor-a in contrast to desferroxamine and phenylarsine oxide. J Biol Chem 2001;276:39805-39811.
    • (2001) J Biol Chem , vol.276 , pp. 39805-39811
    • Sandau, K.B.1    Zhou, J.2    Kietzmann, T.3    Brune, B.4
  • 33
    • 0027768808 scopus 로고
    • Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas
    • Brown LF, Berse B, Jackman RW, Tognazzi K, Manseau EJ, Dvorak HF, Senger DR: Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas. Am J Pathol 1993;143:1255-1262.
    • (1993) Am J Pathol , vol.143 , pp. 1255-1262
    • Brown, L.F.1    Berse, B.2    Jackman, R.W.3    Tognazzi, K.4    Manseau, E.J.5    Dvorak, H.F.6    Senger, D.R.7
  • 34
    • 0030895147 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression is increased in renal cell carcinoma
    • Nicol D, Hii SI, Walsh M, Teh B, Thompson L, Kennett C, Gotley D: Vascular endothelial growth factor expression is increased in renal cell carcinoma. J Urol 1997;157:1482-1486.
    • (1997) J Urol , vol.157 , pp. 1482-1486
    • Nicol, D.1    Hii, S.I.2    Walsh, M.3    Teh, B.4    Thompson, L.5    Kennett, C.6    Gotley, D.7
  • 35
    • 0029066004 scopus 로고
    • Angiogenesis and vascular endothelial growth factor (VEGF): Is it relevant in renal patients?
    • Grone HJ: Angiogenesis and vascular endothelial growth factor (VEGF): is it relevant in renal patients? Nephrol Dial Transplant 1995;10:761-763.
    • (1995) Nephrol Dial Transplant , vol.10 , pp. 761-763
    • Grone, H.J.1
  • 37
    • 0034889558 scopus 로고    scopus 로고
    • Vascular endothelial growth factor enhances glomerular capillary repair and accelerates resolution of experimentally induced glomerulonephritis
    • Masuda Y, Shimizu A, Mori T, Ishiwata T, Kitamura H, Ohashi R, Ishizaki M, Asano G, Sugisaki Y, Yamanaka N: Vascular endothelial growth factor enhances glomerular capillary repair and accelerates resolution of experimentally induced glomerulonephritis. Am J Pathol 2001;159:599-608.
    • (2001) Am J Pathol , vol.159 , pp. 599-608
    • Masuda, Y.1    Shimizu, A.2    Mori, T.3    Ishiwata, T.4    Kitamura, H.5    Ohashi, R.6    Ishizaki, M.7    Asano, G.8    Sugisaki, Y.9    Yamanaka, N.10
  • 38
    • 0034917262 scopus 로고    scopus 로고
    • Impaired angiogenesis in the remnant kidney model: II. Vascular endothelial growth factor administration reduces renal fibrosis and stabilizes renal function
    • Kang DH, Hughes J, Mazzali M, Schreiner GF, Johnson RJ: Impaired angiogenesis in the remnant kidney model: II. vascular endothelial growth factor administration reduces renal fibrosis and stabilizes renal function. J Am Soc Nephrol 2001;12:1448-1457.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 1448-1457
    • Kang, D.H.1    Hughes, J.2    Mazzali, M.3    Schreiner, G.F.4    Johnson, R.J.5
  • 39
    • 0035171101 scopus 로고    scopus 로고
    • Different response of urinary excretion of VEGF in patients with chronic and acute renal failure
    • Kitamoto Y, Matsuo K, Tomita K: Different response of urinary excretion of VEGF in patients with chronic and acute renal failure. Kidney Int 2001;59:385-386.
    • (2001) Kidney Int , vol.59 , pp. 385-386
    • Kitamoto, Y.1    Matsuo, K.2    Tomita, K.3
  • 40
    • 0033947341 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is a survival factor for renal tubular epithelial cells
    • Kanellis J, Fraser S, Katerelos M, Power DA: Vascular endothelial growth factor is a survival factor for renal tubular epithelial cells. Am J Physiol Renal Physiol 2000;278:F905-F915.
    • (2000) Am J Physiol Renal Physiol , vol.278
    • Kanellis, J.1    Fraser, S.2    Katerelos, M.3    Power, D.A.4


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