Therapeutic effects and anti-inflammatory mechanisms of heparin on acute lung injury in rabbits

Academic Emergency Medicine

Volumn 15, Issue 7, 2008, Pages 656-663

  Wang, Meitang ^a   He, Jian ^a   Mei, Bin ^a   Ma, Xiuqiang ^a   Huo, Zhenglu ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Acute lung injury (ALI); Acute respiratory distress syndrome (ARDS); Heparin; Low molecular weight heparin (LMWH); Nuclear factor B (NF B); p38 mitogen activated protein kinase (p38 MAPK); Tumor necrosis factor (TNF )

Indexed keywords

DALTEPARIN; HEPARIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; LOW MOLECULAR WEIGHT HEPARIN; MITOGEN ACTIVATED PROTEIN KINASE P38; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTERIAL OXYGEN TENSION; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; LUNG ALVEOLUS OXYGEN TENSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT;

ACUTE LUNG INJURY; ANALYSIS OF VARIANCE; ANIMALS; HEPARIN; HEPARIN, LOW-MOLECULAR-WEIGHT; NF-KAPPA B; OXYGEN; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RABBITS; STATISTICS, NONPARAMETRIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 56849090241     PISSN: 10696563     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1553-2712.2008.00146.x     Document Type: Article

References (15)

1. Zhang P, Martin M, Michalek SM, Katz J. Role of mitogen-activated protein kinases and NF-kappa B in the regulation of pro-inflammatory and anti-inflammatory cytokines by porphyromonas gingivalis Hemagglutinin B. Infect Immun. 2005; 73:3990-8.
2. Schwartz MD, Moore EE, Moore FA, et al. Nuclear factor-kappaB is activated in alveolar macrophages from patients with acute respiratory distress syndrome. Crit Care Med. 1996; 24(8):1285-92.
3. Abraham E. Coagulation abnormalities in acute lung injury and sepsis. Am J Respir Cell Mol Biol. 2000; 22:401-4.
4. Liu YG, Li CS. Coagulation dysfunctions in patients with systemic inflammatory response syndrome. Zhonghua Nei Ke Za Zhi. 2004; 43:94-7.
5. Haslett C, Guthrie LA, Kopaniak MM, Johnston RB Jr, Henson PM. Modulation of multiple neutrophil functions by preparative methods of trace concentration of bacterial LPS. Am J Pathol. 1985; 119:101-10.
6. Nishina K, Mikawa K, Takao Y, Maekawa N, Shiga M, Obara H. ONO-5046, an elastase inhibitor, attenuates endotoxin-induced acute lung injury in rabbits. Anesth Analg. 1997; 84:1097-103.
7. Luan B, Zhang Z, Wu Y, Kang J, Pei G. Beta-arrestin2 functions as a phosphorylation-regulated suppressor of UV-induced NF-kappaB activation. EMBO J. 2005; 24:4237-46.
8. Jia L, Wang C, Pang BS, Dai HP, Huang KW. The changes of anticoagulant protein in acute lung injury and therapeutic effects of heparin on acute lung injury in rabbits. Chin J Tuberc Respir Dis. 2003; 26:641-2.
9. Fisher CJ, Yan SB. Protein C levels as a prognostic indicator of outcome in sepsis and related diseases. Crit Care Med. 2000; 9(suppl):S49-S56.
10. Vincent JL. New therapeutic implications of anticoagulation mediator replacement in sepsis and acute respiratory distress syndrome. Crit Care Med. 2000; 28:S83-5.
11. Gando S, Kameue T, Matsuda N, et al. Imbalances between the levels of tissue factor and tissue factor pathway inhibitor in ARDS patients. Thromb Res. 2003; 109:119-24.
12. Tyrrell DJ, Horne AP, Holme KR, Preuss JM, Page CP. Heparin in inflammation: potential therapeutic applications beyond anticoagulation. Adv Pharmacol. 1999; 46:151-208.
13. Farrokhnia N, Roos MW, Terent A, Lennmyr F. Differential early mitogen-activated protein kinase activation in hyperglycemic ischemic brain injury in the rat. Eur J Clin Invest. 2005; 35:457-63.
14. Kang JL, Park W, Pack IS, et al. Inhaled nitric oxide attenuates acute lung injury via inhibition of nuclear factor-κB and inflammation. J Appl Physiol. 2002; 92:795-801.
15. Miskolci V, Rollins J, Vu HY, Ghosh CC, Davidson D, Vancurova I. NFkappaB is persistently activated in continuously stimulated human neutrophils. Mol Med. 2007; 13:134-42.