Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages

Infection and Immunity

Volumn 74, Issue 7, 2006, Pages 4354-4356

  Scheel, Olaf ^a   Papavlassopoulos, Martin ^a   Blunck, Rikard ^d   Gebert, Andreas ^b   Hartung, Thomas ^c   Zähringer, Ulrich ^a   Seydel, Ulrich ^a   Schromm, Andra B ^a  

^a RESEARCH CENTER BORSTEL   (Germany)

^b UNIVERSITY OF LÜBECK   (Germany)

^c UNIVERSITY OF KONSTANZ   (Germany)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CYTOKINE; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; PEPTIDOGLYCAN; POTASSIUM CHANNEL; POTASSIUM CHANNEL MAXIK; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; MACROPHAGE; MEMBRANE POTENTIAL; PATCH CLAMP; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL;

CELL LINE; HUMANS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; LIGANDS; MACROPHAGE ACTIVATION; MACROPHAGES; MULTIGENE FAMILY; RECEPTORS, INTERLEUKIN-1; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 33745608998     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.01783-05     Document Type: Article

References (14)

1. Akashi, S., S. Saitoh, Y. Wakabayashi, T. Kikuchi, N. Takamura, Y. Nagai, Y. Kusumoto, K. Fukase, S. Kusumoto, Y. Adachi, A. Kosugi, and K. Miyake. 2003. Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14. J. Exp. Med. 198:1035-1042.
2. Akira, S, and K. Takeda. 2004. Toll-like receptor signalling. Nat. Rev. Immunol. 4:499-511.
3. + channel in transmembrane signaling. J. Immunol. 166:1009-1015.
4. Cohen, J. 2002. The immunopathogenesis of sepsis. Nature 420:885-891.
5. da Silva, C. J., K. Soldau, U. Christen, P. S. Tobias, and R. J. Ulevitch. 2001. Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. Transfer from CD14 to TLR4 and MD-2. J. Biol. Chem. 276:21129-21135.
6. Galanos, C., O. Lüderitz, E. T. Rietschel, O. Westphal, H. Brade, L. Brade, M. Freudenberg, U. Schade, M. Imoto, H. Yoshimura, and T. Shiba. 1985. Synthetic and natural Escherichia coli free lipid A express identical endotoxic activities. Eur. J. Biochem. 148:1-5.
7. 6a. Glasbey, C. A., and R. J. Martin. 1988. The distribution of numbers of open channels in multi-channel patches. J. Neurosci. Methods 24:283-287.
8. Morath, S., A. Geyer, and T. Hartung. 2001. Structure-function relationship of cytokine induction by lipoteichoic acid from Staphylococcus aureus. J. Exp. Med. 193:393-397.
9. Poltorak, A., X. He, I. Smirnova, M-Y. Liu, C. Van Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, M. Freudenberg, P. Ricciardi-Castagnoli, B. Layton, and B. Beutler. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085-2088.
10. Rosenthal, R. S., and R. Dziarski. 1994. Isolation of peptidoglycan and soluble peptidoglycan fragments. Methods Enzymol. 235:253-285.
11. Schromm, A. B., E. Lien, P. Henneke, J. C. Chow, A. Yoshimura, H. Heine, E. Latz, B. G. Monks, D. A. Schwartz, K. Miyake, and D. T. Golenbock. 2001. Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling. J. Exp. Med. 194:79-88.
12. + channel is involved in LPS signaling. J. Endotoxin Res. 7:243-247.
13. Shimazu, R., S. Akashi, H. Ogata, Y. Nagai, K. Fukudome, K. Miyake, and M. Kimoto. 1999. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189:1777-1782.
14. Takeuchi, O., K. Hoshino, T. Kawai, H. Sanjo, H. Takada, T. Ogawa, K. Takeda, and S. Akira. 1999. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11:443-451.