MicroRNAs: Potential biomarker in organ transplantation

Transplant Immunology

Volumn 24, Issue 4, 2011, Pages 210-215

  Shan, Juan ^a   Feng, Li ^a   Luo, Lei ^a   Wu, Wenqiao ^a   Li, Chengwen ^a   Li, Shengfu ^a   Li, Youping ^a,b  

^a SICHUAN UNIVERSITY   (China)

^b Chinese Evidence Based Medicine Centre   (China)

Author keywords

Biomarker; Immune regulation; MicroRNA; Transplantation

Indexed keywords

DUAL SPECIFICITY PHOSPHATASE 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MICRORNA; MICRORNA 155; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; PROTEIN TYROSINE PHOSPHATASE SHP 2; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

BIOGENESIS; CELLULAR IMMUNITY; DENDRITIC CELL; DIAGNOSTIC VALUE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC MARKER; HUMAN; HUMORAL IMMUNITY; KIDNEY ALLOGRAFT; KIDNEY GRAFT REJECTION; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; PROGNOSIS; REGULATORY T LYMPHOCYTE; REVIEW; RNA DEGRADATION; TRANSLATION REGULATION;

ANIMALS; BIOLOGICAL MARKERS; GENE THERAPY; GRAFT REJECTION; HUMANS; IMMUNITY, CELLULAR; MICROARRAY ANALYSIS; MICRORNAS; ORGAN TRANSPLANTATION; T-LYMPHOCYTE SUBSETS; TREATMENT OUTCOME;

EID: 79955536976     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trim.2011.03.004     Document Type: Review

References (67)

1. Bartel D.P., Chen C.Z. Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat Rev Genet 2004, 5:396-400.
2. Lu Li-Fan, Liston Adrian MicroRNA in the immune system, microRNA as an immune system. Immunology 2009, 127(3):291-298.
3. Lee Y., Kim M., Han J., Yeom K.H., Lee S., Baek S.H., et al. MicroRNA genes are transcribed by RNApolymerase II. EMBO J 2004, 23:4051-4060.
4. Ballarino M., Pagano F., Girardi E., Morlando M., Cacchiarelli D., Marchioni M., et al. Coupled RNA processing and transcription of intergenic primary microRNAs. Mol Cell Biol 2009, 29:5632-5638.
5. Yi R., Qin Y., Macara I.G., Cullen B.R. Exportin 5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev 2003, 17:3011-3016.
6. Bohnsack M.T., Czaplinski K., Gorlich D. Exportin 5 is a RanGTP-dependent dsRNAbinding protein that mediates nuclear export of pre-miRNAs. RNA 2004, 10(2):185-191.
7. Ketting R.F., Fischer S.E., Bernstein E., Sijen T., Hannon G.J., Plasterk R.H. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev 2001, 15:2654-2659.
8. Lingel A., Simon B., Izaurralde E., Sattler M. Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Nature 2003, 426:465-469.
9. Liu J., Carmell M.A., Rivas F.V., Marsden C.G., Thomson J.M., Song J.J., et al. Argonaute2 is the catalytic engine of mammalian RNAi. Science 2004, 305:1437-1441.
10. Bartel D.P. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 2004, 116:281-297.
11. Engels B.M., Hutvagner G. Principles and effects of microRNA-mediated posttranscriptional gene regulation. Oncogene 2006, 25:6163-6169.
12. Vasudevan S., Tong Y., Steitz J.A. Switching from repression to activation: microRNAs can up-regulate translation. Science 2007, 318:1931-1934.
13. Sui W.G., Dai Y., Huang Y.S., Lana H.J., Yana Q., Huang H. Microarray analysis of MicroRNA expression in acute rejection after renal transplantation. Transpl Immunol 2008, 19:81-85.
14. Anglicheaua D., Sharmaa V.K., Dinga R., Hummela A., Snopkowskia C., Dadhania D., et al. MicroRNA expression profiles predictive of human renal allograft status. Proc Natl Acad Sci U S A Mar. 31 2009, 106(13):5330-5335.
15. Potter A., Maluf D., Suh J., Whitehill B., Yanek K., Fisher R., et al. Overexpression of microRNAs associated with tubularathrophy and interstitial fibrosis post kidney transplantation. Am J Transplant 2009, (250-251).
16. Sotolongo B., Asaoka T., Island E., Carreno M., Delacruz V., Cova D., et al. Gene expression profiling of microRNAs in small-bowel transplantation paraffin-embedded mucosal biopsy tissue. Transplant Proc 2010, 42:62-65.
17. Valadi H., Ekström K., Bossios A., Sjöstrand M., Lee J.J., Lötvall J.O. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007, 9:654-659.
18. Skog J., Würdinger T., Rijn S.V., Meijer D.H., Gainche L., Curry W.T., et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 2008, 10:1470-1476.
19. Zhang Y.J., Liu D.Q., Chen X., Li J., Li L., Bian Z., et al. Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell 2010, 39:133-144.
20. Farid W.R.R., Pan Q., De Ruiter P., Metselaar H.J., Kwekkeboom J., Tilanus H.W., et al. Liver-specific MicroRNAs are serum biomarkers for hepatic injury and acute rejection. Liver Transpl 2010, 16(S1):173.
21. Morelli Adrian E., Thomson Angus W. Tolerogenic dendritic cells and the quest for transplant tolerance. Nature 2007, 7(8):610-621.
22. Taganov K.D., Boldin M.P., Chang K.J., Baltimore D. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A August 15 2006, 103(33):12481-12486.
23. Rodriguez A., Vigorito E., Clare S., Warren M.V., Couttet P., Soond D.R., et al. Requirement of bic/microRNA-155 for normal immune function. Science April 27 2007, 316(5824):608-611.
24. Evel-Kabler K., Song X.T., Aldrich M., Huang X.F., Chen S.Y. SOCS1 restricts dendritic cells' ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling. J Clin Invest 2006, 116:90-100.
25. Lu L.F., Liston A. MicroRNA in the immune system, microRNA as an immune system. Immunology 2009, 127:291-298.
26. Ceppia M., Pereira P.M., Sauthierf I.D., Barrasf E., Reithf W., Santos M.A., et al. MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells. Proc Natl Acad Sci U S A 2009, 106(8):2735-2740.
27. Lu F., Weidmer A., Liu C.G., Volinia S., Croce C.M., Lieberman P.M. Epstein-Barr virus-induced miR-155 attenuates NF-κB signaling and stabilizes latent virus persistence. J Virol 2008, 82:10436-10443.
28. Li M., Zhang X., Zheng X., Lian D., Zhang Z.X., Ge W., et al. Immune modulation and tolerance induction by RelB-silenced dendritic cells through RNA interference. J Immunol May 1 2007, 178(9):5480-5487.
29. Wu H.Q., Neilson J.R., Kumar P., Manocha M., Shankar P., Sharp P.A., et al. miRNA profiling of naive, effector and memory CD8 T cells. PLoS One 2007, 2(10):e1020.
30. Cobb B.S., Hertweck A., Smith J., O'Connor E., Graf D., Cook T., et al. A role for Dicer in immune regulation. J Exp Med 2006, 203:2519-2527.
31. Li Q.J., Chau J., Ebert P.J. MiR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell 2007, 129:147-161.
32. Sporri B., Kovanen P.E., Sasaki A., Yoshimura A., Leonard W.J. JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling. Blood 2001, 97(1):221-226.
33. Stahl HF, Fauti T, Ullrich N, Bopp T, Kubach J, Rust W, et al. miR-155 inhibition sensitizes CD4+ Th cells for Treg mediated suppression. PLoS ONE 4(9): e7158- e7158.
34. Banerjee Arnob, Schambach Felix, Dejong Caitlin S., Hammond Scott M, Reiner Steven L., et al. Micro-RNA-155 inhibits IFN-c signaling in CD4+ T cells. Eur J Immunol 2010, 40:225-231.
35. D'elios Mario M., Josien Régis, Manghetti Marta, et al. Predominant Th1 cell infiltration in acute rejection episodes of human kidney grafts. Kidney Int 1997, 51:1876-1884.
36. Sayegh M.H., Akalin E., Hancock W~.V., Russell M.E., Carpenter C.B., Linsley P.S. Turka LA: CD28-B7 blockade after alloantigenic challenge in vivo inhibits Thl cytokines but spares Th2. J Exp Med 1995, 181:1869-1874.
37. Kist-Van Holthe Joana E., Gasser Martin, Womer Karl, Nader Najafian, Victor Dong, Dimitry V Samsonov, et al. Regulatory functions of alloreactive Th2 clones in human renal transplant recipients. Kidney Int 2002, 62:627-631.
38. Akdis C.A., Blaser K. Mechanisms of interleukin-10-mediated immune suppression. Immunology 2001, 103:131-136.
39. Matesic D., Valujskikh A., Pearlman E., Higgins A.W., Gilliam A.C., Heeger P.S. Type 2 immune deviation has differential effects on alloreactive CD4+ and CD8+ T cells. J Immunol 1998, 161:5236-5244.
40. Le Moine A., Goldman M., Abramowicz D. Multiple pathways to allograft rejection. Transplantation 2002, 73:1373-1381.
41. Sarwal M., Chua M.S., Kambham N., Szu-Chuan Hsieh M.S., Thomas Satterwhite B.S., Marilyn Masek M.S., et al. Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. N Engl J Med 2003, 349:125-138.
42. Tsai E.W., Rianthavorn P., Gjertson D.W., Wallace W.D., Reed E.F., Ettenger R.B. CD20+ lymphocytes in renal allografts are associated with poor graft survival in pediatric patients. Transplantation 2006, 82:1769-1773.
43. Hippen B.E., DeMattos A., Cook W.J., Kew C.E., Gaston R.S. Association of CD20+ infiltrates with poorer clinical outcomes in acute cellular rejection of renal allografts. Am J Transplant 2005, 5:2248-2252.
44. Martins H.L., Silva C., Martini D., Noronha I.L. Detection of B lymphocytes (CD20+) in renal allograft biopsy specimens. Transplant Proc 2007, 39:432-434.
45. Muorah M.R., Brogan P.A., Sebire N.J., Trompeter R.S., Marks S.D. Dense B cell infiltrates in paediatric renal transplant biopsies are predictive of allograft loss. Pediatr Transplant 2009, 13(2):217-222.
46. Zarkhin V., Kambham N., Li L., Kwok S., Hsieh S.C., Salvatierra O., et al. Characterization of intra-graft B cells during renal allograft rejection. Kidney Int 2008, 85(12):1705-1714.
47. Eleni Tsitsiou, Lindsay Mark A. microRNAs and the immune response. Curr Opin Pharmacol 2009, 9:514-520.
48. Das H., Groh V., Kuijl C., Sugita M., Morita C.T., Spies T., et al. MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector function. Immunity 2001, 15:83-93.
49. Groh V., Bahran S., Bauer S., Herman A., Beauchamp M., Spies T. Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc Natl Acad Sci U S A 1996, 93:12445-12450.
50. Suárez-Álvarez B., López-Vázquez A., Gonzalez M.Z., Fdez-Morera J.L., Díaz-Molina B., Blanco-Gelaz M.A., et al. The relationship of anti-MICA antibodies and MICA expression with heart allograft rejection. Am J Transplant 2007, 7:1842-1848.
51. Racca A.L., Veaute C.M., Bailat A.S., Gaite L., Arriola M., Hajos S.E., et al. Expression of HLA-G and MICA mRNA in renal allograft. Transpl Immunol 2009, 21:10-12.
52. Zou Y., Stastny P., Susal C., Dohler B., Opelz G. Antibodies against MICA antigens and kidney-transplant rejection. N Engl J Med 2007, 357:1293-1300.
53. Terasaki P.I., Ozawa M., Castro R. Four-year follow-up of a prospective trial of HLA and MICA antibodies on kidney graft survival. Am J Transplant 2007, 7:408-415.
54. Panigrahi A., Gupta N., Siddiqui J.A., Margoob A., Bhowmik D., Guleria S., et al. Post transplant development of MICA and anti-HLA antibodies is associated with acute rejection episodes and renal allograft loss. Hum Immunol 2007, 68:362-367.
55. Stern-Ginossar N., Gur C., Biton M., Horwitz E., Elboim M., Stanietsky N., et al. Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D. Nat Immunol 2008, 9:1065-1073.
56. Nachmani D., Stern-Ginossar N., Sarid R., Mandelboim O. Diverse herpesvirus microRNAs target the stress-induced immune ligand MICB to escape recognition by natural killer cells. Cell Host Microbe 2009, 5:376-385.
57. Hendrikx TK, Van Gurp EAFJ, Sewgobind VDKD, et al. Generation of donor-specific regulatory t-cell function in kidney transplant patients. 2009; 87:376-383.
58. Wang Z., Fu X.Y., Shi B.Y., Qian Y.Y., Xiao L., Bai H.W. Antigen-specific suppression by induced CD4+CD25 high regulatory T cells in kidney recipients. Proceedings 2009, 41:1574-1576.
59. Yoshizawa A., Ito A., Li Y., Koshiba T., Sakaguchi S., Wood K.J., et al. The roles of CD25+CD4+ regulatory T cells in operational tolerance after living donor liver transplantation. Transplant Proc 2005, 37(1):37-39.
60. Zhou X., Jeker L.T., Fife B.T., Zhu S., Anderson M.S., McManus M.T., et al. Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J Exp Med 2008, 205:1983-1991.
61. Liston A., Lu L.F., O'Carroll D., Tarakhovsky A., Rudensky A.Y. Dicer-dependent microRNA pathway safeguards regulatory T cell function. J Exp Med 2008, 205:1993-2004.
62. Lu L.F., Thai T.H., Calado D.P., Chaudhry A., Kubo M., Tanaka K., et al. Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity 2009, 30:80-91.
63. Huang B., Zhao J., Lei Z., Shen S., Li D., Shen G.X., et al. miR-142-3p restricts cAMP production in CD4+CD25- T cells and CD4+CD25+ TREG cells by targeting AC9 mRNA. EMBO Rep 2009, 10:180-185.
64. McLaughlin J., Cheng D., Singer O., Lukacs R.U., Radu C.G., Verma I.M., et al. Sustained suppression of Bcr-Abl-driven lymphoid leukemia by microRNA mimics. Proc Natl Acad Sci U S A December 18 2007, 104(51):20501-20506.
65. Fasanaro P., Greco S., Ivan M., Capogrossi M.C., Martelli F. microRNA: emerging therapeutic targets in acute ischemic diseases. Pharmacol Ther 2010, 125:92-104.
66. Krutzfeldt J., Rajewsky N., Braich R., Rajeev K.G., Tuschl T., Manoharan M., et al. Silencing of microRNAs in vivo with 'antagomirs'. Nature 2005, 438(7068):685-689.
67. Elmen J., Lindow M., Schutz S., Lawrence M., Petri A., Obad S., et al. LNAmediated microRNA silencing in non-human primates. Nature 2008, 452(7189):896-899.