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Francis, M.B.1
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High-throughput strategies for the discovery of catalysts
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Chem Biol
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Shimizu, K.D.1
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0013579124
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Catalyst discovery through combinatorial chemistry
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Hoveyda AH: Catalyst discovery through combinatorial chemistry. Chem Eur J 1998, 4:1885-1889.
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Chem Eur J
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Hoveyda, A.H.1
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0029764025
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Discovery of chiral catalysts through ligand diversity: Ti-catalyzed enantioselective addition of TMSCN to meso epoxides
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Cole BM, Shimizu KD, Krueger CA, Harrity JP, Snapper ML, Hoveyda AH: Discovery of chiral catalysts through ligand diversity: Ti-catalyzed enantioselective addition of TMSCN to meso epoxides. Angew Chem Int Ed Engl 1996, 35:1668-1671.
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Cole, B.M.1
Shimizu, K.D.2
Krueger, C.A.3
Harrity, J.P.4
Snapper, M.L.5
Hoveyda, A.H.6
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5
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0030766272
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Search for chiral catalysts through ligand diversity: Substrate-specific catalysts and ligand screening on solid phase
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Shimizu KD, Cole BM, Krueger CA, Kuntz KW, Snapper ML, Hoveyda AH: Search for chiral catalysts through ligand diversity: Substrate-specific catalysts and ligand screening on solid phase. Angew Chem Int Ed Engl 1997, 36:1704-1707. The ability to screen catalysts attached to a resin is demonstrated. Unique catalysts were found for each substrate examined.
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Angew Chem Int Ed Engl
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Shimizu, K.D.1
Cole, B.M.2
Krueger, C.A.3
Kuntz, K.W.4
Snapper, M.L.5
Hoveyda, A.H.6
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6
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0033526392
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Ti-catalyzed enantioselective addition of cyanide to imines accelerated by alcohol additives. Efficient and practical synthesis of optically pure α-amino acids
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in press
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Krueger CA, Kuntz KW, Dzierba CD, Wirschun WG, Gleason JD, Snapper ML, Hoveyda AH: Ti-catalyzed enantioselective addition of cyanide to imines accelerated by alcohol additives. Efficient and practical synthesis of optically pure α-amino acids. J Am Chem Soc 1999, 121:in press. A positional optimization strategy was used to find selective catalysts for the formation of enantiomerically pure amino acids.
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J Am Chem Soc
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Krueger, C.A.1
Kuntz, K.W.2
Dzierba, C.D.3
Wirschun, W.G.4
Gleason, J.D.5
Snapper, M.L.6
Hoveyda, A.H.7
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7
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0003554758
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Schiff base catalysts for the asymmetric Strecker reaction identified and optimized from parallel synthetic libraries
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Sigman MS, Jacobsen EN: Schiff base catalysts for the asymmetric Strecker reaction identified and optimized from parallel synthetic libraries. J Am Chem Soc 1998, 120:4901-4902. Combinatorial and classical optimization strategies were used to identify a Schiff base peptide catalyst for cyanide addition to imines.
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J Am Chem Soc
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Sigman, M.S.1
Jacobsen, E.N.2
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0029990764
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Asymmetric catalysis of the Strecker amino acid synthesis by a cyclic dipeptide
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Iyer, M.S.1
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0000684017
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Investigation of a new family of chiral ligands for enantioselective catalysis via parallel synthesis and high-throughput screening
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Gennari C, Ceccarelli S, Piarulli U, Montalbetti CAGN, Jackson RFW: Investigation of a new family of chiral ligands for enantioselective catalysis via parallel synthesis and high-throughput screening. J Org Chem 1998, 63:5312-5313.
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J Org Chem
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Gennari, C.1
Ceccarelli, S.2
Piarulli, U.3
Montalbetti, C.A.G.N.4
Jackson, R.F.W.5
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10
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0032569819
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A parallel combinatorial approach to locating homochiral lewis acid catalysts for asymmetric aza-Diels-Alder reaction of an imino dienophile
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Bromidge S, Wilson PC, Whiting A: A parallel combinatorial approach to locating homochiral lewis acid catalysts for asymmetric aza-Diels-Alder reaction of an imino dienophile. Tetrahedron Lett 1998, 39:8905-8908.
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Tetrahedron Lett
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Bromidge, S.1
Wilson, P.C.2
Whiting, A.3
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11
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0032538022
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Design and optimization of new phosphine oxazoline ligands via high-throughput catalyst screening
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Porte AM, Reibenspies J, Burgess K: Design and optimization of new phosphine oxazoline ligands via high-throughput catalyst screening. J Am Chem Soc 1998, 120:9180-9187.
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J Am Chem Soc
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Porte, A.M.1
Reibenspies, J.2
Burgess, K.3
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12
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0032502884
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Thermographic selection of effective catalysts from an encoded polymer-bound library
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Taylor SJ, Morken JP: Thermographic selection of effective catalysts from an encoded polymer-bound library. Science 1998, 280:267-270. IR thermography is used to study resin-bound catalysts for the first time. Thousands of catalysts synthesized by split and pool techniques were analyzed simultaneously.
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Science
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Taylor, S.J.1
Morken, J.P.2
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13
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0027362628
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Complex synthetic chemical libraries indexed with molecular tags
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Reader, J.C.4
Asouline, G.5
Kobayashi, R.6
Wigler, M.7
Still, W.C.8
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14
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0032538361
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Time-resolved IR-thermographic detection and screening of enantioselectivity in catalytic reactions
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Reetz MT, Becker MH, Kuhling KM, Holzwarth A: Time-resolved IR-thermographic detection and screening of enantioselectivity in catalytic reactions. Angew Chem Int Ed Engl 1998, 37:2647-2650.
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Angew Chem Int Ed Engl
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Reetz, M.T.1
Becker, M.H.2
Kuhling, K.M.3
Holzwarth, A.4
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15
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0032538479
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Detection of catalytic activity in combinatorial libraries of heterogeneous catalysts by IR thermography
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Holzwarth A, Schmidt H-W, Maier WF: Detection of catalytic activity in combinatorial libraries of heterogeneous catalysts by IR thermography. Angew Chem Int Ed Engl 1998, 37:2644-2647.
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Angew Chem Int Ed Engl
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Holzwarth, A.1
Schmidt, H.-W.2
Maier, W.F.3
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16
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0032546499
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High-throughput synthesis and direct screening for the discovery of novel hydrolytic metal complexes
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Berg T, Vandersteen AM, Janda KD: High-throughput synthesis and direct screening for the discovery of novel hydrolytic metal complexes. Bioorg Med Chem Lett 1998, 8:1221-1224.
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Bioorg Med Chem Lett
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Berg, T.1
Vandersteen, A.M.2
Janda, K.D.3
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17
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0032600832
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A combined parallel synthesis and screening of macrocyclic lanthanide complexes for the cleavage of phospho di- and triesters and double stranded DNA
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Berg T, Vandersteen AM, Janda KD: A combined parallel synthesis and screening of macrocyclic lanthanide complexes for the cleavage of phospho di- and triesters and double stranded DNA. J Comb Chem 1999, 1:96-100.
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J Comb Chem
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Berg, T.1
Vandersteen, A.M.2
Janda, K.D.3
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18
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0032581922
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Reactive dyes as a method for rapid screening of homogeneous catalysts
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Cooper AC, McAlexander LH, Lee D-H, Torres MT, Crabtree RH: Reactive dyes as a method for rapid screening of homogeneous catalysts. J Am Chem Soc 1998, 120:9971-9972. A visual method for monitoring conversion in catalytic reactions is discussed.
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J Am Chem Soc
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Cooper, A.C.1
McAlexander, L.H.2
Lee, D.-H.3
Torres, M.T.4
Crabtree, R.H.5
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19
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0033577277
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A fluorescence-based assay for high throughput screening of coupling reactions. Application to Heck chemistry
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Shaughnessy KH, Kim P, Hartwig JF: A fluorescence-based assay for high throughput screening of coupling reactions. Application to Heck chemistry. J Am Chem Soc 1999, 121:2123-2132. A versatile fluorescence technique determines relative incorporation of a fluorescent dye onto a solid support, thus determining activity of catalysts for a Heck coupling.
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J Am Chem Soc
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Shaughnessy, K.H.1
Kim, P.2
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20
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0001809323
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Single-bead fluorescence microspectroscopy: Detection of self-quenching in fluorescence-labeled resin beads
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J Comb Chem
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Yan, B.1
Martin, P.C.2
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0033526393
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A chemosensor-based approach to catalyst discovery in solution and on solid support
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Copeland GT, Miller SJ: A chemosensor-based approach to catalyst discovery in solution and on solid support. J Am Chem Soc 1999, 121:in press. A pH-sensitive fluorescent marker is used to monitor the production of acid in a reaction. The amount of fluorescence correlates to the activity of the catalyst.
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(1999)
J Am Chem Soc
, pp. 121
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Copeland, G.T.1
Miller, S.J.2
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22
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0032564916
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Kinetic resolution of alcohols catalyzed by tripeptides containing the n-alkylimidazole substructure
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Miller SJ, Copeland GT, Papaioannou N, Horstmann TE, Ruel EM: Kinetic resolution of alcohols catalyzed by tripeptides containing the n-alkylimidazole substructure. J Am Chem Soc 1998, 120:1629-1630.
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J Am Chem Soc
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Miller, S.J.1
Copeland, G.T.2
Papaioannou, N.3
Horstmann, T.E.4
Ruel, E.M.5
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23
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0000089981
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Minimal Acylase-like peptides. Conformational control of absolute stereospecificity
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Copeland GT, Jarvo ER, Miller SJ: Minimal Acylase-like peptides. Conformational control of absolute stereospecificity. J Org Chem 1998, 63:6784-6785.
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J Org Chem
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Copeland, G.T.1
Jarvo, E.R.2
Miller, S.J.3
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24
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0032560748
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High-throughput screening of solid-state catalyst libraries
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Senkan SM: High-throughput screening of solid-state catalyst libraries. Nature 1998, 394:350-353.
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Nature
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, pp. 350-353
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Senkan, S.M.1
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25
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0032510984
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Combinatorial electrochemistry: A highly parallel, optical screening method for discovery of better electrocatalysts
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Reddington E, Sapienza A, Gurau B, Viswanathan R, Sarangapani S, Smotkin ES, Mallouk TE: Combinatorial electrochemistry: A highly parallel, optical screening method for discovery of better electrocatalysts. Science 1998, 280:1735-1737.
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Science
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Reddington, E.1
Sapienza, A.2
Gurau, B.3
Viswanathan, R.4
Sarangapani, S.5
Smotkin, E.S.6
Mallouk, T.E.7
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