Structural basis of inhibition of cysteine proteases by E-64 and its derivatives

Biopolymers - Peptide Science Section

Volumn 51, Issue 1, 1999, Pages 99-107

  Matsumoto, Keita ^a   Mizoue, Kazutoshi ^a   Kitamura, Kunihiro ^a   Tse, Wai Ching ^b,c   Huber, Carol P ^b,d   Ishida, Toshimasa ^e  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^c University of Ottawa ^*  (Canada)

^d UNIVERSITY OF OTTAWA   (Canada)

^e OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Actinidin; Binding mode; Cathepsin B; Cathepsin K; Cathepsin L; Cysteine protease; E 64; E 64 derivative; Inhibitory mechanism; Papain

Indexed keywords

CRYSTAL STRUCTURE; MOLECULAR DYNAMICS; MOLECULAR STRUCTURE;

CYSTEINE PROTEASES;

ENZYME INHIBITION;

ACTINIDIN; CATHEPSIN B; CATHEPSIN K; CYSTEINE PROTEINASE INHIBITOR; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; PAPAIN;

ARTICLE; CONFORMATIONAL TRANSITION; DRUG CONFORMATION; DRUG POTENCY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SPECIFICITY; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DRUG DESIGN; ELECTROSTATICS; EPOXY COMPOUNDS; LEUCINE; MODELS, MOLECULAR; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUCCINIC ACID;

EID: 0033037118     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0282(1999)51:1<99::AID-BIP11>3.0.CO;2-R     Document Type: Article

References (20)

1. Katsunuma, N.; Kominami, E. Rev Physiol Biochem Pharmacomol 1987, 108, 1-20.
2. Delaisse, J. M.; Eeckhout, Y.; Vaes, G. Biochem Biophys Res Commun 1984, 125, 441-447.
3. Denhardt, D.; Greenberg, A. H.; Egan, S. E.; Hamilton, R. T.; Wright, J. A. Oncogene 1987, 2, 55-59.
4. Hanada, K.; Tamai, M.; Yamagishi, S.; Ohmura, S.; Sawada, J.; Tanaka, I. Agric Biol Chem 1978, 42, 523-528.
5. Hanada, K.; Tamai, M.; Yamagishi, S.; Ohmura, S.; Sawada, J.; Tanaka, I. Agric Biol Chem 1978, 42, 529-536.
6. Varughese, K. I.; Ahmed, F. R.; Carey, P. R.; Hasnain, S.; Huber, C. P.; Storer, A. C. Biochemistry 1989, 28, 1330-1332.
7. Varughese, K. I.; Su, Y.; Cromwell, D.; Hasnain, S.; Xuong, N. Biochemistry 1992, 31, 5172-5176.
8. Fujishima, Y.; Imai, Y.; Nomura, T.; Fujisawa, Y.; Yamamoto, Y.; Sugawara, T. FEBS Lett 1997, 407, 47-50.
9. Zhao, B.; Janson, C. A.; Amegadzie, B. Y.; D'Alessio, K.; Griffin, C.; Hanning, C. R.; Jones, C.; Kurdyla, J.; McQueney, M.; Qiu, X.; Smith, W. W.; Abdel-Meguid, S. S. Nature Struct Biol 1997, 4, 109-111.
10. Katerelos, N. A.; Taylor, M. A. J.; Scott, M.; Goodenough, P. W.; Pickersgill, R. W. FEBS Lett 1996, 392, 35-39.
11. Katerelos, N. A.; Goodenough, P. W. Biochemistry 1996, 35, 14763-14772.
12. Yamamoto, D.; Matsumoto, K.; Ohishi, H.; Ishida, T.; Inoue, M.; Kitamura, K.; Mizuno, H. J Biol Chem 1991, 266, 14771-14777.
13. Kim, M.-J.; Yamamoto, D.; Matsumoto, K.; Inoue, M.; Ishida, T.; Mizuno, H.; Sumiya, S.; Kitamura, K. Biochem J 1992, 287, 797-803.
14. Matsumoto, K.; Murata, M.; Sumiya, S.; Kitamura, K.; Ishida, T. Biochim Biophys Acta 1994, 1208, 268-276.
15. Matsumoto, K.; Murata, M.; Sumiya, S.; Mizoue, K.; Kitamura, K.; Ishida, T. Biochim Biophys Acta 1998, 1383, 93-100.
16. Sumiya, S.; Yoneda, T.; Kitamura, K.; Murata, M.; Yokoo, C.; Tamai, M.; Yamamoto, A.; Inoue, M.; Ishida, T. Chem Pharm Bull 1992, 40, 299-303.
17. Turk, D.; Podobnik, M.; Popovic, T.; Katsunuma, N.; Bode, W.; Huber, R.; Turk, V. Biochemistry 1995, 34, 4791-4797.
18. Yamamoto, A.; Hara, T.; Tomoo, K.; Ishida, T.; Fujii, T.; Hata, Y.; Murata, M.; Kitamura, K. J Biochem 1997, 121, 974-977.
19. Musil, D.; Zucic, D.; Turk, D.; Engh, R. A.; Mayr, I.; Huber, R.; Popovic, T.; Turk, V.; Towatari, T.; Katunuma, N.; Bode, W. EMBO J 1991, 10, 2321-2330.
20. Illy, C.; Quraishi, O.; Wang, J.; Purisima, E.; Vernet, T.; Mort, J. S. J Biol Chem 1997, 272, 1197-1202.