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Volumn 6, Issue 4, 2011, Pages

Dispersal of group a streptococcal biofilms by the cysteine protease SpeB leads to increased disease severity in a murine model

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; PROTEIN SPEB; UNCLASSIFIED DRUG; STREPTOPAIN;

EID: 79955560044     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018984     Document Type: Article
Times cited : (60)

References (71)
  • 1
    • 33847407971 scopus 로고    scopus 로고
    • Acute bacterial skin infections and cellulitis
    • Gabillot-Carre M, Roujeau JC, (2007) Acute bacterial skin infections and cellulitis. Curr Opin Infect Dis 20: 118-123.
    • (2007) Curr Opin Infect Dis , vol.20 , pp. 118-123
    • Gabillot-Carre, M.1    Roujeau, J.C.2
  • 3
    • 33750580258 scopus 로고    scopus 로고
    • Skin and soft tissue infections
    • Rogers RL, Perkins J, (2006) Skin and soft tissue infections. Prim Care 33: 697-710.
    • (2006) Prim Care , vol.33 , pp. 697-710
    • Rogers, R.L.1    Perkins, J.2
  • 4
    • 27744448866 scopus 로고    scopus 로고
    • Practice guidelines for the diagnosis and management of skin and soft-tissue infections
    • Stevens DL, Bisno AL, Chambers HF, Everett ED, Dellinger P, et al. (2005) Practice guidelines for the diagnosis and management of skin and soft-tissue infections. Clin Infect Dis 41: 1373-1406.
    • (2005) Clin Infect Dis , vol.41 , pp. 1373-1406
    • Stevens, D.L.1    Bisno, A.L.2    Chambers, H.F.3    Everett, E.D.4    Dellinger, P.5
  • 5
    • 0033939735 scopus 로고    scopus 로고
    • Pathogenesis of group A streptococcal infections
    • Cunningham MW, (2000) Pathogenesis of group A streptococcal infections. Clin Microbiol Rev 13: 470-511.
    • (2000) Clin Microbiol Rev , vol.13 , pp. 470-511
    • Cunningham, M.W.1
  • 6
    • 33747886895 scopus 로고    scopus 로고
    • Severe acute middle ear infections: microbiology and treatment
    • Heslop A, Ovesen T, (2006) Severe acute middle ear infections: microbiology and treatment. Int J Pediatr Otorhinolaryngol 70: 1811-1816.
    • (2006) Int J Pediatr Otorhinolaryngol , vol.70 , pp. 1811-1816
    • Heslop, A.1    Ovesen, T.2
  • 7
    • 28244489930 scopus 로고    scopus 로고
    • Toward a genome-wide systems biology analysis of host-pathogen interactions in group A Streptococcus
    • Musser JM, DeLeo FR, (2005) Toward a genome-wide systems biology analysis of host-pathogen interactions in group A Streptococcus. Am J Pathol 167: 1461-1472.
    • (2005) Am J Pathol , vol.167 , pp. 1461-1472
    • Musser, J.M.1    DeLeo, F.R.2
  • 9
    • 41049089659 scopus 로고    scopus 로고
    • Mastoiditis in children: a prospective, observational study comparing clinical presentation, microbiology, computed tomography, surgical findings and histology
    • Stahelin-Massik J, Podvinec M, Jakscha J, Rust ON, Greisser J, et al. (2008) Mastoiditis in children: a prospective, observational study comparing clinical presentation, microbiology, computed tomography, surgical findings and histology. Eur J Pediatr 167: 541-548.
    • (2008) Eur J Pediatr , vol.167 , pp. 541-548
    • Stahelin-Massik, J.1    Podvinec, M.2    Jakscha, J.3    Rust, O.N.4    Greisser, J.5
  • 10
    • 0031906945 scopus 로고    scopus 로고
    • Genetic inactivation of an extracellular cysteine protease (SpeB) expressed by Streptococcus pyogenes decreases resistance to phagocytosis and dissemination to organs
    • Lukomski S, Burns EH Jr, Wyde PR, Podbielski A, Rurangirwa J, et al. (1998) Genetic inactivation of an extracellular cysteine protease (SpeB) expressed by Streptococcus pyogenes decreases resistance to phagocytosis and dissemination to organs. Infect Immun 66: 771-776.
    • (1998) Infect Immun , vol.66 , pp. 771-776
    • Lukomski, S.1    Burns Jr., E.H.2    Wyde, P.R.3    Podbielski, A.4    Rurangirwa, J.5
  • 11
    • 15044355967 scopus 로고    scopus 로고
    • Molecular basis of group A streptococcal pyrogenic exotoxin B
    • Nagamune H, Ohkura K, Ohkuni H, (2005) Molecular basis of group A streptococcal pyrogenic exotoxin B. J Infect Chemother 11: 1-8.
    • (2005) J Infect Chemother , vol.11 , pp. 1-8
    • Nagamune, H.1    Ohkura, K.2    Ohkuni, H.3
  • 12
    • 23944451658 scopus 로고    scopus 로고
    • Evolutionary origin and emergence of a highly successful clone of serotype M1 group a Streptococcus involved multiple horizontal gene transfer events
    • Sumby P, Porcella SF, Madrigal AG, Barbian KD, Virtaneva K, et al. (2005) Evolutionary origin and emergence of a highly successful clone of serotype M1 group a Streptococcus involved multiple horizontal gene transfer events. J Infect Dis 192: 771-782.
    • (2005) J Infect Dis , vol.192 , pp. 771-782
    • Sumby, P.1    Porcella, S.F.2    Madrigal, A.G.3    Barbian, K.D.4    Virtaneva, K.5
  • 13
    • 0035905930 scopus 로고    scopus 로고
    • Acute pharyngitis
    • Bisno AL, (2001) Acute pharyngitis. N Engl J Med 344: 205-211.
    • (2001) N Engl J Med , vol.344 , pp. 205-211
    • Bisno, A.L.1
  • 14
    • 0141737691 scopus 로고    scopus 로고
    • Assessment of Streptococcus pyogenes microcolony formation in infected skin by confocal laser scanning microscopy
    • Akiyama H, Morizane S, Yamasaki O, Oono T, Iwatsuki K, (2003) Assessment of Streptococcus pyogenes microcolony formation in infected skin by confocal laser scanning microscopy. J Dermatol Sci 32: 193-199.
    • (2003) J Dermatol Sci , vol.32 , pp. 193-199
    • Akiyama, H.1    Morizane, S.2    Yamasaki, O.3    Oono, T.4    Iwatsuki, K.5
  • 15
    • 25144472650 scopus 로고    scopus 로고
    • Patterns of virulence gene expression differ between biofilm and tissue communities of Streptococcus pyogenes
    • Cho KH, Caparon MG, (2005) Patterns of virulence gene expression differ between biofilm and tissue communities of Streptococcus pyogenes. Mol Microbiol 57: 1545-1556.
    • (2005) Mol Microbiol , vol.57 , pp. 1545-1556
    • Cho, K.H.1    Caparon, M.G.2
  • 16
    • 61449235432 scopus 로고    scopus 로고
    • Biofilm formation by group A Streptococcus: a role for the streptococcal regulator of virulence (Srv) and streptococcal cysteine protease (SpeB)
    • Doern CD, Roberts AL, Hong W, Nelson J, Lukomski S, et al. (2009) Biofilm formation by group A Streptococcus: a role for the streptococcal regulator of virulence (Srv) and streptococcal cysteine protease (SpeB). Microbiology 155: 46-52.
    • (2009) Microbiology , vol.155 , pp. 46-52
    • Doern, C.D.1    Roberts, A.L.2    Hong, W.3    Nelson, J.4    Lukomski, S.5
  • 17
    • 3342981167 scopus 로고    scopus 로고
    • Proapoptotic Effect of Proteolytic Activation of Matrix Metalloproteinases by Streptococcus pyogenes Thiol Proteinase (Streptococcus Pyrogenic Exotoxin B)
    • Tamura F, Nakagawa R, Akuta T, Okamoto S, Hamada S, et al. (2004) Proapoptotic Effect of Proteolytic Activation of Matrix Metalloproteinases by Streptococcus pyogenes Thiol Proteinase (Streptococcus Pyrogenic Exotoxin B). Infect Immun 72: 4836-4847.
    • (2004) Infect Immun , vol.72 , pp. 4836-4847
    • Tamura, F.1    Nakagawa, R.2    Akuta, T.3    Okamoto, S.4    Hamada, S.5
  • 18
    • 54449083249 scopus 로고    scopus 로고
    • Effects of streptococcal pyrogenic exotoxin B on pathogenesis of Streptococcus pyogenes
    • Chiang-Ni C, Wu JJ, (2008) Effects of streptococcal pyrogenic exotoxin B on pathogenesis of Streptococcus pyogenes. J Formos Med Assoc 107: 677-685.
    • (2008) J Formos Med Assoc , vol.107 , pp. 677-685
    • Chiang-Ni, C.1    Wu, J.J.2
  • 19
    • 0027290733 scopus 로고
    • Cleavage of interleukin 1 beta (IL-1 beta) precursor to produce active IL-1 beta by a conserved extracellular cysteine protease from Streptococcus pyogenes
    • Kapur V, Majesky MW, Li LL, Black RA, Musser JM, (1993) Cleavage of interleukin 1 beta (IL-1 beta) precursor to produce active IL-1 beta by a conserved extracellular cysteine protease from Streptococcus pyogenes. Proc Natl Acad Sci U S A 90: 7676-7680.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 7676-7680
    • Kapur, V.1    Majesky, M.W.2    Li, L.L.3    Black, R.A.4    Musser, J.M.5
  • 20
    • 0033042528 scopus 로고    scopus 로고
    • Extracellular cysteine protease produced by Streptococcus pyogenes participates in the pathogenesis of invasive skin infection and dissemination in mice
    • Lukomski S, Montgomery CA, Rurangirwa J, Geske RS, Barrish JP, et al. (1999) Extracellular cysteine protease produced by Streptococcus pyogenes participates in the pathogenesis of invasive skin infection and dissemination in mice. Infect Immun 67: 1779-1788.
    • (1999) Infect Immun , vol.67 , pp. 1779-1788
    • Lukomski, S.1    Montgomery, C.A.2    Rurangirwa, J.3    Geske, R.S.4    Barrish, J.P.5
  • 21
    • 0036892170 scopus 로고    scopus 로고
    • EndoS and SpeB from Streptococcus pyogenes Inhibit Immunoglobulin-Mediated Opsonophagocytosis
    • Collin M, Svensson MD, Sjoholm AG, Jensenius JC, Sjobring U, et al. (2002) EndoS and SpeB from Streptococcus pyogenes Inhibit Immunoglobulin-Mediated Opsonophagocytosis. Infect Immun 70: 6646-6651.
    • (2002) Infect Immun , vol.70 , pp. 6646-6651
    • Collin, M.1    Svensson, M.D.2    Sjoholm, A.G.3    Jensenius, J.C.4    Sjobring, U.5
  • 22
    • 44449096769 scopus 로고    scopus 로고
    • Group A Streptococcal Cysteine Protease Degrades C3 (C3b) and Contributes to Evasion of Innate Immunity
    • Terao Y, Mori Y, Yamaguchi M, Shimizu Y, Ooe K, et al. (2008) Group A Streptococcal Cysteine Protease Degrades C3 (C3b) and Contributes to Evasion of Innate Immunity. J Biol Chem 283: 6253-6260.
    • (2008) J Biol Chem , vol.283 , pp. 6253-6260
    • Terao, Y.1    Mori, Y.2    Yamaguchi, M.3    Shimizu, Y.4    Ooe, K.5
  • 23
    • 33646713439 scopus 로고    scopus 로고
    • Streptococcal pyrogenic exotoxin B causes mitochondria damage to polymorphonuclear cells preventing phagocytosis of group A streptococcus
    • Chiang-Ni C, Wang CH, Tsai PJ, Chuang WJ, Lin YS, et al. (2006) Streptococcal pyrogenic exotoxin B causes mitochondria damage to polymorphonuclear cells preventing phagocytosis of group A streptococcus. Med Microbiol Immunol 195: 55-63.
    • (2006) Med Microbiol Immunol , vol.195 , pp. 55-63
    • Chiang-Ni, C.1    Wang, C.H.2    Tsai, P.J.3    Chuang, W.J.4    Lin, Y.S.5
  • 24
    • 58149278915 scopus 로고    scopus 로고
    • Streptococcus pyogenes induces oncosis in macrophages through the activation of an inflammatory programmed cell death pathway
    • Goldmann O, Sastalla I, Wos-Oxley M, Rohde M, Medina E, (2009) Streptococcus pyogenes induces oncosis in macrophages through the activation of an inflammatory programmed cell death pathway. Cell Microbiol 11: 138-155.
    • (2009) Cell Microbiol , vol.11 , pp. 138-155
    • Goldmann, O.1    Sastalla, I.2    Wos-Oxley, M.3    Rohde, M.4    Medina, E.5
  • 25
    • 0032434852 scopus 로고    scopus 로고
    • A secreted streptococcal cysteine protease can cleave a surface-expressed M1 protein and alter the immunoglobulin binding properties
    • Raeder R, Woischnik M, Podbielski A, Boyle MD, (1998) A secreted streptococcal cysteine protease can cleave a surface-expressed M1 protein and alter the immunoglobulin binding properties. Res Microbiol 149: 539-548.
    • (1998) Res Microbiol , vol.149 , pp. 539-548
    • Raeder, R.1    Woischnik, M.2    Podbielski, A.3    Boyle, M.D.4
  • 26
    • 0028941597 scopus 로고
    • Streptococcal cysteine proteinase releases biologically active fragments of streptococcal surface proteins
    • Berge A, Bjorck L, (1995) Streptococcal cysteine proteinase releases biologically active fragments of streptococcal surface proteins. J Biol Chem 270: 9862-9867.
    • (1995) J Biol Chem , vol.270 , pp. 9862-9867
    • Berge, A.1    Bjorck, L.2
  • 27
    • 2942618331 scopus 로고    scopus 로고
    • SpeB modulates fibronectin-dependent internalization of Streptococcus pyogenes by efficient proteolysis of cell-wall-anchored protein F1
    • Nyberg P, Rasmussen M, Von Pawel-Rammingen U, Bjorck L, (2004) SpeB modulates fibronectin-dependent internalization of Streptococcus pyogenes by efficient proteolysis of cell-wall-anchored protein F1. Microbiology 150: 1559-1569.
    • (2004) Microbiology , vol.150 , pp. 1559-1569
    • Nyberg, P.1    Rasmussen, M.2    Von Pawel-Rammingen, U.3    Bjorck, L.4
  • 28
    • 51149120168 scopus 로고    scopus 로고
    • Point mutations within the streptococcal regulator of virulence (Srv) alter protein-DNA interactions and Srv function
    • Doern CD, Holder RC, Reid SD, (2008) Point mutations within the streptococcal regulator of virulence (Srv) alter protein-DNA interactions and Srv function. Microbiology 154: 1998-2007.
    • (2008) Microbiology , vol.154 , pp. 1998-2007
    • Doern, C.D.1    Holder, R.C.2    Reid, S.D.3
  • 29
    • 33750053544 scopus 로고    scopus 로고
    • Inactivation of the group A Streptococcus regulator srv results in chromosome wide reduction of transcript levels, and changes in extracellular levels of Sic and SpeB
    • Reid SD, Chaussee MS, Doern CD, Chaussee MA, Montgomery AG, et al. (2006) Inactivation of the group A Streptococcus regulator srv results in chromosome wide reduction of transcript levels, and changes in extracellular levels of Sic and SpeB. FEMS Immunol Med Microbiol 48: 283-292.
    • (2006) FEMS Immunol Med Microbiol , vol.48 , pp. 283-292
    • Reid, S.D.1    Chaussee, M.S.2    Doern, C.D.3    Chaussee, M.A.4    Montgomery, A.G.5
  • 30
    • 0029976625 scopus 로고    scopus 로고
    • Genetic and phenotypic diversity among isolates of Streptococcus pyogenes from invasive infections
    • Chaussee MS, Liu J, Stevens DL, Ferretti JJ, (1996) Genetic and phenotypic diversity among isolates of Streptococcus pyogenes from invasive infections. J Infect Dis 173: 901-908.
    • (1996) J Infect Dis , vol.173 , pp. 901-908
    • Chaussee, M.S.1    Liu, J.2    Stevens, D.L.3    Ferretti, J.J.4
  • 31
    • 0030948560 scopus 로고    scopus 로고
    • Temporal production of streptococcal erythrogenic toxin B (streptococcal cysteine proteinase) in response to nutrient depletion
    • Chaussee MS, Phillips ER, Ferretti JJ, (1997) Temporal production of streptococcal erythrogenic toxin B (streptococcal cysteine proteinase) in response to nutrient depletion. Infect Immun 65: 1956-1959.
    • (1997) Infect Immun , vol.65 , pp. 1956-1959
    • Chaussee, M.S.1    Phillips, E.R.2    Ferretti, J.J.3
  • 32
    • 0036228505 scopus 로고    scopus 로고
    • Biofilms: survival mechanisms of clinically relevant microorganisms
    • Donlan RM, Costerton JW, (2002) Biofilms: survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev 15: 167-193.
    • (2002) Clin Microbiol Rev , vol.15 , pp. 167-193
    • Donlan, R.M.1    Costerton, J.W.2
  • 34
    • 0031107625 scopus 로고    scopus 로고
    • Biofilm susceptibility to antimicrobials
    • Gilbert P, Das J, Foley I, (1997) Biofilm susceptibility to antimicrobials. Adv Dent Res 11: 160-167.
    • (1997) Adv Dent Res , vol.11 , pp. 160-167
    • Gilbert, P.1    Das, J.2    Foley, I.3
  • 35
    • 0032889976 scopus 로고    scopus 로고
    • Multivalent group A streptococcal vaccine designed to optimize the immunogenicity of six tandem M protein fragments
    • Dale JB, (1999) Multivalent group A streptococcal vaccine designed to optimize the immunogenicity of six tandem M protein fragments. Vaccine 17: 193-200.
    • (1999) Vaccine , vol.17 , pp. 193-200
    • Dale, J.B.1
  • 36
    • 33747186343 scopus 로고    scopus 로고
    • Therapeutic failures of antibiotics used to treat macrolide-susceptible Streptococcus pyogenes infections may be due to biofilm formation
    • Baldassarri L, Creti R, Recchia S, Imperi M, Facinelli B, et al. (2006) Therapeutic failures of antibiotics used to treat macrolide-susceptible Streptococcus pyogenes infections may be due to biofilm formation. J Clin Microbiol 44: 2721-2727.
    • (2006) J Clin Microbiol , vol.44 , pp. 2721-2727
    • Baldassarri, L.1    Creti, R.2    Recchia, S.3    Imperi, M.4    Facinelli, B.5
  • 37
    • 0041419116 scopus 로고    scopus 로고
    • Biofilm formation by group a streptococci: is there a relationship with treatment failure?
    • Conley J, Olson ME, Cook LS, Ceri H, Phan V, et al. (2003) Biofilm formation by group a streptococci: is there a relationship with treatment failure? J Clin Microbiol 41: 4043-4048.
    • (2003) J Clin Microbiol , vol.41 , pp. 4043-4048
    • Conley, J.1    Olson, M.E.2    Cook, L.S.3    Ceri, H.4    Phan, V.5
  • 38
    • 33646118749 scopus 로고    scopus 로고
    • Characterization of biofilm formation by clinically relevant serotypes of group A streptococci
    • Lembke C, Podbielski A, Hidalgo-Grass C, Jonas L, Hanski E, et al. (2006) Characterization of biofilm formation by clinically relevant serotypes of group A streptococci. Appl Environ Microbiol 72: 2864-2875.
    • (2006) Appl Environ Microbiol , vol.72 , pp. 2864-2875
    • Lembke, C.1    Podbielski, A.2    Hidalgo-Grass, C.3    Jonas, L.4    Hanski, E.5
  • 39
    • 48749089667 scopus 로고    scopus 로고
    • Role of Mga in group A streptococcal infection at the skin epithelium
    • Luo F, Lizano S, Banik S, Zhang H, Bessen DE, (2008) Role of Mga in group A streptococcal infection at the skin epithelium. Microb Pathog 45: 217-224.
    • (2008) Microb Pathog , vol.45 , pp. 217-224
    • Luo, F.1    Lizano, S.2    Banik, S.3    Zhang, H.4    Bessen, D.E.5
  • 40
    • 34248374752 scopus 로고    scopus 로고
    • Streptococcus pyogenes pili promote pharyngeal cell adhesion and biofilm formation
    • Manetti AG, Zingaretti C, Falugi F, Capo S, Bombaci M, et al. (2007) Streptococcus pyogenes pili promote pharyngeal cell adhesion and biofilm formation. Mol Microbiol 64: 968-983.
    • (2007) Mol Microbiol , vol.64 , pp. 968-983
    • Manetti, A.G.1    Zingaretti, C.2    Falugi, F.3    Capo, S.4    Bombaci, M.5
  • 41
    • 78049355070 scopus 로고    scopus 로고
    • Allelic replacement of the streptococcal cysteine protease SpeB in a Deltasrv mutant background restores biofilm formation
    • Roberts AL, Holder RC, Reid SD, (2010) Allelic replacement of the streptococcal cysteine protease SpeB in a Deltasrv mutant background restores biofilm formation. BMC Res Notes 3: 281.
    • (2010) BMC Res Notes , vol.3 , pp. 281
    • Roberts, A.L.1    Holder, R.C.2    Reid, S.D.3
  • 42
    • 78049426340 scopus 로고    scopus 로고
    • Loss of the group A Streptococcus regulator Srv decreases biofilm formation in vivo in an otitis media model of infection
    • Roberts AL, Connolly KL, Doern CD, Holder RC, Reid SD, (2010) Loss of the group A Streptococcus regulator Srv decreases biofilm formation in vivo in an otitis media model of infection. Infect Immun.
    • (2010) Infect Immun
    • Roberts, A.L.1    Connolly, K.L.2    Doern, C.D.3    Holder, R.C.4    Reid, S.D.5
  • 43
    • 0033117343 scopus 로고    scopus 로고
    • Purification of active cysteine proteases by affinity chromatography with attached E-64 inhibitor
    • Govrin E, Levine A, (1999) Purification of active cysteine proteases by affinity chromatography with attached E-64 inhibitor. Protein Expr Purif 15: 247-250.
    • (1999) Protein Expr Purif , vol.15 , pp. 247-250
    • Govrin, E.1    Levine, A.2
  • 44
    • 0033037118 scopus 로고    scopus 로고
    • Structural basis of inhibition of cysteine proteases by E-64 and its derivatives
    • Matsumoto K, Mizoue K, Kitamura K, Tse WC, Huber CP, et al. (1999) Structural basis of inhibition of cysteine proteases by E-64 and its derivatives. Biopolymers 51: 99-107.
    • (1999) Biopolymers , vol.51 , pp. 99-107
    • Matsumoto, K.1    Mizoue, K.2    Kitamura, K.3    Tse, W.C.4    Huber, C.P.5
  • 46
    • 0030960001 scopus 로고    scopus 로고
    • Inactivation of Streptococcus pyogenes extracellular cysteine protease significantly decreases mouse lethality of serotype M3 and M49 strains
    • Lukomski S, Sreevatsan S, Amberg C, Reichardt W, Woischnik M, et al. (1997) Inactivation of Streptococcus pyogenes extracellular cysteine protease significantly decreases mouse lethality of serotype M3 and M49 strains. J Clin Invest 99: 2574-2580.
    • (1997) J Clin Invest , vol.99 , pp. 2574-2580
    • Lukomski, S.1    Sreevatsan, S.2    Amberg, C.3    Reichardt, W.4    Woischnik, M.5
  • 47
    • 0035884264 scopus 로고    scopus 로고
    • Streptococcal pyrogenic exotoxin B enhances tissue damage initiated by other Streptococcus pyogenes products
    • Saouda M, Wu W, Conran P, Boyle MD, (2001) Streptococcal pyrogenic exotoxin B enhances tissue damage initiated by other Streptococcus pyogenes products. J Infect Dis 184: 723-731.
    • (2001) J Infect Dis , vol.184 , pp. 723-731
    • Saouda, M.1    Wu, W.2    Conran, P.3    Boyle, M.D.4
  • 48
    • 33645776051 scopus 로고    scopus 로고
    • Genome-wide analysis of group a streptococci reveals a mutation that modulates global phenotype and disease specificity
    • Sumby P, Whitney AR, Graviss EA, DeLeo FR, Musser JM, (2006) Genome-wide analysis of group a streptococci reveals a mutation that modulates global phenotype and disease specificity. PLoS Pathog 2: e5.
    • (2006) PLoS Pathog , vol.2 , pp. 5
    • Sumby, P.1    Whitney, A.R.2    Graviss, E.A.3    DeLeo, F.R.4    Musser, J.M.5
  • 49
    • 0033744193 scopus 로고    scopus 로고
    • Role for a secreted cysteine proteinase in the establishment of host tissue tropism by group A streptococci
    • Svensson MD, Scaramuzzino DA, Sjobring U, Olsen A, Frank C, et al. (2000) Role for a secreted cysteine proteinase in the establishment of host tissue tropism by group A streptococci. Mol Microbiol 38: 242-253.
    • (2000) Mol Microbiol , vol.38 , pp. 242-253
    • Svensson, M.D.1    Scaramuzzino, D.A.2    Sjobring, U.3    Olsen, A.4    Frank, C.5
  • 50
    • 0035139884 scopus 로고    scopus 로고
    • Identification of Rgg-regulated exoproteins of Streptococcus pyogenes
    • Chaussee MS, Watson RO, Smoot JC, Musser JM, (2001) Identification of Rgg-regulated exoproteins of Streptococcus pyogenes. Infect Immun 69: 822-831.
    • (2001) Infect Immun , vol.69 , pp. 822-831
    • Chaussee, M.S.1    Watson, R.O.2    Smoot, J.C.3    Musser, J.M.4
  • 51
    • 0033053646 scopus 로고    scopus 로고
    • A response regulator that represses transcription of several virulence operons in the group A streptococcus
    • Federle MJ, McIver KS, Scott JR, (1999) A response regulator that represses transcription of several virulence operons in the group A streptococcus. J Bacteriol 181: 3649-3657.
    • (1999) J Bacteriol , vol.181 , pp. 3649-3657
    • Federle, M.J.1    McIver, K.S.2    Scott, J.R.3
  • 52
    • 0031669931 scopus 로고    scopus 로고
    • Identification of csrR/csrS, a genetic locus that regulates hyaluronic acid capsule synthesis in group A Streptococcus
    • Levin JC, Wessels MR, (1998) Identification of csrR/csrS, a genetic locus that regulates hyaluronic acid capsule synthesis in group A Streptococcus. Mol Microbiol 30: 209-219.
    • (1998) Mol Microbiol , vol.30 , pp. 209-219
    • Levin, J.C.1    Wessels, M.R.2
  • 53
    • 0041387460 scopus 로고    scopus 로고
    • Role of RopB in growth phase expression of the SpeB cysteine protease of Streptococcus pyogenes
    • Neely MN, Lyon WR, Runft DL, Caparon M, (2003) Role of RopB in growth phase expression of the SpeB cysteine protease of Streptococcus pyogenes. J Bacteriol 185: 5166-5174.
    • (2003) J Bacteriol , vol.185 , pp. 5166-5174
    • Neely, M.N.1    Lyon, W.R.2    Runft, D.L.3    Caparon, M.4
  • 54
    • 77749271269 scopus 로고    scopus 로고
    • Dissection of the molecular basis for hypervirulence of an in vivo-selected phenotype of the widely disseminated M1T1 strain of group A Streptococcus bacteria
    • Kansal RG, Datta V, Aziz RK, Abdeltawab NF, Rowe S, et al. (2010) Dissection of the molecular basis for hypervirulence of an in vivo-selected phenotype of the widely disseminated M1T1 strain of group A Streptococcus bacteria. J Infect Dis 201: 855-865.
    • (2010) J Infect Dis , vol.201 , pp. 855-865
    • Kansal, R.G.1    Datta, V.2    Aziz, R.K.3    Abdeltawab, N.F.4    Rowe, S.5
  • 55
    • 34047270709 scopus 로고    scopus 로고
    • Control of Streptococcus pyogenes virulence: modeling of the CovR/S signal transduction system
    • Mitrophanov AY, Churchward G, Borodovsky M, (2007) Control of Streptococcus pyogenes virulence: modeling of the CovR/S signal transduction system. J Theor Biol 246: 113-128.
    • (2007) J Theor Biol , vol.246 , pp. 113-128
    • Mitrophanov, A.Y.1    Churchward, G.2    Borodovsky, M.3
  • 56
    • 4744339973 scopus 로고    scopus 로고
    • Post-proteomic identification of a novel phage-encoded streptodornase, Sda1, in invasive M1T1 Streptococcus pyogenes
    • Aziz RK, Ismail SA, Park HW, Kotb M, (2004) Post-proteomic identification of a novel phage-encoded streptodornase, Sda1, in invasive M1T1 Streptococcus pyogenes. Mol Microbiol 54: 184-197.
    • (2004) Mol Microbiol , vol.54 , pp. 184-197
    • Aziz, R.K.1    Ismail, S.A.2    Park, H.W.3    Kotb, M.4
  • 57
    • 0347595329 scopus 로고    scopus 로고
    • Invasive M1T1 group A Streptococcus undergoes a phase-shift in vivo to prevent proteolytic degradation of multiple virulence factors by SpeB
    • Aziz RK, Pabst MJ, Jeng A, Kansal R, Low DE, et al. (2004) Invasive M1T1 group A Streptococcus undergoes a phase-shift in vivo to prevent proteolytic degradation of multiple virulence factors by SpeB. Mol Microbiol 51: 123-134.
    • (2004) Mol Microbiol , vol.51 , pp. 123-134
    • Aziz, R.K.1    Pabst, M.J.2    Jeng, A.3    Kansal, R.4    Low, D.E.5
  • 58
    • 33646233984 scopus 로고    scopus 로고
    • Analysis of the role of CovR and CovS in the dissemination of Streptococcus pyogenes in invasive skin disease
    • Dalton TL, Hobb RI, Scott JR, (2006) Analysis of the role of CovR and CovS in the dissemination of Streptococcus pyogenes in invasive skin disease. Microb Pathog 40: 221-227.
    • (2006) Microb Pathog , vol.40 , pp. 221-227
    • Dalton, T.L.1    Hobb, R.I.2    Scott, J.R.3
  • 59
    • 0035313287 scopus 로고    scopus 로고
    • Spontaneous mutations in the CsrRS two-component regulatory system of Streptococcus pyogenes result in enhanced virulence in a murine model of skin and soft tissue infection
    • Engleberg NC, Heath A, Miller A, Rivera C, DiRita VJ, (2001) Spontaneous mutations in the CsrRS two-component regulatory system of Streptococcus pyogenes result in enhanced virulence in a murine model of skin and soft tissue infection. J Infect Dis 183: 1043-1054.
    • (2001) J Infect Dis , vol.183 , pp. 1043-1054
    • Engleberg, N.C.1    Heath, A.2    Miller, A.3    Rivera, C.4    DiRita, V.J.5
  • 60
    • 67651230633 scopus 로고    scopus 로고
    • CovS simultaneously activates and inhibits the CovR-mediated repression of distinct subsets of group A Streptococcus virulence factor-encoding genes
    • Trevino J, Perez N, Ramirez-Pena E, Liu Z, Shelburne SA 3rd, et al. (2009) CovS simultaneously activates and inhibits the CovR-mediated repression of distinct subsets of group A Streptococcus virulence factor-encoding genes. Infect Immun 77: 3141-3149.
    • (2009) Infect Immun , vol.77 , pp. 3141-3149
    • Trevino, J.1    Perez, N.2    Ramirez-Pena, E.3    Liu, Z.4    Shelburne 3rd., S.A.5
  • 61
    • 34547693093 scopus 로고    scopus 로고
    • DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection
    • Walker MJ, Hollands A, Sanderson-Smith ML, Cole JN, Kirk JK, et al. (2007) DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection. Nat Med 13: 981-985.
    • (2007) Nat Med , vol.13 , pp. 981-985
    • Walker, M.J.1    Hollands, A.2    Sanderson-Smith, M.L.3    Cole, J.N.4    Kirk, J.K.5
  • 62
    • 2942511333 scopus 로고    scopus 로고
    • CovS inactivates CovR and is required for growth under conditions of general stress in Streptococcus pyogenes
    • Dalton TL, Scott JR, (2004) CovS inactivates CovR and is required for growth under conditions of general stress in Streptococcus pyogenes. J Bacteriol 186: 3928-3937.
    • (2004) J Bacteriol , vol.186 , pp. 3928-3937
    • Dalton, T.L.1    Scott, J.R.2
  • 63
    • 30744463313 scopus 로고    scopus 로고
    • Regulation of SpeB in Streptococcus pyogenes by pH and NaCl: a model for in vivo gene expression
    • Loughman JA, Caparon M, (2006) Regulation of SpeB in Streptococcus pyogenes by pH and NaCl: a model for in vivo gene expression. J Bacteriol 188: 399-408.
    • (2006) J Bacteriol , vol.188 , pp. 399-408
    • Loughman, J.A.1    Caparon, M.2
  • 64
    • 32944465559 scopus 로고    scopus 로고
    • DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps
    • Buchanan JT, Simpson AJ, Aziz RK, Liu GY, Kristian SA, et al. (2006) DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps. Curr Biol 16: 396-400.
    • (2006) Curr Biol , vol.16 , pp. 396-400
    • Buchanan, J.T.1    Simpson, A.J.2    Aziz, R.K.3    Liu, G.Y.4    Kristian, S.A.5
  • 65
    • 0037312503 scopus 로고    scopus 로고
    • Selective modulation of superantigen-induced responses by streptococcal cysteine protease
    • Kansal RG, Nizet V, Jeng A, Chuang WJ, Kotb M, (2003) Selective modulation of superantigen-induced responses by streptococcal cysteine protease. J Infect Dis 187: 398-407.
    • (2003) J Infect Dis , vol.187 , pp. 398-407
    • Kansal, R.G.1    Nizet, V.2    Jeng, A.3    Chuang, W.J.4    Kotb, M.5
  • 66
    • 0019948262 scopus 로고
    • L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L
    • Barrett AJ, Kembhavi AA, Brown MA, Kirschke H, Knight CG, et al. (1982) L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. Biochem J 201: 189-198.
    • (1982) Biochem J , vol.201 , pp. 189-198
    • Barrett, A.J.1    Kembhavi, A.A.2    Brown, M.A.3    Kirschke, H.4    Knight, C.G.5
  • 67
    • 22644433729 scopus 로고    scopus 로고
    • SpeB-Spi: a novel protease-inhibitor pair from Streptococcus pyogenes
    • Kagawa TF, O'Toole PW, Cooney JC, (2005) SpeB-Spi: a novel protease-inhibitor pair from Streptococcus pyogenes. Mol Microbiol 57: 650-666.
    • (2005) Mol Microbiol , vol.57 , pp. 650-666
    • Kagawa, T.F.1    O'Toole, P.W.2    Cooney, J.C.3
  • 68
    • 4444351650 scopus 로고    scopus 로고
    • Synthesis of group A streptococcal virulence factors is controlled by a regulatory RNA molecule
    • Mangold M, Siller M, Roppenser B, Vlaminckx BJ, Penfound TA, et al. (2004) Synthesis of group A streptococcal virulence factors is controlled by a regulatory RNA molecule. Mol Microbiol 53: 1515-1527.
    • (2004) Mol Microbiol , vol.53 , pp. 1515-1527
    • Mangold, M.1    Siller, M.2    Roppenser, B.3    Vlaminckx, B.J.4    Penfound, T.A.5
  • 69
    • 1342344893 scopus 로고    scopus 로고
    • Identification of srv, a PrfA-like regulator of group A streptococcus that influences virulence
    • Reid SD, Montgomery AG, Musser JM, (2004) Identification of srv, a PrfA-like regulator of group A streptococcus that influences virulence. Infect Immun 72: 1799-1803.
    • (2004) Infect Immun , vol.72 , pp. 1799-1803
    • Reid, S.D.1    Montgomery, A.G.2    Musser, J.M.3
  • 70
    • 0033955513 scopus 로고    scopus 로고
    • Nonpolar inactivation of the hypervariable streptococcal inhibitor of complement gene (sic) in serotype M1 Streptococcus pyogenes significantly decreases mouse mucosal colonization
    • Lukomski S, Hoe NP, Abdi I, Rurangirwa J, Kordari P, et al. (2000) Nonpolar inactivation of the hypervariable streptococcal inhibitor of complement gene (sic) in serotype M1 Streptococcus pyogenes significantly decreases mouse mucosal colonization. Infect Immun 68: 535-542.
    • (2000) Infect Immun , vol.68 , pp. 535-542
    • Lukomski, S.1    Hoe, N.P.2    Abdi, I.3    Rurangirwa, J.4    Kordari, P.5
  • 71
    • 10744223970 scopus 로고    scopus 로고
    • Characterization of an extracellular virulence factor made by group A Streptococcus with homology to the Listeria monocytogenes internalin family of proteins
    • Reid SD, Montgomery AG, Voyich JM, DeLeo FR, Lei B, et al. (2003) Characterization of an extracellular virulence factor made by group A Streptococcus with homology to the Listeria monocytogenes internalin family of proteins. Infect Immun 71: 7043-7052.
    • (2003) Infect Immun , vol.71 , pp. 7043-7052
    • Reid, S.D.1    Montgomery, A.G.2    Voyich, J.M.3    DeLeo, F.R.4    Lei, B.5


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