Thyroid-stimulating hormone receptor activity after internalization;L'activité du récepteur de la TSH après son internalisation

Annales d'Endocrinologie

Volumn 72, Issue 2, 2011, Pages 64-67

  Calebiro, D ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Cyclic AMP; Fluorescence resonance energy transfer; G protein coupled receptor; Thyrotropin receptor

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; PARATHYROID HORMONE RECEPTOR; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; THYROTROPIN; THYROTROPIN RECEPTOR;

ARTICLE; CELL SURFACE; ENDOCYTOSIS; ENDOSOME; HORMONE ACTION; HUMAN; INTERNALIZATION; INTRACELLULAR SPACE; PROTEIN DEGRADATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; ANIMALS; CYCLIC AMP; ENDOSOMES; MICE; MICE, TRANSGENIC; PROTEIN TRANSPORT; RECEPTORS, THYROTROPIN; SIGNAL TRANSDUCTION; THYROID GLAND;

EID: 79955713826     PISSN: 00034266     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ando.2011.03.008     Document Type: Article

References (40)

1. Pierce K.L., Premont R.T., Lefkowitz R.J. Seven-transmembrane receptors. Nat Rev Mol Cell Biol 2002, 3:639-650.
2. Lagerstrom M.C., Schioth H.B. Structural diversity of G-protein-coupled receptors and significance for drug discovery. Nat Rev Drug Discov 2008, 7:339-357.
3. Vassart G., Dumont J.E. The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocr Rev 1992, 13:596-611.
4. Medina D.L., Santisteban P. Thyrotropin-dependent proliferation of in vitro rat thyroid cell systems. Eur J Endocrinol 2000, 143:161-178.
5. Vassart G., Pardo L., Costagliola S. A molecular dissection of the glycoprotein hormone receptors. Trends Biochem Sci 2004, 29:119-126.
6. Baratti-Elbaz C., Ghinea N., Lahuna O., Loosfelt H., Pichon C., Milgrom E. Internalization and recycling pathways of the thyrotropin receptor. Mol Endocrinol 1999, 13:1751-1765.
7. Lahuna O., Quellari M., Achard C., Nola S., Meduri G., Navarro C., et al. Thyrotropin receptor trafficking relies on the hScrib-βPIX-GIT1-ARF6 pathway. EMBO J 2005, 24:1364-1374.
8. Frenzel R., Voigt C., Paschke R. The human thyrotropin receptor is predominantly internalized by β-arrestin 2. Endocrinology 2006, 147:3114-3122.
9. Hanyaloglu A.C., von Zastrow M. Regulation of GPCRs by endocytic membrane trafficking and its potential implications. Annu Rev Pharmacol Toxicol 2008, 48:537-568.
10. Sorkin A., von Zastrow M Endocytosis and signaling: intertwining molecular networks. Nat Rev Mol Cell Biol 2009, 10:609-622.
11. Lohse M.J. Molecular mechanisms of membrane receptor desensitization. Biochim Biophys Acta 1993, 1179:171-188.
12. Calebiro D., Nikolaev V.O., Persani L., Lohse M.J. Signaling by internalized G-protein-coupled receptors. Trends Pharmacol Sci 2010, 31:221-228.
13. Calebiro D., Nikolaev V.O., Lohse M.J. Imaging of persistent cAMP signaling by internalized G-protein-coupled receptors. J Mol Endocrinol 2010, 45:1-8.
14. Yu S.S., Lefkowitz R.J., Hausdorff W.P. β-adrenergic receptor sequestration. A potential mechanism of receptor resensitization. J Biol Chem 1993, 268:337-341.
15. Pippig S., Andexinger S., Lohse M.J. Sequestration and recycling of β2-adrenergic receptors permit receptor resensitization. Mol Pharmacol 1995, 47:666-676.
16. Krueger K.M., Daaka Y., Pitcher J.A., Lefkowitz R.J. The role of sequestration in G-protein-coupled receptor resensitization. Regulation of β2-adrenergic receptor dephosphorylation by vesicular acidification. J Biol Chem 1997, 272:5-8.
17. Daaka Y., Luttrell L.M., Ahn S., Della Rocca G.J., Ferguson S S.S., Caron M.G., et al. Essential role for G-protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. J Biol Chem 1998, 273:685-688.
18. DeWire S.M., Ahn S., Lefkowitz R.J., Shenoy S.K. β-arrestins and cell signaling. Annu Rev Physiol 2007, 69:483-510.
19. Slessareva J.E., Routt S.M., Temple B., Bankaitis V.A., Dohlman H.G. Activation of the phosphatidylinositol 3-kinase Vps34 by a G-protein α subunit at the endosome. Cell 2006, 126:191-203.
20. Diaz Anel A.M. Phospholipase C β3 is a key component in the Gβγ/PKCη/PKD-mediated regulation of trans-Golgi network to plasma membrane transport. Biochem J 2007, 406:157-165.
21. Garcia-Regalado A., Guzman-Hernandez M.L., Ramirez-Rangel I., Robles-Molina E., Balla T., Vazquez-Prado J., et al. G-protein-coupled receptor-promoted trafficking of Gβ1γ2 leads to AKT activation at endosomes via a mechanism mediated by Gβ1γ2-Rab11a interaction. Mol Biol Cell 2008, 19:4188-4200.
22. Lohse M.J., Nikolaev V.O., Hein P., Hoffmann C., Vilardaga J.P., Bünemann M. Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors. Trends Pharmacol Sci 2008, 29:159-165.
23. Persani L., Calebiro D., Bonomi M. Technology Insight: modern methods to monitor protein-protein interactions reveal functional TSH receptor oligomerization. Nat Clin Pract Endocrinol Metab 2007, 3:180-190.
24. Calebiro D., de Filippis T., Lucchi S S., Covino C., Panigone S., Beck-Peccoz P., et al. Intracellular entrapment of wild-type TSH receptor by oligomerization with mutants linked to dominant TSH resistance. Hum Mol Genet 2005, 14:2991-3002.
25. Vilardaga J.P., Bünemann M., Krasel C., Castro M., Lohse M.J. Measurement of the millisecond activation switch of G-protein-coupled receptors in living cells. Nat Biotechnol 2003, 21:807-812.
26. Castro M., Nikolaev V.O., Palm D., Lohse M.J., Vilardaga J.P. Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism. Proc Natl Acad Sci U S A 2005, 102:16084-16089.
27. Janetopoulos C., Jin T., Devreotes P. Receptor-mediated activation of heterotrimeric G-proteins in living cells. Science 2001, 291:2408-2411.
28. Bünemann M., Frank M., Lohse M.J. Gi-protein activation in intact cells involves subunit rearrangement rather than dissociation. Proc Natl Acad Sci U S A 2003, 100:16077-16082.
29. Nikolaev V.O., Bünemann M., Hein L., Hannawacker A., Lohse M.J. Novel single chain cAMP sensors for receptor-induced signal propagation. J Biol Chem 2004, 279:37215-37218.
30. DiPilato L.M., Cheng X., Zhang J. Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proc Natl Acad Sci U S A 2004, 101:16513-16518.
31. Ponsioen B., Zhao J., Riedl J., Zwartkruis F., van der Krogt G., Zaccolo M., et al. Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator. EMBO Rep 2004, 5:1176-1180.
32. Nikolaev V.O., Bünemann M., Schmitteckert E., Lohse M.J., Engelhardt S. Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching β1-adrenergic but locally confined β2-adrenergic receptor-mediated signaling. Circ Res 2006, 99:1084-1091.
33. Lissandron V., Rossetto M.G., Erbguth K., Fiala A., Daga A., Zaccolo M. Transgenic fruit-flies expressing a FRET-based sensor for in vivo imaging of cAMP dynamics. Cell Signal 2007, 19:2296-2303.
34. Shafer O.T., Kim D.J., Dunbar-Yaffe R., Nikolaev V.O., Lohse M.J., Taghert P.H. Widespread receptivity to neuropeptide PDF throughout the neuronal circadian clock network of Drosophila revealed by real-time cyclic AMP imaging. Neuron 2008, 58:223-237.
35. Calebiro D., Nikolaev V.O., Gagliani M.C., de Filippis T., Dees C., Tacchetti C., et al. Persistent cAMP-signals triggered by internalized G-protein-coupled receptors. PLoS Biol 2009, 7:e1000172.
36. Jacobs S., Calebiro D., Nikolaev V.O., Lohse M.J., Schulz S. Real-time monitoring of somatostatin receptor-cAMP signaling in live pituitary. Endocrinology 2010, 151:4560-4565.
37. Ferrandon S., Feinstein T.N., Castro M., Wang B., Bouley R., Potts J.T., et al. Sustained cyclic AMP production by parathyroid hormone receptor endocytosis. Nat Chem Biol 2009, 5:734-742.
38. Müllershausen F., Zecri F., Cetin C., Billich A., Guerini D., Seuwen K. Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors. Nat Chem Biol 2009, 5:428-434.
39. Sato M., Blumer J.B., Simon V., Lanier S.M. Accessory proteins for G-proteins: partners in signaling. Annu Rev Pharmacol Toxicol 2006, 46:151-187.
40. Helms J.B. Role of heterotrimeric GTP binding proteins in vesicular protein transport: indications for both classical and alternative G-protein cycles. FEBS Lett 1995, 369:84-88.