Cocaine-mediated supersensitivity of 5-HT2A receptors in hypothalamic paraventricular nucleus is a withdrawal-induced phenomenon

Neuroscience

Volumn 143, Issue 1, 2006, Pages 7-13

  Carrasco, G A ^a   Van de Kar, L D ^a   Sullivan, N R ^a   Landry, M ^a   Garcia, F ^a   Muma, N A ^a   Battaglia, G ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

corticosterone; G proteins; hypothalamus; prolactin; rats; serotonin

Indexed keywords

4 IODO 2,5 DIMETHOXYAMPHETAMINE; COCAINE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; IODINE 125; SEROTONIN 2A RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; COCAINE DEPENDENCE; CONTROLLED STUDY; CYTOSOL; DENSITY; DRUG DEPENDENCE TREATMENT; HYPOTHALAMUS; ISOTOPE LABELING; MALE; MEMBRANE; NEUROENDOCRINE SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; RAT; RECEPTOR BINDING; RECEPTOR SENSITIVITY; THALAMUS MIDLINE NUCLEUS; WITHDRAWAL SYNDROME;

AMPHETAMINES; ANIMALS; BLOTTING, WESTERN; COCAINE; CORTICOSTERONE; DOPAMINE UPTAKE INHIBITORS; DRUG INTERACTIONS; GTP-BINDING PROTEIN ALPHA SUBUNITS; IODINE ISOTOPES; MALE; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PROTEIN BINDING; RADIOIMMUNOASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; SEROTONIN AGONISTS; SUBSTANCE WITHDRAWAL SYNDROME; TIME FACTORS;

EID: 33750507484     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2006.09.021     Document Type: Article

References (28)

1. Aghajanian G.K., and Marek G.J. Serotonin model of schizophrenia: emerging role of glutamate mechanisms. Brain Res Rev 31 (2000) 302-312
2. 1c receptors in rat brain. J Pharmacol Exp Ther 255 (1990) 843-857
3. 2/1C agonist DOI. Biol Psychiatry 34 (1993) 576-577
4. Baumann M.H., and Rothman R.B. Alterations in serotonergic responsiveness during cocaine withdrawal in rats: Similarities to major depression in humans. Biol Psychiatry 44 (1998) 578-591
5. Carrasco G.A., Barker S.A., Zhang Y., Damjanoska K.J., Sullivan N.R., Garcia F., D'Souza D.N., Muma N.A., and Van de Kar L.D. Estrogen treatment increases the levels of regulator of G protein signaling-Z1 in the hypothalamic paraventricular nucleus: possible role in desensitization of 5-hydroxytryptamine(1A) receptors. Neuroscience 127 (2004) 261-267
6. Carrasco G.A., Damjanoska K.J., D'Souza D.N., Zhang Y., Garcia F., Battaglia G., Muma N.A., and Van de Kar L.D. Short-term cocaine treatment causes neuroadaptive changes in G{alpha}q and G{alpha}11 proteins in rats undergoing withdrawal. J Pharmacol Exp Ther 311 (2004) 349-355
7. Carrasco G.A., Zhang Y., Damjanoska K.J., D'Souza D.N., Garcia F., Battaglia G., Muma N.A., and Van de Kar L.D. A region-specific increase in Gαq and Gα11 proteins in brains of rats during cocaine withdrawal. J Pharmacol Exp Ther 307 (2003) 1012-1019
8. Damjanoska K.J., Heidenreich B.A., Kindel G.H., D'Souza D.N., Zhang Y., Garcia F., Battaglia G., Wolf W.A., Van de Kar L.D., and Muma N.A. Agonist-induced serotonin 2A receptor desensitization in the rat frontal cortex and hypothalamus. J Pharmacol Exp Ther 309 (2004) 1043-1050
9. Fox H.C., Talih M., Malison R., Anderson G.M., Kreek M.J., and Sinha R. Frequency of recent cocaine and alcohol use affects drug craving and associated responses to stress and drug-related cues. Psychoneuroendocrinology 30 (2005) 880-891
10. 2A receptors by agonists and antagonists. Brain Res Bull 56 (2001) 441-451
11. Hanley N.R., and Hensler J.G. Mechanisms of ligand-induced desensitization of the 5-hydroxytryptamine(2A) receptor. J Pharmacol Exp Ther 300 (2002) 468-477
12. Kroeze W.K., Kristiansen K., and Roth B.L. Molecular biology of serotonin receptors structure and function at the molecular level. Curr Top Med Chem 2 (2002) 507-528
13. 2 receptor agonist DOI. Eur J Pharmacol 221 (1992) 121-127
14. Levy A.D., Rittenhouse P.A., Bonadonna A.M., Alvarez Sanz M.C., Bethea C.L., and Van de Kar L.D. Repeated exposure to cocaine produces long-lasting deficits in the serotonergic stimulation of prolactin and renin, but not adrenocorticotropin secretion. Eur J Pharmacol 241 (1993) 275-278
15. Li Q., Brownfield M.S., Battaglia G., Cabrera T.M., Levy A.D., Rittenhouse P.A., and Van de Kar L.D. Long-term treatment with the antidepressants fluoxetine and desipramine potentiates endocrine responses to the serotonin agonists 6-chloro-2-[1-piperazinyl]-pyrazine (MK-212) and (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCI (DOI). J Pharmacol Exp Ther 266 (1993) 836-844
16. 1A receptors. J Pharmacol Exp Ther 282 (1997) 1581-1590
17. Mantsch J.R., Yuferov V., Mathieu-Kia A.M., Ho A., and Kreek M.J. Neuroendocrine alterations in a high-dose, extended-access rat self-administration model of escalating cocaine use. Psychoneuroendocrinology 28 (2003) 836-862
18. Mendelson J.H., Sholar M., Mello N.K., Teoh S.K., and Sholar J.W. Cocaine tolerance: Behavioral, cardiovascular, and neuroendocrine function in men. Neuropsychopharmacology 18 (1998) 263-271
19. Peltier R.L., Guerin G.F., Dorairaj N., and Goeders N.E. Effects of saline substitution on responding and plasma corticosterone in rats trained to self-administer different doses of cocaine. J Pharmacol Exp Ther 299 (2001) 114-120
20. Roth B.L., Berry S.A., Kroeze W.K., Willins D.L., and Kristiansen K. Serotonin 5-HT2A receptors: molecular biology and mechanisms of regulation. Crit Rev Neurobiol 12 (1998) 319-338
21. Samson W.K., Taylor M.M., and Baker J.R. Prolactin-releasing peptides. Regul Pept 114 (2003) 1-5
22. Sinha R., Fuse T., Aubin L.R., and O'Malley S.S. Psychological stress, drug-related cues and cocaine craving. Psychopharmacology (Berl) 152 (2000) 140-148
23. Sinha R., Garcia M., Paliwal P., Kreek M.J., and Rounsaville B.J. Stress-induced cocaine craving and hypothalamic-pituitary-adrenal responses are predictive of cocaine relapse outcomes. Arch Gen Psychiatry 63 (2006) 324-331
24. Sinha R., Talih M., Malison R., Cooney N., Anderson G.M., and Kreek M.J. Hypothalamic-pituitary-adrenal axis and sympatho-adreno-medullary responses during stress-induced and drug cue-induced cocaine craving states. Psychopharmacology (Berl) 170 (2003) 62-72
25. Steel R.G.D., and Torrie J.H. Principles and procedures of statistics with special reference to the biological sciences (1960), McGraw-Hill, New York
26. Vescovi P.P., Coiro V., Volpi R., and Passeri M. Diurnal variations in plasma ACTH, cortisol and beta-endorphin levels in cocaine addicts. Horm Res 37 (1992) 221-224
27. Zhang Y., Damjanoska K.J., Carrasco G.A., Dudas B., D'Souza D.N., Tetzlaff J., Garcia F., Hanley N.R., Scripathirathan K., Petersen B.R., Gray T.S., Battaglia G., Muma N.A., and Van de Kar L.D. Evidence that 5-HT2A receptors in the hypothalamic paraventricular nucleus mediate neuroendocrine responses to (-)DOI. J Neurosci 22 (2002) 9635-9642
28. Zhou Y., Spangler R., Schlussman S.D., Ho A., and Kreek M.J. Alterations in hypothalamic-pituitary-adrenal axis activity and in levels of proopiomelanocortin and corticotropin-releasing hormone-receptor 1 mRNAs in the pituitary and hypothalamus of the rat during chronic "binge" cocaine and withdrawal. Brain Res 964 (2003) 187-199