메뉴 건너뛰기




Volumn 10, Issue 4, 2011, Pages 670-678

Context dependence of checkpoint kinase 1 as a therapeutic target for pancreatic cancers deficient in the BRCA2 tumor suppressor

Author keywords

[No Author keywords available]

Indexed keywords

BRCA2 PROTEIN; CHECKPOINT KINASE 1; GEMCITABINE; MITOMYCIN C;

EID: 79955758170     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-10-0781     Document Type: Article
Times cited : (21)

References (35)
  • 1
    • 0035099044 scopus 로고    scopus 로고
    • BRCA2 is required for homology-directed repair of chromosomal breaks
    • DOI 10.1016/S1097-2765(01)00174-5
    • Moynahan ME, Pierce AJ, Jasin M. BRCA2 is required for homology-directed repair of chromosomal breaks. Mol Cell 2001;7:263-72. (Pubitemid 32206494)
    • (2001) Molecular Cell , vol.7 , Issue.2 , pp. 263-272
    • Moynahan, M.E.1    Pierce, A.J.2    Jasin, M.3
  • 2
    • 63049108452 scopus 로고    scopus 로고
    • Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment
    • Venkitaraman AR. Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment. Annu Rev Pathol 2009;4:461-87.
    • (2009) Annu Rev Pathol , vol.4 , pp. 461-487
    • Venkitaraman, A.R.1
  • 5
    • 0032126029 scopus 로고    scopus 로고
    • Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells
    • Abbott DW, Freeman ML, Holt JT. Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells. J Natl Cancer Inst 1998;90:978-85. (Pubitemid 28340438)
    • (1998) Journal of the National Cancer Institute , vol.90 , Issue.13 , pp. 978-985
    • Abbott, D.W.1    Freeman, M.L.2    Holt, J.T.3
  • 6
    • 74949093142 scopus 로고    scopus 로고
    • A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors
    • Evers B, Schut E, Van Der Burg E, Braumuller TM, Egan DA, Holstege H, et al. A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors. Clin Cancer Res 2010;16:99-108.
    • (2010) Clin Cancer Res , vol.16 , pp. 99-108
    • Evers, B.1    Schut, E.2    Van Der Burg, E.3    Braumuller, T.M.4    Egan, D.A.5    Holstege, H.6
  • 7
    • 0030667434 scopus 로고    scopus 로고
    • Integrating genetic approaches into the discovery of anticancer drugs
    • DOI 10.1126/science.278.5340.1064
    • Hartwell LH, Szankasi P, Roberts CJ, Murray AW, Friend SH. Integrating genetic approaches into the discovery of anticancer drugs. Science 1997;278:1064-8. (Pubitemid 27517876)
    • (1997) Science , vol.278 , Issue.5340 , pp. 1064-1068
    • Hartwell, L.H.1    Szankasi, P.2    Roberts, C.J.3    Murray, A.W.4    Friend, S.H.5
  • 8
    • 25444497278 scopus 로고    scopus 로고
    • The concept of synthetic lethality in the context of anticancer therapy
    • Kaelin WG Jr. The concept of synthetic lethality in the context of anticancer therapy. Nat Rev Cancer 2005;5:689-98.
    • (2005) Nat Rev Cancer , vol.5 , pp. 689-698
    • Kaelin Jr., W.G.1
  • 11
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M, et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009;361:123-34.
    • (2009) N Engl J Med , vol.361 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3    Tutt, A.4    Wu, P.5    Mergui-Roelvink, M.6
  • 15
    • 0029125820 scopus 로고
    • K-ras mutation and pancreatic adenocarcinoma
    • Caldas C, Kern SE. K-ras mutation and pancreatic adenocarcinoma. Int J Pancreatol 1995;18:1-6.
    • (1995) Int J Pancreatol , vol.18 , pp. 1-6
    • Caldas, C.1    Kern, S.E.2
  • 16
    • 0028308492 scopus 로고
    • P53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions
    • Redston MS, Caldas C, Seymour AB, Hruban RH, da Costa L, Yeo CJ, et al. p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions. Cancer Res 1994;54:3025-33. (Pubitemid 24187791)
    • (1994) Cancer Research , vol.54 , Issue.11 , pp. 3025-3033
    • Redston, M.S.1    Caldas, C.2    Seymour, A.B.3    Hruban, R.H.4    Da, C.L.5    Yeo, C.J.6    Kern, S.E.7
  • 17
    • 78249247414 scopus 로고    scopus 로고
    • Germline Brca2 heterozygosity promotes Kras (G12D)-driven carcinogenesis in a murine model of familial pancreatic cancer
    • Skoulidis F, Cassidy LD, Pisupati V, Jonasson JG, Bjarnason H, Eyfjord JE, et al. Germline Brca2 heterozygosity promotes Kras (G12D)-driven carcinogenesis in a murine model of familial pancreatic cancer. Cancer Cell 2010;18:499-509.
    • (2010) Cancer Cell , vol.18 , pp. 499-509
    • Skoulidis, F.1    Cassidy, L.D.2    Pisupati, V.3    Jonasson, J.G.4    Bjarnason, H.5    Eyfjord, J.E.6
  • 19
    • 74549189337 scopus 로고    scopus 로고
    • New insights into checkpoint kinase 1 in the DNA damage response signaling network
    • Dai Y, Grant S. New insights into checkpoint kinase 1 in the DNA damage response signaling network. Clin Cancer Res 2010;16:376-83.
    • (2010) Clin Cancer Res , vol.16 , pp. 376-383
    • Dai, Y.1    Grant, S.2
  • 20
    • 33846523617 scopus 로고    scopus 로고
    • Targeted anti-mitotic therapies: Can we improve on tubulin agents?
    • Jackson JR, Patrick DR, Dar MM, Huang PS. Targeted anti-mitotic therapies: can we improve on tubulin agents? Nat Rev Cancer 2007;7:107-17.
    • (2007) Nat Rev Cancer , vol.7 , pp. 107-117
    • Jackson, J.R.1    Patrick, D.R.2    Dar, M.M.3    Huang, P.S.4
  • 21
    • 33846676987 scopus 로고    scopus 로고
    • Chemical Genetics: Where Genetics and Pharmacology Meet
    • DOI 10.1016/j.cell.2007.01.021, PII S0092867407001195
    • Knight ZA, Shokat KM. Chemical genetics: where genetics and pharmacology meet. Cell 2007;128:425-30. (Pubitemid 46198904)
    • (2007) Cell , vol.128 , Issue.3 , pp. 425-430
    • Knight, Z.A.1    Shokat, K.M.2
  • 24
    • 65449142073 scopus 로고    scopus 로고
    • CHK1 inhibition as a strategy for targeting Fanconi anemia (FA) DNA repair pathway deficient tumors
    • Chen CC, Kennedy RD, Sidi S, Look AT, D'Andrea A. CHK1 inhibition as a strategy for targeting Fanconi anemia (FA) DNA repair pathway deficient tumors. Mol Cancer 2009;8:24.
    • (2009) Mol Cancer , vol.8 , pp. 24
    • Chen, C.C.1    Kennedy, R.D.2    Sidi, S.3    Look, A.T.4    D'Andrea, A.5
  • 26
    • 0034326813 scopus 로고    scopus 로고
    • The role of cell cycle progression in radiosensitization by 2′,2′-difluoro-2′-deoxycytidine
    • Ostruszka LJ, Shewach DS. The role of cell cycle progression in radiosensitization by 2′,2′-difluoro-2′-deoxycytidine. Cancer Res 2000;60:6080-8.
    • (2000) Cancer Res , vol.60 , pp. 6080-6088
    • Ostruszka, L.J.1    Shewach, D.S.2
  • 27
    • 67650085633 scopus 로고    scopus 로고
    • Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer
    • Azorsa DO, Gonzales IM, Basu GD, Choudhary A, Arora S, Bisanz KM, et al. Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. J Transl Med 2009;7:43.
    • (2009) J Transl Med , vol.7 , pp. 43
    • Azorsa, D.O.1    Gonzales, I.M.2    Basu, G.D.3    Choudhary, A.4    Arora, S.5    Bisanz, K.M.6
  • 28
    • 77953506262 scopus 로고    scopus 로고
    • Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase
    • McNeely S, Conti C, Sheikh T, Patel H, Zabludoff S, Pommier Y, et al. Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase. Cell Cycle 2010;9:995-1004.
    • (2010) Cell Cycle , vol.9 , pp. 995-1004
    • McNeely, S.1    Conti, C.2    Sheikh, T.3    Patel, H.4    Zabludoff, S.5    Pommier, Y.6
  • 29
    • 51049105757 scopus 로고    scopus 로고
    • Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair
    • Toulany M, Kehlbach R, Florczak U, Sak A, Wang S, Chen J, et al. Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair. Mol Cancer Ther 2008;7:1772-81.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1772-1781
    • Toulany, M.1    Kehlbach, R.2    Florczak, U.3    Sak, A.4    Wang, S.5    Chen, J.6
  • 30
    • 0023835721 scopus 로고
    • The ras oncogenes increase the intrinsic resistance of NIH 3T3 cells to ionizing radiation
    • Sklar MD. The ras oncogenes increase the intrinsic resistance of NIH 3T3 cells to ionizing radiation. Science 1988;239:645-7. (Pubitemid 18066229)
    • (1988) Science , vol.239 , Issue.4840 , pp. 645-647
    • Sklar, M.D.1
  • 31
    • 0034548724 scopus 로고    scopus 로고
    • Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines
    • Bernhard EJ, Stanbridge EJ, Gupta S, Gupta AK, Soto D, Bakanauskas VJ, et al. Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines. Cancer Res 2000;60:6597-600.
    • (2000) Cancer Res , vol.60 , pp. 6597-6600
    • Bernhard, E.J.1    Stanbridge, E.J.2    Gupta, S.3    Gupta, A.K.4    Soto, D.5    Bakanauskas, V.J.6
  • 33
    • 55249124825 scopus 로고    scopus 로고
    • Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells
    • Dai Y, Chen S, Pei XY, Almenara JA, Kramer LB, Venditti CA, et al. Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells. Blood 2008;112:2439-49.
    • (2008) Blood , vol.112 , pp. 2439-2449
    • Dai, Y.1    Chen, S.2    Pei, X.Y.3    Almenara, J.A.4    Kramer, L.B.5    Venditti, C.A.6
  • 34
    • 1942502234 scopus 로고    scopus 로고
    • Tracing the network connecting BRCA and Fanconi anaemia proteins
    • Venkitaraman AR. Tracing the network connecting BRCA and Fanconi anaemia proteins. Nat Rev Cancer 2004;4:266-76. (Pubitemid 38525282)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.4 , pp. 266-276
    • Venkitaraman, A.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.