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Rapid sequencing of library-derived peptides by partial edman degradation and mass spectrometry
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DOI 10.1021/cc000102l
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Wang, P.; Arabaci, G.; Pei, D. Rapid Sequencing of Library-Derived Peptides by Partial Edman Degradation and Mass Spectrometry J. Comb. Chem. 2001, 3, 251-254 (Pubitemid 33616446)
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(2001)
Journal of Combinatorial Chemistry
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Wang, P.1
Arabaci, G.2
Pei, D.3
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46
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0029109073
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Generation and Screening of Combinatorial Peptide Libraries Designed for Rapid Sequencing by Mass Spectrometry
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Commonly used linkers also contain Asn and Arg residues which aid in detection and likely help to solubilize peptides in aqueous solutions. However, we avoided these two polar residues in our linker, as we wished to evaluate the peptide catalysts in organic solvents; these residues might also be unstable to our reaction conditions (e.g., via N-H oxidation). See
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Commonly used linkers also contain Asn and Arg residues which aid in detection and likely help to solubilize peptides in aqueous solutions. However, we avoided these two polar residues in our linker, as we wished to evaluate the peptide catalysts in organic solvents; these residues might also be unstable to our reaction conditions (e.g., via N-H oxidation). See: Youngquist, R. S.; Fuentes, G. R.; Lacey, M. P.; Keough, T. Generation and Screening of Combinatorial Peptide Libraries Designed for Rapid Sequencing by Mass Spectrometry J. Am. Chem. Soc. 1995, 117, 3900-3906
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J. Am. Chem. Soc.
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, pp. 3900-3906
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Youngquist, R.S.1
Fuentes, G.R.2
Lacey, M.P.3
Keough, T.4
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47
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0141563651
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An improved method for rapid sequencing of support-bound peptides by partial Edman degradation and mass spectrometry
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DOI 10.1021/cc020113+
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Sweeney, M. C.; Pei, D. An Improved Method for Rapid Sequencing of Support-Bound Peptides by Partial Edman Degradation and Mass Spectrometry J. Comb. Chem. 2003, 5, 218-222 (Pubitemid 37140567)
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(2003)
Journal of Combinatorial Chemistry
, vol.5
, Issue.3
, pp. 218-222
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Sweeney, M.C.1
Pei, D.2
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48
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79955852167
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See Supporting Information for synthesis
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See Supporting Information for synthesis.
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49
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0001300285
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Thiopyran 1,1,-Dioxide Derivatives from Addition of Amines to Propargyl Sulfone
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Skatterbøl, L.; Boulette, B.; Solomon, S. Thiopyran 1,1,-Dioxide Derivatives from Addition of Amines to Propargyl Sulfone J. Org. Chem. 1968, 33, 548-552
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(1968)
J. Org. Chem.
, vol.33
, pp. 548-552
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Skatterbøl, L.1
Boulette, B.2
Solomon, S.3
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50
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0001067208
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Selective Cleavage of the Methionyl Peptide Bonds in Ribonuclease with Cyanogen Bromide
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Gross, E.; Witkop, B. Selective Cleavage of the Methionyl Peptide Bonds in Ribonuclease with Cyanogen Bromide J. Am. Chem. Soc. 1961, 83, 1510-1511
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(1961)
J. Am. Chem. Soc.
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, pp. 1510-1511
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Gross, E.1
Witkop, B.2
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51
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33747621649
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Traceless capping agent for peptide sequencing by partial Edman degradation and mass spectrometry
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DOI 10.1021/ac0607414
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Thakkar, A.; Wavreille, A.-S.; Pei, D. Traceless Capping Agent for Peptide Sequencing by Partial Edman Degradation and Mass Spectrometry Anal. Chem. 2006, 78, 5935-5939 (Pubitemid 44265059)
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(2006)
Analytical Chemistry
, vol.78
, Issue.16
, pp. 5935-5939
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Thakkar, A.1
Wavreille, A.-S.2
Pei, D.3
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52
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79955842304
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See Supporting Information for performance data.
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See Supporting Information for performance data.
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