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Volumn 57, Issue 6, 2005, Pages 1545-1556

Patterns of virulence gene expression differ between biofilm and tissue communities of Streptococcus pyogenes

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; STREPTOKINASE; VIRULENCE FACTOR;

EID: 25144472650     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2005.04786.x     Document Type: Article
Times cited : (136)

References (46)
  • 1
    • 0141737691 scopus 로고    scopus 로고
    • Assessment of Streptococcus pyogenes microcolony formation in infected skin by confocal laser scanning microscopy
    • Akiyama, H., Morizane, S., Yamasaki, O., Oono, T., and Iwatsuki, K. (2003) Assessment of Streptococcus pyogenes microcolony formation in infected skin by confocal laser scanning microscopy. J Dermatol Sci 32: 193-199.
    • (2003) J Dermatol Sci , vol.32 , pp. 193-199
    • Akiyama, H.1    Morizane, S.2    Yamasaki, O.3    Oono, T.4    Iwatsuki, K.5
  • 2
    • 0032145096 scopus 로고    scopus 로고
    • Molecular analysis of the role of the group a streptococcal cysteine protease, hyaluronic acid capsule, and M protein in a murine model of human invasive soft-tissue infection
    • Ashbaugh, C.D., Warren, H.B., Carey, V.J., and Wessels, M.R. (1998a) Molecular analysis of the role of the group A streptococcal cysteine protease, hyaluronic acid capsule, and M protein in a murine model of human invasive soft-tissue infection. J Clin Invest 102: 550-560.
    • (1998) J Clin Invest , vol.102 , pp. 550-560
    • Ashbaugh, C.D.1    Warren, H.B.2    Carey, V.J.3    Wessels, M.R.4
  • 3
    • 0031656714 scopus 로고    scopus 로고
    • Molecular analysis of the capsule gene region of group a Streptococcus: The hasAB genes are sufficient for capsule expression
    • Ashbaugh, C.D., Alberti, S., and Wessels, M.R. (1998b) Molecular analysis of the capsule gene region of group A Streptococcus: the hasAB genes are sufficient for capsule expression. J Bacteriol 180: 4955-4959.
    • (1998) J Bacteriol , vol.180 , pp. 4955-4959
    • Ashbaugh, C.D.1    Alberti, S.2    Wessels, M.R.3
  • 4
    • 0037586531 scopus 로고    scopus 로고
    • Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatis
    • Belland, R.J., Zhong, G., Crane, D.D., Hogan, D., Sturdevant, D., Sharma, J., et al. (2003) Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatis. Proc Natl Acad Sci USA 100: 8478-8483.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8478-8483
    • Belland, R.J.1    Zhong, G.2    Crane, D.D.3    Hogan, D.4    Sturdevant, D.5    Sharma, J.6
  • 5
    • 0032036480 scopus 로고    scopus 로고
    • Reduced virulence of group a streptococcal Tn916 mutants that do not produce streptolysin S
    • Betschel, S.D., Borgia, S.M., Barg, N.L., Low, D.E., and De Azavedo, J.C. (1998) Reduced virulence of group A streptococcal Tn916 mutants that do not produce streptolysin S. Infect Immun 66: 1671-1679.
    • (1998) Infect Immun , vol.66 , pp. 1671-1679
    • Betschel, S.D.1    Borgia, S.M.2    Barg, N.L.3    Low, D.E.4    De Azavedo, J.C.5
  • 6
    • 12344298832 scopus 로고    scopus 로고
    • The PerR regulon in peroxide resistance and virulence of Streptococcus pyogenes
    • Brenot, A., King, K.Y., and Caparon, M.G. (2005) The PerR regulon in peroxide resistance and virulence of Streptococcus pyogenes. Mol Microbiol 55: 221-234.
    • (2005) Mol Microbiol , vol.55 , pp. 221-234
    • Brenot, A.1    King, K.Y.2    Caparon, M.G.3
  • 7
    • 0025751633 scopus 로고
    • Genetic manipulation of pathogenic streptococci
    • Caparon, M.G., and Scott, J.R. (1991) Genetic manipulation of pathogenic streptococci. Methods Enzymol 204: 556-586.
    • (1991) Methods Enzymol , vol.204 , pp. 556-586
    • Caparon, M.G.1    Scott, J.R.2
  • 8
    • 0033591467 scopus 로고    scopus 로고
    • Bacterial biofilms: A common cause of persistent infections
    • Costerton, J.W., Stewart, P.S., and Greenberg, E.P. (1999) Bacterial biofilms: a common cause of persistent infections. Science 284: 1318-1322.
    • (1999) Science , vol.284 , pp. 1318-1322
    • Costerton, J.W.1    Stewart, P.S.2    Greenberg, E.P.3
  • 9
    • 0029099312 scopus 로고
    • Hyaluronic acid synthesis operon (has) expression in group A streptococci
    • Crater, D.L., and van de Rijn, I. (1995) Hyaluronic acid synthesis operon (has) expression in group A streptococci. J Biol Chem 270: 18452-18458.
    • (1995) J Biol Chem , vol.270 , pp. 18452-18458
    • Crater, D.L.1    Van De Rijn, I.2
  • 10
    • 0035887796 scopus 로고    scopus 로고
    • Biofilm formation: A clinically relevant microbiological process
    • Donlan, R.M. (2001) Biofilm formation: a clinically relevant microbiological process. Clin Infect Dis 33: 1387-1392.
    • (2001) Clin Infect Dis , vol.33 , pp. 1387-1392
    • Donlan, R.M.1
  • 11
    • 0036228505 scopus 로고    scopus 로고
    • Biofilms: Survival mechanisms of clinically relevant microorganisms
    • Donlan, R.M., and Costerton, J.W. (2002) Biofilms: survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev 15: 167-193.
    • (2002) Clin Microbiol Rev , vol.15 , pp. 167-193
    • Donlan, R.M.1    Costerton, J.W.2
  • 12
    • 0028032079 scopus 로고
    • Molecular characterization of hasA from an operon required for hyaluronic acid synthesis in group A streptococci
    • Dougherty, B.A., and van de Rijn, I. (1994) Molecular characterization of hasA from an operon required for hyaluronic acid synthesis in group A streptococci. J Biol Chem 269: 169-175.
    • (1994) J Biol Chem , vol.269 , pp. 169-175
    • Dougherty, B.A.1    Van De Rijn, I.2
  • 13
    • 0035313287 scopus 로고    scopus 로고
    • Spontaneous mutations in the CsrRS two-component regulatory system of Streptococcus pyogenes result in enhanced virulence in a murine model of skin and soft tissue infection
    • Engleberg, N.C., Heath, A., Miller, A., Rivera, C., and DiRita, V.J. (2001) Spontaneous mutations in the CsrRS two-component regulatory system of Streptococcus pyogenes result in enhanced virulence in a murine model of skin and soft tissue infection. J Infect Dis 183: 1043-1054.
    • (2001) J Infect Dis , vol.183 , pp. 1043-1054
    • Engleberg, N.C.1    Heath, A.2    Miller, A.3    Rivera, C.4    Dirita, V.J.5
  • 16
    • 0043246710 scopus 로고    scopus 로고
    • Growth, development, and gene expression in a persistent Streptococcus gordonii biofilm
    • Gilmore, K.S., Srinivas, P., Akins, D.R., Hatter, K.L., and Gilmore, M.S. (2003) Growth, development, and gene expression in a persistent Streptococcus gordonii biofilm. Infect Immun 71: 4759-4766.
    • (2003) Infect Immun , vol.71 , pp. 4759-4766
    • Gilmore, K.S.1    Srinivas, P.2    Akins, D.R.3    Hatter, K.L.4    Gilmore, M.S.5
  • 17
    • 0037108912 scopus 로고    scopus 로고
    • Virulence control in group a Streptococcus by a two-component gene regulatory system: Global expression profiling and in vivo infection modeling
    • Graham, M.R., Smoot, L.M., Migliaccio, C.A., Virtaneva, K., Sturdevant, D.E., Porcella, S.F., et al. (2002) Virulence control in group A Streptococcus by a two-component gene regulatory system: global expression profiling and in vivo infection modeling. Proc Natl Acad Sci USA 99: 13855-13860.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13855-13860
    • Graham, M.R.1    Smoot, L.M.2    Migliaccio, C.A.3    Virtaneva, K.4    Sturdevant, D.E.5    Porcella, S.F.6
  • 18
    • 0035726288 scopus 로고    scopus 로고
    • Regulation of capsule gene expression by group a Streptococcus during pharyngeal colonization and invasive infection
    • Gryllos, I., Cywes, C., Shearer, M.H., Cary, M., Kennedy, R.C., and Wessels, M.R. (2001) Regulation of capsule gene expression by group A Streptococcus during pharyngeal colonization and invasive infection. Mol Microbiol 42: 61-74.
    • (2001) Mol Microbiol , vol.42 , pp. 61-74
    • Gryllos, I.1    Cywes, C.2    Shearer, M.H.3    Cary, M.4    Kennedy, R.C.5    Wessels, M.R.6
  • 19
    • 0026661424 scopus 로고
    • Protein F, a fibronectin-binding protein, is an adhesin of the group A Streptococcus Streptococcus pyogenes
    • Hanski, E., and Caparon, M. (1992) Protein F, a fibronectin-binding protein, is an adhesin of the group A Streptococcus Streptococcus pyogenes. Proc Natl Acad Sci USA 89: 6172-6176.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6172-6176
    • Hanski, E.1    Caparon, M.2
  • 20
    • 0032856769 scopus 로고    scopus 로고
    • A two-component regulatory system, CsrR-CsrS, represses expression of three Streptococcus pyogenes virulence factors, hyaluronic acid capsule, streptolysin S, and pyrogenic exotoxin B
    • Heath, A., DiRita, V.J., Barg, N.L., and Engleberg, N.C. (1999) A two-component regulatory system, CsrR-CsrS, represses expression of three Streptococcus pyogenes virulence factors, hyaluronic acid capsule, streptolysin S, and pyrogenic exotoxin B. Infect Immun 67: 5298-5305.
    • (1999) Infect Immun , vol.67 , pp. 5298-5305
    • Heath, A.1    DiRita, V.J.2    Barg, N.L.3    Engleberg, N.C.4
  • 21
    • 10744222840 scopus 로고    scopus 로고
    • Effect of a bacterial pheromone peptide on host chemokine degradation in group A streptococcal necrotising soft-tissue infections
    • Hidalgo-Grass, C., Dan-Goor, M., Maly, A., Eran, Y., Kwinn, L.A., Nizet, V., et al. (2004) Effect of a bacterial pheromone peptide on host chemokine degradation in group A streptococcal necrotising soft-tissue infections. Lancet 363: 696-703.
    • (2004) Lancet , vol.363 , pp. 696-703
    • Hidalgo-Grass, C.1    Dan-Goor, M.2    Maly, A.3    Eran, Y.4    Kwinn, L.A.5    Nizet, V.6
  • 22
    • 0029572448 scopus 로고
    • Biological properties of a Streptococcus pyogenes mutant generated by Tn916 insertion in Mga
    • Kihlberg, B.M., Cooney, J., Caparon, M.G., Olsen, A., and Bjorck, L. (1995) Biological properties of a Streptococcus pyogenes mutant generated by Tn916 insertion in Mga. Microb Pathog 19: 299-315.
    • (1995) Microb Pathog , vol.19 , pp. 299-315
    • Kihlberg, B.M.1    Cooney, J.2    Caparon, M.G.3    Olsen, A.4    Bjorck, L.5
  • 23
    • 0016302499 scopus 로고
    • Transformation of Salmonella typhimurium by plasmid deoxyribonucleic acid
    • Lederberg, E.M., and Cohen, S.N. (1974) Transformation of Salmonella typhimurium by plasmid deoxyribonucleic acid. J Bacteriol 119: 1072-1074.
    • (1974) J Bacteriol , vol.119 , pp. 1072-1074
    • Lederberg, E.M.1    Cohen, S.N.2
  • 24
    • 0033042528 scopus 로고    scopus 로고
    • Extracellular cysteine protease produced by Streptococcus pyogenes participates in the pathogenesis of invasive skin infection and dissemination in mice
    • Lukomski, S., Montgomery, C.A., Rurangirwa, J., Geske, R.S., Barrish, J.P., Adams, G.J., and Musser, J.M. (1999) Extracellular cysteine protease produced by Streptococcus pyogenes participates in the pathogenesis of invasive skin infection and dissemination in mice. Infect Immun 67: 1779-1788.
    • (1999) Infect Immun , vol.67 , pp. 1779-1788
    • Lukomski, S.1    Montgomery, C.A.2    Rurangirwa, J.3    Geske, R.S.4    Barrish, J.P.5    Adams, G.J.6    Musser, J.M.7
  • 25
    • 0032476656 scopus 로고    scopus 로고
    • A role for trigger factor and an rgg-like regulator in the transcription, secretion and processing of the cysteine proteinase of Streptococcus pyogenes
    • Lyon, W.R., Gibson, C.M., and Caparon, M.G. (1998) A role for trigger factor and an rgg-like regulator in the transcription, secretion and processing of the cysteine proteinase of Streptococcus pyogenes. EMBO J 17: 6263-6275.
    • (1998) EMBO J , vol.17 , pp. 6263-6275
    • Lyon, W.R.1    Gibson, C.M.2    Caparon, M.G.3
  • 26
    • 0035726295 scopus 로고    scopus 로고
    • Mutation of luxS affects growth and virulence factor expression in Streptococcus pyogenes
    • Lyon, W.R., Madden, J.C., Levin, J.C., Stein, J.L., and Caparon, M.G. (2001) Mutation of luxS affects growth and virulence factor expression in Streptococcus pyogenes. Mol Microbiol 42: 145-157.
    • (2001) Mol Microbiol , vol.42 , pp. 145-157
    • Lyon, W.R.1    Madden, J.C.2    Levin, J.C.3    Stein, J.L.4    Caparon, M.G.5
  • 27
    • 0028857768 scopus 로고
    • Specific binding of the activator Mga to promoter sequences of the emm and scpA genes in the group A streptococcus
    • McIver, K.S., Heath, A.S., Green, B.D., and Scott, J.R. (1995) Specific binding of the activator Mga to promoter sequences of the emm and scpA genes in the group A streptococcus. J Bacteriol 177: 6619-6624.
    • (1995) J Bacteriol , vol.177 , pp. 6619-6624
    • McIver, K.S.1    Heath, A.S.2    Green, B.D.3    Scott, J.R.4
  • 28
    • 0029930804 scopus 로고    scopus 로고
    • Identification of isp, a locus encoding an immunogenic secreted protein conserved among group A streptococci
    • McIver, K.S., Subbarao, S., Kellner, E.M., Heath, A.S., and Scott, J.R. (1996) Identification of isp, a locus encoding an immunogenic secreted protein conserved among group A streptococci. Infect Immun 64: 2548-2555.
    • (1996) Infect Immun , vol.64 , pp. 2548-2555
    • McIver, K.S.1    Subbarao, S.2    Kellner, E.M.3    Heath, A.S.4    Scott, J.R.5
  • 30
    • 0036081383 scopus 로고    scopus 로고
    • Streptococcus-zebrafish model of bacterial pathogenesis
    • Neely, M.N., Pfeifer, J.D., and Caparon, M. (2002) Streptococcus- zebrafish model of bacterial pathogenesis. Infect Immun 70: 3904-3914.
    • (2002) Infect Immun , vol.70 , pp. 3904-3914
    • Neely, M.N.1    Pfeifer, J.D.2    Caparon, M.3
  • 31
    • 0031970701 scopus 로고    scopus 로고
    • Initiation of biofilm formation in Pseudomonas fluorescens WCS365 proceeds via multiple, convergent signalling pathways: A genetic analysis
    • O'Toole, G.A., and Kolter, R. (1998) Initiation of biofilm formation in Pseudomonas fluorescens WCS365 proceeds via multiple, convergent signalling pathways: a genetic analysis. Mol Microbiol 28: 449-461.
    • (1998) Mol Microbiol , vol.28 , pp. 449-461
    • O'Toole, G.A.1    Kolter, R.2
  • 32
    • 0033758602 scopus 로고    scopus 로고
    • Biofilm formation as microbial development
    • O'Toole, G., Kaplan, H.B., and Kolter, R. (2000) Biofilm formation as microbial development. Annu Rev Microbiol 54: 49-79.
    • (2000) Annu Rev Microbiol , vol.54 , pp. 49-79
    • O'Toole, G.1    Kaplan, H.B.2    Kolter, R.3
  • 33
    • 0036731842 scopus 로고    scopus 로고
    • Influence of hydrodynamics and cell signaling on the structure and behavior of Pseudomonas aeruginosa biofilms
    • Purevdorj, B., Costerton, J.W., and Stoodley, P. (2002) Influence of hydrodynamics and cell signaling on the structure and behavior of Pseudomonas aeruginosa biofilms. Appl Environ Microbiol 68: 4457-4464.
    • (2002) Appl Environ Microbiol , vol.68 , pp. 4457-4464
    • Purevdorj, B.1    Costerton, J.W.2    Stoodley, P.3
  • 34
    • 0034064660 scopus 로고    scopus 로고
    • Humanized in vivo model for streptococcal impetigo
    • Scaramuzzino, D.A., McNiff, J.M., and Bessen, D.E. (2000) Humanized in vivo model for streptococcal impetigo. Infect Immun 68: 2880-2887.
    • (2000) Infect Immun , vol.68 , pp. 2880-2887
    • Scaramuzzino, D.A.1    McNiff, J.M.2    Bessen, D.E.3
  • 35
    • 1342346635 scopus 로고    scopus 로고
    • Capsule shields the function of short bacterial adhesins
    • Schembri, M.A., Dalsgaard, D., and Klemm, P. (2004) Capsule shields the function of short bacterial adhesins. J Bacteriol 186: 1249-1257.
    • (2004) J Bacteriol , vol.186 , pp. 1249-1257
    • Schembri, M.A.1    Dalsgaard, D.2    Klemm, P.3
  • 36
    • 0031440588 scopus 로고    scopus 로고
    • Inactivation of single genes within the virulence regulon of an M2 group A streptococcal isolate result in differences in virulence for chicken embryos and for mice
    • Schmidt, K.H., Podbielski, A., Raeder, R., and Boyle, M.D. (1997) Inactivation of single genes within the virulence regulon of an M2 group A streptococcal isolate result in differences in virulence for chicken embryos and for mice. Microb Pathog 23: 347-355.
    • (1997) Microb Pathog , vol.23 , pp. 347-355
    • Schmidt, K.H.1    Podbielski, A.2    Raeder, R.3    Boyle, M.D.4
  • 37
    • 0032523209 scopus 로고    scopus 로고
    • Hyaluronic acid capsule modulates M protein-mediated adherence and acts as a ligand for attachment of group A Streptococcus to CD44 on human keratinocytes
    • Schrager, H.M., Alberti, S., Cywes, C., Dougherty, G.J., and Wessels, M.R. (1998) Hyaluronic acid capsule modulates M protein-mediated adherence and acts as a ligand for attachment of group A Streptococcus to CD44 on human keratinocytes. J Clin Invest 101: 1708-1716.
    • (1998) J Clin Invest , vol.101 , pp. 1708-1716
    • Schrager, H.M.1    Alberti, S.2    Cywes, C.3    Dougherty, G.J.4    Wessels, M.R.5
  • 38
    • 0016381606 scopus 로고
    • A turbid plaque-forming mutant of phage P1 that cannot lysogenize Escherichia coli
    • Scott, J.R. (1974) A turbid plaque-forming mutant of phage P1 that cannot lysogenize Escherichia coli. Virology 62: 344-349.
    • (1974) Virology , vol.62 , pp. 344-349
    • Scott, J.R.1
  • 39
    • 0025190287 scopus 로고
    • Coregulation of type 12 M protein and streptococcal C5a peptidase genes in group A streptococci: Evidence for a virulence regulon controlled by the virR locus
    • Simpson, W.J., LaPenta, D., Chen, C., and Cleary, P.P. (1990) Coregulation of type 12 M protein and streptococcal C5a peptidase genes in group A streptococci: evidence for a virulence regulon controlled by the virR locus. J Bacteriol 172: 696-700.
    • (1990) J Bacteriol , vol.172 , pp. 696-700
    • Simpson, W.J.1    LaPenta, D.2    Chen, C.3    Cleary, P.P.4
  • 40
    • 0034641962 scopus 로고    scopus 로고
    • Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms
    • Singh, P.K., Schaefer, A.L., Parsek, M.R., Moninger, T.O., Welsh, M.J., and Greenberg, E.P. (2000) Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature 407: 762-764.
    • (2000) Nature , vol.407 , pp. 762-764
    • Singh, P.K.1    Schaefer, A.L.2    Parsek, M.R.3    Moninger, T.O.4    Welsh, M.J.5    Greenberg, E.P.6
  • 41
    • 0029827703 scopus 로고    scopus 로고
    • Streptococcal pyrogenic exotoxin A release, distribution, and role in a murine model of fasciitis and multiorgan failure due to Streptococcus pyogenes
    • Sriskandan, S., Moyes, D., Buttery, L.K., Krausz, T., Evans, T.J., Polak, J., and Cohen, J. (1996) Streptococcal pyrogenic exotoxin A release, distribution, and role in a murine model of fasciitis and multiorgan failure due to Streptococcus pyogenes. J Infect Dis 173: 1399-1407.
    • (1996) J Infect Dis , vol.173 , pp. 1399-1407
    • Sriskandan, S.1    Moyes, D.2    Buttery, L.K.3    Krausz, T.4    Evans, T.J.5    Polak, J.6    Cohen, J.7
  • 42
    • 0029063833 scopus 로고
    • Biofilm structural heterogeneity visualized by three microscopic methods
    • Stewart, P.S., Murga, R., Srinivasan, R., and de Beer, D. (1995) Biofilm structural heterogeneity visualized by three microscopic methods. Water Res 29: 2006-2009.
    • (1995) Water Res , vol.29 , pp. 2006-2009
    • Stewart, P.S.1    Murga, R.2    Srinivasan, R.3    De Beer, D.4
  • 43
    • 0033956060 scopus 로고    scopus 로고
    • The COG database: A tool for genome-scale analysis of protein functions and evolution
    • Tatusov, R.L., Galperin, M.Y., Natale, D.A., and Koonin, E.V. (2000) The COG database: a tool for genome-scale analysis of protein functions and evolution. Nucleic Acids Res 28: 33-36.
    • (2000) Nucleic Acids Res , vol.28 , pp. 33-36
    • Tatusov, R.L.1    Galperin, M.Y.2    Natale, D.A.3    Koonin, E.V.4
  • 44
    • 0032795615 scopus 로고    scopus 로고
    • Staging of the baboon response to group A streptococci administered intramuscularly: A descriptive study of the clinical symptoms and clinical chemical response patterns
    • Taylor, F.B., Jr, Bryant, A.E., Blick, K.E., Hack, E., Jansen, P.M., Kosanke, S.D., and Stevens, D.L. (1999) Staging of the baboon response to group A streptococci administered intramuscularly: a descriptive study of the clinical symptoms and clinical chemical response patterns. Clin Infect Dis 29: 167-177.
    • (1999) Clin Infect Dis , vol.29 , pp. 167-177
    • Taylor Jr., F.B.1    Bryant, A.E.2    Blick, K.E.3    Hack, E.4    Jansen, P.M.5    Kosanke, S.D.6    Stevens, D.L.7
  • 45
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • Tusher, V.G., Tibshirani, R., and Chu, G. (2001) Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 98: 5116-5121.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 46
    • 0032884074 scopus 로고    scopus 로고
    • Growth-phase-dependent expression of virulence factors in an M1T1 clinical isolate of Streptococcus pyogenes
    • Unnikrishnan, M., Cohen, J., and Sriskandan, S. (1999) Growth-phase-dependent expression of virulence factors in an M1T1 clinical isolate of Streptococcus pyogenes. Infect Immun 67: 5495-5499.
    • (1999) Infect Immun , vol.67 , pp. 5495-5499
    • Unnikrishnan, M.1    Cohen, J.2    Sriskandan, S.3


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