Role of intrapulmonary expression of inducible nitric oxide synthase gene and nuclear factor κb activation in severe pancreatitis-associated lung injury

Inflammation

Volumn 33, Issue 5, 2010, Pages 287-294

  Kan, Shi Hai ^a   Huang, Fei ^a   Tang, Jing ^c   Gao, Yun ^b   Yu, Chong Lin ^b  

^a BINZHOU MEDICAL UNIVERSITY   (China)

^b SOUTHWEST MEDICAL UNIVERSITY   (China)

^c Department of Laboratory Medicine   (China)

Author keywords

iNOS; lung injury; NF B; pancreatitis

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; PYRROLIDINE DITHIOCARBAMATE;

ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE LOCATION; LUNG INJURY; LUNG PARENCHYMA; MALE; NONHUMAN; PANCREAS; RAT; SHAM PROCEDURE;

ACUTE DISEASE; AMYLASES; ANIMALS; BIOLOGICAL MARKERS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IMMUNOHISTOCHEMISTRY; LUNG; LUNG INJURY; MALE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PANCREAS; PANCREATITIS; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; THIOCARBAMATES; TIME FACTORS; TRANSCRIPTION FACTOR RELA;

RATTUS;

EID: 77956056894     PISSN: 03603997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10753-010-9184-5     Document Type: Article

References (21)

1. H Algul M Treiber M Lesina H Nakhai D Saur F Geisler A Pfeifer S Paxian RM Schmid 2007 Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis Journal of Clinical Investigation 117 1490 1501 10.1172/JCI29882 17525802
2. P Renzulli SM Jakob M Tauber D Candinas B Gloor 2005 Severe acute pancreatitis: case-oriented discussion of interdisciplinary management Pancreatology 5 145 156 10.1159/000085266 15849485
3. M Hirota H Sugita K Maeda A Ichibara M Ogawa 2004 Concept of SIRS and severe acute pancreatitis Nippon Rinsho 62 2128 2136 15552899
4. M Surbatovic K Jovanovic S Radakovic N Filipovic 2005 Pathophysiological aspects of severe acute pancreatitis-associated lung injury Srpski Arhiv za Celokupno Lekarstvo 133 76 81 10.2298/SARH0502076S 16053182
5. Z Rakonczay Jr P Hegyi T Takacs J McCarroll AK Saluja 2008 The role of NF-kappaB activation in the pathogenesis of acute pancreatitis Gut 57 259 267 10.1136/gut.2007.124115 1:CAS:528:DC%2BD1cXisVyjsLg%3D 17675325
6. KD Gray MO Simovic TS Blackwell JW Christman AK May KS Parman WC Chapman SC Stain 2006 Activation of nuclear factor kappa B and severe hepatic necrosis may mediate systemic inflammation in choline-deficient/ethionine-supplemented diet-induced pancreatitis Pancreas 33 260 267 10.1097/01.mpa.0000240599.95817.34 1:CAS:528:DC%2BD28XhtFertL7L 17003648
7. HY Pang G Liu GT Liu 2009 Compound FLZ inhibits lipopolysaccharide- induced inflammatory effects via down-regulation of the TAK-IKK and TAK-JNK/p38MAPK pathways in RAW264.7 macrophages Acta Pharmacologica Sinica 30 209 218 10.1038/aps.2008.29 1:CAS:528:DC%2BD1MXhsVClurw%3D 19169268
8. XP Zhang L Zhang LJ Chen QH Cheng JM Wang W Cai HP Shen J Cai 2007 Influence of dexamethasone on inflammatory mediators and NF-kappaB expression in multiple organs of rats with severe acute pancreatitis World Journal of Gastroenterology 13 548 556 10.3748/wjg.13.6385 17278220
9. AD Ang S Adhikari SW Ng M Bhatia 2008 Expression of nitric oxide synthase isoforms and nitric oxide production in acute pancreatitis and associated lung injury Pancreatology 9 150 159 10.1159/000178886 19077466
10. HJ Aho TJ Nevalainen 1980 Experimental pancreatitis in the rat. Ultrastructure of sodium taurocholate-induced pancreatic lesions Scandinavian Journal of Gastroenterology 15 417 424 10.3109/00365528009181494 1:STN:280:DyaL3M%2Fls1aitQ%3D%3D 7433904
11. TD Schmittgen KJ Livak 2008 Analyzing real-time PCR data by the comparative C(T) method Nature Protocols 3 1101 1108 10.1038/nprot.2008.73 1:CAS:528:DC%2BD1cXmvVemt7c%3D 18546601
12. G Wang B Sun Y Gao QH Meng HC Jiang 2007 The effect of emodin-assisted early enteral nutrition on severe acute pancreatitis and secondary hepatic injury Mediators of Inflammation 2007 29638 18288270
13. XP Zhang L Zhang HM Xu YP Xu QH Cheng JM Wang HP Shen 2008 Application of tissue microarrays to study the influence of dexamethasone on NF-kappaB expression of pancreas in rat with severe acute pancreatitis Digestive Diseases and Sciences 53 571 580 10.1007/s10620-007-9867-4 1:CAS:528:DC%2BD1cXhtFWktro%3D 17574527
14. M Karin 2006 Nuclear factor-kappaB in cancer development and progression Nature 441 431 436 10.1038/nature04870 1:CAS:528:DC%2BD28XkvVyrsrw%3D 16724054
15. Y Liu K Kimura R Yanai T Chikama T Nishida 2008 Cytokine, chemokine, and adhesion molecule expression mediated by MAPKs in human corneal fibroblasts exposed to poly(I:C) Investigative Ophthalmology and Visual Science 49 3336 3344 10.1167/iovs.07-0972 18660424
16. YS Choi J Hur S Jeong 2007 Beta-catenin binds to the downstream region and regulates the expression C-reactive protein gene Nucleic Acids Research 35 5511 5519 10.1093/nar/gkm547 1:CAS:528:DC%2BD2sXht1ygtb%2FJ 17704137
17. K van Erp K Dach I Koch J Heesemann R Hoffmann 2006 Role of strain differences on host resistance and the transcriptional response of macrophages to infection with Yersinia enterocolitica Physiological Genomics 25 75 84 10.1152/physiolgenomics.00188.2005 16352694
18. Y Zhang CX Shi YX Li 2005 Effect of Salviae miltiorrhizae on mRNA expression of inducible nitric oxide synthase and organ injury in rats with severe acute pancreatitis Zhongguo Zhong Xi Yi Jie He Za Zhi 25 1012 1015 16355619
19. L Leindler E Morschl F Laszlo Y Mandi T Takacs K Jarmai G Farkas 2004 Importance of cytokines, nitric oxide, and apoptosis in the pathological process of necrotizing pancreatitis in rats Pancreas 29 157 161 10.1097/00006676- 200408000-00011 1:CAS:528:DC%2BD2cXmvF2ksL4%3D 15257108
20. A Satoh T Shimosegawa K Kimura S Moriizumi A Masamune M Koizumi T Toyota 1998 Nitric oxide is overproduced by peritoneal macrophages in rat taurocholate pancreatitis: the mechanism of inducible nitric oxide synthase expression Pancreas 17 402 411 10.1097/00006676-199811000-00012 1:STN:280: DyaK1M%2FjvVKhtg%3D%3D 9821183
21. YQ Li ZX Zhang YJ Xu W Ni SX Chen Z Yang D Ma 2006 N-Acetyl-L-cysteine and pyrrolidine dithiocarbamate inhibited nuclear factor-kappaB activation in alveolar macrophages by different mechanisms Pharmacologica Sinica 27 339 346 10.1111/j.1745-7254.2006.00264.x 1:CAS:528:DC%2BD28XisFKkt74%3D