Anticancer clinical utility of the apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1)

Chinese Journal of Cancer

Volumn 29, Issue 3, 2010, Pages 333-339

  Zhang, Ying ^a   Wang, Jian ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apurinic apyrimidinic endonuclease; Gene therapy; Neoplasm

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CISPLATIN; FLOXURIDINE; FLUOROURACIL; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PLATINUM DERIVATIVE; PROTEIN P53; REDOX EFFECTOR FACTOR 1; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR AP 1;

APOPTOSIS; BLADDER CANCER; CANCER GROWTH; CANCER RESEARCH; CANCER TISSUE; CARCINOGENESIS; CLINICAL RESEARCH; DNA REPAIR; DRUG CYTOTOXICITY; DRUG TARGETING; GENE EXPRESSION REGULATION; HUMAN; NONHUMAN; OXIDATION REDUCTION REACTION; PRECANCER; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; RADIOSENSITIVITY; REVIEW; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SOLID TUMOR; TRANSCRIPTION REGULATION; TUMOR PROMOTION;

EID: 79955826078     PISSN: 1000467X     EISSN: 1944446X     Source Type: Journal    
DOI: 10.5732/cjc.009.10285     Document Type: Review

References (64)

1. Fritz G. Human APE/Ref-1 protein [J]. Int J Biochem Cell Biol, 2000, 32(9): 925-929.
2. Wilson DM, Barsky D. The major human abasic endonuclease: formation, consequences and repair of abasic lesions in DNA [J]. Mutat Res, 2001, 485(4): 283-307.
3. Demple B, Harrison L. Repair of oxidative damage to DNA: enzymology and biology [J]. Annu Rev Biochem, 1994, 63: 915-948.
4. Fan J, Wilson DM, 3rd. Protein-protein interactions and posttranslational modifications in mammalian base excision repair [J]. Free Radic Biol Med, 2005, 38(9): 1121-1138.
5. Evans AR, Limp-Foster M, Kelley MR. Going APE over ref-1 [J]. Mutat Res, 2000, 461 (2): 83-108.
6. Izumi T, Hazra TK, Boldogh I, et al. Requirement for human AP endonuclease 1 for repair of 3'-blocking damage at DNA single-strand breaks induced by reactive oxygen species [J]. Carcinogenesis, 2000, 21 (7): 1329-1334.
7. Chou KM, Cheng YC. An exonucleolytic activity of human apurinic/ apyrimidinic endonuclease on 3' mispaired DNA [J]. Nature, 2002, 415 (6872): 655-659.
8. Gros L, Ishchenko AA, Ide H, et al. The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway [J]. Nucleic Acids Res, 2004, 32(1): 73-81.
9. Xanthoudakis S, Curran T. Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity [J]. EMBO J, 1992, 11(2): 653-665.
10. Tell G, Quadrifoglio F, Tiribelli C, et al. The many functions of APE/Ref-1: not only a DNA repair enzyme [J]. Antioxid Redox Signal, 2008, 11(3): 601-620.
11. Georgiadis MM, Luo M, Gaur RK, et al. Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease [J]. Mutat Res, 2008, 643 (1-2): 54-63.
12. Luo, M., Delaplane, S., Jiang, A., et al. Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1 [J]. Antioxid Redox Signal, 2008, 10(11): 1853-1867.
13. Fujimura M, Morita-Fujimura Y, Kawase M, et al. Early decrease of apurinic/apyrimidinic endonuclease expression after transient focal cerebral ischemia in mice [J]. J Cereb Blood Flow Metab, 1999, 19(5): 495-501.
14. Hall JL, Wang X, Van A, et al. Overexpression of Ref-1 inhibits hypoxia and tumor necrosis factor-induced endothelial cell apoptosis through nuclear factor-kappab-independent and-dependent pathways [J]. Circ Res, 2001, 88(12): 1247-1253.
15. Demple B, Sung JS. Molecular and biological roles of Ape1 protein in mammalian base excision repair [J]. DNA Repair, 2005, 4(12): 1442-1449.
16. Grosch S, Fritz G, Kaina B. Apurinic endonuclease (Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation [J]. Cancer Res, 1998, 58(19): 4410-4416.
17. Grosch S, Kaina B. Transcriptional activation of apurinic/apyrimidinic endonuclease (Ape, Ref-1) by oxidative stress requires CREB [J]. Biochem Biophys Res Commun, 1999, 261(3): 859-863.
18. Ramana CV, Boldogh I, Izumi T, et al. Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals [J]. Proc Natl Acad Sci USA, 1998, 95(9): 5061-5066.
19. Hsieh MM, Hegde V, Kelley MR, et al. Activation of APE/Ref-1 redox activity is mediated by reactive oxygen species and PKC phosphorylation [J]. Nucleic Acids Res, 2001, 29(14): 3116-3122.
20. Kuninger DT, Izumi T, Papaconstantinou J, et al. Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter [J]. Nucleic Acids Res, 2002, 30(3): 823-829.
21. Tell G, Zecca A, Pellizzari L, et al. An 'environment to nucleus' signaling system operates in B lymphocytes: redox status modulates BSAP/Pax-5 activation through Ref-1 nuclear translocation [J]. Nucleic Acids Res, 2000, 28(5): 1099-1105.
22. Futagami S, Hiratsuka T, Shindo T, et al. Expression of apurinic/ apyrimidinic endonuclease-1 (APE-1) in H. pylori-associated gastritis, gastric adenoma, and gastric cancer [J]. Helicobacter, 2008, 13 (3): 209-218.
23. Di Maso V, Avellini C, Croce LS, et al. Subcellular localization of APE/Ref-1 in human hepatocellular carcinoma: possible prognostic significance [J]. Mol Med, 2007, 13(1-2): 89-96.
24. Yoo DG, Song YJ, Cho EJ, et al. Alteration of APE/Ref-1 expression in non-small cell lung cancer: the implications of impaired extracellular superoxide dismutase and catalase antioxidant systems [J]. Lung Cancer, 2008, 60(2): 277-284.
25. Puglisi F, Barbone F, Tell G, et al. Prognostic role of Ape/Ref-1 subcellular expression in stage I-III breast carcinomas [J]. Oncol Rep, 2002, 9(1): 11-17.
26. Bobola MS, Blank A, Berger MS, et al. Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas [J]. Clin Cancer Res, 2001, 7(11): 3510-3518.
27. Kakolyris S, Kaklamanis L, Engels K, et al. Human apurinic endonuclease 1 expression in a colorectal adenoma-carcinoma sequence [J]. Cancer Res, 1997, 57(9): 1794-1797.
28. Noike T, Miwa S, Soeda J, et al. Increased expression of thioredoxin-1, vascular endothelial growth factor, and redox factor-1 is associated with poor prognosis in patients with liver metastasis from colorectal cancer [J]. Hum Pathol, 2008, 39(2): 201-208.
29. Wang D, Luo M, Kelley MR. Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition [J]. Mol Cancer Ther, 2004, 3(6): 679-86.
30. Kakolyris S, Kaklamanis L, Engels K, et al. Human AP endonuclease 1 (HAP1) protein expression in breast cancer correlates with lymph node status and angiogenesis [J]. Br J Cancer, 1998, 77(7): 1169-73.
31. Koukourakis MI, Giatromanolaki A, Kakolyris S, et al. Nuclear expression of human apurinic/apyrimidinic endonuclease (HAP1/Ref-1) in head-and-neck cancer is associated with resistance to chemoradiotherapy and poor outcome [J]. Int J Radiat Oncol Biol Phys, 2001, 50(1): 27-36.
32. Shinmura K, Yamaguchi S, Saitoh T, et al. Somatic mutations and single nucleotide polymorphisms of base excision repair genes involved in the repair of hydroxyguanine in damaged DNA [J]. Cancer Lett, 2001, 166(1): 65-69.
33. Pieretti M, Khattar NH, Smith SA. Common polymorphisms and somaticmutations in human base excision repair genes in ovarian and endometrial cancers [J]. Mutat Res, 2001, 432(324): 53-59.
34. Hu JJ, Smith TR, Miller MS, et al. Amino acid substitution variants of APE1 and XRCC1 genes associated with ionizing radiation sensitivity [J]. Carcinogenesis, 2001, 22(6): 917-922.
35. Narter KF, Ergen A, Agachan B, et al. Bladder cancer and polymorphisms of DNA repair genes (XRCC1, XRCC3, XPD, XPG, APE1, hOGG1) [J]. Anticancer Res, 2009, 29(4): 1389-1393.
36. Agachan B, Kucukhuseyin O, Aksoy P, et al. Apurinic/apyrimidinic endonuclease (APE1) gene polymorphisms and lung cancer risk in relation to tobacco smoking [J]. Anticancer Res, 2009, 29(6): 2417-2420.
37. Su D, Ma S, Liu P, et al. Genetic polymorphisms and treatment response in advanced non-small cell lung cancer [J]. Lung Cancer, 2007, 56(2): 281-288.
38. Chen L, Ambrosone CB, Lee J, et al. Association between polymorphisms in the DNA repair genes XRCC1 and APE1, and the risk of prostate cancer in white and black Americans [J]. J Urol, 2006, 175(1): 108-112.
39. Chang-Claude J, Popanda O, Tan XL, et al. Association between polymorphisms in the DNA repair genes, XRCC1, APE1, and XPD and acute side effects of radiotherapy in breast cancer patients [J]. Clin Cancer Res, 2005, 11(13): 4802-4809.
40. Herring CJ, West CM, Wilks DP, et al. Levels of the DNA repair enzyme human apurinic/apyrimidinic endonuclease (APE1, APEX, Ref-1) are associated with the intrinsic radiosensitivity of cervical cancers [J]. Br J Cancer, 1998, 78(9): 1128-1133.
41. Sak SC, Harnden P, Paul A, et al. APE1 and XRCC1 protein expression as predictors of response to radiotherapy in bladder cancer [J]. Clin Cancer Res, 2005, 11(17): 6205-6211.
42. Robertson KA, Bullock HA, Xu Y, et al. Altered expression of APE/Ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation [J]. Cancer Res, 2001, 61(5): 2220-2225.
43. Bobola MS, Emond MJ, Blank A, et al. Apurinic endonuclease activity in adult gliomas and time to tumor progression after alkylating agent-based chemotherapy and after radiotherapy [J]. Clin Cancer Res, 2004, 10(23): 7875-7883.
44. Silber JR, Bobola MS, Blank A, et al. The apurinic/apyrimidinic endonuclease activity of APE/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress [J]. Clin Cancer Res. 2002, 8(9): 3008-3018.
45. Wang D, Xiang DB, Yang XQ, et al. APE1 overexpression is associated with cisplatin resistance in non-small cell lung cancer and targeted inhibition of APE1 enhances the activity of cisplatin in A549 cells [J]. Lung Cancer, 2009, 66(3): 298-304.
46. Fung H, Demple B. A vital role for Ape1/Ref1 protein in repairing spontaneous DNA damage in human cells [J]. Mol Cell, 2005, 17(3): 463-470.
47. Seiple L, Jaruga P, Dizdaroglu M, et al. Linking uracil base excision repair and 5-fluorouracil toxicity in yeast [J]. Nucleic Acids Res, 2006, 34 (1): 140-151.
48. Bobola MS, Finn LS, Ellenbogen RG, et al. Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors [J]. Clin Cancer Res, 2005, 11(20): 7405-7414.
49. Fishel ML, Kelley MR. The DNA base excision repair protein APE/Ref-1 as a therapeutic and chemopreventive target [J]. Mol Aspects Med, 2007, 28 (3-4): 375-395.
50. Raffoul JJ, Banerjee S, Singh-Gupta V, et al. Down-regulation of apurinic/ apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo [J]. Cancer Res, 2007, 67(5): 2141-2149.
51. Chattopadhyay R, Das S, Maiti AK, et al. Regulatory role of human AP-endonuclease (APE/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1 [J]. Mol Cell Biol, 2008, 28(23): 7066-7080.
52. Walker LJ, Craig RB, Harris AL, et al. A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress [J]. Nucleic Acids Res, 1994, 22(23): 4884-4889.
53. Ono Y, Furuta T, Ohmoto T, et al. Stable expression in rat glioma cells of sense and antisense nucleic acids to a human multifunctional DNA repair enzyme, APEX nuclease [J]. Mutat Res, 1994, 315(1): 55-63.
54. Fishel ML, He Y, Reed AM, et al. Knockdown of the DNA repair and redox signaling protein APE/Ref-1 blocks ovarian cancer cell and tumor growth [J]. DNA Repair, 2008, 7(2): 177-186.
55. Xiang DB, Chen ZT, Wang D, et al. Chimeric adenoviral vector Ad5/F35-mediated APE1 siRNA enhances sensitivity of human colorectal cancer cells to radiotherapy in vitro and in vivo [J]. Cancer Gene Ther, 2008, 15 (10): 625-635.
56. Wang D, Zhong ZY, Li MX, et al. Vector-based Ape1 small interfering RNA enhances the sensitivity of human osteosarcoma cells to endostatin in vivo [J]. Cancer Sci, 2007, 98(12): 1993-2001.
57. McNeill DR, Lam W, Deweese TL, Cheng YC, Wilson DM, 3rd. Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites [J]. Mol Cancer Res, 2009 May 26.
58. Yang S, Irani K, Heffron SE, et al. Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor [J]. Mol Cancer Ther, 2005, 4(12): 1923-1935.
59. Zou GM, Maitra A. Small-molecule inhibitor of the AP endonuclease 1/ REF-1 E3330 inhibits pancreatic cancer cell growth and migration [J]. Mol Cancer Ther, 2008, 7(7): 2012-2021.
60. Taverna P, Liu L, Hwang HS, et al. Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells [J]. Mutat Res, 2001, 485(4): 269-281.
61. Luo M, Kelley MR. Inhibition of the human apurinic/apyrimidinic endonuclease (APE1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone [J]. Anticancer Res, 2004, 24(4): 2127-2134.
62. Fishel ML, He Y, Smith ML, et al. Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide [J]. Clin Cancer Res, 2007, 13(1): 260-267.
63. Rinne M, Caldwell D, Kelley MR. Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells [J]. Mol Cancer Ther, 2004, 3(8): 955-967.
64. Liu L, Nakatsuru Y, Gerson SL. Base excision repair as a therapeutic target in colon cancer [J]. Clin Cancer Res, 2002, 8(9): 2985-2991.