Drugs of abuse: Epigenetic mechanisms in toxicity and addiction

Current Medicinal Chemistry

Volumn 18, Issue 12, 2011, Pages 1765-1774

  Kovatsi, L ^a   Fragou, D ^a   Samanidou, V ^a   Njau, S ^a   Kouidou, S ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Abuse; Amphetamines; Cocaine; Drugs; Epigenetics; Ethanol; Heroin

Indexed keywords

ALCOHOL; AMPHETAMINE; COCAINE; DIAMORPHINE;

ALCOHOL INTOXICATION; AMPHETAMINE ADDICTION; ARTICLE; CANCER RISK; COCAINE DEPENDENCE; DNA METHYLATION; DRUG ABUSE; DRUG DEPENDENCE; EPIGENETICS; FETAL ALCOHOL SYNDROME; FETUS GROWTH; HEROIN DEPENDENCE; HISTONE ACETYLATION; HISTONE METHYLATION; HISTONE PHOSPHORYLATION; HUMAN; INTRAUTERINE GROWTH RETARDATION; NONHUMAN; PATHOGENESIS; SUBSTANCE ABUSE;

BEHAVIOR, ADDICTIVE; EPIGENESIS, GENETIC; HUMANS; SUBSTANCE-RELATED DISORDERS;

EID: 79955704453     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986711795496836     Document Type: Article

References (81)

1. Nowak, S.J.; Corces, V.G. Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation. Trends Genet., 2004, 20, 214-220. (Pubitemid 38369193)
2. McClung, C.A.; Nestler, E.J. Regulation of gene expression and cocaine reward by CREB and DeltaFosB. Nat. Neurosci., 2003, 6, 1208-1215. (Pubitemid 37346042)
3. Yuferov, V.; Kroslak, T.; Laforge, K.S.; Zhou, Y.; Ho, A.; Kreek, M.J. Differential gene expression in the rat caudate putamen after "binge" cocaine administration: advantage of triplicate microarray analysis. Synapse, 2003, 48, 157-169. (Pubitemid 36520649)
4. McClung, C.A.; Nestler, E.J.; Zachariou, V. Regulation of gene expression by chronic morphine and morphine withdrawal in the locus ceruleus and ventral tegmental area. J. Neurosci., 2005, 25, 6005-6015. (Pubitemid 40911432)
5. Hyman, S.E.; Malenka, R.C.; Nestler, E.J. Neural mechanisms of addiction: the role of reward-related learning and memory. Annu. Rev. Neurosci., 2006, 29, 565-598. (Pubitemid 44476856)
6. McClung, C.A.; Nestler, E.J. Neuroplasticity mediated by altered gene expression. Neuropsychopharmacology, 2008, 33, 3-17. (Pubitemid 350191310)
7. Cadet, J.L.; Jayanthi, S.; Deng, X. Methamphetamine-induced neuronal apoptosis involves the activation of multiple death pathways. Review. Neurotox Res., 2005, 8, 199-206.
8. Zhang, H.; Meyer, K.D.; Zhang, L. Fetal exposure to cocaine causes programming of Prkce gene repression in the left ventricle of adult rat offspring. Biol. Reprod., 2009, 80, 440-448.
9. Wang, L.L.; Yang, A.K.; He, S.M.; Liang, J.; Zhou, Z.W.; Li, Y.; Zhou, S.F. Identification of molecular targets associated with ethanol toxicity and implications in drug development. Curr. Pharm. Des., 2010, 16, 1313-1355.
10. Tsankova, N.; Renthal, W.; Kumar, A.; Nestler, E.J. Epigenetic regulation in psychiatric disorders. Nat. Rev. Neurosci., 2007, 8, 355-367. (Pubitemid 46652469)
11. Lutz, U.C. Alterations in homocysteine metabolism among alcohol dependent patients--clinical, pathobiochemical and genetic aspects. Curr. Drug Abuse Rev., 2008, 1, 47-55.
12. Nestler, E.J. Review. Transcriptional mechanisms of addiction: role of DeltaFosB. Philos. Trans. R. Soc. Lond. B. Biol. Sci., 2008, 363, 3245-3255.
13. Renthal, W.; Nestler, E.J. Epigenetic mechanisms in drug addiction. Trends Mol. Med., 2008, 14, 341-350.
14. Haycock, P.C. Fetal alcohol spectrum disorders: the epigenetic perspective. Biol. Reprod., 2009, 81, 607-617.
15. Renthal, W.; Nestler, E.J. Chromatin regulation in drug addiction and depression. Dialogues Clin. Neurosci., 2009, 11, 257-268.
16. Kalsi, G.; Prescott, C.A.; Kendler, K.S.; Riley, B.P. Unraveling the molecular mechanisms of alcohol dependence. Trends Genet., 2009, 25, 49-55.
17. Malvaez, M.; Barrett, R.M.; Wood, M.A.; Sanchis-Segura, C. Epigenetic mechanisms underlying extinction of memory and drug-seeking behavior. Mamm. Genome, 2009, 20, 612-623.
18. McQuown, S.C.; Wood, M.A. Epigenetic regulation in substance use disorders. Curr. Psychiatry Rep., 2010, 12, 145-153.
19. Garro, A.J.; McBeth, D.L.; Lima, V.; Lieber, C.S. Ethanol consumption inhibits fetal DNA methylation in mice: implications for the fetal alcohol syndrome. Alcohol. Clin. Exp. Res., 1991, 15, 395-398.
20. Liu, Y.; Balaraman, Y.; Wang, G.; Nephew, K.P.; Zhou, F.C. Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation. Epigenetics, 2009, 4, 500-511.
21. Nan, H.M.; Song, Y.J.; Yun, H.Y.; Park, J.S.; Kim, H. Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer .World J. Gastroenterol., 2005, 11, 3834-3841. (Pubitemid 41025233)
22. Ishida, E.; Nakamura, M.; Ikuta, M.; Shimada, K.; Matsuyoshi, S.; Kirita, T.; Konishi, N. Promotor hypermethylation of p14ARF is a key alteration for progression of oral squamous cell carcinoma. Oral Oncol., 2005, 41, 614-622. (Pubitemid 40828879)
23. Chang, H.W.; Ling, G.S.; Wei, W.I.; Yuen, A.P. Smoking and drinking can induce p15 methylation in the upper aerodigestive tract of healthy individuals and patients with head and neck squamous cell carcinoma. Cancer, 2004, 101, 125-132. (Pubitemid 38812431)
24. van Engeland, M.; Weijenberg, M.P.; Roemen, G.M.; Brink, M.; de Bruine, A.P.; Goldbohm, R.A.; van den Brandt, P.A.; Baylin, S.B.; de Goeij, A.F.; Herman, J.G. Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer. Cancer Res., 2003, 63, 3133-3137. (Pubitemid 36735864)
25. Hamid, A.; Wani, N.A.; Kaur, J. New perspectives on folate transport in relation to alcoholism-induced folate malabsorption--association with epigenome stability and cancer development. FEBS J., 2009, 276, 2175-2191.
26. Kim, J.S.; Shukla, S.D. Acute in vivo effect of ethanol (binge drinking) on histone H3 modifications in rat tissues. Alcohol Alcohol., 2006, 41, 126-132.
27. Bonsch, D.; Lenz, B.; Reulbach, U.; Kornhuber, J.; Bleich, S. Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism. J. Neural Transm., 2004, 111, 1611-1616. (Pubitemid 40064478)
28. Bonsch, D.; Lenz, B.; Fiszer, R.; Frieling, H.; Kornhuber, J.; Bleich, S. Lowered DNA methyltransferase (DNMT-3b) mRNA expression is associated with genomic DNA hypermethylation in patients with chronic alcoholism. J. Neural Transm., 2006, 113, 1299-1304. (Pubitemid 44291023)
29. Kim, J.S.; Shukla, S.D. Histone h3 modifications in rat hepatic stellate cells by ethanol. Alcohol Alcohol., 2005, 40, 367-372. (Pubitemid 41222394)
30. Bardag-Gorce, F.; French, B.A.; Joyce, M.; Baires, M.; Montgomery, R.O.; Li, J.; French, S. Histone acetyltransferase p300 modulates gene expression in an epigenetic manner at high blood alcohol levels. Exp. Mol. Pathol., 2007, 82, 197-202. (Pubitemid 46483380)
31. Bardag-Gorce, F.; Oliva, J.; Dedes, J.; Li, J.; French, B.A.; French, S.W. Chronic ethanol feeding alters hepatocyte memory which is not altered by acute feeding. Alcohol. Clin. Exp. Res., 2009, 33, 684-692.
32. Park, P.H.; Miller, R.; Shukla, S.D. Acetylation of histone H3 at lysine 9 by ethanol in rat hepatocytes. Biochem. Biophys. Res. Commun., 2003, 306, 501-504. (Pubitemid 36683102)
33. Park, P.H.; Lim, R.W.; Shukla, S.D. Involvement of histone acetyltransferase (HAT) in ethanol-induced acetylation of histone H3 in hepatocytes: potential mechanism for gene expression. Am. J. Physiol. Gastrointest. Liver Physiol., 2005, 289, G1124-36. (Pubitemid 41740619)
34. Pal-Bhadra, M.; Bhadra, U.; Jackson, D.E.; Mamatha, L.; Park, P.H.; Shukla, S.D. Distinct methylation patterns in histone H3 at Lys-4 and Lys-9 correlate with up- & down-regulation of genes by ethanol in hepatocytes. Life Sci., 2007, 81, 979-987. (Pubitemid 47384784)
35. Esfandiari, F.; Medici, V.; Wong, D.H.; Jose, S.; Dolatshahi, M.; Quinlivan, E.; Dayal, S.; Lentz, S.R.; Tsukamoto, H.; Zhang, Y.H.; French, S.W.; Halsted, C.H. Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse. Hepatology, 2010, 51, 932-941.
36. Lee, Y.J.; Shukla, S.D. Histone H3 phosphorylation at serine 10 and serine 28 is mediated by p38 MAPK in rat hepatocytes exposed to ethanol and acetaldehyde. Eur. J. Pharmacol., 2007, 573, 29-38. (Pubitemid 47470061)
37. Moonat, S.; Starkman, B.G.; Sakharkar, A.; Pandey, S.C. Neuroscience of alcoholism: molecular and cellular mechanisms. Cell Mol. Life Sci., 2010, 67, 73-88.
38. Marutha Ravindran, C.R.; Ticku, M.K. Changes in methylation pattern of NMDA receptor NR2B gene in cortical neurons after chronic ethanol treatment in mice. Brain Res. Mol. Brain Res., 2004, 121, 19-27. (Pubitemid 38224166)
39. Biermann, T.; Reulbach, U.; Lenz, B.; Frieling, H.; Muschler, M.; Hillemacher, T.; Kornhuber, J.; Bleich, S. N-methyl-D-aspartate 2b receptor subtype (NR2B) promoter methylation in patients during alcohol withdrawal. J. Neural Transm., 2009, 116, 615-622.
40. Philibert, R.A.; Gunter, T.D.; Beach, S.R.; Brody, G.H.; Madan, A. MAOA methylation is associated with nicotine and alcohol dependence in women. Am. J. Med. Genet. B. Neuropsychiatr. Genet., 2008, 147B, 565-570. (Pubitemid 351961658)
41. Pascual, M.; Boix, J.; Felipo, V.; Guerri, C. Repeated alcohol administration during adolescence causes changes in the mesolimbic dopaminergic and glutamatergic systems and promotes alcohol intake in the adult rat. J. Neurochem., 2009, 108, 920-931.
42. Bonsch, D.; Greifenberg, V.; Bayerlein, K.; Biermann, T.; Reulbach, U.; Hillemacher, T.; Kornhuber, J.; Bleich, S. Alpha-synuclein protein levels are increased in alcoholic patients and are linked to craving. Alcohol. Clin. Exp. Res., 2005, 29, 763-765. (Pubitemid 40686545)
43. Bonsch, D.; Lenz, B.; Kornhuber, J.; Bleich, S. DNA hypermethylation of the alpha synuclein promoter in patients with alcoholism. Neuroreport, 2005, 16, 167-170. (Pubitemid 40250393)
44. Hillemacher, T.; Frieling, H.; Hartl, T.; Wilhelm, J.; Kornhuber, J.; Bleich, S. Promoter specific methylation of the dopamine transporter gene is altered in alcohol dependence and associated with craving. J. Psychiatr. Res., 2009, 43, 388-392.
45. Hillemacher, T.; Frieling, H.; Luber, K.; Yazici, A.; Muschler, M.A.; Lenz, B.; Wilhelm, J.; Kornhuber, J.; Bleich, S. Epigenetic regulation and gene expression of vasopressin and atrial natriuretic peptide in alcohol withdrawal. Psychoneuroendocrinology, 2009, 34, 555-560.
46. Muschler, M.A.; Hillemacher, T.; Kraus, C.; Kornhuber, J.; Bleich, S.; Frieling, H. DNA methylation of the POMC gene promoter is associated with craving in alcohol dependence. J. Neural Transm., 2010, 117, 513-519.
47. Pandey, S.C.; Ugale, R.; Zhang, H.; Tang, L.; Prakash, A. Brain chromatin remodeling: a novel mechanism of alcoholism. J. Neurosci., 2008, 28, 3729-3737.
48. Bleich, S.; Lenz, B.; Ziegenbein, M.; Beutler, S.; Frieling, H.; Kornhuber, J.; Bonsch, D. Epigenetic DNA hypermethylation of the HERP gene promoter induces down-regulation of its mRNA expression in patients with alcohol dependence. Alcohol. Clin. Exp. Res., 2006, 30, 587-591.
49. Bleich, S.; Hillemacher, T. Homocysteine, alcoholism and its molecular networks. Pharmacopsychiatry, 2009, 42 Suppl 1, S102-9.
50. Zhang, H.; Darwanto, A.; Linkhart, T.A.; Sowers, L.C.; Zhang, L. Maternal cocaine administration causes an epigenetic modification of protein kinase Cepsilon gene expression in fetal rat heart. Mol. Pharmacol., 2007, 71, 1319-1328. (Pubitemid 46658685)
51. Meyer, K.; Zhang, H.; Zhang, L. Direct effect of cocaine on epigenetic regulation of PKCepsilon gene repression in the fetal rat heart. J. Mol. Cell. Cardiol., 2009, 47, 504-511.
52. Cassel, S.; Carouge, D.; Gensburger, C.; Anglard, P.; Burgun, C.; Dietrich, J.B.; Aunis, D.; Zwiller, J. Fluoxetine and cocaine induce the epigenetic factors MeCP2 and MBD1 in adult rat brain. Mol. Pharmacol., 2006, 70, 487-492. (Pubitemid 44092309)
53. Carouge, D.; Host, L.; Aunis, D.; Zwiller, J.; Anglard, P. CDKL5 is a brain MeCP2 target gene regulated by DNA methylation. Neurobiol. Dis., 2010, 38, 414-424.
54. Novikova, S.I.; He, F.; Bai, J.; Cutrufello, N.J.; Lidow, M.S.; Undieh, A.S. Maternal cocaine administration in mice alters DNA methylation and gene expression in hippocampal neurons of neonatal and prepubertal offspring. PLoS One, 2008, 3, e1919.
55. Romieu, P.; Host, L.; Gobaille, S.; Sandner, G.; Aunis, D.; Zwiller, J. Histone deacetylase inhibitors decrease cocaine but not sucrose selfadministration in rats. J. Neurosci., 2008, 28, 9342-9348.
56. Malvaez, M.; Sanchis-Segura, C.; Vo, D.; Lattal, K.M.; Wood, M.A. Modulation of chromatin modification facilitates extinction of cocaine-induced conditioned place preference. Biol. Psychiatry, 2010, 67, 36-43.
57. Schroeder, F.A.; Penta, K.L.; Matevossian, A.; Jones, S.R.; Konradi, C.; Tapper, A.R.; Akbarian, S. Drug-induced activation of dopamine D(1) receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and modulate cocaine-related behaviors. Neuropsychopharmacology, 2008, 33, 2981-2992.
58. Sun, J.; Wang, L.; Jiang, B.; Hui, B.; Lv, Z.; Ma, L. The effects of sodium butyrate, an inhibitor of histone deacetylase, on the cocaine- and sucrosemaintained self-administration in rats. Neurosci. Lett., 2008, 441, 72-76.
59. Freeman, W.M.; Patel, K.M.; Brucklacher, R.M.; Lull, M.E.; Erwin, M.; Morgan, D.; Roberts, D.C.; Vrana, K.E. Persistent alterations in mesolimbic gene expression with abstinence from cocaine self-administration. Neuropsychopharmacology, 2008, 33, 1807-1817. (Pubitemid 351832593)
60. Kumar, A.; Choi, K.H.; Renthal, W.; Tsankova, N.M.; Theobald, D.E.; Truong, H.T.; Russo, S.J.; Laplant, Q.; Sasaki, T.S.; Whistler, K.N.; Neve, R.L.; Self, D.W.; Nestler, E.J. Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron, 2005, 48, 303-314. (Pubitemid 41476363)
61. Levine, A.A.; Guan, Z.; Barco, A.; Xu, S.; Kandel, E.R.; Schwartz, J.H. CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum. Proc. Natl. Acad. Sci. U. S. A., 2005, 102, 19186-19191. (Pubitemid 43049587)
62. Brami-Cherrier, K.; Valjent, E.; Herve, D.; Darragh, J.; Corvol, J.C.; Pages, C.; Arthur, S.J.; Girault, J.A.; Caboche, J. Parsing molecular and behavioral effects of cocaine in mitogen- and stress-activated protein kinase-1-deficient mice. J. Neurosci., 2005, 25, 11444-11454. (Pubitemid 43083716)
63. Renthal, W.; Maze, I.; Krishnan, V.; Covington, H.E.,3rd; Xiao, G.; Kumar, A.; Russo, S.J.; Graham, A.; Tsankova, N.; Kippin, T.E.; Kerstetter, K.A.; Neve, R.L.; Haggarty, S.J.; McKinsey, T.A.; Bassel-Duby, R.; Olson, E.N.; Nestler, E.J. Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron, 2007, 56, 517-529. (Pubitemid 350030878)
64. Renthal, W.; Kumar, A.; Xiao, G.; Wilkinson, M.; Covington, H.E.,3rd; Maze, I.; Sikder, D.; Robison, A.J.; LaPlant, Q.; Dietz, D.M.; Russo, S.J.; Vialou, V.; Chakravarty, S.; Kodadek, T.J.; Stack, A.; Kabbaj, M.; Nestler, E.J. Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. Neuron, 2009, 62, 335-348.
65. Maze, I.; Covington, H.E.,3rd; Dietz, D.M.; LaPlant, Q.; Renthal, W.; Russo, S.J.; Mechanic, M.; Mouzon, E.; Neve, R.L.; Haggarty, S.J.; Ren, Y.; Sampath, S.C.; Hurd, Y.L.; Greengard, P.; Tarakhovsky, A.; Schaefer, A.; Nestler, E.J. Essential role of the histone methyltransferase G9a in cocaineinduced plasticity. Science, 2010, 327, 213-216.
66. Black, Y.D.; Maclaren, F.R.; Naydenov, A.V.; Carlezon, W.A.,Jr; Baxter, M.G.; Konradi, C. Altered attention and prefrontal cortex gene expression in rats after binge-like exposure to cocaine during adolescence. J. Neurosci., 2006, 26, 9656-9665. (Pubitemid 44427704)
67. Shen, H.Y.; Kalda, A.; Yu, L.; Ferrara, J.; Zhu, J.; Chen, J.F. Additive effects of histone deacetylase inhibitors and amphetamine on histone H4 acetylation, cAMP responsive element binding protein phosphorylation and DeltaFosB expression in the striatum and locomotor sensitization in mice. Neuroscience, 2008, 157, 644-655.
68. Kalda, A.; Heidmets, L.T.; Shen, H.Y.; Zharkovsky, A.; Chen, J.F. Histone deacetylase inhibitors modulates the induction and expression of amphetamine- induced behavioral sensitization partially through an associated learning of the environment in mice. Behav. Brain Res., 2007, 181, 76-84. (Pubitemid 46765005)
69. Adachi, M.; Monteggia, L.M. Synergistic interactions between histone deacetylase inhibitors and drugs of abuse. Neuropsychopharmacology, 2009, 34, 2619-2620.
70. McClung, C.A.; Ulery, P.G.; Perrotti, L.I.; Zachariou, V.; Berton, O.; Nestler, E.J. DeltaFosB: a molecular switch for long-term adaptation in the brain. Brain Res. Mol. Brain Res., 2004, 132, 146-154. (Pubitemid 39586757)
71. Renthal, W.; Carle, T.L.; Maze, I.; Covington, H.E.,3rd; Truong, H.T.; Alibhai, I.; Kumar, A.; Montgomery, R.L.; Olson, E.N.; Nestler, E.J. Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure. J. Neurosci., 2008, 28, 7344-7349.
72. Numachi, Y.; Shen, H.; Yoshida, S.; Fujiyama, K.; Toda, S.; Matsuoka, H.; Sora, I.; Sato, M. Methamphetamine alters expression of DNA methyltransferase 1 mRNA in rat brain. Neurosci. Lett., 2007, 414, 213-217.
73. Kreek, M.J.; Bart, G.; Lilly, C.; LaForge, K.S.; Nielsen, D.A. Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. Pharmacol. Rev., 2005, 57, 1-26. (Pubitemid 40283968)
74. Bart, G.; Heilig, M.; LaForge, K.S.; Pollak, L.; Leal, S.M.; Ott, J.; Kreek, M.J. Substantial attributable risk related to a functional mu-opioid receptor gene polymorphism in association with heroin addiction in central Sweden. Mol. Psychiatry, 2004, 9, 547-549.
75. Nielsen, D.A.; Yuferov, V.; Hamon, S.; Jackson, C.; Ho, A.; Ott, J.; Kreek, M.J. Increased OPRM1 DNA methylation in lymphocytes of methadonemaintained former heroin addicts. Neuropsychopharmacology, 2009, 34, 867-873.
76. Yuferov, V.; Levran, O.; Proudnikov, D.; Nielsen, D.A.; Kreek, M.J. Search for genetic markers and functional variants involved in the development ofopiate and cocaine addiction and treatment. Ann. N. Y. Acad. Sci., 2010, 1187, 184-207.
77. Newton, S.S.; Duman, R.S. Chromatin remodeling: a novel mechanism of psychotropic drug action. Mol. Pharmacol., 2006, 70, 440-443. (Pubitemid 44092302)
78. Shukla, S.D.; Aroor, A.R. Epigenetic effects of ethanol on liver and gastrointestinal injury. World J. Gastroenterol., 2006, 12, 5265-5271. (Pubitemid 44501767)
79. Wang, Y.; Krishnan, H.R.; Ghezzi, A.; Yin, J.C.; Atkinson, N.S. Druginduced epigenetic changes produce drug tolerance. PLoS Biol., 2007, 5, e265.
80. Shukla, S.D.; Velazquez, J.; French, S.W.; Lu, S.C.; Ticku, M.K.; Zakhari, S. Emerging role of epigenetics in the actions of alcohol. Alcohol. Clin. Exp. Res., 2008, 32, 1525-1534.
81. Renthal, W.; Nestler, E.J. Histone acetylation in drug addiction. Semin. Cell Dev. Biol., 2009, 20, 387-394.