Cdc2: A monopotent or pluripotent CDK?

Cell Proliferation

Volumn 44, Issue 3, 2011, Pages 205-211

  Hu, X ^a   Moscinski, L C ^b  

^a BARRY UNIVERSITY   (United States)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN 20; CYCLIN DEPENDENT KINASE 1; CYCLINE; PROTEIN P21; PROTEIN P27; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTION FACTOR RUNX;

CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; EUKARYOTIC CELL; HUMAN; INTERPHASE; INTRACELLULAR SIGNALING; NONHUMAN; REVIEW;

ANIMALS; CDC2-CDC28 KINASES; CELL CYCLE; CYCLIN B; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; P21-ACTIVATED KINASES; PHOSPHORYLATION;

EUKARYOTA; MAMMALIA;

EID: 79955375782     PISSN: 09607722     EISSN: 13652184     Source Type: Journal    
DOI: 10.1111/j.1365-2184.2011.00753.x     Document Type: Review

References (69)

1. Santamaría D, Barrière C, Cerqueira A, Hunt S, Tardy C, Newton K et al. (2007) Cdk1 is sufficient to drive the mammalian cell cycle. Nature 448, 811-815.
2. Aleem E, Kiyokawa H, Kaldis P (2005) Cdc2-cyclin E complexes regulate the G1/S phase transition. Nat. Cell Biol. 7, 831-836.
3. Nevins JR (1998) Toward an understanding of the functional complexity of the E2F and retinoblastoma families. Cell Growth Differ. 9, 585-593.
4. Wu L, Timmers C, Maiti B, Saabedra HI, Sang L, Chong GT et al. (2001) The E2F1-3 transcription factors are essential for cellular proliferation. Nature 414, 457-462.
5. Rayman JB, Takahashi Y, Indjeian VB, Dannenberg JH, Catchpoles S, Watson RJ et al. (2002) E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex. Genes Dev. 16, 933-947.
6. Takahashi Y, Rayman JB, Dynlacht DB (2000) Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. Genes Dev. 14, 804-816.
7. Masui Y, Markert CL (1971) Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes. J. Exp. Zool. 177, 129-145.
8. Nurse P, Thuriaux P (1980) Regulatory genes controlling mitosis in the fission yeast Schizosaccharomyces pombe. Genetics 96, 627-637.
9. Reed SI, Ferguson J, Groppe JC (1982) Preliminary characterization of the transcriptional and translational products of the Saccharomyces cerevisiae cell division cycle gene CDC28. Mol. Cell. Biol. 2, 412-425.
10. Lohka MJ, Hayer MK, Maller JL (1988) Purification of maturation-promoting factor, an intracellular regulator of early mitotic events. Proc. Natl. Acad. Sci. USA 85, 3009-3015.
11. Dunphy WG, Brizuela L, Beach D, Newport J (1988) The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis. Cell 54, 423-431.
12. +. Nature 335, 251-254.
13. Sherr CJ (1994) G1 phase progression: cycling on cue. Cell 18, 551-555.
14. Malumbres M, Barbacid M (2005) Mammalian cyclin-dependent kinases. Trends Biochem. Sci. 30, 630-641.
15. Dorée M, Peaucellier G, Picard A (1983) Activity of the maturation-promoting factor and the extent of protein phosphorylation oscillate simultaneously during meiotic maturation of starfish oocytes. Dev. Biol. 99, 489-501.
16. Smits VA, Medema RH (2001) Checking out the G(2)/M transition. Biochim. Biophys. Acta 1519, 1-12.
17. Takizawa CG, Morgan DO (2000) Control of mitosis by changes in the subcellular location of cyclin-B1-cdk1 and cdc25c. Curr. Opin. Cell Biol. 12, 658-665.
18. Mueller PR, Coleman TR, Kumagai A, Dunphy WG (1995) Myt1: a membrane-associated inhibitory kinase that phosphorylates cdc2 on both threonine-14 and tyrosine-15. Science 270, 86-90.
19. Featherstone C, Russell P (1991) Fission yeast p107wee 1 mitotic inhibitor is a tyrosine/serine kinase. Nature 349, 808-811.
20. Donzelli M, Draetta GF (2003) Regulating mammalian checkpoints through cdc25 inactivation. EMBO Rep. 4, 671-677.
21. Nilsson I, Hoffmann I (2000) Cell cycle regulation by the Cdc25 phosphatase family. Prog. Cell Cycle Res. 4, 107-114.
22. Timofeev O, Cizmecioglu O, Settele F, Kempf T, Hoffmann I (2010) Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition. J. Biol. Chem. 285, 16978-16990.
23. Graves PR, Lovly CM, Uy GL, Piwnica-Worms H (2001) Localization of human cdc25C is regulated both by nuclear export and 14-3-3 protein binding. Oncogene 20, 1839-1851.
24. Kumagai A, Dunphy WG (1999) Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer cdc25. Genes Dev. 13, 1067-1072.
25. Lee J, Kumagai A, Dunphy WG (2001) Positive regulation of Wee1 by Chk1 and 14-3-3 proteins. Mol. Biol. Cell 12, 551-563.
26. Rane SG, Dubus P, Mettus RV, Galbreath EJ, Boden G, Reddy EP et al. (1999) Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat. Genet. 1, 44-52.
27. Rodriguez-Puebla ML, de Marval PL, LaCava M, Moons DS, Kiyokawa H, Conti CJ (2002) Cdk4 deficiency inhibits skin tumor development but does not affect normal keratinocyte proliferation. Am. J. Pathol. 161, 405-411.
28. Tsutsui T, Hesabi B, Moons DS, Pandolfi PP, Hansel KS, Koff A et al. (1999) Targeted disruption of CDK4 delays cell cycle entry with enhanced p27Kip1 activity. Mol. Cell. Biol. 19, 7011-7019.
29. Malumbres M, Sotillo R, Santamaria D, Galan J, Cerezo A, Ortega S et al. (2004) Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell 118, 493-504.
30. Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A, Sicinska E et al. (2004) Mouse development and cell proliferation in the absence of D-cyclins. Cell 118, 477-491.
31. Okuda M, Horn HF, Tarapore P, Tokuyama Y, Smulian AG, Chan PK et al. (2000) Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell 103, 127-140.
32. Ma T, Van Tine BA, Wei Y, Garrett MD, Nelson D, Adams PD et al. (2000) Cell cycle-regulated phosphorylation of p220(NPAT) by cyclinE/cdk2 in Cajal bodies promotes histone gene transcription. Genes Dev. 14, 2298-2313.
33. Zhao J, Kennedy BK, Lawrence BD, Barbie DA, Matera AG, Fletcher JA et al. (2000) NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription. Genes Dev. 14, 2283-2287.
34. Berthet C, Aleem E, Coppola V, Tessarollo L, Kaldis P (2003) Cdk2 knockout mice are viable. Curr. Biol. 13, 1775-1785.
35. Ortega S, Prieto I, Odajima J, Martin A, Dubus P, Sotillo R et al. (2003) Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat. Genet. 35, 25-31.
36. Geng Y, Yu Q, Sicinska E, Das M, Schneider JE, Bhattacharya S et al. (2003) Cyclin E ablation in the mouse. Cell 114, 431-443.
37. Parisi T, Beck AR, Rougier N, McNeil T, Lucian L, Werb Z et al. (2003) Cyclins E1 and E2are required for endoreplication in placental trophoblast giant cells. EMBO J. 22, 4794-4803.
38. Satyanarayana A, Hilton MB, Kaldis P (2008) p21 inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint. Mol. Biol. Cell 19, 65-77.
39. Meijer L, Borgne A, Mulner O, Chong JP, Blow JJ, Inagaki N et al. (1997) Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur. J. Biochem. 243(1-2), 527-536.
40. Goke R, Barth P, Schmidt A, Samans B, Lankat-Buttgereit B (2004) Programmed cell death protein 4 suppresses cdk1/cdc2 via induction of p21. Am. J. Physiol. Cell Physiol. 287, c1541-c1546.
41. Pomerening J, Ubersax J, Ferrell J Jr (2008) Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF. Mol. Biol. Cell 19, 3426-3441.
42. Tommasi S, Pfeifer GP (1995) In vivo structure of the human cdc2 promoter: release of a p130-E2F-4 complex from sequences immediately upstream of the transcription initiation site coincides with induction of cdc2 expression. Mol. Cell. Biol. 12, 6901-6913.
43. Hu X, Cui D, Moscinski L, Zhang X, Maccachero V, Zuckerman KS (2007) TGFβ regulates the expression and activities of G2 checkpoint kinases in human myeloid leukemia cells. Cytokine 37, 155-162.
44. Westbrook L, Manuvakhova M, Kern FG, Estes NR II, Ramanathan HN, Thottassery JV (2007) Cks1 regulates cdk1 expression: a novel role during mitotic entry in breast cancer cells. Cancer Res. 67, 11393-11401.
45. Tachibana K, Hara M, Hattori Y, Kishimoto T (2008) Cyclin B-cdk1 controls pronuclear union in interphase. Curr. Biol. 18, 1308-1313.
46. Dyson N (1998) The regulation of E2F by pRB-family proteins. Genes Dev. 12, 2245-2262.
47. Nevins JR (2001) The Rb/E2F pathway and cancer. Hum. Mol. Genet. 10, 699-703.
48. Taieb F, Karaiskou A, Rime H, Jessus C (1998) Human retinoblastoma protein (Rb) is phosphorylated by cdc2 kinase and MAP kinase in Xenopus maturing oocytes. FEBS Lett. 425, 465-471.
49. Choi KS, Eom YW, Kang Y, Ha MJ, Rhee H, Yoon JW et al. (1999) Cdc2 and cdk2 kinase activated by transforming growth factor-β1 trigger apoptosis through the phosphorylation of retinoblastoma protein in FaO hepatoma cells. J. Biol. Chem. 274, 31775-31783.
50. Frolov MV, Dyson NJ (2004) Molecular mechanisms of E2F-dependent activation and pRB-mediated repression. J. Cell Sci. 117, 2173-2181.
51. 1/S transition. Proc. Natl. Acad. Sci. USA 106, 486-491.
52. Taylor WR, Schonthal AH, Galante J, Stark GR (2001) p130/E2F4 binds to and represses the cdc2 promoter in response to p53. J. Biol. Chem. 276, 1998-2006.
53. Zhu W, Giangrande PH, Nevins JR (2004) E2Fs link the control of G1/S and G2/M transcription. EMBO J. 23, 4615-4626.
54. Martín A, Odajima J, Hunt SL, Dubus P, Ortega S, Malumbres M et al. (2005) Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1). Cancer Cell 7, 591-598.
55. Tuteja G, Kaestner KH (2007a) SnapShot: forkhead transcription factors I. Cell 130, 1160.
56. Tuteja G, Kaestner KH (2007b) SnapShot: forkhead transcription factors II. Cell 131, 192.
57. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS et al. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857-868.
58. Dijkers PF, Medema RH, Lammers JW, Koenderman L, Coffer PJ (2000) Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr. Biol. 10, 1201-1204.
59. Modur V, Nagarajan R, Evers BM, Milbrandt J (2002) FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer. J. Biol. Chem. 277, 47928-47937.
60. Medema RH, Kops GJ, Bos JL, Burgering BM (2000) AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 404, 782-787.
61. Nakamura N, Ramaswamy S, Vazquez F, Signoretti S, Loda M, Sellers WR (2000) Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol. Cell. Biol. 20, 8969-8982.
62. Kops GJ, Medema RH, Glassford J, Essers MA, Dijkers PF, Coffer PJ et al. (2002) Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. Mol. Cell. Biol. 22, 2025-2036.
63. Sakamaki J, Daitoku H, Yoshimochi K, Miwa M, Fukamizu A (2009) Regulation of FOXO1-mediated transcription and cell proliferation by PARP-1. Biochem. Biophys. Res. Commun. 382, 497-502.
64. Ai J, Jingjing D, Xiaoyan L, Mianzhi C, Qiutan Y, Huan S et al. (2010) Overexpression of FoxO1 causes proliferation of cultured pancreatic β cells exposed to low nutrition. Biochemistry 49, 218-225.
65. Yuan Z, Becker EB, Merlo P, Yamada T, DiBacco S, Konishi Y et al. (2008) Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons. Science 319, 1665-1668.
66. Liu P, Kao TP, Huang H (2008) CDK1 promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factor. Oncogene 27, 4733-4744.
67. Sun L, Vitolo MI, Qiao M, Anglin IE, Passaniti A (2004) Regulation of TGFb1-mediated growth inhibition and apoptosis by RUNX2 isoforms in endothelial cells. Oncogene 23, 4722-4734.
68. Westendorf JJ, Zaidi SK, Cascino JE, Kahler R, van Wijnen AJ, Lian JB et al. (2002) Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter. Mol. Cell. Biol. 22, 7982-7992.
69. Qiao M, Shapiro P, Fosbrink M, Rus H, Kumar R, Passaniti A (2006) Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. J. Biol. Chem. 281, 7118-7128.