APE1 overexpression is associated with cisplatin resistance in non-small cell lung cancer and targeted inhibition of APE1 enhances the activity of cisplatin in A549 cells

Lung Cancer

Volumn 66, Issue 3, 2009, Pages 298-304

  Wang, Dong ^a   Xiang, De Bing ^a   Yang, Xue qin ^a   Chen, Lian Sheng ^a   Li, Meng Xia ^a   Zhong, Zhao Yang ^a   Zhang, Yun Song ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Adenoviral vector; APE1; Chemotherapy; Cisplatin; Non small cell lung cancer

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ADENOVIRUS VECTOR; CISPLATIN; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE 1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER INHIBITION; CANCER RESISTANCE; CANCER SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DRUG ACTIVITY; DRUG POTENTIATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; NICK END LABELING; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN TARGETING; VIRAL GENE DELIVERY SYSTEM; WESTERN BLOTTING;

ADENOVIRIDAE; ADULT; AGED; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CISPLATIN; DISEASE PROGRESSION; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; PROGNOSIS; RNA, SMALL INTERFERING; TRANSDUCTION, GENETIC;

EID: 70350622182     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lungcan.2009.02.019     Document Type: Article

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