-
1
-
-
0015972948
-
A simple graphical method for determining the inhibition constants of mixed, uncompetitive and non-competitive inhibitors
-
Cornish-Bowden A. A simple graphical method for determining the inhibition constants of mixed, uncompetitive and non-competitive inhibitors. Biochemistry J 1974; 137:143-144.
-
(1974)
Biochemistry J
, vol.137
, pp. 143-144
-
-
Cornish-Bowden, A.1
-
2
-
-
0004205267
-
Fundamentals of Enzyme Kinetics
-
London: Portland Press
-
Cornish-Bowden A. Fundamentals of Enzyme Kinetics. London: Portland Press; 2004.
-
(2004)
-
-
Cornish-Bowden, A.1
-
3
-
-
0037048522
-
Pyrene.pyrene complexes at the active site of cytochrome P450 3A4: evidence for a multiple substrate binding site
-
Dabrowski MJ, Schrag ML, Wienkers LC, Atkins WM. Pyrene.pyrene complexes at the active site of cytochrome P450 3A4: evidence for a multiple substrate binding site. J Am Chem Soc 2002;124:11866-11867.
-
(2002)
J Am Chem Soc
, vol.124
, pp. 11866-11867
-
-
Dabrowski, M.J.1
Schrag, M.L.2
Wienkers, L.C.3
Atkins, W.M.4
-
4
-
-
77049143386
-
The determination of enzyme inhibitor constants
-
Dixon M. The determination of enzyme inhibitor constants. Biochemistry 1953;55:170-171.
-
(1953)
Biochemistry
, vol.55
, pp. 170-171
-
-
Dixon, M.1
-
5
-
-
3242801426
-
A comparison of estimates of Michaelis-Menten kinetic constants from various linear transformations
-
Dowd JE, Riggs DS. A comparison of estimates of Michaelis-Menten kinetic constants from various linear transformations. J Biol Chem 1965;240:863-869.
-
(1965)
J Biol Chem
, vol.240
, pp. 863-869
-
-
Dowd, J.E.1
Riggs, D.S.2
-
6
-
-
0037799740
-
In vivo CYP3A4 heteroactivation is a possible mechanism for the drug interaction between felbamate and carbamazepine
-
Egnell AC, Houston JB, Boyer CS. In vivo CYP3A4 heteroactivation is a possible mechanism for the drug interaction between felbamate and carbamazepine. J Pharmacol Exp Ther 2003;305:1251-1262.
-
(2003)
J Pharmacol Exp Ther
, vol.305
, pp. 1251-1262
-
-
Egnell, A.C.1
Houston, J.B.2
Boyer, C.S.3
-
7
-
-
0028342648
-
Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance
-
Houston JB. Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance. Biochem Pharmacol 1994;47:1469-1479.
-
(1994)
Biochem Pharmacol
, vol.47
, pp. 1469-1479
-
-
Houston, J.B.1
-
8
-
-
2642555502
-
Effector-mediated alteration of substrate orientation in cytochrome P450 2C9
-
Hummel MA, Gannett PM, Aguilar JS, Tracy TS. Effector-mediated alteration of substrate orientation in cytochrome P450 2C9. Biochemistry 2004;43:7207-7214.
-
(2004)
Biochemistry
, vol.43
, pp. 7207-7214
-
-
Hummel, M.A.1
Gannett, P.M.2
Aguilar, J.S.3
Tracy, T.S.4
-
9
-
-
0034956877
-
Dapsone activation of CYP2C9-mediated metabolism: evidence for activation of multiple substrates and a two-site model
-
Hutzler JM, Hauer MJ, Tracy TS. Dapsone activation of CYP2C9-mediated metabolism: evidence for activation of multiple substrates and a two-site model. Drug Metab Dispos 2001;29:1029-1034.
-
(2001)
Drug Metab Dispos
, vol.29
, pp. 1029-1034
-
-
Hutzler, J.M.1
Hauer, M.J.2
Tracy, T.S.3
-
10
-
-
0036201594
-
Atypical kinetic profiles in drug metabolism reactions
-
Hutzler JM, Tracy TS. Atypical kinetic profiles in drug metabolism reactions. Drug Metab Dispos 2002;30:355-362.
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 355-362
-
-
Hutzler, J.M.1
Tracy, T.S.2
-
11
-
-
0037325958
-
Activation of cytochrome P450 2C9-mediated metabolism: mechanistic evidence in support of kinetic observations
-
Hutzler JM, Wienkers LC, Wahlstrom JL, Carlson TJ, Tracy TS. Activation of cytochrome P450 2C9-mediated metabolism: mechanistic evidence in support of kinetic observations. Arch Biochem Biophys 2003;410:16-24.
-
(2003)
Arch Biochem Biophys
, vol.410
, pp. 16-24
-
-
Hutzler, J.M.1
Wienkers, L.C.2
Wahlstrom, J.L.3
Carlson, T.J.4
Tracy, T.S.5
-
12
-
-
0035193493
-
Multisite kinetic models for CYP3 A4:simultaneous activation and inhibition of diazepam and testosterone metabolism
-
Kenworthy KE, Clarke SE, Andrews J, Houston JB. Multisite kinetic models for CYP3 A4:simultaneous activation and inhibition of diazepam and testosterone metabolism. Drug Metab Dispos 2001;29:1644-1651.
-
(2001)
Drug Metab Dispos
, vol.29
, pp. 1644-1651
-
-
Kenworthy, K.E.1
Clarke, S.E.2
Andrews, J.3
Houston, J.B.4
-
13
-
-
0000574406
-
Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites
-
Korzekwa KR, Krishnamachary N, Shou M, Ogai A, Parise RA, Rettie AE, Gonzalez FJ, Tracy TS. Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites. Biochemistry 1998;37:4137-4147.
-
(1998)
Biochemistry
, vol.37
, pp. 4137-4147
-
-
Korzekwa, K.R.1
Krishnamachary, N.2
Shou, M.3
Ogai, A.4
Parise, R.A.5
Rettie, A.E.6
Gonzalez, F.J.7
Tracy, T.S.8
-
14
-
-
0035059509
-
Substrate inhibition kinetics for cytochrome P450-catalyzed reactions
-
Lin Y, Lu P, Tang C, Mei Q, Sandig G, Rodrigues AD, Rushmore TH, Shou M. Substrate inhibition kinetics for cytochrome P450-catalyzed reactions. Drug Metab Dispos 2001;29:368-374.
-
(2001)
Drug Metab Dispos
, vol.29
, pp. 368-374
-
-
Lin, Y.1
Lu, P.2
Tang, C.3
Mei, Q.4
Sandig, G.5
Rodrigues, A.D.6
Rushmore, T.H.7
Shou, M.8
-
15
-
-
27944483765
-
Isoflavones modulate the glucuronidation of estradiol in human liver microsomes
-
Pfeiffer E, Treiling CR, Hoehle SI, Metzler M. Isoflavones modulate the glucuronidation of estradiol in human liver microsomes. Carcinogenesis 2005;26:2172-2178.
-
(2005)
Carcinogenesis
, vol.26
, pp. 2172-2178
-
-
Pfeiffer, E.1
Treiling, C.R.2
Hoehle, S.I.3
Metzler, M.4
-
16
-
-
0038691508
-
A method for determining two substrates binding in the same active site of cytochrome P450B M3: an explanation of high energy omega product formation
-
Rock DA, Perkins BN, Wahlstrom J, Jones JP. A method for determining two substrates binding in the same active site of cytochrome P450B M3: an explanation of high energy omega product formation. Arch Biochem Biophys 2003;416:9-16.
-
(2003)
Arch Biochem Biophys
, vol.416
, pp. 9-16
-
-
Rock, D.A.1
Perkins, B.N.2
Wahlstrom, J.3
Jones, J.P.4
-
17
-
-
0008916170
-
Rapid Equilibrium Bireactant and Terreactant Systems
-
New York: John Wiley & Sons, Inc.
-
Segel IH. Rapid Equilibrium Bireactant and Terreactant Systems. New York: John Wiley & Sons, Inc.; 1975.
-
(1975)
-
-
Segel, I.H.1
-
18
-
-
0028307539
-
Activation of CYP3A4: Evidence for the simultaneous binding of two substrates in a cytochrome P450 active site
-
Shou M, Grogan J, Mancewicz JA, Krausz KW, Gonzalez FJ, Gelboin HV, Korzekwa KR. Activation of CYP3A4: Evidence for the simultaneous binding of two substrates in a cytochrome P450 active site. Biochemistry 1994;33:6450-6455.
-
(1994)
Biochemistry
, vol.33
, pp. 6450-6455
-
-
Shou, M.1
Grogan, J.2
Mancewicz, J.A.3
Krausz, K.W.4
Gonzalez, F.J.5
Gelboin, H.V.6
Korzekwa, K.R.7
-
19
-
-
0033564235
-
Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives
-
Shou M, Mei Q, Ettore MW, Jr, Dai R, Baillie TA, Rushmore TH. Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives. Biochem J 1999; 340 (Pt 3):845-853.
-
(1999)
Biochem J
, vol.340
, Issue.3 PT
, pp. 845-853
-
-
Shou, M.1
Mei, Q.2
Ettore Jr., M.W.3
Dai, R.4
Baillie, T.A.5
Rushmore, T.H.6
-
20
-
-
0004006847
-
Mechanism-Based Enzyme Inactivation: Chemistry and Enzymology
-
Boca Raton: CRC Press
-
Silverman RB. Mechanism-Based Enzyme Inactivation: Chemistry and Enzymology. Boca Raton: CRC Press; 1998.
-
(1998)
-
-
Silverman, R.B.1
-
21
-
-
27544483787
-
Functional assessment of multiple P-glycoprotein (P-gp) probe substrates: influence of cell line and modulator concentration on P-gp activity
-
Taub ME, Podila L, Ely D, Almeida I. Functional assessment of multiple P-glycoprotein (P-gp) probe substrates: influence of cell line and modulator concentration on P-gp activity. Drug Metab Dispos 2005;33:1679-1687.
-
(2005)
Drug Metab Dispos
, vol.33
, pp. 1679-1687
-
-
Taub, M.E.1
Podila, L.2
Ely, D.3
Almeida, I.4
-
22
-
-
0032968065
-
Sigmoidal kinetics of CYP3A substrates: an approach for scaling dextromethorphan metabolism in hepatic microsomes and isolated hepatocytes to predict in vivo clearance in rat
-
Witherow LE, Houston JB. Sigmoidal kinetics of CYP3A substrates: an approach for scaling dextromethorphan metabolism in hepatic microsomes and isolated hepatocytes to predict in vivo clearance in rat. J Pharmacol Exp Ther 1999;290:58-65.
-
(1999)
J Pharmacol Exp Ther
, vol.290
, pp. 58-65
-
-
Witherow, L.E.1
Houston, J.B.2
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