Differential regulation of 5-HT 2A receptor mRNA expression following withdrawal from a chronic escalating dose regimen of D-amphetamine

Brain Research

Volumn 1390, Issue , 2011, Pages 10-20

  Horner, Kristen A ^a   Gilbert, Yamiece E ^a   Noble, Erika S ^a  

^a MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cortex; Depression; Limbic system; Psychostimulant; Serotonin receptor

Indexed keywords

DEXAMPHETAMINE; MESSENGER RNA; SEROTONIN 2A RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CAUDATE NUCLEUS; CINGULATE GYRUS; CONTROLLED STUDY; HIPPOCAMPUS; HISTOCHEMISTRY; IN SITU HYBRIDIZATION; LIMBIC SYSTEM; MALE; MESSENGER RNA SYNTHESIS; MOTOR CORTEX; NONHUMAN; NUCLEUS ACCUMBENS; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUTAMEN; RAT; REGULATORY MECHANISM;

ANIMALS; DEXTROAMPHETAMINE; GENE EXPRESSION REGULATION; HIPPOCAMPUS; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; RNA, MESSENGER; SUBSTANCE WITHDRAWAL SYNDROME;

ANIMALIA; RATTUS;

EID: 79955601770     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2011.03.033     Document Type: Article

References (103)

1. Adams, D.H., Hanson, G.R., Keefe, K.A., 2003. Distinct effects of methamphetamine and cocaine on preprodynorphin messenger RNA in rat striatal patch and matrix. J. Neurochem. 84, 87-93. (Pubitemid 36182068)
2. Aghajanian, G.K., Marek, G.J., 1997. Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells. Neuropharmacology 36, 589-599. (Pubitemid 27272104)
3. Aghajanian, G.K., Marek, G.J., 1999. Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release. Brain Res. 825, 161-171. (Pubitemid 29222872)
4. Aharonovich, E., Hasin, D.S., Brooks, A.C., Liu, X., Bisaga, A., Nunes, E.V., 2006. Cognitive deficits predict low treatment retention in cocaine-dependent patients. Drug Alcohol Dep. 81, 313-322. (Pubitemid 43152458)
5. Araneda, R., Andrade, R., 1991. 5-Hydroxytryptamine2 and 5-hydroxytryptamine 1A receptors mediate opposing responses on membrane excitability in rat association cortex. Neuroscience 40, 399-412.
6. Armagos-Bosch, M., Bortolozzi, A., Puig, M.V., Serrats, J., Adell, A., Celada, P., Toth, M., Mengod, G., Artigas, F., 2004. Co-expression and in vivo interaction of serotonin1A and serotonin2A receptors in pyramidal neurons of the prefrontal cortex. Cereb. Cortex 14, 281-299. (Pubitemid 38252721)
7. Arvanov, V.L., Liang, X.F., Magro, P., Roberts, R., Wang, R.Y., 1999. A pre- and postsynaptic modulatory action of 5-HT and the 5-HT2A(2C) receptor agonist DOB on NMDA-evoked responses in the rat medial prefrontal cortex. Eur. J. Neurosci. 11, 2917-2934.
8. Ashby Jr., C.R., Jiang, L.H., Kasser, R.J., Wang, R.Y., 1990. Electrophysiological characterization of 5-hydroxytryptamine-2 receptors in the rat medial prefrontal cortex. J. Pharmacol. Exp. Ther. 252, 171-178.
9. Barr, A.M., Fiorina, D.F., Phillips, A.G., 1999. Effects of withdrawal from an escalating dose schedule of D-amphetamine on sexual behavior of the male rat. Pharm. Biochem. Behav. 64, 597-604.
10. Barr, A.M., Phillips, A.G., 1999. Withdrawal following repeated exposure to D-amphetamine decreases responding for a sucrose solution as measured by a progressive ratio schedule of reinforcement. Psychopharmacology 141, 99-106. (Pubitemid 29193301)
11. Barr, A.M., Markou, A., Phillips, A.G., 2002. A "crash" course on psychostimulant withdrawal as a model of depression. Trends Pharmacol. Sci. 23, 475-482.
12. Barr, A.M., Phillips, A.G., 2002. Increased successive negative contrast in rats withdrawn from an escalating-dose schedule of D-amphetamine. Pharm. Biochem. Behav. 71, 293-299.
13. Barr, A.M., Markou, A., 2005. Psychostimulant withdrawal as an inducing condition in animal models of depression. Neurosci. Biobehav. Rev. 29, 675-706.
14. Baumann, M.H., Rothman, R.B., 1998. Alterations in serotonergic responsiveness during cocaine withdrawal in rats: similarities to depression in humans. Biol. Psychiatry 44, 578-591. (Pubitemid 28496685)
15. Baxter Jr., L.R., Schwartz, J.M., Phelps, M.E., Mazziotta, J.C., Guze, B.H., Selin, C.E., Gerner, R.H., Sumida, R.M., 1989. Reduction of prefrontal cortex glucosemetabolismcommon to three types of depression. Arch. Gen. Psychiatry 46, 243-250.
16. Berendse, H.W., Galis-de Graaf, Y., Groenewegen, H.J., 1992. Topographical organization and relationship with ventral striatal compartments of prefrontal corticostriatal projections in the rat. J. Comp. Neurol. 316, 314-347.
17. Bonhomme, N., Cador, M., Stinus, L., LeMoal, M., Spampinato, U., 1995. Short and long-term changes in dopamine and serotonin receptor binding sites in amphetamine-sensitized rats: a quantitative autoradiographic study. Brain Res. 675, 215-223.
18. Bortolozzi, A., Díaz-Mataix, L., Scorza, M.C., Celada, P., Artigas, F., 2005. The activation of 5-HT2A receptors in prefrontal cortex enhances dopaminergic activity. J. Neurochem. 95, 1597-1607. (Pubitemid 41804057)
19. Burnet, P.W.J., Eastwood, S.L., Harrison, P.J., 1996. 5-HT1A and 5-HT2A receptor mRNAs and binding sites densities are differentially altered in schizophrenia. Neuropsychopharmacology 15, 442-455. (Pubitemid 26389868)
20. Burns, L.H., Everitt, B.J., Kelley, A.E., Robbins, T.W., 1994. Glutamate-dopamine interactions in the ventral striatum: role in locomotor activity and responding with conditioned reinforcement. Psychopharmacology 115, 516-528. (Pubitemid 24248443)
21. Cami, J., Farre, M., 2003. Drug addiction. N. Engl. J. Med. 349, 975-986.
22. Carr, D.B., O'Donnell, P., Card, J.P., Sesack, S.R., 1999. Dopamine terminals in the rat prefrontal cortex synapse on pyramidal cells that project to the nucleus accumbens. J. Neurosci. 19, 11049-11060. (Pubitemid 30235748)
23. Carr, D.B., Sesack, S.R., 1999. Terminals from the rat prefrontal cortex synapse on mesoaccumbens VTA neurons. Ann. NY Acad. Sci. 877, 676-678.
24. Carrasco, G.A., Zhang, Y., Damjanoska, K.J., D'Souza, D.N., Garcia, F., Battaglia, G., Muma, N.A., Van de Kar, L.D., 2003. A region-specific increase in Galphαq and Galphα11 proteins in brains of rats during cocaine withdrawal. J. Pharmacol. Exp. Ther. 307, 1012-1019.
25. Carrasco, G.A., Van de Kar, L.D., Sullivan, N.R., Landry, M., Garcia, F., Muma, N., Battaglia, G., 2006. Cocaine-mediated supersensitivity of 5-HT2A receptors in hypothalamic paraventricular nucleus is a withdrawal-induced phenomenon. Neuroscience 143, 7-13. (Pubitemid 44667320)
26. Celada, P., Puig, M.V., Amargos-Bosch, M., Adell, A., Artigas, F., 2004. The therapeutic role of 5-HT1A and 5-HT2A receptors in depression. J. Psychiatry Neurosci. 29, 252-265. (Pubitemid 39185866)
27. Christie, M.J., James, L.B., Beart, P.M., 1985. An excitant amino acid projection from the medial prefrontal cortex to the anterior part of nucleus accumbens in the rat. J. Neurochem. 45, 477-482. (Pubitemid 15233949)
28. Clow, D.W., Hammer Jr., R.P., 1991. Cocaine abstinence following chronic treatment alters cerebral metabolism in dopaminergic reward regions; bromocriptine enhances recovery. Neuropsychopharmacology 4, 71-75.
29. Coffey, S.F., Dansky, B.S., Carrigan, M.H., Brady, K.T., 2000. Acute and protracted cocaine abstinence in an outpatient population: a prospective study of mood, sleep and withdrawal symptoms. Drug Alcohol Dep. 59, 277-286. (Pubitemid 30254242)
30. Cornea-Hebert, V., Riad, M., Wu, C., Singh, S.K., Descarries, L., 1999. Cellular and subcellular distribution of the serotonin 5-HT2A receptor in the central nervous system of the adult rat. J. Comp. Neurol. 409, 187-209.
31. Darmani, N.A., Martin, B.R., Glennon, R.A., 1992. Repeated administration of low doses of cocaine enhances the sensitivity of 5-HT2 receptor function. Pharm. Biochem. Behav. 41, 519-527.
32. Darmani, N.A., 1997. Deficits in the d-fenfluramine-sensitive pool of brain 5-HT following withdrawal from chronic cocaine exposure. Life Sci. 61, 2575-2582. (Pubitemid 28035582)
33. Di Chiara, G., 2002. Nucleus accumbens shell and core dopamine: differential role in behavior and addiction. Behav. Brain Res. 137, 75-114.
34. Feltstein, M.W., See, R.E., 2008. The neurocircuitry of addiction: an overview. Br. J. Pharmacol. 154, 261-274.
35. Fuchs, R.A., Evans, K.A., Ledford, C.C., Parker, M.P., Case, J.M., Mehta, R.H., See, R.E., 2005. The role of the dorsomedial prefrontal cortex, basolateral amygdala, and dorsal hippocampus in contextual reinstatement of cocaine seeking in rats. Neuropsychopharmacology 30, 296-309. (Pubitemid 40129481)
36. Fuchs, R.A., Eaddy, J.L., Su, Z.-I., Bell, G.H., 2007. Interactions of the basolateral amygdala within the dorsal hippocampus and dorsomedial prefrontal cortex regulate drug context-induced reinstatement of cocaine-seeking in rats. Eur. J. Neurosci. 26, 487-498.
37. Gardner, E.L., 2000. What we have learned about addiction from animal models of drug self-administration. Am. J. Addict. 9, 285-313.
38. Gawin, F.H., Kleber, H.D., 1986. Abstinence symptomology and psychiatric diagnosis in cocaine abusers. Arch. Gen. Psychiatry 43, 107-113.
39. Ghitza, U.E., Fabbricatore, A.T., Propenko, V.F., Pawlak, A.P., West, M.O., 2003. Persistent cue-evoked activity of accumbens neurons following prolonged abstinence from self-administered cocaine. J. Neurosci. 23, 7239-7245. (Pubitemid 36999512)
40. Ghitza, U.E., Fabbricatore, A.T., Propenko, V.F., West, M.O., 2004. Difference between accumbens core and shell neurons exhibiting phasic firing patterns related to drug-seeking behavior during a discriminative-stimulus task. J. Neurophysiol. 92, 1608-1614. (Pubitemid 39100659)
41. Gillin, J.C., Pulvirenti, L., Withers, N., Golsham, S., Koob, G., 1994. The effects of lisuride on mood and sleep during acute withdrawal in stimulant abusers: a preliminary report. Biol. Psychiatry 35, 843-849. (Pubitemid 24165008)
42. Goldstein, R.Z., Volkow, N.D., 2002. Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. Am. J. Psychiatry 159, 1642-1652.
43. Gorelova, N., Yang, C.R., 1997. The course of the neuron projection from the prefrontal cortex to the nucleus accumbens in the rat. Neuroscience 76, 689-706. (Pubitemid 27013410)
44. Haber, S.N., Fudge, J.L., McFarland, N.R., 2000. Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum. J. Neurosci. 20, 2369-2382.
45. Halliday, G.M., Tork, I., 1989. Serotonin-like immunoreactive cells and fibres in the rat ventromedial mesencephalic tegmentum. Brain Res. Bull. 22, 725-735.
46. Heimer, L., Alheid, G.F., de Olmos, J.S., Groenewegen, H.J., Haber, S.N., Harlan, R.E., Zahm, D.S., 1997. The accumbens: beyond the core-shell dichotomy. J. Neuropsychiatry Clin. Neurosci. 9, 354-381.
47. Horner, K.A., Adams, D.H., Hanson, G.R., Keefe, K.A., 2005. Blockade of stimulant-induced preprodynorphin mRNA expression in the rat striatal matrix by serotonin depletion. Neuroscience 131, 67-77. (Pubitemid 40170489)
48. Horner, K.A., Keefe, K.A., 2006. Regulation of psychostimulant-induced preprodynorphin, c-fos and zif/268 messenger RNA expression in the rat dorsal striatum by mu opioid receptor blockade. Eur. J. Pharmacol. 532, 61-73.
49. Horner, K.A., Noble, E.N., Lauterbach, E.C., 2009. Differential regulation of prodynorphin, c-fos and serotonin transporter mRNA during withdrawal from a chronic, escalating dose regimen of D-amphetamine. Synapse 63, 257-268.
50. Horner, K.A., Noble, E.S., Gilbert, Y.E., 2010. Methamphetamine-induced stereotypy correlates negatively with patch-enhanced prodynorphin and arc mRNA expression in the rat caudate putamen: the role of mu opioid receptor activation. Pharmacol. Biochem. Behav. 95, 410-421.
51. Huang, C.C., Liang, Y.-C., Lee, C.-C., Wu, M.-Y., Hsu, K.-S., 2009. Repeated cocaine administration decreases 5-HT2A receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex. Neuropsychopharmacology 34, 1979-1992.
52. Hyman, S.E., Malenka, R.C., Nestler, E.J., 2006. Neural mechanisms of addiction: the role of reward-related learning and memory. Ann. Rev. Neurosci. 29, 565-598.
53. 2A serotonin receptors in the primate cerebral cortex: possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites. Proc. Natl Acad. Sci. U.S.A. 95, 735-740.
54. Jakab, R.L., Goldman-Rakic, P.S., 2000. Segregation of serotonin 5-HT2A and 5-HT3 receptors in inhibitory circuits of the primate cerebral cortex. J. Comp. Neurol. 417, 337-348.
55. Javaid, J.I., Sahni, S.K., Pandey, S.C., Davis, J.M., 1993. Repeated cocaine administration does not affect 5-HT receptor subtypes (5-HT1A, 5-HT2) in several rat brain regions. Eur. J. Pharmacol. 238, 425-429.
56. Jentsch, J.D., Taylor, J.R., 1999. Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli. Psychopharmacology 146, 373-390. (Pubitemid 29513278)
57. Johnson, J.G., Gerfen, C.R., Haber, S.N., van der Kooy, D., 1990. Mechanisms of striatal pattern formation: conservation of mammalian compartmentalization. Dev. Brain Res. 57, 93-102.
58. Johnson, R.G., Fiorella, D., Rabin, R.A., 1993. Effects of chronic cocaine administration on the serotonergic system in the rat brain. Pharmacol. Biochem. Behav. 46, 289-293.
59. Kalivas, P.W., Volkow, N.D., 2005. The neural basis of addiction: a pathology of motivation and choice. Am. J. Psychiatry 162, 1403-1413. (Pubitemid 41105554)
60. Kourrich, S., Thomas, M.J., 2009. Similar neurons, opposite adaptations: psychostimulant experience differentially alters firing properties in the accumbens core versus shell. J. Neurosci. 29, 12275-12283.
61. 2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in the rat medial prefrontal cortex and prefrontal cortex. Brain Res. 972, 216-221.
62. Luttgen, M., Ogren, S.O., Meister, B., 2004. Chemical identity of 5-HT2A receptor immunoreactive neurons of the rat septal complex and dorsal hippocampus. Brain Res. 1010, 156-165. (Pubitemid 38569864)
63. Mann, J.J., McBride, P.A., Malone, K.M., DeMeo, M., Keilp, J., 1995. Blunted serotonergic responsitivity in depressed patients. Neuropsychopharmacology 13, 53-64.
64. Martin-Ruiz, R., Puig, M.V., Celada, P., Shapiro, D.A., Roth, B.L., Mengod, G., Artigas, F., 2001. Control of serotonergic function in medial prefrontal cortex by serotonin-2A receptors through a glutamate-dependent mechanism. J. Neurosci. 27, 9856-9866. (Pubitemid 34184070)
65. McQuade, R., Sharp, T., 1997. Functional mapping of dorsal and median raphe 5-hydroxytryptamine pathways in forebrain of the rat using microdialysis. J. Neurochem. 69, 791-796. (Pubitemid 27327983)
66. Miller, E.K., Cohen, J.D., 2001. An integrative theory of prefrontal cortex function. Annu. Rev. Neurosci. 24, 167-202.
67. Mjinster, M.J., Raimundo, A.G.V., Koskuba, K., Klop, H., Docter, G.J., Groenewegen, H.J., Voorn, P., 1997. Regional and cellular distribution of serotonin 5-hydroxytryptamine2a receptor mRNA in the nucleus accumbens, olfactory tubercle, and caudate putamen of the rat. J. Comp. Neurol. 389, 1-11.
68. Moore, R.Y., Halaris, A.E., 1975. Hippocampal innervation by serotonin neurons of the midbrain raphe in the rat. J. Comp. Neurol. 164, 171-183.
69. Nestler, E.J., Barrot, M., DiLeone, R.J., Eisch, A.J., Gold, S.J., Monteggia, L.M., 2002. Neurobiology of depression. Neuron 34, 13-25. (Pubitemid 34270695)
70. Nestler, E.J., Hyman, S.E., Malenka, R.C., 2009. Mood and emotion. In: Syder, A., Brown, R.Y. (Eds.), Molecular Neuropharmacology: A Foundation for Clinical Neuroscience. McGraw Hill Medical, New York, NY.
71. O'Donnell, P., Grace, A.A., 1995. Synaptic interaction among excitatory afferents to nucleus accumbens neurons: hippocampal gating of prefrontal cortical input. J. Neurosci. 15, 3622-3639.
72. Pace-Schott, E.F., Morgan, P.T., Malison, R.T., Hart, C.L., Edgar, C., Walker, M., Stickgold, R., 2008. Cocaine users differ from normals on cognitive tasks which show poorer performance during drug abstinence. Am. J. Drug Alcohol Abuse 34, 109-121.
73. Parsons, L.H., Koob, G.F., Weiss, F., 1995. Serotonin dysfunction in the nucleus accumbens of rats during withdrawal after unlimited access to intravenous cocaine. J. Pharmacol. Exp. Ther. 274, 1182-1191.
74. Parsons, L.H., Koob, G., Weiss, F., 1996. Extracellular serotonin is decreased in the nucleus accumbens during withdrawal from cocaine self-administration. Behav. Brain Res. 73, 225-228.
75. Paxinos, G., Watson, C., 2005. The Rat Brain in Sterotaxic Coordinates. Elsevier Academic Press, New York, NY.
76. Persico, A.M., Schindler, C.W., Zaczek, R., Brannock, M.T., Uhl, G.R., 1995. Brain transcription factor gene expression, neurotransmitter levels, and novelty response behaviors: alterations during rat amphetamine withdrawal and following chronic injection stress. Synapse 19, 212-227.
77. Persico, A.M., Uhl, G.R., 1996. Transcription factors: potential roles in drug-induced neuroplasticity. Rev. Neurosci. 7, 233-275.
78. Pompeiano, M., Palacios, J.M., Mengod, G., 1994. Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors. Brain Res. Mol. Brain Res. 23, 163-178.
79. Puig, M.V., Celada, P., Diaz-Mataix, L., Artigas, F., 2003. In vivo modulation of the activity of pyramidal neurons in the rat medial prefrontal cortex by 5-HT2A receptors: relationship to thalamocortical afferents. Cereb. Cortex 13, 870-882.
80. Robbins, T.W., Cador, M., Taylor, J.R., Everitt, B.J., 1989. Limbic-striatal interactions in reward-related processes. Neurosci. Biobehav. Rev. 13, 155-162.
81. Robbins, T.W., Ersche, K.D., Everitt, B.J., 2008. Drug addiction and the memory systems of the brain. Ann. NY Acad. Sci. 1141, 1-21.
82. Rogers, J.L., See, R.E., 2007. Selective inactivation of the ventral hippocampus attenuates cue-induced and cocaine-primed reinstratement of drug-seeking in rats. Neurobiol. Learn. Mem. 87, 688-692.
83. Saltzman, A.G., Morse, B., Whitman, M.M., Ivanshchenko, Y., Jaye, M., Felder, S., 1991. Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes. Biochem. Biophys. Res. Commun. 181, 1469-1478.
84. See, R.E., 2005. Neural substrates of cocaine-cue associations that trigger relapse. Eur. J. Pharmacol. 526, 140-146.
85. Szucs, R.P., Frankel, P.S., McMahon, L.R., Cunningham, K.A., 2005. Relationship of cocaine-induced c-Fos expression to behaviors and the role of 5-HT2A receptors in cocaine-induced c-Fos expression. Behav. Neurosci. 119, 1173-1183.
86. Thompson, P.M., Hayashi, K.M., Simon, S.L., Geaga, J.A., Hong, M.S., Sui, Y., Lee, J.Y., Toga, A.W., Ling, W., London, E.D., 2004. Structural abnormalities in the brains of human subjects who use methamphetamine. J. Neurosci. 24, 6028-6036. (Pubitemid 38859399)
87. Trulson, M.E., Jacobs, B.L., 1979. Chronic amphetamine administration to cats: behavioral and neurochemical evidence for decreased central serotonergic function. J. Pharmacol. Exp. Ther. 211, 375-384.
88. Vacca, G., Ahn, S., Phillips, A.G., 2007. Effects of short-term abstinence from escalating doses of D-amphetamine on drug and sucrose-evoked dopamine efflux in the rat nucleus accumbens. Neuropsychopharmacology 32, 932-939. (Pubitemid 46426177)
89. van Bockstaele, E.J., Biswas, A., Pickel, V.M., 1993. Topography of serotonin neurons in the dorsal raphe nucleus that send axon collaterals to the rat prefrontal cortex and nucleus accumbens. Brain Res. 624, 188-198. (Pubitemid 23281819)
90. 2A receptors. Cereb. Cortex 19, 1678-1686.
91. Volkow, N.D., Fowler, J.S., Wolf, A.P., Schlyer, D., Shiue, C.Y., Alpert, R., Dewey, S.L., Logan, J., Bendriem, B., Christman, D., et al., 1990. Effects of chronic cocaine abuse on postsynaptic dopamine receptors. Am. J. Psychiatry 147, 719-724. (Pubitemid 20188509)
92. Volkow, N.D., Fowler, J.S., Wang, G.J., Hitzemann, R., Logan, J., Schlyer, D.J., Dewey, S.L., Wolf, A.P., 1993. Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers. Synapse 14, 169-177. (Pubitemid 23157765)
93. Volkow, N.D., Fowler, J.S., Wang, G.J., 2003. The addicted human brain: insights from imaging studies. J. Clin. Invest. 111, 1444-1451.
94. Wang, G.J., Volkow, N.D., Logan, J., Fowler, J.S., Schlyer, D., MacGregor, R.R., Hitzemann, R.J., Gjedde, A., Wolf, A.P., 1995. Serotonin 5-HT2 receptor availability in chronic cocaine abusers. Life Sci. 56, PL299-PL303.
95. Ward, R.P., Dorsa, D.M., 1996. Colocalization of serotonin receptor subtypes 5-HT2A, 5-HT2C, and 5-HT6 with neuropeptides in rat striatum. J. Comp. Neurol. 370, 405-414.
96. Williams, G.V., Rao, S.G., Goldman-Rakic, P.S., 2002. The physiological role of 5-HT2A receptors in working memory. J. Neurosci. 22, 2843-2854. (Pubitemid 37465833)
97. Willins, D.L., Deutch, A.Y., Roth, B.L., 1997. Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex. Synapse 27, 79-82. (Pubitemid 27327604)
98. Wise, R.A., 1996. Neurobiology of addiction. Curr. Opin. Neurobiol. 6, 243-251.
99. Wise, R.A., 2008. Dopamine and reward: the anhedonia hypothesis 30 years on. Neurotox. Res. 14, 169-183.
100. Xu, T., Pandey, S.C., 2000. Cellular localization of serotonin(2A) (5HT(2A)) receptors in the rat brain. Brain Res. Bull. 51, 499-505.
101. Yan, Q.S., Reith, M.E., Yan, S., 2000. Enhanced accumbal dopamine release following 5-HT2A receptor stimulation in rats pretreated with intermittent cocaine. Brain Res. 863, 254-258. (Pubitemid 30201606)
102. Zahm, D.S., 1999. Functional-anatomical implications of the nucleus accumbens core and shell subterritories. Ann. NY Acad. Sci. 877, 113-128.
103. Zhou, F.M., Hablitz, J.J., 1999. Activation of serotonin receptors modulates synaptic transmission in rat cerebral cortex. J. Neurophysiol. 82, 2989-2999. (Pubitemid 30017427)