Inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds: Pig versus minipig acetylcholinesterase

Toxicology

Volumn 244, Issue 1, 2008, Pages 35-41

  Worek, F ^a   Aurbek, N ^a   Wetherell, J ^b   Pearce, P ^b   Mann, T ^b   Thiermann, H ^a  

^a BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

^b DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

Author keywords

Acetylcholinesterase; Aging; Human; Inhibition; Organophosphorus compounds; Oximes; Pig; Reactivation

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ACETYLCHOLINESTERASE; CYCLOSARIN; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; NERVE GAS; OBIDOXIME; ORGANOPHOSPHORUS COMPOUND; PARAOXON; PRALIDOXIME; UNCLASSIFIED DRUG; VR;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME REACTIVATION; MINIPIG; NONHUMAN; PRIORITY JOURNAL; SWINE; TOXICOKINETICS;

ACETYLCHOLINESTERASE; AGING; ALGORITHMS; ANIMALS; BUTYRYLCHOLINESTERASE; CATALYSIS; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KINETICS; MODELS, ANIMAL; MOLECULAR STRUCTURE; ORGANOPHOSPHORUS COMPOUNDS; ORGANOTHIOPHOSPHORUS COMPOUNDS; OXIMES; PARAOXON; SWINE; SWINE, MINIATURE;

ANIMALIA; SUIDAE;

EID: 37349070353     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2007.10.021     Document Type: Article

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