Effect of potassium channel and cytochrome P450 inhibition on transient hypotension and survival during lipopolysaccharide-induced endotoxic shock in the rat

Pharmacology

Volumn 73, Issue 3, 2005, Pages 113-120

  Clayton, Nicholas P ^a   LeDuc, Barbara W ^a   Kelly, Laurie J ^a  

^a MA Coll of Pharm and Hlth Sci   (United States)

Author keywords

Endotoxic shock; Epoxyeicosatrienoic acids; Ketoconazole; Mean arterial pressure; Proadifen; Tetraethylammonium chloride

Indexed keywords

ARACHIDONIC ACID; CYTOCHROME P450; CYTOCHROME P450 INHIBITOR; KETOCONAZOLE; LIPOPOLYSACCHARIDE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; PROADIFEN; SODIUM CHLORIDE; TETRYLAMMONIUM CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ENZYME INHIBITION; HEART RATE; HYPOTENSION; IN VIVO STUDY; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SEPTIC SHOCK; SURVIVAL RATE; SYSTOLIC BLOOD PRESSURE;

ANIMALS; BLOOD PRESSURE; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HYPOTENSION; LIPOPOLYSACCHARIDES; MALE; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; SHOCK, SEPTIC;

EID: 14044271462     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000081631     Document Type: Article

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