Adenosine inhibits ENaC via cytochrome P-450 epoxygenase-dependent metabolites of arachidonic acid

American Journal of Physiology - Renal Physiology

Volumn 290, Issue 5, 2006, Pages

  Wei, Yuan ^a   Sun, Peng ^a   Wang, ZhiJian ^b   Yang, BaoFeng ^b   Carroll, Mairead A ^a   Wang, Wen Hui ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Adenosine receptor; Collecting duct; Epithelial sodium channel; Phospholipase A2; Phospholipase C; Protein kinase C

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE; ADENOSINE RECEPTOR STIMULATING AGENT; ARACHIDONIC ACID; ARACHIDONYL TRIFLUOROMETHYL KETONE; CYCLOHEXYLADENOSINE; CYTOCHROME P450; INDOMETACIN; PHOSPHOLIPASE A2 INHIBITOR; SODIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; HYPERPOLARIZATION; KIDNEY COLLECTING TUBULE; KIDNEY METABOLISM; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT;

EID: 33646593174     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00301.2005     Document Type: Article

References (32)

1. Burnatowska-Hledin MA and Spielman WS. Effects of adenosine on cAMP production and cytosolic Ca in cultured rabbit medullary thick ascending limb cells. Am J Physiol Cell Physiol 260: C143-C150, 1991.
2. Capdevila JH, Wei S, Yan J, Karara A, Jacobson HR, Falck JR, and Guengerich FP. Cytochrome P-450 arachidonic acid epoxygenase regulatory control of the renal epoxygenase by dietary salt loading. J Biol Chem 267: 21720-21726, 1992.
3. Eaton DC, Becchetti A, Ma H, and Ling BN. Renal sodium channels: regulation and single channel properties. Kidney Int 48: 941-949, 1995.
4. + current in renal inner medullary collecting duct cells. Am J Physiol Cell Physiol 286: C965-C974, 2004.
5. Fredholm BB, Ijzerman AP, Jacobson KA, Klotz KN, and Linden J. International union of pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53: 527-552, 2001.
6. Frindt G and Palmer LG. Regulation of Na channels in the rat cortical collecting tubule: effects of cAMP and methyl donors. Am J Physiol Renal Fluid Electrolyte Physiol 271: F1086-F1092, 1996.
7. Frindt G, Windhager EE, and Taylor A. Hydroosmotic response of collecting tubules to ADH or cAMP at reduced peritubular Sodium. Am J Physiol Renal Fluid Electrolyte Physiol 243: F503-F513, 1982.
8. Garty H and Palmer LG. Epithelial sodium channels: function, structure, and regulation. Physiol Rev 77: 359-396, 1997.
9. Holla VR, Makita K, Zaphiropoulos PG, and Capdevila JH. The kidney cytochrome P450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading. J Clin Invest 104: 751-760, 1999.
10. Jackson EK and Dubey RK. Role of the extracellular cAMP-adenosine pathway in renal physiology. Am J Physiol Renal Physiol 281: F597-F612, 2001.
11. Kemendy AE, Kleyman TR, and Eaton DC. Aldosterone alters the open probability of amiloride-blockable sodium channels in A6 epithelia. Am J Physiol Cell Physiol 263: C825-C837, 1992.
12. Loffing J, Pietri L, Aregger F, Bloch-Faure W, Ziegler U, Meneton P, Rossier BC, and Kaissling B. Differential subcellular location of ENaC subunits in mouse kidney in response to high and low-Na diets. Am J Physiol Renal Physiol 279: F252-F258, 2000.
13. 1 adenosine receptors mediate sodium transport in cultured renal epithelial (A6) cells. Am J Physiol Renal Physiol 283: F1216-F1225, 2002.
14. Makita K, Takahashi K, Kerara A, Jacobson HR, Falck JR, and Capdevila JH. Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet. J Clin Invest 94: 2414-2420, 1994.
15. Modlinger PS and Welch WJ. Adenosine A1 receptor antagonists and the kidney. Curr Opin Nephrol Hypertens 12: 497-502, 2003.
16. Natke E Jr and Stoner LC. Na transport properties of the peritubular membrane of cortical collecting tubule. Am J Physiol Renal Fluid Electrolyte Physiol 242: F664-F671, 1982.
17. 2A adenosine receptor: a novel therapeutic target in renal disease. Am J Physiol Renal Physiol 282: F10-F18, 2002.
18. Pácha J, Frindt G, Antonian L, Silver RB, and Palmer LG. Regulation of Na channels of the rat cortical collecting tubule by aldosterone. J Gen Physiol 102: 25-42, 1993.
19. Palmer LG. Potassium secretion and the regulation of distal nephron K channels. Am J Physiol Renal Physiol 277: F821-F825, 1999.
20. Palmer LG and Frindt G. Effect of cell Ca and pH on Na channels from rat cortical collecting tubule. Am J Physiol Renal Fluid Electrolyte Physiol 253: F333-F339, 1987.
21. Roman RJ. P450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev 82: 131-185, 2004.
22. Schnermann J and Levine DZ. Paracrine factor in tubuloglomerular feedback: adenosine, ATP, and nitric oxide. Annu Rev Physiol 65: 501-529, 2003.
23. Schulte G and Fredholm BB. Signalling from adenosine receptors to mitogen-activated protein kinases. Cell Signal 15: 813-827, 2003.
24. Siragy HM and Linden J. Sodium intake markedly alters renal interstitial fluid adenosine. Hypertension 27: 404-407, 1996.
25. + channels. Annu Rev Physiol 53: 509-530, 1991.
26. Spielman WS and Arend LJ. Adenosine receptors and signaling in the kidney. Hypertension 17: 117-130, 1991.
27. Verrey F, Hummler E, Schild L, and Rossier BC. Control of Na transport by aldosterone. In: The Kidney: Physiology &Pathophysiology, edited by Seldin DW and Giebisch G. Philadelphia, PA: Lippincott Williams & Wilkins, 2000, p. 1441-1472.
28. Vitzthum H, Weiss B, Bachleitner W, Krämer BK, and Kurtz A. Gene expression of adenosine receptors along the nephron. Kidney Int 65: 1180-1190, 2004.
29. Wei Y, Lin DH, Kemp R, Yaddanapudi GSS, Nasjletti A, Falck JR, and Wang WH. Arachidonic acid inhibits epithelial Na channel via cytochrome P450 (CYP) epoxygenase-dependent metabolic pathways. J Gen Physiol 124: 719-727, 2004.
30. Yamaguchi S, Umemura S, Tamura K, Iwamoto T, Nyui N, Ishgami T, and Ishii M. Adenosine A1 receptor mRNA in microdissected rat nephron segments. Hypertension 26: 1181-1185, 1995.
31. Zhao X, Pollock DM, Inscho EW, Zeldin DC, and Imig JD. Decreased renal cytochrome P450 2C enzymes and impaired vasodilation are associated with angiotensin salt-sensitive hypertension. Hypertension 41: 709-714, 2003.
32. Zhou AP, Wu F, Li PL, and Cowley AW Jr. Effect of chronic salt loading on adenosine metabolism and receptor expression in renal cortex and medulla in rats. Hypertension 33: 511-516, 1999.