BK large conductance Ca2+-activated K+ channel-deficient mice are not resistant to hypotension and display reduced survival benefit following polymicrobial sepsis

Shock

Volumn 35, Issue 5, 2011, Pages 485-491

  O'Brien, Alastair J ^a,c   Terala, Deepti ^a   Orie, Nelson N ^a   Davies, Nathan A ^a   Zolfaghari, Parjam ^b   Singer, Mervyn ^a,b   Clapp, Lucie H ^a  

^a University College   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

BK null mice; echocardiography; hypotension; Large conductance calcium activated potassium (BK) channels; mortality; sepsis; tetraethylammonium chloride

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 6; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT; NITRATE; NITRITE; TETRYLAMMONIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

ACIDEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PH; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE MONITORING; CECUM; CONTROLLED STUDY; CORE TEMPERATURE; DRUG DOSE COMPARISON; DRUG MEGADOSE; ECHOCARDIOGRAPHY; GENE EXPRESSION; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; HEMODYNAMICS; HYPOTENSION; LIGATION; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PERITONITIS; PUNCTURE; SEPSIS; SURVIVAL; WILD TYPE;

ANIMALS; BLOOD PRESSURE; GENOTYPE; HYPOTENSION; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; MALE; MICE; MICE, KNOCKOUT; POTASSIUM CHANNEL BLOCKERS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEPSIS; TETRAETHYLAMMONIUM;

EID: 79955546956     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e31820860f5     Document Type: Article

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