Imaging of persistent cAMP signaling by internalized G protein-coupled receptors

Journal of Molecular Endocrinology

Volumn 45, Issue 1, 2010, Pages 1-8

  Calebiro, Davide ^a   Nikolaev, Viacheslav O ^a   Lohse, Martin J ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; PHOTOPROTEIN;

ENDOSOME; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; INTERNALIZATION; MOLECULAR DYNAMICS; MOLECULAR IMAGING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW; SIGNAL TRANSDUCTION; THYROID FOLLICLE; ANIMAL; CYTOLOGY; DEVICES; ENDOCYTOSIS; METABOLISM; PHYSIOLOGY; PROCEDURES; SECOND MESSENGER; THYROID GLAND; ULTRASTRUCTURE;

ANIMALS; CYCLIC AMP; ENDOCYTOSIS; ENDOSOMES; FLUORESCENCE RESONANCE ENERGY TRANSFER; LUMINESCENT PROTEINS; RECEPTORS, G-PROTEIN-COUPLED; SECOND MESSENGER SYSTEMS; THYROID GLAND;

EID: 77954710506     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1677/JME-10-0014     Document Type: Review

References (53)

1. Adams SR, Harootunian AT, Buechler YJ, Taylor SS & Tsien RY 1991 Fluorescence ratio imaging of cyclic AMP in single cells. Nature 349 694-697.
2. Bacskai BJ, Hochner B, Mahaut-Smith M, Adams SR, Kaang BK, Kandel ER & Tsien RY 1993 Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons. Science 260 222-226. (Pubitemid 23140889)
3. Baratti-Elbaz C, Ghinea N, Lahuna O, Loosfelt H, Pichon C & Milgrom E 1999 Internalization and recycling pathways of the thyrotropin receptor. Molecular Endocrinology 13 1751-1765. (Pubitemid 30648837)
4. 4 receptor signalling. EMBO Journal 28 2706-2718.
5. Bünemann M, Frank M & Lohse MJ 2003 Gi protein activation in intact cells involves subunit rearrangement rather than dissociation. PNAS 100 16077-16082.
6. Calebiro D, Nikolaev VO, Gagliani MC, de Filippis T, Dees C, Tacchetti C, Persani L & Lohse MJ 2009 Persistent cAMP-signals triggered by internalized G-protein-coupled receptors. PLoS Biology 7 e1000172.
7. Castro M, Nikolaev VO, Palm D, Lohse MJ & Vilardaga JP 2005 Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism. PNAS 102 16084-16089.
8. Dean T, Vilardaga JP, Potts JT Jr & Gardella TJ 2008 Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor. Molecular Endocrinology 22 156-166.
9. Diaz Anel AM 2007 Phospholipase C β3 is a key component in the Gβγ/PKCη/PKD-mediated regulation of trans-Golgi network to plasma membrane transport. Biochemical Journal 406 157-165.
10. DiPilato LM, Cheng X & Zhang J 2004 Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. PNAS 101 16513-16518.
11. Dupré DJ, Robitaille M, Rebois RV & Hebert TE 2009 The role of Gβγ subunits in the organization, assembly, and function of GPCR signaling complexes. Annual Review of Pharmacology and Toxicology 49 31-56.
12. m cyclic nucleotide phosphodiesterases in the regulation of the concentration of adenosine 3′,5′-cyclic monophosphate in animal cells. Journal of Theoretical Biology 84 361-385.
13. Ferrandon S, Feinstein TN, Castro M, Wang B, Bouley R, Potts JT, Gardella TJ & Vilardaga JP 2009 Sustained cyclic AMP production by parathyroid hormone receptor endocytosis. Nature Chemical Biology 5 734-742.
14. Frenzel R, Voigt C & Paschke R 2006 The human thyrotropin receptor is predominantly internalized by β-arrestin 2. Endocrinology 147 3114-3122. (Pubitemid 43764647)
15. Garcia-Regalado A, Guzman-Hernandez ML, Ramirez-Rangel I, Robles-Molina E, Balla T, Vazquez-Prado J & Reyes-Cruz G 2008 G protein-coupled receptor-promoted trafficking of Gβ1γ2 leads to AKT activation at endosomes via a mechanism mediated by Gβ1γ2-Rab11a interaction. Molecular Biology of the Cell 19 4188-4200.
16. Gilman AG 1987 G proteins: transducers of receptor-generated signals. Annual Review of Biochemistry 56 615-649.
17. Gobeil F Jr, Bernier SG, Vazquez-Tello A, Brault S, Beauchamp MH, Quiniou C, Marrache AM, Checchin D, Sennlaub F, Hou X et al. 2003 Modulation of pro-inflammatory gene expression by nuclear lysophosphatidic acid receptor type-1. Journal of Biological Chemistry 278 38875-38883.
18. Goichot B, Brandenberger G, Saini J, Wittersheim G & Follenius M 1994 Nycthemeral patterns of thyroid hormones and their relationships with thyrotropin variations and sleep structure. Journal of Endocrinological Investigation 17 181-187.
19. Hanyaloglu AC & von Zastrow M 2008 Regulation of GPCRs by endocytic membrane trafficking and its potential implications. Annual Review of Pharmacology and Toxicology 48 537-568.
20. Hempel CM, Vincent P, Adams SR, Tsien RY & Selverston AI 1996 Spatio-temporal dynamics of cyclic AMP signals in an intact neural circuit. Nature 384 166-169. (Pubitemid 26386471)
21. Janetopoulos C, Jin T & Devreotes P 2001 Receptor-mediated activation of heterotrimeric G-proteins in living cells. Science 291 2408-2411. (Pubitemid 32231802)
22. 2+ channels by β-adrenergic agonists. PNAS 93 295-299.
23. Kappos L, Antel J, Comi G, Montalban X, O'Connor P, Polman CH, Haas T, Korn AA, Karlsson G & Radue EW 2006 Oral fingolimod (FTY720) for relapsing multiple sclerosis. New England Journal of Medicine 355 1124-1140. (Pubitemid 44394919)
24. 2-adrenergic receptor dephosphorylation by vesicular acidification. Journal of Biological Chemistry 272 5-8.
25. Kusakabe T, Kawaguchi A, Hoshi N, Kawaguchi R, Hoshi S & Kimura S 2006 Thyroid-specific enhancer-binding protein/NKX2.1 is required for the maintenance of ordered architecture and function of the differentiated thyroid. Molecular Endocrinology 20 1796-1809. (Pubitemid 44148085)
26. Lagerstrom MC & Schioth HB 2008 Structural diversity of G protein-coupled receptors and significance for drug discovery. Nature Reviews. Drug Discovery 7 339-357.
27. Lahuna O, Quellari M, Achard C, Nola S, Meduri G, Navarro C, Vitale N, Borg JP & Misrahi M 2005 Thyrotropin receptor trafficking relies on the hScrib-βPIX-GIT1-ARF6 pathway. EMBO Journal 24 1364-1374. (Pubitemid 40593057)
28. Liao JJ, Huang MC, Graler M, Huang Y, Qiu H & Goetzl EJ 2007 Distinctive T cell-suppressive signals from nuclearized type 1 sphingosine 1-phosphate G protein-coupled receptors. Journal of Biological Chemistry 282 1964-1972.
29. Lohse MJ 1993 Molecular mechanisms of membrane receptor desensitization. Biochimica et Biophysica Acta 1179 171-188.
30. Lohse MJ, Nikolaev VO, Hein P, Hoffmann C, Vilardaga JP & Bünemann M 2008 Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors. Trends in Pharmacological Sciences 29 159-165.
31. Magner JA 1990 Thyroid-stimulating hormone: biosynthesis, cell biology, and bioactivity. Endocrine Reviews 11 354-385.
32. Mathew D, Ataman B, Chen J, Zhang Y, Cumberledge S & Budnik V 2005 Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2. Science 310 1344-1347.
33. Miaczynska M, Pelkmans L & Zerial M 2004 Not just a sink: endosomes in control of signal transduction. Current Opinion in Cell Biology 16 400-406. (Pubitemid 38903146)
34. Müllershausen F, Zecri F, Cetin C, Billich A, Guerini D & Seuwen K 2009 Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors. Nature Chemical Biology 5 428-434.
35. Nikolaev VO, Bünemann M, Hein L, Hannawacker A & Lohse MJ 2004 Novel single chain cAMP sensors for receptor-induced signal propagation. Journal of Biological Chemistry 279 37215-37218. (Pubitemid 39195424)
36. 2-adrenergic receptor-mediated signaling. Circulation Research 99 1084-1091.
37. Pierce KL, Premont RT & Lefkowitz RJ 2002 Seven-transmembrane receptors. Nature Reviews. Molecular Cell Biology 3 639-650.
38. 2-adrenergic receptors permit receptor resensitization. Molecular Pharmacology 47 666-676.
39. Ponsioen B, Zhao J, Riedl J, Zwartkruis F, van der Krogt G, Zaccolo M, Moolenaar WH, Bos JL & Jalink K 2004 Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator. EMBO Reports 5 1176-1180. (Pubitemid 40103613)
40. Revankar CM, Cimino DF, Sklar LA, Arterburn JB & Prossnitz ER 2005 A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 307 1625-1630.
41. Robben JH, Kortenoeven ML, Sze M, Yae C, Milligan G, Oorschot VM, Klumperman J, Knoers NV & Deen PM 2009 Intracellular activation of vasopressin V2 receptor mutants in nephrogenic diabetes insipidus by nonpeptide agonists. PNAS 106 12195-12200.
42. Slessareva JE, Routt SM, Temple B, Bankaitis VA & Dohlman HG 2006 Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein α subunit at the endosome. Cell 126 191-203.
43. Sorkin A & von Zastrow M 2009 Endocytosis and signalling: intertwining molecular networks. Nature Reviews. Molecular Cell Biology 10 609-622.
44. Toda S, Watanabe K, Yokoi F, Matsumura S, Suzuki K, Ootani A, Aoki S, Koike N & Sugihara H 2002 A new organotypic culture of thyroid tissue maintains three-dimensional follicles with C cells for a long term. Biochemical and Biophysical Research Communications 294 906-911. (Pubitemid 34687202)
45. Tsao P, Cao T & von Zastrow M 2001 Role of endocytosis in mediating downregulation of G-protein-coupled receptors. Trends in Pharmacological Sciences 22 91-96. (Pubitemid 32146487)
46. Vassart G & Dumont JE 1992 The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocrine Reviews 13 596-611.
47. Vieira AV, Lamaze C & Schmid SL 1996 Control of EGF receptor signaling by clathrin-mediated endocytosis. Science 274 2086-2089. (Pubitemid 27020702)
48. Vilardaga JP, Bünemann M, Krasel C, Castro M & Lohse MJ 2003 Measurement of the millisecond activation switch of G protein-coupled receptors in living cells. Nature Biotechnology 21 807-812. (Pubitemid 36791401)
49. 2+ channel regulation in guinea-pig ventricular myocytes. Journal of Physiology 580 765-776.
50. Yu SS, Lefkowitz RJ & Hausdorff WP 1993 β-Adrenergic receptor sequestration. A potential mechanism of receptor resensitization. Journal of Biological Chemistry 268 337-341.
51. Zaccolo M & Pozzan T 2002 Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes. Science 295 1711-1715.
52. Zaccolo M, De Giorgi F, Cho CY, Feng L, Knapp T, Negulescu PA, Taylor SS, Tsien RY & Pozzan T 2000 A genetically encoded, fluorescent indicator for cyclic AMP in living cells. Nature Cell Biology 2 25-29.
53. Zidar DA, Violin JD, Whalen EJ & Lefkowitz RJ 2009 Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands. PNAS 106 9649-9654.