Identification of human cathepsin G as a functional target of Boswellic acids from the anti-inflammatory remedy frankincense

Journal of Immunology

Volumn 183, Issue 5, 2009, Pages 3433-3442

  Tausch, Lars ^a   Henkel, Arne ^b   Siemoneit, Ulf ^b   Poeckel, Daniel ^b   Kather, Nicole ^c   Franke, Lutz ^a   Hofmann, Bettina ^a   Schneider, Gisbert ^a   Angioni, Carlo ^d   Geisslinger, Gerd ^d   Skarke, Carsten ^d   Holtmeier, Wolfgang ^d   Beckhaus, Tobias ^a   Karas, Michael ^a   Jauch, Johann ^c   Werz, Oliver ^b  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

^d UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

[2 [3 [METHYL [1 (2 NAPHTHOYL) PIPERIDIN 4 YL] AMINO] CARBONYL] 2 NAPHTHYL] 1 (1 NAPHTHYL) 2 OXOETHYLPHOSPHONIC ACID; BOSWELLIA SERRATA EXTRACT; BOSWELLIC ACID; CALCIUM ION; CATHEPSIN G; CHYMASE; CHYMOTRYPSIN; JNJ 10311795; LEUKOCYTE ELASTASE; MYELOBLASTIN; SEPHAROSE; SERINE PROTEINASE INHIBITOR; TRYPTASE; UNCLASSIFIED DRUG; 11 KETO BOSWELLIC ACID; 11-KETO-BOSWELLIC ACID; CATHEPSIN; NONSTEROID ANTIINFLAMMATORY AGENT; PLANT EXTRACT; SERINE PROTEINASE; TRITERPENE;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING SITE; BOSWELLIA; CHEMOTAXIS; COMPETITIVE INHIBITION; CONTROLLED STUDY; CROHN DISEASE; DRUG BLOOD LEVEL; DRUG STRUCTURE; ENZYME ACTIVITY; EX VIVO STUDY; FRANKINCENSE; HUMAN; HUMAN CELL; IC 50; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MEDICINAL PLANT; MOLECULAR DOCKING; NEUTROPHIL; PRECIPITATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN TARGETING; SINGLE DRUG DOSE; THROMBOCYTE; AMINO ACID SEQUENCE; ANIMAL; BINDING COMPETITION; BLOOD; CLINICAL TRIAL; DRUG ANTAGONISM; DRUG DELIVERY SYSTEM; DRUG EFFECT; HYDROLYSIS; METABOLISM; MOLECULAR GENETICS; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PHASE 3 CLINICAL TRIAL; PHYSIOLOGY; PROTEIN BINDING;

ADULT; AMINO ACID SEQUENCE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BINDING, COMPETITIVE; BOSWELLIA; CATHEPSINS; DRUG DELIVERY SYSTEMS; HUMANS; HYDROLYSIS; MOLECULAR SEQUENCE DATA; PLANT EXTRACTS; PROTEIN BINDING; SERINE ENDOPEPTIDASES; TRITERPENES;

EID: 70349260405     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0803574     Document Type: Article

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