Therapeutic effects of pyrrolidine dithiocarbamate on acute lung injury in rabbits

Journal of Translational Medicine

Volumn 9, Issue , 2011, Pages

  Wang, Meitang ^a   Liu, Tao ^a   Wang, Dian ^b   Zheng, Yonghua ^b   Wang, Xiangdong ^b   He, Jian ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b ZHONGSHAN HOSPITAL OF FUDAN UNIVERSITY   (China)

Author keywords

Acute lung injury TNF ICAM 1; NF B; Pyrrolidine dithiocarbamate

Indexed keywords

CATHEPSIN G; DEXAMETHASONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; PYRROLIDINE DITHIOCARBAMATE; TUMOR NECROSIS FACTOR ALPHA; OXYGEN; PYRROLIDINE DERIVATIVE; PYRROLIDINE DITHIOCARBAMIC ACID; THIOCARBAMIC ACID DERIVATIVE;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL OXYGEN TENSION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG MECHANISM; ENDOTOXEMIA; FEMALE; LEUKOCYTE ADHERENCE; LUNG ALVEOLUS OXYGEN TENSION; LUNG EDEMA; LUNG WEIGHT; MALE; NEUTROPHIL; NONHUMAN; RABBIT; ANIMAL; BLOOD; CAPILLARY; CELL ADHESION; CELL CULTURE; CELL FRACTIONATION; DRUG EFFECT; LUNG; LUNG ALVEOLUS; METABOLISM; ORGAN SIZE; PATHOLOGY;

ACUTE LUNG INJURY; ANIMALS; CAPILLARIES; CATHEPSIN G; CELL ADHESION; CELLS, CULTURED; FEMALE; INTERCELLULAR ADHESION MOLECULE-1; LUNG; MALE; NEUTROPHILS; NF-KAPPA B; ORGAN SIZE; OXYGEN; PULMONARY ALVEOLI; PYRROLIDINES; RABBITS; SUBCELLULAR FRACTIONS; THIOCARBAMATES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79955830030     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-9-61     Document Type: Article

References (39)

1. Matthay MA, Zimmerman GA. Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management. Am J Respir Cell Mol Biol 2005, 33:319-327. 10.1165/rcmb.F305, 2715340, 16172252.
2. Chen H, Bai C, Wang X. The value of the lipopolysaccharide-induced acute lung injury model in respiratory medicine. Expert Rev Respir Med 2010, 4:773-83. 10.1586/ers.10.71, 21128752.
3. Deng XM, Wang XD, Lasson T, Sun ZW, Soltesz V, Andersson R. The involvement of multiple protease-antiprotease systems and gut origin sepsis in zymosan-associated endothelial barrier injury and multiple organ dysfunction in rats. Shock 2001, 16:298-303. 10.1097/00024382-200116040-00012, 11580114.
4. Liu SF, Malik AB. NF-κB activation as a pathologic mechanism of septic shock and inflammation. Am J Physiol Lung Cell Mol Physiol 2006, 290:L622-L645. 10.1152/ajplung.00477.2005, 16531564.
5. Everhart MB, Han W, Sherrill TP, et al. Duration and Intensity of NF-κB Activity Determine the Severity of Endotoxin-Induced Acute Lung Injury. J Immunol 2006, 176:4995-5005.
6. Nishina K, Mikawa K, Takao Y, Maekawa N, Shiga M, Obara H. ONO-5046, an elastase inhibitor, attenuates endotoxin-induced acute lung injury in rabbits. Anesth Analg 1997, 84:1097-1103.
7. Chang SC, Chang HI, Shiao GM, Perng RP. Effect of body position on gas exchange in patients with unilateral central airway lesions. Down with the good lung?. Chest 1993, 103:787-791. 10.1378/chest.103.3.787, 8449069.
8. Wang M, He J, Mei B, Ma X, Huo Z. Therapeutic effects and anti-inflammatory mechanisms of heparin on acute lung injury in rabbits. Acad Emerg Med 2008, 15:656-63. 10.1111/j.1553-2712.2008.00146.x, 19086324.
9. Tausch L, Henkel A, Siemoneit U, Poeckel D, Kather N, Franke L, Hofmann B, Schneider G, Angioni C, Geisslinger G, Skarke C, Holtmeier W, Beckhaus T, Karas M, Jauch J, Werz O. Identification of human cathepsin G as a functional target of boswellic acids from the anti-inflammatory remedy frankincense. J Immunol 2009, 183:3433-42. 10.4049/jimmunol.0803574, 19648270.
10. Attucci S, Korkmaz B, Juliano L, Hazouard E, Girardin C, Brillard-Bourdet M, Réhault S, Anthonioz P, Gauthier F. Measurement of free and membrane-bound cathepsin G in human neutrophils using new sensitive fluorogenic substrates. Biochem J 2002, 366:965-70. 1222843, 12088507.
11. Weber C, Erl W, Pietsch A, Weber PC. Aspirin inhibits nuclear factor-kappa B mobilization and monocyte adhesion in stimulated human endothelial cells. Circulation 1995, 91:1914-1917.
12. Wang XD, Andersson R, Soltesz V, Bengmark S. Bacterial translocation after major hepatectomy in patients and rats. Arch Surg 1992, 127:1101-1106.
13. Wang XD, Andersson R, Soltesz V, Guo W, Bengmark S. Water-soluble ethylhydroxyethyl cellulose prevents bacterial translocation induced by major liver resection in the rat. Ann Surg 1993, 217:155-167. 10.1097/00000658-199302000-00010, 1242755, 8439213.
14. Andersson R, Wang XD, Sun ZW, Deng XM, Soltesz V, Ihse I. The effect of a platelet-activating factor antagonist on pancreatitis-associated gut barrier dysfunction in rats. Pancreas 1998, 17:107-119. 10.1097/00006676-199808000-00001, 9700940.
15. Deng XM, Wang XD, Andersson R. Endothelial barrier resistance in multiple organs after septic and non-septic challenges in the rat. J Appl Physiol 1995, 78:2052-2061.
16. Wang XD, Zhao X, Shi CB, Börjesson A, Chen Z, Axelsson J, Zhao H, Andersson R. Potential mechanisms and significance of acute pancreatitis-associated liver injury. Scand J Gastroenterol 2006, 41:604-13. 10.1080/00365520500347105, 16638705.
17. Deng XM, Wang XD, Lasson T, Sun ZW, Soltesz V, Andersson R. The involvement of multiple protease-antiprotease systems and gut origin sepsis in zymosan-associated endothelial barrier injury and multiple organ dysfunction in rats. Shock 2001, 16:298-303. 10.1097/00024382-200116040-00012, 11580114.
18. Tanaka S, Nishiumi S, Nishida M, Mizushina Y, Kobayashi K, Masuda A, Fujita T, Morita Y, Mizuno S, Kutsumi H, Azuma T, Yoshida M. Vitamin K3 attenuates lipopolysaccharide-induced acute lung injury through inhibition of nuclear factor-kappaB activation. Clin Exp Immunol 2010, 160:283-92. 2857952, 20030669.
19. Nathens AB, Bitar R, Davreux C, Bujard M, Marshall JC, Dackiw AP, Watson RW, Rotstein OD. Pyrrolidine dithiocarbamate attenuates endotoxin-induced acute lung injury. Am J Respir Cell Mol Biol 1997, 17:608-16.
20. Kan SH, Huang F, Tang J, Gao Y, Yu CL. Role of intrapulmonary expression of inducible nitric oxide synthase gene and nuclear factor kappaB activation in severe pancreatitis-associated lung injury. Inflammation 2010, 33:287-94. 10.1007/s10753-010-9184-5, 20143141.
21. Zeni F, Freeman B, Natanson C. Anti-inflammatory therapies to treat sepsis and septic shock: a reassessment. Crit Care Med 1997, 25:1095-1100. 10.1097/00003246-199707000-00001, 9233726.
22. Christman JW, Holden EP, Blackwell TS. Strategies for blocking the systemic effects of cytokines in the sepsis syndrome. Crit Care Med 1995, 23:955-963. 10.1097/00003246-199505000-00027, 7736757.
23. Wang XD, Wang Y, Zhao X, Andersson R, Song Z, Yang D. Potential effects of peroxisome proliferator-activated receptor activator on LPS-induced lung injury in rats. Pulm Pharmacol Ther 2009, 22:318-25. 10.1016/j.pupt.2009.01.004, 19489131.
24. Kabay B, Teke Z, Aytekin FO, Yenisey C, Bir F, Sacar M, Erdem E, Ozden A. Pyrrolidine dithiocarbamate reduces lung injury caused by mesenteric ischemia/reperfusion in a rat model. World J Surg 2007, 31:1707-15. 10.1007/s00268-007-9112-5, 17551782.
25. Lindström P, Lerner R, Palmblad J, Patarroyo M. Rapid adhesive responses of endothelial cells and of neutrophils induced by leukotriene B4 are mediated by leucocytic adhesion protein CD18. Scand J Immunol 1990, 31:737-44. 10.1111/j.1365-3083.1990.tb02825.x, 1972589.
26. Meliton AY, Muñoz NM, Meliton LN, Binder DC, Osan CM, Zhu X, Dudek SM, Leff AR. Cytosolic group IVa phospholipase A2 mediates IL-8/CXCL8-induced transmigration of human polymorphonuclear leukocytes in vitro. J Inflamm (Lond) 2010, 18(7):14.
27. Di Cioccio V, Strippoli R, Bizzarri C, Troiani G, Cervellera MN, Gloaguen I, Colagrande A, Cattozzo EM, Pagliei S, Santoni A, Colotta F, Mainiero F, Bertini R. Key role of proline-rich tyrosine kinase 2 in interleukin-8 (CXCL8/IL-8)-mediated human neutrophil chemotaxis. Immunology 2004, 111:407-15. 10.1111/j.1365-2567.2004.01822.x, 1782435, 15056377.
28. Lynn WA, Raetz CR, Qureshi N, Golenbock DT. Lipopolysaccharide-induced stimulation of CD11b/CD18 expression on neutrophils. Evidence of specific receptor-based response and inhibition by lipid A-based antagonists. J Immunol 1991, 147:3072-9.
29. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000, 342:1334-1349. 10.1056/NEJM200005043421806, 10793167.
30. Bhatia M, Moochhala S. Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol 2004, 202:145-156. 10.1002/path.1491, 14743496.
31. Schwartz MD, Moore EE, Moore FA, Shenkar R, Moine P, Haenel JB, Abraham E. Nuclear factor- B is activated in alveolar macrophages from patients with acute respiratory distress syndrome. Crit Care Med 1996, 24:1285-1292. 10.1097/00003246-199608000-00004, 8706481.
32. Tyrrell DJ, Horne AP, Holme KR, Preuss JM, Page CP. Heparin in inflammation: potential therapeutic applications beyond anticoagulation. Adv Pharmacol 1999, 46:151-208.
33. Farrokhnia N, Roos MW, Terént A, Lennmyr F. Differential early mitogen-activated protein kinase activation in hyperglycemic ischemic brain injury in the rat. Eur J Clin Invest 2005, 35:457-463. 10.1111/j.1365-2362.2005.01512.x, 16008548.
34. Everhart MB, Han W, Sherrill TP, Arutiunov M, Polosukhin VV, Burke JR, Sadikot RT, Christman JW, Yull FE, Blackwell TS. Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury. J Immunol 2006, 176:4995-5005.
35. De Rosa S, Cirillo P, Paglia A, Sasso L, Di Palma V, Chiariello M. Reactive oxygen species and antioxidants in the pathophysiology of cardiovascular disease: does the actual knowledge justify a clinical approach?. Curr Vasc Pharmacol 2010, 8:259-75. 10.2174/157016110790887009, 19758111.
36. Watanabe K, Kazakova I, Furniss M, Miller SC. Dual activity of pyrrolidine dithiocarbamate on kappaB-dependent gene expression in U937 c. Cell Signal 1999, 11:371-83. 10.1016/S0898-6568(99)00022-4, 10376811.
37. Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC, Woscholski R, Parker PJ, Waterfield MD. Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem 2001, 70:535-602. 10.1146/annurev.biochem.70.1.535, 11395417.
38. Liu Y, Jiang N, Wu J, Dai W, Rosenblum JS. Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects. J Biol Chem 2007, 282:2505-11.
39. Sunil Y, Ramadori G, Raddatzc D. Influence of NFkappaB inhibitors on IL-1beta-induced chemokine CXCL8 and -10 expression levels in intestinal epithelial cell lines: glucocorticoid ineffectiveness and paradoxical effect of PDTC. Int J Colorectal Dis 2010, 25:323-33. 10.1007/s00384-009-0847-3, 2814033, 19921217.