Human sialidase inhibitors: Design, synthesis, and biological evaluation of 4-acetamido-5-acylamido-2-fluoro benzoic acids

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 13, 2009, Pages 4595-4603

  Magesh, Sadagopan ^a,d   Savita, Vats ^a   Moriya, Setsuko ^b   Suzuki, Tohru ^c   Miyagi, Taeko ^b   Ishida, Hideharu ^a   Kiso, Makoto ^a,d  

^a GIFU UNIVERSITY   (Japan)

^b MIYAGI CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c GIFU UNIVERSITY   (Japan)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

De novo design; Docking; Fluoro benzoic acid; Inhibitor design; Ludi CAP; Sialidase; Virtual screening

Indexed keywords

4 ACETAMIDO 5 (BIPHENYL 4 YLCARBOXAMIDO) 2 FLUOROBENZOIC ACID; BENZOIC ACID DERIVATIVE; ISOENZYME; NEURAMINIDASE 2; SIALIC ACID; SIALIDASE; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME STRUCTURE; HUMAN; HUMAN CELL; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION;

4-AMINOBENZOIC ACID; ACETANILIDES; CELL LINE; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEURAMINIDASE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 66449108124     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.04.065     Document Type: Article

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