메뉴 건너뛰기




Volumn 17, Issue 6, 2011, Pages 1428-1435

Optimizing thiopurine therapy in inflammatory bowel disease

Author keywords

inflammatory bowel disease; optimization; thiopurines

Indexed keywords

MERCAPTOPURINE; THIOPURINE METHYLTRANSFERASE;

EID: 79955820771     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.21494     Document Type: Review
Times cited : (31)

References (64)
  • 1
    • 33644869450 scopus 로고    scopus 로고
    • American gastroenterological association institute technical review on corticosteroids, immunomodulators, and infliximab in inflammatory bowel disease
    • DOI 10.1053/j.gastro.2006.01.048, PII S0016508506000746
    • Lichtenstein GR, Abreu MT, Cohen R, et al. American Gastroenterological Association Institute medical position statement on corticosteroids, immunomodulators, and infliximab in inflammatory bowel disease. Gastroenterology. 2006; 130: 940-987. (Pubitemid 43374543)
    • (2006) Gastroenterology , vol.130 , Issue.3 , pp. 940-987
    • Lichtenstein, G.R.1    Abreu, M.T.2    Cohen, R.3    Tremaine, W.4
  • 2
    • 75149161836 scopus 로고    scopus 로고
    • The second European evidence-based consensus on the diagnosis and management of Crohn's disease: Current management
    • Dignass A, Van Assche G, Lindsay JO, et al. The second European evidence-based consensus on the diagnosis and management of Crohn's disease: current management. J Crohn's Colitis. 2010; 4: 28-62.
    • (2010) J Crohn's Colitis. , vol.4 , pp. 28-62
    • Dignass, A.1    Van Assche, G.2    Lindsay, J.O.3
  • 4
    • 46149125761 scopus 로고    scopus 로고
    • Crohn's disease: Beyond antagonists of tumour necrosis factor
    • DOI 10.1016/S0140-6736(08)60995-2, PII S0140673608609952
    • Peyrin-Biroulet L, Desreumaux P, Sandborn WJ, et al. Crohn's disease: beyond antagonists of tumour necrosis factor. Lancet. 2008; 372: 67-81. (Pubitemid 351902263)
    • (2008) The Lancet , vol.372 , Issue.9632 , pp. 67-81
    • Peyrin-Biroulet, L.1    Desreumaux, P.2    Sandborn, W.J.3    Colombel, J.-F.4
  • 5
    • 60749103646 scopus 로고    scopus 로고
    • Optimizing conventional therapy for inflammatory bowel disease
    • Schwartz M, Cohen R,. Optimizing conventional therapy for inflammatory bowel disease. Curr Gastroenterol Rep. 2008; 10: 585-590.
    • (2008) Curr Gastroenterol Rep , vol.10 , pp. 585-590
    • Schwartz, M.1    Cohen, R.2
  • 7
    • 67649867062 scopus 로고    scopus 로고
    • Meta-analysis: The efficacy of azathioprine and mercaptopurine in ulcerative colitis
    • Gisbert JP, Linares PM, McNicholl AG, et al. Meta-analysis: the efficacy of azathioprine and mercaptopurine in ulcerative colitis. Aliment Pharmacol Ther. 2009; 30: 126-137.
    • (2009) Aliment Pharmacol Ther. , vol.30 , pp. 126-137
    • Gisbert, J.P.1    Linares, P.M.2    McNicholl, A.G.3
  • 8
    • 70349512283 scopus 로고    scopus 로고
    • Incidence and clinical significance of immunogenicity to infliximab in Crohn's disease: A critical systematic review
    • Cassinotti A, Travis S., Incidence and clinical significance of immunogenicity to infliximab in Crohn's disease: a critical systematic review. Inflamm Bowel Dis. 2009; 15: 1264-1275.
    • (2009) Inflamm Bowel Dis. , vol.15 , pp. 1264-1275
    • Cassinotti, A.1    Travis, S.2
  • 9
    • 77949429893 scopus 로고    scopus 로고
    • Pharmacogenetics of thiopurines in inflammatory bowel disease
    • Derijks LJ, Wong DR., Pharmacogenetics of thiopurines in inflammatory bowel disease. Curr Pharm Des. 2010; 16: 145-154.
    • (2010) Curr Pharm Des. , vol.16 , pp. 145-154
    • Derijks, L.J.1    Wong, D.R.2
  • 11
    • 0018822866 scopus 로고
    • Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity
    • Weinshilboum RM, Sladek SL., Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet. 1980; 32: 651-662. (Pubitemid 10061685)
    • (1980) American Journal of Human Genetics , vol.32 , Issue.5 , pp. 651-662
    • Weinshilboum, R.M.1    Sladek, S.L.2
  • 15
    • 0026758498 scopus 로고
    • The clinical pharmacology of 6-mercaptopurine
    • Lennard L., The clinical pharmacology of 6-mercaptopurine. Eur J Clin Pharmacol. 1992; 43: 329-339.
    • (1992) Eur J Clin Pharmacol. , vol.43 , pp. 329-339
    • Lennard, L.1
  • 16
    • 33748756416 scopus 로고    scopus 로고
    • Two cases of thiopurine methyltransferase (TPMT) deficiency - A lucky save and a near miss with azathioprine
    • DOI 10.1111/j.1365-2125.2005.02474.x
    • Gardiner SJ, Gearry RB, Barclay ML, et al. Two cases of thiopurine methyltransferase (TPMT) deficiencyâa lucky save and a near miss with azathioprine. Br J Clin Pharmacol. 2006; 62: 473-476. (Pubitemid 44401530)
    • (2006) British Journal of Clinical Pharmacology , vol.62 , Issue.4 , pp. 473-476
    • Gardiner, S.J.1    Gearry, R.B.2    Barclay, M.L.3    Begg, E.J.4
  • 18
    • 44749084416 scopus 로고    scopus 로고
    • Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold
    • Gardiner SJ, Gearry RB, Begg EJ, et al. Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold. Clin Gastroenterol Hepatol. 2008; 6: 654-660.
    • (2008) Clin Gastroenterol Hepatol. , vol.6 , pp. 654-660
    • Gardiner, S.J.1    Gearry, R.B.2    Begg, E.J.3
  • 19
    • 52149099443 scopus 로고    scopus 로고
    • Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease
    • Ansari A, Arenas M, Greenfield SM, et al. Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease. Aliment Pharmacol Ther. 2008; 28: 973-983.
    • (2008) Aliment Pharmacol Ther. , vol.28 , pp. 973-983
    • Ansari, A.1    Arenas, M.2    Greenfield, S.M.3
  • 22
    • 67651163895 scopus 로고    scopus 로고
    • Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease
    • Smith MA, Marinaki AM, Arenas M, et al. Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease. Aliment Pharmacol Ther. 2009; 30: 375-384.
    • (2009) Aliment Pharmacol Ther. , vol.30 , pp. 375-384
    • Smith, M.A.1    Marinaki, A.M.2    Arenas, M.3
  • 24
    • 9244237558 scopus 로고    scopus 로고
    • Lack of association between the ITPA 94C>A polymorphism and adverse effects from azathioprine
    • DOI 10.1097/00008571-200411000-00010
    • Gearry RB, Roberts RL, Barclay ML, et al. Lack of association between the ITPA 94C>A polymorphism and adverse effects from azathioprine. Pharmacogenetics. 2004; 14: 779-781. (Pubitemid 39552794)
    • (2004) Pharmacogenetics , vol.14 , Issue.11 , pp. 779-781
    • Gearry, R.B.1    Roberts, R.L.2    Barclay, M.L.3    Kennedy, M.A.4
  • 25
    • 51649130245 scopus 로고    scopus 로고
    • Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine
    • Hawwa AF, Millership JS, Collier PS, et al. Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine. Br J Clin Pharmacol. 2008; 66: 517-528.
    • (2008) Br J Clin Pharmacol. , vol.66 , pp. 517-528
    • Hawwa, A.F.1    Millership, J.S.2    Collier, P.S.3
  • 26
    • 27744461917 scopus 로고    scopus 로고
    • Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease
    • DOI 10.1111/j.1440-1746.2005.03832.x
    • Gearry RB, Barclay ML., Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease. J Gastroenterol Hepatol. 2005; 20: 1149-1157. (Pubitemid 41602556)
    • (2005) Journal of Gastroenterology and Hepatology , vol.20 , Issue.8 , pp. 1149-1157
    • Gearry, R.B.1    Barclay, M.L.2
  • 27
    • 33745665758 scopus 로고    scopus 로고
    • Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease
    • DOI 10.1136/gut.2005.074930
    • Hindorf, U, Lindqvist, M, Peterson, C, et al. Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease. Gut. 2006; 55: 1423-1431. (Pubitemid 44476786)
    • (2006) Gut , vol.55 , Issue.10 , pp. 1423-1431
    • Hindorf, U.1    Lindqvist, M.2    Peterson, C.3    Soderkvist, P.4    Strom, M.5    Hjortswang, H.6    Pousette, A.7    Almer, S.8
  • 28
    • 72549100745 scopus 로고    scopus 로고
    • Optimizing conventional therapies for inflammatory bowel disease
    • Sparrow, MP, Irving, PM, Hanauer, SB,. Optimizing conventional therapies for inflammatory bowel disease. Curr Gastroenterol Rep. 2009; 11: 496-503.
    • (2009) Curr Gastroenterol Rep , vol.11 , pp. 496-503
    • Sparrow, M.P.1    Irving, P.M.2    Hanauer, S.B.3
  • 31
    • 33646011261 scopus 로고    scopus 로고
    • Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: A meta-analysis
    • Osterman MT, Kundu R, Lichtenstein GR, et al. Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: a meta-analysis. Gastroenterology. 2006; 130: 1047-1053.
    • (2006) Gastroenterology. , vol.130 , pp. 1047-1053
    • Osterman, M.T.1    Kundu, R.2    Lichtenstein, G.R.3
  • 32
    • 0034771188 scopus 로고    scopus 로고
    • Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease
    • DOI 10.1136/gut.49.5.665
    • Lowry PW, Franklin CL, Weaver AL, et al. Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease. Gut. 2001; 49: 665-670. (Pubitemid 32989203)
    • (2001) Gut , vol.49 , Issue.5 , pp. 665-670
    • Lowry, P.W.1    Franklin, C.L.2    Weaver, A.L.3    Gennett Pike, M.4    Mays, D.C.5    Tremaine, W.J.6    Lipsky, J.J.7    Sandborn, W.J.8
  • 33
  • 37
    • 79955568740 scopus 로고    scopus 로고
    • T1192 A randomized trial of metabolite-adjusted versus weight-based dosing of azathioprine in Crohn's disease. [Clinicaltrials.Gov Identifier Nct00113503]
    • A-519
    • Dassopoulos T, Martin CF, Galanko J, et al. T1192 A randomized trial of metabolite-adjusted versus weight-based dosing of azathioprine in Crohn's disease. [Clinicaltrials.Gov Identifier Nct00113503]. Gastroenterology. 2009; 136:A-519.
    • (2009) Gastroenterology , vol.136
    • Dassopoulos, T.1    Martin, C.F.2    Galanko, J.3
  • 38
    • 0028917479 scopus 로고
    • Sulphasalazine inhibition of thiopurine methyltransferase: Possible mechanism for interaction with 6-mercaptopurine and azathioprine
    • Szumlanski CL, Weinshilboum RM., Sulphasalazine inhibition of thiopurine methyltransferase: possible mechanism for interaction with 6-mercaptopurine and azathioprine. Br J Clin Pharmacol. 1995; 39: 456-459.
    • (1995) Br J Clin Pharmacol. , vol.39 , pp. 456-459
    • Szumlanski, C.L.1    Weinshilboum, R.M.2
  • 39
    • 33646778817 scopus 로고    scopus 로고
    • 5-Aminosalicylate therapy is associated with higher 6-thioguanine levels in adults and children with inflammatory bowel disease in remission on 6-mercaptopurine or azathioprine
    • Hande S, Wilson-Rich N, Bousvaros A, et al. 5-Aminosalicylate therapy is associated with higher 6-thioguanine levels in adults and children with inflammatory bowel disease in remission on 6-mercaptopurine or azathioprine. Inflamm Bowel Dis. 2006; 12: 251-257.
    • (2006) Inflamm Bowel Dis. , vol.12 , pp. 251-257
    • Hande, S.1    Wilson-Rich, N.2    Bousvaros, A.3
  • 41
    • 70349196312 scopus 로고    scopus 로고
    • Prospective study of the effects of concomitant medications on thiopurine metabolism in inflammatory bowel disease
    • Daperno M, Sostegni R, Canaparo R, et al. Prospective study of the effects of concomitant medications on thiopurine metabolism in inflammatory bowel disease. Aliment Pharmacol Ther. 2009; 30: 843-853.
    • (2009) Aliment Pharmacol Ther. , vol.30 , pp. 843-853
    • Daperno, M.1    Sostegni, R.2    Canaparo, R.3
  • 42
    • 0013926855 scopus 로고
    • Metabolic studies of allopurinol, an inhibitor of xanthine oxidase
    • Elion GB, Kovensky A, Hitchings GH., Metabolic studies of allopurinol, an inhibitor of xanthine oxidase. Biochem Pharmacol. 1966; 15: 863-880.
    • (1966) Biochem Pharmacol. , vol.15 , pp. 863-880
    • Elion, G.B.1    Kovensky, A.2    Hitchings, G.H.3
  • 43
    • 0027161587 scopus 로고
    • Low-dose allopurinol plus azathioprine/cyclosporin/prednisolone, a novel immunosuppressive regimen
    • DOI 10.1016/0140-6736(93)91287-V
    • Chocair P, Duley J, Simmonds HA, et al. Low-dose allopurinol plus azathioprine/cyclosporin/prednisolone, a novel immunosuppressive regimen. Lancet. 1993; 342: 83-84. (Pubitemid 23192425)
    • (1993) Lancet , vol.342 , Issue.8863 , pp. 83-84
    • Chocair, P.1    Duley, J.2    Simmonds, H.A.3    Cameron, J.S.4    Ianhez, L.5    Arap, S.6    Sabbaga, E.7
  • 44
    • 24344480999 scopus 로고    scopus 로고
    • Allopurinol safely and effectively optimizes tioguanine metabolites in inflammatory bowel disease patients not responding to azathioprine and mercaptopurine
    • DOI 10.1111/j.1365-2036.2005.02583.x
    • Sparrow MP, Hande SA, Friedman S, et al. Allopurinol safely and effectively optimizes tioguanine metabolites in inflammatory bowel disease patients not responding to azathioprine and mercaptopurine. Aliment Pharmacol Ther. 2005; 22: 441-446. (Pubitemid 41248111)
    • (2005) Alimentary Pharmacology and Therapeutics , vol.22 , Issue.5 , pp. 441-446
    • Sparrow, M.P.1    Hande, S.A.2    Friedman, S.3    Lim, W.C.4    Reddy, S.I.5    Cao, D.6    Hanauer, S.B.7
  • 45
    • 33846820178 scopus 로고    scopus 로고
    • Effect of Allopurinol on Clinical Outcomes in Inflammatory Bowel Disease Nonresponders to Azathioprine or 6-Mercaptopurine
    • DOI 10.1016/j.cgh.2006.11.020, PII S1542356506011980
    • Sparrow MP, Hande SA, Friedman S, et al. Effect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine. Clin Gastroenterol Hepatol. 2007; 5: 209-214. (Pubitemid 46216945)
    • (2007) Clinical Gastroenterology and Hepatology , vol.5 , Issue.2 , pp. 209-214
    • Sparrow, M.P.1    Hande, S.A.2    Friedman, S.3    Cao, D.4    Hanauer, S.B.5
  • 46
    • 67651083623 scopus 로고    scopus 로고
    • Long term efficacy and safety of allopurinol and azathioprine or 6-mercaptopurine in patients with inflammatory bowel disease
    • Leung Yea,. Long term efficacy and safety of allopurinol and azathioprine or 6-mercaptopurine in patients with inflammatory bowel disease. J Crohn's Colitis. 2009; 3: 162-167.
    • (2009) J Crohn's Colitis , vol.3 , pp. 162-167
    • Leung, Y.1
  • 47
    • 49849088177 scopus 로고    scopus 로고
    • Long-term outcome of using allopurinol co-therapy as a strategy for overcoming thiopurine hepatotoxicity in treating inflammatory bowel disease
    • Ansari A, Elliott T, Baburajan B, et al. Long-term outcome of using allopurinol co-therapy as a strategy for overcoming thiopurine hepatotoxicity in treating inflammatory bowel disease. Aliment Pharmacol Ther. 2008; 28: 734-741.
    • (2008) Aliment Pharmacol Ther. , vol.28 , pp. 734-741
    • Ansari, A.1    Elliott, T.2    Baburajan, B.3
  • 48
    • 52149089035 scopus 로고    scopus 로고
    • Initial clinical experience with allopurinol-thiopurine combination therapy in pediatric inflammatory bowel disease
    • Rahhal RM, Bishop WP., Initial clinical experience with allopurinol-thiopurine combination therapy in pediatric inflammatory bowel disease. Inflamm Bowel Dis. 2008; 14: 1678-1682.
    • (2008) Inflamm Bowel Dis. , vol.14 , pp. 1678-1682
    • Rahhal, R.M.1    Bishop, W.P.2
  • 49
    • 42449087386 scopus 로고    scopus 로고
    • Use of allopurinol with low-dose 6-mercaptopurine in inflammatory bowel disease to achieve optimal active metabolite levels: A review of four cases and the literature
    • Witte TN, Ginsberg AL., Use of allopurinol with low-dose 6-mercaptopurine in inflammatory bowel disease to achieve optimal active metabolite levels: a review of four cases and the literature. Can J Gastroenterol. 2008; 22: 181-185.
    • (2008) Can J Gastroenterol. , vol.22 , pp. 181-185
    • Witte, T.N.1    Ginsberg, A.L.2
  • 50
    • 76449085161 scopus 로고    scopus 로고
    • Low-dose azathioprine or mercaptopurine in combination with allopurinol can bypass many adverse drug reactions in patients with inflammatory bowel disease
    • Ansari A, Patel N, Sanderson J, et al. Low-dose azathioprine or mercaptopurine in combination with allopurinol can bypass many adverse drug reactions in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2010; 31: 640-647.
    • (2010) Aliment Pharmacol Ther. , vol.31 , pp. 640-647
    • Ansari, A.1    Patel, N.2    Sanderson, J.3
  • 51
    • 77950991811 scopus 로고    scopus 로고
    • High thiopurine metabolite concentrations associated with lymphopenia in inflammatory bowel disease pediatric patients receiving aminosalicylates combined with azathioprine
    • Nguyen TM, Le Gall C, Lachaux A, et al. High thiopurine metabolite concentrations associated with lymphopenia in inflammatory bowel disease pediatric patients receiving aminosalicylates combined with azathioprine. Int J Clin Pharmacol Ther. 2010; 48: 275-281.
    • (2010) Int J Clin Pharmacol Ther. , vol.48 , pp. 275-281
    • Nguyen, T.M.1    Le Gall, C.2    Lachaux, A.3
  • 54
    • 70349314937 scopus 로고    scopus 로고
    • Inflammatory bowel disease and lymphoproliferative disorders: The dust is starting to settle
    • Sokol H, Beaugerie L., Inflammatory bowel disease and lymphoproliferative disorders: the dust is starting to settle. Gut. 2009; 58: 1427-1436.
    • (2009) Gut. , vol.58 , pp. 1427-1436
    • Sokol, H.1    Beaugerie, L.2
  • 55
    • 0033795223 scopus 로고    scopus 로고
    • Increased incidence of non-Hodgkin's lymphoma in inflammatory bowel disease patients on immunosuppressive therapy but overall risk is low
    • Farrell RJ, Ang Y, Kileen P, et al. Increased incidence of non-Hodgkin's lymphoma in inflammatory bowel disease patients on immunosuppressive therapy but overall risk is low. Gut. 2000; 47: 514-519.
    • (2000) Gut. , vol.47 , pp. 514-519
    • Farrell, R.J.1    Ang, Y.2    Kileen, P.3
  • 56
    • 0036024192 scopus 로고    scopus 로고
    • Long-term risk of malignancy after treatment of inflammatory bowel disease with azathioprine
    • Fraser AG, Orchard TR, Robinson EM, et al. Long-term risk of malignancy after treatment of inflammatory bowel disease with azathioprine. Aliment Pharmacol Ther. 2002; 16: 1225-1232.
    • (2002) Aliment Pharmacol Ther. , vol.16 , pp. 1225-1232
    • Fraser, A.G.1    Orchard, T.R.2    Robinson, E.M.3
  • 57
    • 22644446331 scopus 로고    scopus 로고
    • Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine
    • DOI 10.1136/gut.2004.049460
    • Kandiel A, Fraser AG, Korelitz BI, et al. Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine. Gut. 2005; 54: 1121-1125. (Pubitemid 41025906)
    • (2005) Gut , vol.54 , Issue.8 , pp. 1121-1125
    • Kandiel, A.1    Fraser, A.G.2    Korelitz, B.I.3    Brensinger, C.4    Lewis, J.D.5
  • 60
    • 70449100743 scopus 로고    scopus 로고
    • Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: A prospective observational cohort study
    • Beaugerie L, Brousse N, Bouvier AM, et al. Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study. Lancet. 2009; 374: 1617-1625.
    • (2009) Lancet. , vol.374 , pp. 1617-1625
    • Beaugerie, L.1    Brousse, N.2    Bouvier, A.M.3
  • 61
    • 77953801701 scopus 로고    scopus 로고
    • Review article: Malignancy on thiopurine treatment with special reference to inflammatory bowel disease
    • Smith MA, Irving PM, Marinaki AM, et al. Review article: malignancy on thiopurine treatment with special reference to inflammatory bowel disease. Aliment Pharmacol Ther. 2010; 32: 119-130.
    • (2010) Aliment Pharmacol Ther. , vol.32 , pp. 119-130
    • Smith, M.A.1    Irving, P.M.2    Marinaki, A.M.3
  • 62
    • 77950988234 scopus 로고    scopus 로고
    • Infliximab, azathioprine, or combination therapy for Crohn's disease
    • Colombel JF, Sandborn WJ, Reinisch W, et al. Infliximab, azathioprine, or combination therapy for Crohn's disease. N Engl J Med. 2010; 362: 1383-1395.
    • (2010) N Engl J Med. , vol.362 , pp. 1383-1395
    • Colombel, J.F.1    Sandborn, W.J.2    Reinisch, W.3
  • 63
    • 63849251824 scopus 로고    scopus 로고
    • Long-term safety of infliximab for the treatment of inflammatory bowel disease: A single-centre cohort study
    • Fidder H, Schnitzler F, Ferrante M, et al. Long-term safety of infliximab for the treatment of inflammatory bowel disease: a single-centre cohort study. Gut. 2009; 58: 501-508.
    • (2009) Gut. , vol.58 , pp. 501-508
    • Fidder, H.1    Schnitzler, F.2    Ferrante, M.3
  • 64
    • 33646147141 scopus 로고    scopus 로고
    • Serious infections and mortality in association with therapies for Crohn's disease: TREAT registry
    • Lichtenstein GR, Feagan BG, Cohen RD, et al. Serious infections and mortality in association with therapies for Crohn's disease: TREAT registry. Clin Gastroenterol Hepatol. 2006; 4: 621-630.
    • (2006) Clin Gastroenterol Hepatol. , vol.4 , pp. 621-630
    • Lichtenstein, G.R.1    Feagan, B.G.2    Cohen, R.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.