Initial clinical experience with allopurinol-thiopurine combination therapy in pediatric inflammatory bowel disease

Inflammatory Bowel Diseases

Volumn 14, Issue 12, 2008, Pages 1678-1682

  Rahhal, Riad M ^a   Bishop, Warren P ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Allopurinol; Inflammatory bowel disease; Pediatric; Thiopurine metabolism

Indexed keywords

6 METHYL MERCAPTOPURINE; ALLOPURINOL; AMINOSALICYLIC ACID; AMINOTRANSFERASE; AZATHIOPRINE; DRUG METABOLITE; INFLIXIMAB; MERCAPTOPURINE; MESALAZINE; PREDNISONE; TIOGUANINE; UNCLASSIFIED DRUG; 6-METHYLTHIOPURINE; ANTIMETABOLITE; DRUG DERIVATIVE; METHYLMERCAPTOPURINE;

ADOLESCENT; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CHILD; CLINICAL ARTICLE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG POTENTIATION; DRUG WITHDRAWAL; ENTERITIS; ERYTHROCYTE COUNT; FEMALE; FOLLOW UP; HUMAN; MALE; NEUTROPENIA; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; RETROSPECTIVE STUDY; BLOOD; COHORT ANALYSIS; CROHN DISEASE; DRUG COMBINATION; PRESCHOOL CHILD; PROGNOSIS; REMISSION; TREATMENT OUTCOME; ULCERATIVE COLITIS;

6-MERCAPTOPURINE; ADOLESCENT; ALLOPURINOL; ANTIMETABOLITES; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; COLITIS, ULCERATIVE; CROHN DISEASE; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; PROGNOSIS; REMISSION INDUCTION; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 52149089035     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.20522     Document Type: Article

References (17)

1. Dubinsky MC. Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin Gastroenteroll Hepatol. 2004;2:731-743.
2. Banerjee S. Bishop WP. Evolution of thiopurine use in pediatric inflammatory bowel disease in an academic center. J Pediatr Gastroenterol Nutr. 2006;43:353-356.
3. Pearson DC, May GR, Fick GH, et. al. Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis. Ann Intern Med. 1995; 123:1321-142.
4. Korelitz BI. A history of immunosuppressive drugs in the treatment of inflammatory bowel disease: origins at the Mount Sinai Hospital. Mt Sinai J Med. 2000;67:214-226.
5. Steinhart AH, Baker JP, Brzezinski A, et al. Azathioprine therapy in chronic ulcerative colitis. J Clin Gastroenterol. 1990;12:271-275.
6. Theodor E, Niv Y, Bat L. Imuran in the treatment of ulcerative colitis. Am J Gastroenterol. 1981;76:262-266.
7. Kader HA, Wenner WJ Jr, Telega GW, et al. Normal thiopurine methyltransferase levels do not eliminate 6-mercaptopurine or azathioprine toxicity in children with inflammatory bowel disease. J Clin Gastroenterol. 2000;30:409-413.
8. Bloomfeld RS, Onken JE. Mercaptopurine metabolite results in clinical gastroenterology practice. Aliment Pharmacol Ther. 2003;17:69-73.
9. Dubinsky MC, Lamothe S, Yang HY, et al. Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease. Gastroenterology. 2000;118:705-713.
10. Osterman MT, Kundu R, Lichtenstein GR, et al. Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: a meta-analysis. Gastroenterology. 2006;130:1047-1053.
11. Seidman EG. Clinical use and practical application of TPMT enzyme and 6-mercaptopurine metabolite monitoring in IBD. Rev Gastroenterol Disord. 2003;3(suppl 1):S30-38.
12. Sparrow MP, Hande SA, Friedman S, et al. Effect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine. Clin Gastroenterol Hepatol. 2007;5: 209-214.
13. Sparrow MP, Hande SA, Friedman S, et al. Allopurinol safely and effectively optimizes tioguanine metabolites in inflammatory bowel disease patients not responding to azathioprine and mercaptopurine. Aliment Pharmacol Ther. 2005;22:441-446.
14. Bowen D, Selby W. Use of 6-mercaptopurine in patients with inflammatory bowel disease previously intolerant of azathioprine. Dig Dis Sci. 2000;45:1810-1813.
15. Chocair P, Duley J, Simmonds HA, et al. Low-dose allopurinol plus azathioprine/cyclosporin/prednisolone, a novel immunosuppressive regimen. Lancet. 1993;342:83-84.
16. Duley JA, Chocair PR, Florin TH. Observations on the use of allopurinol in combination with azathioprine or mercaptopurine. Aliment Pharmacol Ther. 2005;22:1161-1162
17. Allopurinol. In: DRUGDEX Evaluations [intranet database]. Version 5.1. Greenwood Village, CO: Thomson Healthcare. Accessed March 24, 2008.