Identifying selective inhibitors against the human cytosolic sialidase NEU2 by substrate specificity studies

Molecular BioSystems

Volumn 7, Issue 4, 2011, Pages 1060-1072

  Li, Yanhong ^a   Cao, Hongzhi ^a,b   Yu, Hai ^a   Chen, Yi ^a   Lau, Kam ^a   Qu, Jingyao ^a   Thon, Vireak ^a   Sugiarto, Go ^a   Chen, Xi ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CATION; ENZYME INHIBITOR; NEU2 PROTEIN, HUMAN; RECOMBINANT PROTEIN; SIALIDASE;

AMINO ACID SEQUENCE; ARTICLE; BACTERIUM; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; ENZYME ACTIVATION; ENZYME SPECIFICITY; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; HIGH THROUGHPUT SCREENING; HUMAN; IC 50; KINETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PH; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMINO ACID SEQUENCE; BACTERIA; BASE SEQUENCE; CATIONS; DRUG DESIGN; ENZYME ACTIVATION; ENZYME INHIBITORS; ESCHERICHIA COLI; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; HYDROGEN-ION CONCENTRATION; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEURAMINIDASE; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS);

EID: 79952689648     PISSN: 1742206X     EISSN: 17422051     Source Type: Journal    
DOI: 10.1039/c0mb00244e     Document Type: Article

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