Kinetic prerequisites of oximes as effective reactivators of organophosphate-inhibited acetylcholinesterase: A theoretical approach

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 26, Issue 3, 2011, Pages 303-308

  Worek, Franz ^a   Aurbek, Nadine ^a   Wille, Timo ^a   Eyer, Peter ^b   Thiermann, Horst ^a  

^a BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

acetylcholinesterase; model calculations; organophosphorus compounds; Oximes; reactivation kinetics

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ACETYLCHOLINESTERASE; BUTYLSARIN; CHOLINESTERASE INHIBITOR; CHOLINESTERASE REACTIVATOR; CYCLOSARIN; METHAMIDOPHOS; METHOXIME; METHYLFLUORO BETA PHOSPHONYLCHOLINE; METHYLFLUOROPHOSPHONYLHOMOCHOLINE; OBIDOXIME; ORGANOPHOSPHATE PESTICIDE; OXIME; PRALIDOXIME; TABUN; TRIMEDOXIME; UNCLASSIFIED DRUG;

ANTICHOLINERGIC EFFECT; BINDING AFFINITY; BODY BURDEN; CHOLINESTERASE INHIBITION; DISSOCIATION CONSTANT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG TOLERANCE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME REACTIVATION; HUMAN; IN VITRO STUDY; INTOXICATION; NEUROMUSCULAR BLOCKING; NEUROMUSCULAR SYNAPSE; NEUROMUSCULAR TRANSMISSION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ACETYLCHOLINESTERASE; ANIMALS; CHOLINESTERASE REACTIVATORS; ENZYME ACTIVATION; HUMANS; KINETICS; ORGANOPHOSPHORUS COMPOUNDS; OXIMES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79955555474     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.3109/14756366.2010.504673     Document Type: Review

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