Polo-like kinases inhibited by Wortmannin: Labeling site and downstream effects

Journal of Biological Chemistry

Volumn 282, Issue 4, 2007, Pages 2505-2511

  Liu, Yongsheng ^a   Jiang, Ning ^b   Wu, Jiangyue ^a   Dai, Wei ^c   Rosenblum, Jonathan S ^a,d  

^a ACTIVX BIOSCIENCES INC   (United States)

^b NEW YORK MEDICAL COLLEGE   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DAMAGE; LIVE CELLS; MITOSIS; WORTMANNIN;

ADENOSINETRIPHOSPHATE; AMINES; BINDING SITES; CELL GROWTH; DNA;

ENZYME INHIBITION;

ADENOSINE TRIPHOSPHATE; AX 7503; PHOSPHATIDYLINOSITOL 3 KINASE; POLO LIKE KINASE; POLO LIKE KINASE 1; POLO LIKE KINASE 3; PROTEIN P53; SERINE; TETRAMETHYLRHODAMINE ETHYL ESTER; UNCLASSIFIED DRUG; WORTMANNIN; ANDROSTANE DERIVATIVE; FUSED HETEROCYCLIC RINGS; LYSINE; PLK3 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; RHODAMINE;

ARTICLE; BINDING SITE; CELL CYCLE REGULATION; CHEMICAL LABELING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DOWNSTREAM PROCESSING; DRUG EFFECT; DRUG TARGETING; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; AMINO ACID SEQUENCE; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; ENZYME SPECIFICITY; GENETICS; MOLECULAR GENETICS; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; ANDROSTADIENES; BINDING SITES; CELL LINE; DNA DAMAGE; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; LYSINE; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RHODAMINES; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY;

EID: 34047276295     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M609603200     Document Type: Article

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