Streptococcal pyrogenic exotoxin B enhances tissue damage initiated by other Streptococcus pyogenes products

Journal of Infectious Diseases

Volumn 184, Issue 6, 2001, Pages 723-731

  Saouda, M ^a   Wu, W ^a   Conran, P ^a   Boyle, M D P ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; EXOTOXIN; PYROGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; IMMUNE RESPONSE; INFLAMMATION; MOUSE; NECROTIZING FASCIITIS; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRAIN DIFFERENCE; STREPTOCOCCUS PYOGENES; TISSUE INJURY; TISSUE NECROSIS; TRANSCRIPTION REGULATION;

ANIMALS; BACTERIAL PROTEINS; BLOTTING, NORTHERN; EPIDERMIS; EXOTOXINS; GENE EXPRESSION REGULATION, BACTERIAL; MEMBRANE PROTEINS; MICE; MUSCLE, SKELETAL; PHENOTYPE; SKIN; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PYOGENES; TIME FACTORS;

EID: 0035884264     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/323083     Document Type: Article

References (36)

1. Inactivation of Streptococcus pyogenes extracellular cysteine protease significantly decreases mouse lethality of serotype M3 and M49 strains
2. Genetic inactivation of an extracellular cysteine protease (SpeB) expressed by Streptococcus pyogenes decreases resistance to phagocytosis and dissemination to organs
3. Extracellular cysteine protease produced by Streptococcus pyogenes participates in the pathogenesis of invasive skin infection and dissemination in mice
4. Role of streptococcal pyrogenic exotoxin B in the mouse model of streptococcal infection
5. Role for a secreted cysteine proteinase in the establishment of host tissue tropism by group A streptococci
6. Vaccination with streptococcal extracellular cysteine protease (interleukin-1B convertase) protects mice against challenge with heterologous group A streptococci
7. Molecular analysis of the role of the group A cysteine protease, hyaluronic acid capsule, and M protein in a murine model of haman invasive soft-tissue infection
8. Properties of IgG-binding proteins expressed by Streptococcus pyogenes isolates are predictive of invasive potential
9. Absence of SpeB production in virulent large capsular forms of group A streptococcal strain 64
10. Association of type II immunoglobulin G-binding protein expression and survival of group A streptococci in human blood
11. Association between expression of immunoglobulin G-binding proteins by group A streptococci and virulence in a mouse skin infection model
12. Inverse relation between disease severity and expression of the streptococcal cysteine protease, SpeB, among clonal M1T1 isolates recovered from invasive group A streptococcal infection cases
13. Association of phenotypic and genotypic characteristics of invasive Streptococcus pyogenes isolates with clinical components of toxic shock syndrome
14. A secreted streptococcal cysteine protease can cleave a surface-expressed M1 protein and alter the immunoglobulin binding properties
15. Clot formation by group A streptococci
16. Measurement of leukocyte chemotaxis in vivo
17. Streptococcal cysteine proteinase releases biologically active fragments of streptococcal surface proteins
18. Identification of pel, a Streptococcus pyogenes locus that affects both surface and secreted proteins
19. Functional and serological analysis of type II IgG-binding proteins expressed by pathogenic group A streptococci
20. Protein biotinylation
21. Distinct profiles of immunoglobulin G-binding-protein expression by invasive M1 serotype isolates of Streptococcus pyogenes
22. A role for trigger factor and an rgg-like regulator in the transcription, secretion, and processing of the cysteine proteinase of Streptococcus pyogenes
23. The rgg gene of Streptococcus pyogenes NZ131 positively influences extracellular SpeB production
24. Streptococcal cysteine protease augments lung injury induced by products of group A streptococci
25. A conserved Streptococcus pyogenes extracellular cysteine protease cleaves human fibronectin and degrades vitronectin
26. Cleavage of interleukin 1β (IL-1β) precursor to produce active Il-1β by a conserved extracellular cysteine protease from Streptococcus pyogenes
27. Activation of a 66-kilodalton human endothelial cell matrix metalloprotease by Streptococcus pyogenes extracellular cysteine protease
28. Different forms of streptolysin O produced by Streptococcus pyogenes and by Escherichia coli expressing recombinant toxin: Cleavage by streptococcal cysteine protease
29. Temporal production of streptococcal erythrogenic toxin B (streptococcal cysteine proteinase) in response to nutrient depletion
30. Streptococcal proteinase: The zymogen to enzyme transformation
31. Use of surface-enhanced laser desorption ionization protein chip system to analyze streptococcal exotoxin B activity secreted by Streptococcus pyogenes
32. Generation of a mature streptococcal cysteine proteinase is dependent on cell wall-anchored M1 protein
33. Autocatalytic processing of the streptococcal cysteine protease zymogen
34. Identification of Rgg-regulated exoproteins of Streptococcus pyogenes
35. Spontaneous mutations in the CsrRS two-component regulatory system of Streptococcus pyogenes result in enhanced virulence in a murine model of skin and soft tissue infection
36. Identification of a major, CsrRS-regulated secreted protein of group A streptococcus