Insight into substrate recognition and catalysis by the human neuraminidase 3 (NEU3) through molecular modeling and site-directed mutagenesis

Glycobiology

Volumn 20, Issue 9, 2010, Pages 1127-1138

  Albohy, Amgad ^a   Li, Matthew D ^a   Zheng, Ruixiang Blake ^a   Zou, Chunxia ^a   Cairo, Christopher W ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

glycolipid; glycosidase; mammalian glycosidase; membrane; neuraminidase

Indexed keywords

N ACETYL 2,3 DIDEHYDRO 2 DEOXYNEURAMINIC ACID; NEURAMINIDASE 3; SIALIC ACID; SIALIDASE; UNCLASSIFIED DRUG;

ACID BASE BALANCE; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; ENZYME ACTIVITY; HUMAN; MOLECULAR DOCKING; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEURAMINIDASE; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY; SUBSTRATE SPECIFICITY;

MAMMALIA;

EID: 77955453375     PISSN: 09596658     EISSN: 14602423     Source Type: Journal    
DOI: 10.1093/glycob/cwq077     Document Type: Article

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