Peroxisome proliferator-activated receptor γ antagonists decrease Na+ transport via the epithelial Na+ channel

Molecular Pharmacology

Volumn 76, Issue 6, 2009, Pages 1333-1340

  Pavlov, Tengis S ^a   Levchenko, Vladislav ^a   Karpushev, Alexey V ^a   Vandewalle, Alain ^b   Staruschenko, Alexander ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; 2 CHLORO 5 NITRO N (4 PYRIDYL)BENZAMIDE; 2 CHLORO 5 NITROBENZANILIDE; EPITHELIAL SODIUM CHANNEL; INSULIN; PIOGLITAZONE; ROSIGLITAZONE; TROGLITAZONE;

ARTICLE; CELL VIABILITY; CHO CELL; DOWN REGULATION; HUMAN; KIDNEY COLLECTING TUBULE; KIDNEY TUBULE ABSORPTION; NONHUMAN; PRIORITY JOURNAL; SHORT CIRCUIT CURRENT; SODIUM TRANSPORT;

ANILIDES; ANIMALS; BENZAMIDES; BIOLOGICAL TRANSPORT; CELL SURVIVAL; CHO CELLS; CHROMANS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL SODIUM CHANNEL; HYPOGLYCEMIC AGENTS; INSULIN; MEMBRANE POTENTIALS; PPAR GAMMA; PYRIDINES; SODIUM; TETRAZOLIUM SALTS; THIAZOLES; THIAZOLIDINEDIONES;

EID: 73149107280     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.109.056911     Document Type: Article

References (40)

1. Artunc F, Sandulache D, Nasir O, Boini KM, Friedrich B, Beier N, Dicks E, Pötzsch S, Klingel K, Amann K, Blazer-Yost BL, Scholz W, Risler T, Kuhl D, and Lang F (2008) Lack of the serum and glucocorticoid-inducible kinase SGK1 attenuates the volume retention after treatment with the PPARgamma agonist pioglitazone. Pflugers Arch 456:425-436.
2. Bens M, Vallet V, Cluzeaud F, Pascual-Letallec L, Kahn A, Rafestin-Oblin ME, Rossier BC, and Vandewalle A (1999) Corticosteroid-dependent sodium transport in a novel immortalized mouse collecting duct principal cell line. J Am Soc Nephrol 10:923-934.
3. Bishop-Bailey D and Warner TD (2003) PPARgamma ligands induce prostaglandin production in vascular smooth muscle cells: indomethacin acts as a peroxisome proliferator-activated receptor-gamma antagonist. FASEB J 17:1925-1927.
4. Chen L, Yang B, McNulty JA, Clifton LG, Binz JG, Grimes AM, Strum JC, Harrington WW, Chen Z, Balon TW, et al. (2005) GI262570, a peroxisome proliferatoractivated receptor γ agonist, changes electrolytes and water reabsorption from the distal nephron in rats. J Pharmacol Exp Ther 312:718-725.
5. Chen SY, Bhargava A, Mastroberardino L, Meijer OC, Wang J, Buse P, Firestone GL, Verrey F, and Pearce D (1999) Epithelial sodium channel regulated by aldosterone-induced protein Sgk. Proc Natl Acad Sci U S A 96:2514-2519.
6. Collino M, Patel NS, Lawrence KM, Collin M, Latchman DS, Yaqoob MM, and Thiemermann C (2005) The selective PPARgamma antagonist GW9662 reverses the protection of LPS in a model of renal ischemia-reperfusion. Kidney Int 68:529-536.
7. Dobrian AD, Schriver SD, Khraibi AA, and Prewitt RL (2004) Pioglitazone prevents hypertension and reduces oxidative stress in diet-induced obesity. Hypertension 43:48-56.
8. Guan Y, Hao C, Cha DR, Rao R, Lu W, Kohan DE, Magnuson MA, Redha R, Zhang Y, and Breyer MD (2005) Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption. Nat Med 11: 861-866.
9. Hong G, Lockhart A, Davis B, Rahmoune H, Baker S, Ye L, Thompson P, Shou Y, O'Shaughnessy K, Ronco P, et al. (2003) PPARgamma activation enhances cell surface ENaCalpha via up-regulation of SGK1 in human collecting duct cells. FASEB J 17:1966-1968.
10. Hummler E and Horisberger JD (1999) Genetic disorders of membrane transport. V. The epithelial sodium channel and its implication in human diseases. Am J Physiol 276:G567-G571.
11. Karpushev AV, Levchenko V, Pavlov TS, Lam VY, Vinnakota KC, Vandewalle A, Wakatsuki T, and Staruschenko A (2008) Regulation of ENaC expression at the cell surface by Rab11. Biochem Biophys Res Commun 377:521-525.
12. Lee G, Elwood F, McNally J, Weiszmann J, Lindstrom M, Amaral K, Nakamura M, Miao S, Cao P, Learned RM, et al. (2002) T0070907, a selective ligand for peroxisome proliferator-activated receptor γ, functions as an antagonist of biochemical and cellular activities. J Biol Chem 277:19649- 19657.
13. + absorption produces cystic fibrosis-like lung disease in mice. Nat Med 10:487-493.
14. Nofziger C, Brown KK, Smith CD, Harrington W, Murray D, Bisi J, Ashton TT, Maurio FP, Kalsi K, West TA, et al. (2009) PPARgamma agonists inhibit vasopressin-mediated anion transport in the MDCK-C7 cell line. Am J Physiol Renal Physiol 297:F55-F62.
15. + channel. Pflugers Arch 451:445-453.
16. Ollero M, Junaidi O, Zaman MM, Tzameli I, Ferrando AA, Andersson C, Blanco PG, Bialecki E, and Freedman SD (2004) Decreased expression of peroxisome proliferator activated receptor gamma in Cftr-/- mice. J Cell Physiol 200:235-244.
17. Pochynyuk O, Bugaj V, Vandewalle A, and Stockand JD (2008) Purinergic control of apical plasma membrane PI(4,5)P2 levels sets ENaC activity in principal cells. Am J Physiol Renal Physiol 294:F38-F46.
18. + channel toward the plasma membrane with total internal reflection fluorescence-fluorescence recovery after photobleaching. J Biol Chem 282:14576-14585.
19. Rohatgi R, Greenberg A, Burrow CR, Wilson PD, and Satlin LM (2003) Na transport in autosomal recessive polycystic kidney disease (ARPKD) cyst lining epithelial cells. J Am Soc Nephrol 14:827-836.
20. Rossier BC, Pradervand S, Schild L, and Hummler E (2002) Epithelial sodium channel and the control of sodium balance: interaction between genetic and environmental factors. Annu Rev Physiol 64:877-897.
21. Rossier BC and Schild L (2008) Epithelial sodium channel: mendelian versus essential hypertension. Hypertension 52:595-600.
22. Rubera I, Loffing J, Palmer LG, Frindt G, Fowler-Jaeger N, Sauter D, Carroll T, McMahon A, Hummler E, and Rossier BC (2003) Collecting duct-specific gene inactivation of alphaENaC in the mouse kidney does not impair sodium and potassium balance. J Clin Invest 112:554-565.
23. Saad S, Agapiou DJ, Chen XM, Stevens V, and Pollock CA (2009) The role of Sgk-1 in the upregulation of transport proteins by PPAR-{gamma} agonists in human proximal tubule cells. Nephrol Dial Transplant 24:1130-1141.
24. Schild L (2004) The epithelial sodium channel: from molecule to disease. Rev Physiol Biochem Pharmacol 151:93-107.
25. Song J, Knepper MA, Hu X, Verbalis JG, and Ecelbarger CA (2004) Rosiglitazone activates renal sodium- and water-reabsorptive pathways and lowers blood pressure in normal rats. J Pharmacol Exp Ther 308:426-433.
26. Soundararajan R, Zhang TT, Wang J, Vandewalle A, and Pearce D (2005) A novel role for glucocorticoid-induced leucine zipper protein in epithelial sodium channelmediated sodium transport. J Biol Chem 280:39970- 39981.
27. Staruschenko A, Dorofeeva NA, Bolshakov KV, and Stockand JD (2007a) Subunitdependent cadmium and nickel inhibition of acid-sensing ion channels. Dev Neurobiol 67:97-107.
28. + channel through phosphoinositide 3-OH kinase signaling. J Biol Chem 279:37771-37778.
29. + channel activity by conserved serine/threonine switches within sorting signals. J Biol Chem 280:39161-39167.
30. + channel by phosphatidylinositide 3-OH kinase signaling in native collecting duct principal cells. J Am Soc Nephrol 18: 1652-1661.
31. Sun P, Lin DH, Wang T, Babilonia E, Wang Z, Jin Y, Kemp R, Nasjletti A, and Wang WH (2006) Low Na intake suppresses expression of CYP2C23 and arachidonic acid-induced inhibition of ENaC. Am J Physiol Renal Physiol 291:F1192-F1200.
32. Tiwari S, Blasi ER, Heyen JR, McHarg AD, and Ecelbarger CM (2008) Time course of AQP-2 and ENaC regulation in the kidney in response to PPAR agonists associated with marked edema in rats. Pharmacol Res 57:383-392.
33. Tontonoz P and Spiegelman BM (2008) Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem 77:289-312.
34. Vallon V, Hummler E, Rieg T, Pochynyuk O, Bugaj V, Schroth J, Dechenes G, Rossier B, Cunard R, and Stockand J (2009) Thiazolidinedione-induced fluid retention is independent of collecting duct alphaENaC activity. J Am Soc Nephrol 20:721-729.
35. Vallon V and Lang F (2005) New insights into the role of serum- and glucocorticoidinducible kinase SGK1 in the regulation of renal function and blood pressure. Curr Opin Nephrol Hypertens 14:59-66.
36. + absorption in collecting duct principal cells isolated from BPK ARPKD mice. Am J Physiol Renal Physiol 286:F244-F254.
37. Willson TM, Lambert MH, and Kliewer SA (2001) Peroxisome proliferator-activated receptor gamma and metabolic disease. Annu Rev Biochem 70:341-367.
38. Yang T, Michele DE, Park J, Smart AM, Lin Z, Brosius FC 3rd, Schnermann JB, and Briggs JP (1999) Expression of peroxisomal proliferator-activated receptors and retinoid X receptors in the kidney. Am J Physiol 277:F966-F973.
39. Yoshioka K, Wakino S, Homma K, Kanda T, Tatematsu S, Hasegawa K, Sugano N, Ito O, Omata K, Saruta T, et al. (2008) Renal Cytochrome P450 as a determinant of impaired natriuresis by PPAR-gamma ligands in ovariectomized obese rats. Obesity (Silver Spring) 16:965-971.
40. Zhang H, Zhang A, Kohan DE, Nelson RD, Gonzalez FJ, and Yang T (2005) Collecting duct-specific deletion of peroxisome proliferator-activated receptor γ blocks thiazolidinedione-induced fluid retention. Proc Natl Acad Sci U S A 102:9406-9411.