Downregulation of Akt and FAK phosphorylation reduces invasion of glioblastoma cells by impairment of MT1-MMP shuttling to lamellipodia and downregulates MMPs expression

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1813, Issue 5, 2011, Pages 655-667

  Kwiatkowska, Aneta ^a   Kijewska, Magdalena ^a   Lipko, Maciej ^a   Hibner, Urszula ^b   Kaminska, Bozena ^a  

^a NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

^b INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

Author keywords

Cyclosporin A; Invasion; Migration; MMPs; PI3K Akt signaling; Transcriptional regulation

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; A 443654; CALCINEURIN; CYCLOSPORIN A; FOCAL ADHESION KINASE; GELATINASE A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MATRIX METALLOPROTEINASE 14; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; TACROLIMUS; UNCLASSIFIED DRUG;

ARTICLE; BRAIN SLICE; CANCER INVASION; CARCINOGENICITY; CELL ADHESION; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG TARGETING; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; GLIOBLASTOMA; HUMAN; HUMAN CELL; LAMELLIPODIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL;

ACTINS; ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; CELL SHAPE; CYCLOSPORINE; DOWN-REGULATION; FOCAL ADHESION KINASE 1; GLIOBLASTOMA; HUMANS; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 2; MICE; NEOPLASM INVASIVENESS; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; PSEUDOPODIA; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

MUS;

EID: 79955649201     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2011.01.020     Document Type: Article

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