Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase

Toxicology

Volumn 233, Issue 1-3 SPEC. ISS., 2007, Pages 166-172

  Bartling, A ^a   Worek, F ^a   Szinicz, L ^a   Thiermann, H ^a  

^a BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

Author keywords

Acetylcholinesterase; Aging; Butyrylcholinesterase; Inhibition; Organophosphate; Oxime; Reactivation

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 [2,4 BIS(HYDROXYIMINOMETHYL)PYRIDINIO] 1' (4 CARBAMOYLPYRIDINIO)DIMETHYL ETHER DIIODIDE; 1,1' METHYLENEBIS(4 HYDROXYIMINOMETHYLPYRIDINIUM) DICHLORIDE; ACETYLCHOLINESTERASE; CHOLINESTERASE; CHOLINESTERASE REACTIVATOR; CYCLOSARIN; ETHYLSARIN; ISOBUTYLSARIN; METHYLSARIN; MUSCARINIC RECEPTOR BLOCKING AGENT; N BUTYLSARIN; N PROPYLSARIN; NERVE GAS; NEUROTOXIN; OBIDOXIME; ORGANOPHOSPHATE; OXIME DERIVATIVE; PRALIDOXIME; SARIN; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL WARFARE; DEALKYLATION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME REACTIVATION; HUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE; CHEMICAL WARFARE AGENTS; CHOLINESTERASE REACTIVATORS; ERYTHROCYTE MEMBRANE; HUMANS; KINETICS; MOLECULAR STRUCTURE; SARIN; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

EID: 33947685552     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2006.07.003     Document Type: Article

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