Potential mechanisms and significance of acute pancreatitis-associated liver injury

Scandinavian Journal of Gastroenterology

Volumn 41, Issue 5, 2006, Pages 604-613

  Wang, Xiangdong ^a,d   Zhao, Xia ^a   Shi, Changbin ^a   Börjesson, Anna ^b   Chen, Zhi ^c   Axelsson, Jakob ^b   Zhao, Hong ^a   Andersson, Roland ^b  

^a FUDAN UNIVERSITY   (China)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d NONE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE PANCREATITIS; APOPTOSIS; ASCITES FLUID; CELL DEATH; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; EVIDENCE BASED MEDICINE; HUMAN; INFLAMMATION; KUPFFER CELL; LIVER CELL; LIVER INJURY; LIVER METABOLISM; LUNG INJURY; MEDIATOR RELEASE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ACUTE DISEASE; ANIMALS; APOPTOSIS; DISEASE MODELS, ANIMAL; DOGS; ENDOTHELIAL CELLS; HUMANS; KUPFFER CELLS; LIVER; NECROSIS; PANCREATITIS;

EID: 33646493492     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.1080/00365520500347105     Document Type: Review

References (79)

1. Rau B, Pralle U, Uhl W, Schoenberg MH, Beger HG. Management of sterile necrosis in instances of severe acute pancreatitis. J Am Coll Surg 1995;181:279-88.
2. Neoptolemos JP, Raraty M, Finch M, Sutton R. Acute pancreatitis: the substantial human and financial costs. Gut 1998;42:886-91.
3. Raraty MGT, Connor S, Criddle DN, Dphil RS, Neoptolemos JP. Acute pancreatitis and organ failure: pathophysiology, natural history, and management strategies. Curr Gastroenterol Rep 2004;6:99-103.
4. Johnson CD, Kingsnorth AN, Imrie CW, McMahon MJ, Neoptolemos JP, McKay C, et al. Double-blind, randomised, placebo-controlled study of a platelet activating factor antagonist, lexipafant, in the treatment and prevention of organ failure in predicted severe acute pancreatitis. Gut 2001;48:62-9.
5. Uhl W, Buchler MW, Malfertheiner P, Beger HG, Adler G, Gaus W. A randomised, double-blind, multicentre trial of octreotide in moderate to severe acute pancreatitis. Gut 1999;45:97-104.
6. Mutinga M, Rosenbluth A, Tenner SM, Odze RR, Sica GT, Banks PA. Does mortality occur early or late in acute pancreatitis? Int J Pancreatol 2000;28:91-5.
7. McKay CJ, Evans S, Sinclair M, Carter CR, Imrie CW. High early mortality rate from acute pancreatitis in Scotland, 1984-1995. Br J Surg 1999;86:1302-5.
8. Stenberg W, Tenner S. Acute pancreatitis. N Engl J Med 1994;330:1198-210.
9. Wilson C, Auld CD, Schlinkert R, Hasan AH, Imrie CW, MacSween RN, et al. Hepatobiliary complications in chronic pancreatitis. Gut 1989;30:520-7.
10. Dutta SK, Mobrahan S, Iber FL. Associated liver disease in alcoholic pancreatitis. Am J Dig Dis 1978;23:618-22.
11. Halonen KI, Pettila V, Leppaniemi AK, Kemppainen EA, Puolakkainen PA, Haapiainen RK. Multiple organ dysfunction associated with severe acute pancreatitis. Crit Care Med 2002;30:1274-9.
12. Truhart H. Pankreas, pathologie, pt. 1. Weisbaden, Germany: HLdrbd; 1902.
13. Eloesser L. Die in den letzten 10 jahren an der Heidelberger chir. Klinik beobachteten faille von pankreaskrankungen. Med U Chir 1907;18:195-294.
14. Adamski J. Lebernekrosen bei pankreasfettsgewebsnekrosen, Inaugural dissertation, München, 1912.
15. Archibald E. The experimental production of pancreatitis in animals as the result of resistance of the common duct sphincter. Surg Gynecol Obstet 1919;28:529-45.
16. Dos Reis L. Visceral lesions in acute pancreatitis. Arch Surg 1963;87:604-8.
17. Anderson MC. Hepatic morphology and function, alterations associated with acute pancreatitis. Arch Surg 1965;92:664-71.
18. Lankisch PG, Blum T, Maisonneuve P, Lowenfels AB. Severe acute pancreatitis: when to be concerned? Pancreatology 2003;3:102-10.
19. Schiller W. Liver cell fat necrosis caused by pancreatic reflux. Surg Gynecol Obstet 1941;27:78-80.
20. Kerin RJ, Katzenstein R. Liver disease in chronic relapsing pancreatitis. Meriden Hosp Bull 1949;3:13-22.
21. Fisher ER, McCloy D. Hepatic lesions of acute hemorrhagic pancreatitis. Surgery 1955;37:213-9.
22. Meyers MA, Oliphant M, Berne AS, Feldberg MA. The peritoneal ligaments and mesenteries: pathways of intraabdominal spread of disease. Radiology 1987;165:593-604.
23. Fujiwara T, Takehara Y, Ichijo K, Tooyama N, Kodaira N, Yamamoto H, et al. Anterior extension of acute pancreatitis: CT findings. J Comput Assist Tomogr 1995;19:963-6.
24. Siegelman SS, Copeland BE, Saba GP, Cameron JL, Sanders RC, Zerhouni EA. CT of fluid collections associated with pancreatitis. AJR 1980;134:1121-32.
25. Arita T, Matsunaga N, Takano K, Hara A, Fujita T, Honjo K. Hepatic perfusion abnormalities in acute pancreatitis: CT appearance and clinical importance. Abdominal Imaging 1999;24:157-62.
26. Isogai M, Yamaguchi A, Hori A, Nakano S. Hepatic histopathological changes in biliary pancreatitis. Am J Gastroenterol 1995;90:449-54.
27. Talvinen KA, Kemppainen EA, Nevalainen TJ. Expression of group II phospholipase A2 in the liver in acute pancreatitis. Scand J Gastroenterol 2001;36:1217-21.
28. Tuzhilin SA, Podolsky AE, Dreiling DA. Hepatic lesions in pancreatitis. Clinicoexperimental data. Am J Gastroenterol 1975;64:108-14.
29. Chen H, Hwang T, Chen M. The effect of gabexate mesilate on pancreatic and hepatic microcirculation in acute experimental pancreatitis in rats. J Surg Res 1996;66:147-53.
30. Andrzejewska A, Dlugosz JW, Jurkowska G. The liver ultrastructure in cerulein and taurocholate acute pancreatitis in the rats [abstract]. Rocz Akad Med Bialymst 1998;43:117-36.
31. Takeyama Y, Hori Y, Takase K, Ueda T, Yamamoto M, Kuroda Y. Apoptotic cell death of hepatocytes in rat experimental severe acute pancreatitis. Surgery 2000;127:55-64.
32. Rinderknecht H. Acute necrotizing pancreatitis and its complications, and excessive reaction of natural defence mechanisms? In: The pathogenesis of acute pancreatitis. Manchester: University Press; 1991. pp 86-100.
33. Jacobs ML, Daggett WM, Civetta JM, Vasu MA, Lawson DW, Warshaw AL, et al. Acute pancreatitis: analysis of factors influencing survival. Ann Surg 1977;185:43-51.
34. Robertson CS, Basran GS, Hardy JG. Lung vascular permeability in patients with acute pancreatitis. Pancreas 1988;3:162-5.
35. Zhao X, Andersson R, Wang X, Dib M, Wang XD. Acute pancreatitis- associated lung injury: pathophysiological mechanisms and potential future therapies. Scand J Gastroenterol 2002;37:1351-8.
36. Gray KD, Simovic MO, Christman JW, Blackwell TS, May AK, Chapman WC, et al. Pancreatitis-induced lung injury: mechanism of injury involves hepatic NF-KB and cytokine mediated pathways [abstract]. J Surg Res 2003;114:292.
37. Jaffray C, Mendez C, Denham W, Carter G, Norman J. Specific pancreatic enzymes activate macrophages to produce tumor necrosis factor-alpha: role of nuclear factor kappa B and inhibitory kappa B proteins. J Gastrointest Surg 2000;4:370-7.
38. Closa D, Bardaji M, Hotter G, Prats N, Gelpi E, Fernandez-Cruz L, et al. Hepatic involvement in pancreatitis-associated lung damage. Am J Physiol 1996;270:G6-13.
39. Gray KD, Simovic MO, Chapman WC, Blackwell TS, Cristman JW, Washington MK, et al. Systemic NF-κB activation in a transgenic mouse model of acute pancreatitis. J Surg Res 2003;110:310-4.
40. Murr MM, Yang J, Fier A, Kaylor P, Mastorides S, Norman JG. Pancreatic elastase induces liver injury by activating cytokine production within Kupffer cells via nuclear factor-kappa B. J Gastrointest Surg 2002;6:474-80.
41. Norman JG, Fink GW, Denham W, Yang J, Carter G, Sexton C, et al. Tissue-specific cytokine production during experimental acute pancreatitis: a probable mechanism for distant organ dysfunction. Dig Dis Sci 1997;42:1783-8.
42. Jaffray C, Yang J, Norman J. Elastase mimics pancreatitis-induced hepatic injury via inflammatory mediators. J Surg Res 2000;90:95-101.
43. Hori Y, Takeyama Y, Ueda T, Shinkai M, Takase K, Kuroda Y. Macrophage-derived transforming growth factor-beta1 induces hepatocellular injury via apoptosis in rat severe acute pancreatitis. Surgery 2000;127:641-9.
44. Closa D, Sabater L, Fernandez-Cruz L, Prats N, Gelpi E, Rosello-Catafau J. Activation of alveolar macrophages in lung injury associated with experimental acute pancreatitis is mediated by the liver. Ann Surg 1999;229:230-6.
45. Gilgenast O, Brandt-Nedelev B, Wiswedel I, Lippert H, Halangk W, Reinheckel T. Differential oxidative injury in extrapancreatic tissue during experimental pancreatitis. Dig Dis Sci 2001;46:932-7.
46. Wang XD, Andersson R, Soltesz V, Leveau P, Ihse I. Gut origin sepsis, macrophage function, and oxygen extraction associated with acute pancreatitis in the rat. World J Surg 1996;20:299-308.
47. Gloor B, Todd KE, Lane JS, Lewis MP, Reber HA. Hepatic Kupffer cell blockade reduced mortality in acute hemorrhagic pancreatitis in mice. J Gastrointest Surg 1998;2:430-5.
48. Gloor B, Blinman TA, Rigberg DA, Todd KE, Lane JS, Hines OJ, et al. Kupffer cell blockade reduces hepatic and systemic cytokine levels and lung injury in hemorrhagic pancreatitis in rats. Pancreas 2000;21:414-20.
49. Yang J, Fier A, Carter Y, Liu G, Epling-Burnette PK, Bai F, et al. Liver injury during acute pancreatitis: the role of pancreatitis-associated ascitic fluid (PAAF), p38-MAPK, and caspase-3 in inducing hepatocyte apoptosis. J Gastrointest Surg 2003;7:200-7.
50. Murr MM, Yang J, Fier A, Gallagber SF, Carter G, Gower WR, et al. Regulation of Kupffer cell TNF gene expression during experimental acute pancretitis: the role of p38MAPK, ERK1/2, SAPK/JNK, and NF-κB. J Gastrointest Surg 2003;7:20-5.
51. Wang XD, Börjesson A, Sun ZW, Wallén R, Deng XM, Zhang HY, et al. The association of type II pneumocytes and endothelial permeability with the pulmonary cystocyte system in experimental acute pancreatitis. Eur J Clin Invest 1998;28:778-85.
52. Leindler L, Morschl E, Laszlo F, Mandi Y, Takacs T, Jarmai K, et al. Importance of cytokines, nitric oxide, and apoptosis in the pathological process of necrotizing pancreatitis in rats. Pancreas 2004;29:157-61.
53. Gukovskaya AS, Perkins P, Zaninovic V, Sandoval D, Rutherford R, Fitzsimmons T, et al. Mechanisms of cell death after pancreatic duct obstruction in the opossum and the rat. Gastroenterology 1996;110:875-84.
54. Kaiser AM, Saluja AK, Lu L, Yamanaka K, Yamaguchi Y, Steer ML. Effects of cycloheximide on pancreatic endonuclease activity, apoptosis, and severity of acute pancreatitis. Am J Physiol 1996;271:C982-93.
55. Kaiser AM, Saluja AK, Sengupta A, Saluja M, Steer ML. Relationship between severity, necrosis, and apoptosis in five models of experimental acute pancreatitis. Am J Physiol 1995;269:C1295-304.
56. Bhatia M. Apoptosis versus necrosis in acute pancreatitis. Am J Physiol 2004;286:G189-96.
57. Andersson R, Wang XD. Patterns of pancreatic cell death: apoptosis versus oncosis. Pancreas 1998;17:281-8.
58. Yang J, Denham W, Carter G, Tracey KJ, Norman J. Macrophage pacification reduces rodent pancreatitis-induced hepatocellular injury through down-regulation of hepatic tumor necrosis factor and interleukin-1β. Hepatology 1998;28:1282-90.
59. Ueda T, Takeyama Y, Takase K, Hori Y, Kuroda Y, Ho HS. Hematin is one of the cytotoxic factors in pancreatitis-associated ascitic fluid that causes hepatocellular injury. Surgery 2002;131:66-74.
60. Barros LF, Hermosilla T, Castro J. Necrotic volume increase and the early physiology of necrosis. Comp Biochem Physiol A Mol Integr Physiol 2001;130:401-9.
61. Berridge MJ, Bootman MD, Roderick HL. Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 2003;4:517-29.
62. Ueda T, Ho HS, Anderson SE, Takeyama Y. Pancreatitis-induced ascitic fluid and hepatocellular dysfunction in severe acute pancreatitis. J Surg Res 1999;82:305-11.
63. Ueda T, Takeyama Y, Hori Y, Takase K, Goshima M, Kuroda Y. Pancreatitis-associated ascitic fluid increases intracellular Ca(2+) concentration on hepatocytes. J Surg Res 2000;93:171-6.
64. Dholakia K, Pitchumoni CS, Agarwal N. How often are liver function tests normal in acute biliary pancreatitis? J Clin Gastroenterol 2004;38:81-3.
65. Yadav D, Nair S, Norkus EP, Pitchumoni CS. Nonspecific hyperamylasemia and hyperlipasemia in diabetic ketoacidosis: incidence and correlation with biochemical abnormalities. Am J Gastroenterol 2000;95:3123-8.
66. Isogai M, Yamaguchi A, Hori A, Kaneoka Y. LDH to AST ratio in biliary pancreatitis - a possible indicator of pancreatic necrosis: preliminary results. Am J Gastroenterol 1998;93:363-7.
67. Murr MM, Yang J, Fier A, Foulis PR, Loughorn TP Jr, Epling-Burnette PK, et al. Pancreatitis-associated ascitic fluid induces hepatocyte death independent of local cytokines. J Surg Res 2002;106:308-13.
68. Hartleb M, Nowak A, Nowakowska-Dulawa E, Manczyk I, Becker A, Kacperek T. Effect of acute biliary pancreatitis on liver metabolism of phenazone [abstract]. Pol Arch Med Wewn 1990;83:104-10.
69. Bielecki JW, Dlugosz J, Pawlicka E, Gabryelewicz A. The effect of pancreatitis associated ascitic fluid on some functions of rat liver mitochondria. A possible mechanism of the damage to the liver in acute pancreatitis. Int J Pancreatol 1989;5:145-56.
70. Coticchia JM, Lessler MA, Carey LC, Gower WR, Mayer AD, McMahon MJ. Peritoneal fluid in human acute pancreatitis blocks hepatic mitochondrial respiration. Surgery 1986;100:850-6.
71. Coticchia JM, Lessler MA, Ellison EC, Carey LC. Mitochondrial dysfunction induced by pancreatitis-associated ascitic fluid. Proc Soc Exp Biol Med 1983;172:412-8.
72. Hori Y, Takeyama Y, Ueda T, Nishikawa J, Yamamoto M, Saitoh Y. Impaired transport of lipopolysaccharide across the hepatocytes in rats with cerulein-induced experimental pancreatitis. Pancreas 1998;16:148-53.
73. Migita K, Abiru S, Nakamura M, Komori A, Yoshida Y, Yokoyama T, et al. Lipopolysaccharide signaling induces serum amyloid A (SAA) synthesis in human hepatocytes in vitro. FEBS Lett 2004;569:235-9.
74. Yan LN, Ozawa K, Kobayashi N. Changes in hepatic energy metabolism in experimental acute pancreatitis. Chin Med J (Engl) 1992;105:684-8.
75. Ho HS, Ueda T, Liu H. The impacts of experimental necrotizing pancreatitis on hepatocellular ion homeostasis and energetics: An in vivo nuclear magnetic resonance study. Surgery 1998;124:372-9.
76. Hirano T, Manabe T, Tobe T. Impaired hepatic energy metabolism in rat acute pancreatitis: protective effects of prostaglandin E2 and synthetic protease inhibitor ONO 3307. J Surg Res 1992;53:238-44.
77. Yang J, Gallagher SF, Haines K, Epling-Burnette PK, Bai F, Gower WR, Jr, et al. Kupffer cell-derived Fas ligand plays a role in liver injury and hepatocyte death. J Gastrointest Surg 2004;8:166-74.
78. Zhao H, Zhao X, Bai CX, Wang XD. Potential factors of interorgan signals in the development of pancreatitis-associated acute lung injury and acute respiratory distress syndrome. J Organ Dysfunction 2005;1:32-44.
79. Andersson R, Wang XD. Significance of gut barrier dysfunction in the development of MODS. J Organ Dysfunction 2005; in press.