The animal model of spinal cord injury as an experimental pain model

Journal of Biomedicine and Biotechnology

Volumn 2011, Issue , 2011, Pages

  Nakae, Aya ^a   Nakai, Kunihiro ^a   Yano, Kenji ^a   Hosokawa, Ko ^a   Shibata, Masahiko ^a   Mashimo, Takashi ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID; KAINIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; SPASMOLYTIC AGENT;

ALLODYNIA; ANALGESIA; ANIMAL MODEL; ARTICLE; BEHAVIOR CHANGE; CHRONIC PAIN; CONTUSION; EXCITOTOXICITY; EXPERIMENTAL MODEL; HEALTH CARE COST; HUMAN; LUMBAR SPINE; MOTOR PERFORMANCE; MUSCLE SPASM; MUSCULOSKELETAL PAIN; NERVOUS SYSTEM INJURY; NEUROPATHIC PAIN; NOCICEPTION; NOCICEPTIVE PAIN; NONHUMAN; PAIN; QUALITY OF LIFE; SENSORY DYSFUNCTION; SPINAL CORD INJURY; SPINAL PAIN; SPINOTHALAMIC TRACT; THORACIC SPINE; VERTEBRA DISLOCATION; VERTEBRAL CANAL STENOSIS; VISCERAL PAIN; ANIMAL; DISEASE MODEL; METHODOLOGY; PAIN ASSESSMENT; PATHOPHYSIOLOGY; REVIEW;

ANIMALIA;

ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; PAIN; PAIN MEASUREMENT; SPINAL CORD INJURIES;

EID: 79955090335     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2011/939023     Document Type: Article

References (128)

1. Nepomuceno C., Fine P. R., Richards J. S., Pain in patients with spinal cord injury Archives of Physical Medicine and Rehabilitation 1979 60 12 605 609 (Pubitemid 10201856)
2. Gensel J. C., Tovar C. A., Hamers F. P. T., Deibert R. J., Beattie M. S., Bresnahan J. C., Behavioral and histological characterization of unilateral cervical spinal cord contusion injury in rats Journal of Neurotrauma 2006 23 1 36 54 (Pubitemid 43191085)
3. Tom V. J., Sandrow-Feinberg H. R., Miller K., Santi L., Connors T., Lemay M. A., Houl J. D., Combining peripheral nerve grafts and chondroitinase promotes functional axonal regeneration in the chronically injured spinal cord The Journal of Neuroscience 2009 29 47 14881 14890
4. Sadlaoud K., Tazerart S., Brocard C., Jean-Xavier C., Portalier P., Brocard F., Vinay L., Bras H., Differential plasticity of the GABAergic and glycinergic synaptic transmission to rat lumbar motoneurons after spinal cord injury The Journal of Neuroscience 2010 30 9 3358 3369
5. Mogil J. S., Davis K. D., Derbyshire S. W., The necessity of animal models in pain research Pain 2010 151 1 12 17
6. Bonica J. J., Introduction: semantic, epidemiologic, and educational issues Pain and Central Nervous System Disease: The Central Pain Syndromes 1991 New York, NY, USA Raven Press 13 29
7. Stewart W. F., Ricci J. A., Chee E., Morganstein D., Lipton R., Lost productive time and cost due to common pain conditions in the US workforce Journal of the American Medical Association 2003 290 18 2443 2454 (Pubitemid 37430544)
8. Richards J. S., Meredith R. L., Nepomuceno C., Fine P. R., Bennett G., Psycho-social aspects of chronic pain in spinal cord injury Pain 1980 8 3 355 366 (Pubitemid 10071338)
9. Finnerup N. B., Johannesen I. L., Sindrup S. H., Bach F. W., Jensen T. S., Pain and dysesthesia in patients with spinal cord injury: a postal survey Spinal Cord 2001 39 5 256 262 (Pubitemid 32566072)
10. Siddall P. J., McClelland J. M., Rutkowski S. B., Cousins M. J., A longitudinal study of the prevalence and characteristics of pain in the first 5 years following spinal cord injury Pain 2003 103 3 249 257 (Pubitemid 36638814)
11. Rintala D. H., Loubser P. G., Castro J., Hart K. A., Fuhrer M. J., Chronic pain in a community-based sample of men with spinal cord injury: prevalence, severity, and relationship with impairment, disability, handicap, and subjective well-being Archives of Physical Medicine and Rehabilitation 1998 79 6 604 614 (Pubitemid 28265709)
12. Balazy T. E., Clinical management of chronic pain in spinal cord injury Clinical Journal of Pain 1992 8 2 102 110
13. Turner J. A., Cardenas D. D., Warms C. A., McClellan C. B., Chronic pain associated with spinal cord injuries: a community survey Archives of Physical Medicine and Rehabilitation 2001 82 4 501 508 (Pubitemid 32289714)
14. Cairns D. M., Adkins R. H., Scott M. D., Pain and depression in acute traumatic spinal cord injury: origins of chronic problematic pain? Archives of Physical Medicine and Rehabilitation 1996 77 4 329 335 (Pubitemid 26111746)
15. Segatore M., Understanding chronic pain after spinal cord injury The Journal of Neuroscience Nursing 1994 26 4 230 236
16. Siddall P. J., Yezierski R. P., Loeser J. D., Pain following spinal cord injury: clinical features, prevalence, and taxonomy IASP Newsletter 2000 3 3 7
17. Dalyan M., Cardenas D. D., Gerard B., Upper extremity pain after spinal cord injury Spinal Cord 1999 37 3 191 195 (Pubitemid 29149995)
18. Murray K. C., Nakae A., Stephens M. J., Rank M., D'Amico J., Harvey P. J., Li X., Harris R. L. W., Ballou E. W., Anelli R., Heckman C. J., Mashimo T., Vavrek R., Sanelli L., Gorassini M. A., Bennett D. J., Fouad K., Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT receptors Nature Medicine 2010 16 6 694 700
19. Komisaruk B. R., Gerdes C. A., Whipple B., 'Complete' spinal cord injury does not block perceptual responses to genital self-stimulation in women Archives of Neurology 1997 54 12 1513 1520 (Pubitemid 27521661)
20. Kuhn R. A., Functional capacity of the isolated human spinal cord Brain 1950 73 1 1 51
21. Siddall P. J., Yezierski R. P., Loeser J. D., Yesierski R. P., Burchiel K. J., Taxonomy and epidemiology of spinal cord injury pain Spinal Cord Injury Pain: Assessment, Mechanism, Management, Progress in Pain Research Management 2002 23 Seattle, Wash, USA IASP Press 9 24
22. Vierck C. J. Jr., Light A. R., Sandkuhler J., Bromm B., Gebhart G., Allodynia and hyperalgesia within dermatomes caudal to a spinal cord injury in primates and rodents Nervous System Plasticity and Chronic Pain 2000 129 Amsterdam, The Netherlands Elsevier 411 428 (Pubitemid 35461212)
23. Bryce T. N., Dijkers M. P. J. M., Ragnarsson K. T., Stein A. B., Chen B., Reliability of the Bryce/Ragnarsson spinal cord injury pain taxonomy The Journal of Spinal Cord Medicine 2006 29 2 118 132
24. Price D. D., McGrath P. A., Rafii A., Buckingham B., The validation of visual analogue scales as ratio scale measures for chronic and experimental pain Pain 1983 17 1 45 56 (Pubitemid 13004473)
25. Borsook D., Becerra L., Phenotyping central nervous system circuitry in chronic pain using functional MRI: considerations and potential implications in the clinic Current Pain and Headache Reports 2007 11 3 201 207 (Pubitemid 46851250)
26. Lacroix-Fralish M. L., Mogi J. S., Progress in genetic studies of pain and analgesia Annual Review of Pharmacology and Toxicology 2009 49 97 121
27. Mogil J. S., Simmonds K., Simmonds M. J., Pain research from 1975 to 2007: a categorical and bibliometric meta-trend analysis of every research paper published in the journal, pin Pain 2009 142 1-2 48 58
28. Starkey M. L., Davies M., Yip P. K., Carter L. M., Wong D. J. N., McMahon S. B., Bradbury E. J., Expression of the regeneration-associated protein SPRR1A in primary sensory neurons and spinal cord of the adult mouse following peripheral and central injury Journal of Comparative Neurology 2009 513 1 51 68
29. Marques S. A., Garcez V. F., Del Bel E. A., Martinez A. M. B., A simple, inexpensive and easily reproducible model of spinal cord injury in mice: morphological and functional assessment Journal of Neuroscience Methods 2009 177 1 183 193
30. Kanno H., Ozawa H., Sekiguchi A., Itoi E., Spinal cord injury induces upregulation of Beclin 1 and promotes autophagic cell death Neurobiology of Disease 2009 33 2 143 148
31. Ung R. V., Landry E. S., Rouleau P., Lapointe N. P., Rouillard C., Guertin P. A., Role of spinal 5-HT receptor subtypes in quipazine-induced hindlimb movements after a low-thoracic spinal cord transection European Journal of Neuroscience 2008 28 11 2231 2242
32. Hoschouer E. L., Yin F. Q., Jakeman L. B., L1 cell adhesion molecule is essential for the maintenance of hyperalgesia after spinal cord injury Experimental Neurology 2009 216 1 22 34
33. Kerr B. J., David S., Pain behaviors after spinal cord contusion injury in two commonly used mouse strains Experimental Neurology 2007 206 2 240 247 (Pubitemid 47094766)
34. Tanabe M., Ono K., Honda M., Ono H., Gabapentin and pregabalin ameliorate mechanical hypersensitivity after spinal cord injury in mice European Journal of Pharmacology 2009 609 1-3 65 68
35. Hoschouer E. L., Yin F. Q., Jakeman L. B., L1 cell adhesion molecule is essential for the maintenance of hyperalgesia after spinal cord injury Experimental Neurology 2009 216 1 22 34
36. Gruner J. A., A monitored contusion model of spinal cord injury in the rat Journal of Neurotrauma 1992 9 2 123 128
37. Nakae A., Nakai K., Tanaka T., Takashina M., Hagihira S., Shibata M., Ueda K., Mashimo T., Serotonin2C receptor mRNA editing in neuropathic pain model Neuroscience Research 2008 60 2 228 231 (Pubitemid 351173377)
38. Crown E. D., Ye Z., Johnson K. M., Xu G. Y., McAdoo D. J., Hulsebosch C. E., Increases in the activated forms of ERK 1/2, p38 MAPK, and CREB are correlated with the expression of at-level mechanical allodynia following spinal cord injury Experimental Neurology 2006 199 2 397 407 (Pubitemid 43928968)
39. Meisner J. G., Marsh A. D., Marsh D. R., Loss of GABAergic interneurons in laminae I-III of the spinal cord dorsal horn contributes to reduced GABAergic tone and neuropathic pain after spinal cord injury Journal of Neurotrauma 2010 27 4 729 737
40. Hoschouer E. L., Basso D. M., Jakeman L. B., Aberrant sensory responses are dependent on lesion severity after spinal cord contusion injury in mice Pain 2010 148 2 328 342
41. Mann C. M., Lee J. H. T., Hillyer J., Stammers A. M. T., Tetzlaff W., Kwon B. K., Lack of robust neurologic benefits with simvastatin or atorvastatin treatment after acute thoracic spinal cord contusion injury Experimental Neurology 2010 221 2 285 295
42. Carlton S. M., Du J., Tan H. Y., Nesic O., Hargett G. L., Bopp A. C., Yamani A., Lin Q., Willis W. D., Hulsebosch C. E., Peripheral and central sensitization in remote spinal cord regions contribute to central neuropathic pain after spinal cord injury Pain 2009 147 1-3 265 276
43. Furuya T., Hashimoto M., Koda M., Okawa A., Murata A., Takahashi K., Yamashita T., Yamazaki M., Treatment of rat spinal cord injury with a Rho-kinase inhibitor and bone marrow stromal cell transplantation Brain Research 2009 1295 192 202
44. Hentall I. D., Burns S. B., Restorative effects of stimulating medullary raphe after spinal cord injury Journal of Rehabilitation Research Development 2009 46 1 109 122
45. Hook M. A., Moreno G., Woller S., Puga D., Hoy K., Balden R., Grau J. W., Intrathecal morphine attenuates recovery of function after a spinal cord injury Journal of Neurotrauma 2009 26 5 741 752
46. Lord-Fontaine S., Yang F., Diep Q., Dergham P., Munzer S., Tremblay P., McKerracher L., Local inhibition of Rho signaling by cell-permeable recombinant protein BA-210 prevents secondary damage and promotes functional recovery following acute spinal cord injury Journal of Neurotrauma 2008 25 11 1309 1322
47. Tan A. M., Stamboulian S., Chang Y. W., Zhao P., Hains A. B., Waxman S. G., Hains B. C., Neuropathic pain memory is maintained by Rac1-regulated dendritic spine remodeling after spinal cord injury The Journal of Neuroscience 2008 28 49 13173 13183
48. Knerlich-Lukoschus F., Juraschek M., Blmer U., Lucius R., Mehdorn H. M., Held-Feindt J., Force-dependent development of neuropathic central pain and time-related CCL2/CCR2 expression after graded spinal cord contusion injuries of the rat Journal of Neurotrauma 2008 25 5 427 448 (Pubitemid 351685487)
49. Berrocal Y., Pearse D. D., Singh A., Andrade C. M., McBroom J. S., Puentes R., Eaton M. J., Social and environmental enrichment improves sensory and motor recovery after severe contusive spinal cord injury in the rat Journal of Neurotrauma 2007 24 11 1761 1772 (Pubitemid 351267790)
50. Biernaskie J., Sparling J. S., Liu J., Shannon C. P., Plemel J. R., Xie Y., Miller F. D., Tetzlaff W., Skin-derived precursors generate myelinating Schwann cells that promote remyelination and functional recovery after contusion spinal cord injury The Journal of Neuroscience 2007 27 36 9545 9559 (Pubitemid 47492191)
51. Dombourian M. G., Turner N. A., Gerovac T. A., Vemuganti R., Miranpuri G. S., Treyen K., Satriotomo I., Miletic V., Resnick D. K., B1 and TRPV-1 receptor genes and their relationship to hyperalgesia following spinal cord injury Spine 2006 31 24 2778 2782 (Pubitemid 44772776)
52. Mills C. D., Grady J. J., Hulsebosch C. E., Changes in exploratory behavior as a measure of chronic central pain following spinal cord injury Journal of Neurotrauma 2001 18 10 1091 1105 (Pubitemid 33000678)
53. Hubscher C. H., Fell J. D., Gupta D. S., Sex and hormonal variations in the development of at-level allodynia in a rat chronic spinal cord injury model Neuroscience Letters 2010 477 3 153 156
54. Hubscher C. H., Kaddumi E. G., Johnson R. D., Segmental neuropathic pain does not develop in male rats with complete spinal transections Journal of Neurotrauma 2008 25 10 1241 1245
55. Voda J., Hama A., Sagen J., FK506 reduces the severity of cutaneous hypersensitivity in rats with a spinal cord contusion Neuroscience Research 2007 58 1 95 99 (Pubitemid 46678496)
56. Hains B. C., Klein J. P., Saab C. Y., Craner M. J., Black J. A., Waxman S. G., Upregulation of sodium channel Na1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury The Journal of Neuroscience 2003 23 26 8881 8892 (Pubitemid 37210901)
57. Scheifer C., Hoheisel U., Trudrung P., Unger T., Mense S., Rats with chronic spinal cord transection as a possible model for the at-level pain of paraplegic patients Neuroscience Letters 2002 323 2 117 120 (Pubitemid 34310254)
58. Densmore V. S., Kalous A., Keast J. R., Osborne P. B., Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin Pain 2010 151 1 184 193
59. Crone C., Petersen N. T., Gimenz-Roldn S., Lungholt B., Nyborg K., Nielsen J. B., Reduced reciprocal inhibition is seen only in spastic limbs in patients with neurolathyrism Experimental Brain Research 2007 181 1 193 197 (Pubitemid 47030007)
60. Edgley S. A., Aggelopoulos N. C., Short latency crossed inhibitory reflex actions evoked from cutaneous afferents Experimental Brain Research 2006 171 4 541 550 (Pubitemid 43829402)
61. Bennett A. D., Everhart A. W., Hulsebosch C. E., Intrathecal administration of an NMDA or a non-NMDA receptor antagonist reduces mechanical but not thermal allodynia in a rodent model of chronic central pain after spinal cord injury Brain Research 2000 859 1 72 82 (Pubitemid 30138194)
62. Christensen M. D., Everhart A. W., Pickelman J. T., Hulsebosch C. E., Mechanical and thermal allodynia in chronic central pain following spinal cord injury Pain 1996 68 1 97 107 (Pubitemid 126407761)
63. Hains B. C., Chastain K. M., Everhart A. W., McAdoo D. J., Hulsebosch C. E., Transplants of adrenal medullary chromaffin cells reduce forelimb and hindlimb allodynia in a rodent model of chronic central pain after spinal cord hemisection injury Experimental Neurology 2000 164 2 426 437 (Pubitemid 32010740)
64. Coronel M. F., Labombarda F., Villar M. J., De Nicola A. F., Gonzlez S. L., Progesterone prevents allodynia after experimental spinal cord injury The Journal of Pain 2011 12 1 71 83
65. Roh D. H., Yoon S. Y., Seo H. S., Kang S. Y., Han HO. J., Beitz A. J., Lee J. H., Intrathecal injection of carbenoxolone, a gap junction decoupler, attenuates the induction of below-level neuropathic pain after spinal cord injury in rats Experimental Neurology 2010 224 1 123 132
66. Kim J., Kim J. H., Kim Y., Cho H. Y., Hong S. K., Yoon Y. W., Role of spinal cholecystokinin in neuropathic pain after spinal cord hemisection in rats Neuroscience Letters 2009 462 3 303 307
67. Gwak Y. S., Hulsebosch C. E., Remote astrocytic and microglial activation modulates neuronal hyperexcitability and below-level neuropathic pain after spinal injury in rat Neuroscience 2009 161 3 895 903
68. Marchand F., Tsantoulas C., Singh D., Grist J., Clark A. K., Bradbury E. J., McMahon S. B., Effects of Etanercept and Minocycline in a rat model of spinal cord injury European Journal of Pain 2009 13 7 673 681
69. Lu Y., Zheng J., Xiong L., Zimmermann M., Yang J., Spinal cord injury-induced attenuation of GABAergic inhibition in spinal dorsal horn circuits is associated with down-regulation of the chloride transporter KCC2 in rat The Journal of Physiology 2008 586 23 5701 5715
70. Labombarda F., Coronel M. F., Villar M. J., Nicola A. F. D., Gonzlez S. L., Neuropathic pain and temporal expression of preprodynorphin, protein kinase C and N-methyl-d-aspartate receptor subunits after spinal cord injury Neuroscience Letters 2008 447 2-3 115 119
71. Liu W., Liu Z., Liu LI., Xiao Z., Cao X., Cao Z., Xue LU., Miao L., He X., Li W., A novel human foamy virus mediated gene transfer of GAD67 reduces neuropathic pain following spinal cord injury Neuroscience Letters 2008 432 1 13 18
72. Saad N. E., Amin H. A., Chalouhi S., Baki S. A., Jabbur S. J., Atweh S. F., Spinal pathways involved in supraspinal modulation of neuropathic manifestations in rats Pain 2006 126 1-3 280 293 (Pubitemid 44751974)
73. Peng X. M., Zhou Z. G., Glorioso J. C., Fink D. J., Mata M., Tumor necrosis factor- contributes to below-level neuropathic pain after spinal cord injury Annals of Neurology 2006 59 5 843 851 (Pubitemid 43673162)
74. Kim J., Yoon Y. W., Hong S. K., Na H. S., Cold and mechanical allodynia in both hindpaws and tail following thoracic spinal cord hemisection in rats: time courses and their correlates Neuroscience Letters 2003 343 3 200 204 (Pubitemid 38365984)
75. Hains B. C., Johnson K. M., Eaton M. J., Willis W. D., Hulsebosch C. E., Serotonergic neural precursor cell grafts attenuate bilateral hyperexcitability of dorsal horn neurons after spinal hemisection in rat Neuroscience 2003 116 4 1097 1110 (Pubitemid 36262968)
76. Hains B. C., Chastain K. M., Everhart A. W., McAdoo D. J., Hulsebosch C. E., Transplants of adrenal medullary chromaffin cells reduce forelimb and hindlimb allodynia in a rodent model of chronic central pain after spinal cord hemisection injury Experimental Neurology 2000 164 2 426 437 (Pubitemid 32010740)
77. Gwak Y. S., Hains B. C., Johnson K. M., Hulsebosch C. E., Effect of age at time of spinal cord injury on behavioral outcomes in rat Journal of Neurotrauma 2004 21 8 983 993 (Pubitemid 39096849)
78. Mills C. D., Hains B. C., Johnson K. M., Hulsebosch C. E., Strain and model differences in behavioral outcomes after spinal cord injury in rat Journal of Neurotrauma 2001 18 8 743 756 (Pubitemid 32769771)
79. Lee J. H.T., Tigchelaar S., Liu J., Stammers A. M.T., Streijger F., Tetzlaff W., Kwon B. K., Lack of neuroprotective effects of simvastatin and minocycline in a model of cervical spinal cord injury Experimental Neurology 2010 225 1 219 230
80. Kim J., Jung J. I., Na H. S., Hong S. K., Yoon Y. W., Effects of morphine on mechanical allodynia in a rat model of central neuropathic pain NeuroReport 2003 14 7 1017 1020 (Pubitemid 36829783)
81. Hains B. C., Johnson K. M., McAdoo D. J., Eaton M. J., Hulsebosch C. E., Engraftment of serotonergic precursors enhances locomotor function and attenuates chronic central pain behavior following spinal hemisection injury in the rat Experimental Neurology 2001 171 2 361 378 (Pubitemid 32955298)
82. Watson B. D., Prado R., Dietrich W. D., Photochemically induced spinal cord injury in the rat Brain Research 1986 367 1-2 296 300 (Pubitemid 16011691)
83. Hao J. X., Xu X. J., Aldskogius H., Seiger A., Wiesenfeld-Hallin Z., The excitatory amino acid receptor antagonist MK-801 prevents the hypersensitivity induced by spinal cord ischemia in the rat Experimental Neurology 1991 113 2 182 191
84. Hao J. X., Xu X. J., Aldskogius H., Seiger A., Wiesenfeld-Hallin Z., Allodynia-like effects in rat after ischaemic spinal cord injury photochemically induced by laser irradiation Pain 1991 45 2 175 185
85. Erichsen H. K., Hao J. X., Xu X. J., Blackburn-Munro G., Comparative actions of the opioid analgesics morphine, methadone and codeine in rat models of peripheral and central neuropathic pain Pain 2005 116 3 347 358 (Pubitemid 40957139)
86. Xu X. J., Hao J. X., Aldskogius H., Seiger A., Wiesenfeld-Hallin Z., Chronic pain-related syndrome in rats after ischemic spinal cord lesion: a possible animal model for pain in patients with spinal cord injury Pain 1992 48 2 279 290
87. Prado R., Dietrich W. D., Watson B. D., Ginsberg M. D., Green B. A., Photochemically induced graded spinal cord infarction. Behavioral, electrophysiological, and morphological correlates Journal of Neurosurgery 1987 67 5 745 753 (Pubitemid 17161407)
88. Gaviria M., Haton H., Sandillon F., Privat A., A mouse model of acute ischemic spinal cord injury Journal of Neurotrauma 2002 19 2 205 221 (Pubitemid 34184611)
89. Hao J. X., Sthr T., Selve N., Wiesenfeld-Hallin Z., Xu X. J., Lacosamide, a new anti-epileptic, alleviates neuropathic pain-like behaviors in rat models of spinal cord or trigeminal nerve injury European Journal of Pharmacology 2006 553 1-3 135 140 (Pubitemid 44779609)
90. von Heijne M., Hao J. X., Sollevi A., Xu X. J., Effects of intrathecal morphine, baclofen, clonidine and R-PIA on the acute allodynia-like behaviours after spinal cord ischaemia in rats European Journal of Pain 2001 5 1 1 10 (Pubitemid 32661922)
91. Hao J. X., Xu X. J., Aldskogius H., Seiger A., Wiesenfeld-Hallin Z., Photochemically induced transient spinal ischemia induces behavioral hypersensitivity to mechanical and cold stimuli, but not to noxious-heat stimuli, in the rat Experimental Neurology 1992 118 2 187 194
92. Wu W. P., Hao J. X., Xu X. J., Wiesenfeld-Hallin Z., Koek W., Colpaert F. C., The very-high-efficacy 5-HT receptor agonist, F 13640, preempts the development of allodynia-like behaviors in rats with spinal cord injury European Journal of Pharmacology 2003 478 2-3 131 137 (Pubitemid 37315731)
93. Hao J. X., Xu X. J., Yu Y. X., Seiger A., Wiesenfeld-Hallin Z., Transient spinal cord ischemia induces temporary hypersensitivity of dorsal horn wide dynamic range neurons to myelinated, but not unmyelinated, fiber input Journal of Neurophysiology 1992 68 2 384 391
94. Hao J. X., Xu X. J., Yu Y. X., Seiger A., Wiesenfeld-Hallin Z., Hypersensitivity of dorsal horn wide dynamic range neurons to cutaneous mechanical stimuli after transient spinal cord ischemia in the rat Neuroscience Letters 1991 128 1 105 108
95. Basso D. M., Beattie M. S., Bresnahan J. C., A sensitive and reliable locomotor rating scale for open field testing in rats Journal of Neurotrauma 1995 12 1 1 21
96. Gale K., Kerasidis H., Wrathall J. R., Spinal cord contusion in the rat: behavioral analysis of functional neurologic impairment Experimental Neurology 1985 88 1 123 134 (Pubitemid 15114489)
97. Fairbanks C. A., Schreiber K. L., Brewer K. L., Yu C. G., Stone L. S., Kitto K. F., Nguyen H. O., Grocholski B. M., Shoeman D. W., Kehl L. J., Regunathan S., Reis D. J., Yezierski R. P., Wilcox G. L., Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury Proceedings of the National Academy of Sciences of the United States of America 2000 97 19 10584 10589
98. Yezierski R. P., Liu S., Ruenes G. L., Kajander K. J., Brewer K. L., Excitotoxic spinal cord injury: behavioral and morphological characteristics of a central pain model Pain 1998 75 1 141 155 (Pubitemid 28254865)
99. Siddall P., Xu C. L., Cousins M., Allodynia following traumatic spinal cord injury in the rat NeuroReport 1995 6 9 1241 1244
100. Fehlings M. G., Tator C. H., The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury Experimental Neurology 1995 132 2 220 228
101. Nashmi R., Fehlings M. G., Changes in axonal physiology and morphology after chronic compressive injury of the rat thoracic spinal cord Neuroscience 2001 104 1 235 251 (Pubitemid 32322628)
102. Bruce J. C., Oatway M. A., Weaver L. C., Chronic pain after clip-compression injury of the rat spinal cord Experimental Neurology 2002 178 1 33 48 (Pubitemid 35425607)
103. Marques S. A., Garcez V. F., Del Bel E. A., Martinez A. M.B., A simple, inexpensive and easily reproducible model of spinal cord injury in mice: morphological and functional assessment Journal of Neuroscience Methods 2009 177 1 183 193
104. Kloos A. D., Fisher L. C., Detloff M. R., Hassenzahl D. L., Basso D. M., Stepwise motor and all-or-none sensory recovery is associated with nonlinear sparing after incremental spinal cord injury in rats Experimental Neurology 2005 191 2 251 265 (Pubitemid 40092868)
105. Jakeman L. B., Guan Z., Ping W., Ponnappan R., Dzwonczyk R., Popovich P. G., Stokes B. T., Traumatic spinal cord injury produced by controlled contusion in mouse Journal of Neurotrauma 2000 17 4 299 319 (Pubitemid 30205483)
106. Ito T., Ohtori S., Inoue G., Koshi T., Doya H., Ozawa T., Saito T., Moriya H., Takahashi K., Glial phosphorylated p38 MAP kinase mediates pain in a rat model of lumbar disc herniation and induces motor dysfunction in a rat model of lumbar spinal canal stenosis Spine 2007 32 2 159 167 (Pubitemid 46105802)
107. Sekiguchi M., Kikuchi S., Myers R. R., Experimental spinal stenosis: relationship between degree of cauda equina compression, neuropathology, and pain Spine 2004 29 10 1105 1111 (Pubitemid 38649826)
108. Wang G., Thompson S. M., Maladaptive homeostatic plasticity in a rodent model of central pain syndrome: thalamic hyperexcitability after spinothalamic tract lesions The Journal of Neuroscience 2008 28 46 11959 11969
109. Chaplan S. R., Bach F. W., Pogrel J. W., Chung J. M., Yaksh T. L., Quantitative assessment of tactile allodynia in the rat paw Journal of Neuroscience Methods 1994 53 1 55 63 (Pubitemid 24238751)
110. Yaksh T. L., Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists Pain 1989 37 1 111 123 (Pubitemid 19095624)
111. Bennett G. J., Xie Y. K., A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man Pain 1988 33 1 87 107
112. Choi Y., Yoon Y. W., Na H. S., Kim S. H., Chung J. M., Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain Pain 1994 59 3 369 376
113. Basso D. M., Fisher L. C., Anderson A. J., Jakeman L. B., McTigue D. M., Popovich P. G., Basso mouse scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains Journal of Neurotrauma 2006 23 5 635 659 (Pubitemid 43728052)
114. Martinez M., Brezun J. M., Bonnier L., Xerri C., A new rating scale for open-field evaluation of behavioral recovery after cervical spinal cord injury in rats Journal of Neurotrauma 2009 26 7 1043 1053
115. Gensel J. C., Tovar C. A., Hamers F. P. T., Deibert R. J., Beattie M. S., Bresnahan J. C., Behavioral and histological characterization of unilateral cervical spinal cord contusion injury in rats Journal of Neurotrauma 2006 23 1 36 54 (Pubitemid 43191085)
116. Bertelli J. A., Mira J.-C., Behavioral evaluating methods in the objective clinical assessment of motor function after experimental brachial plexus reconstruction in the rat Journal of Neuroscience Methods 1993 46 3 203 208 (Pubitemid 23091837)
117. Liu Y., Kim D., Himes B. T., Chow S. Y., Schallert T., Murray M., Tessler A., Fischer I., Transplants of fibroblasts genetically modified to express BDNF promote regeneration of adult rat rubrospinal axons and recovery of forelimb function The Journal of Neuroscience 1999 19 11 4370 4387 (Pubitemid 29241090)
118. Webb A. A., Muir G. D., Sensorimotor behaviour following incomplete cervical spinal cord injury in the rat Behavioural Brain Research 2005 165 2 147 159 (Pubitemid 41565525)
119. Ditunno J. F., Little J. W., Tessler A., Burns A. S., Spinal shock revisited: a four-phase model Spinal Cord 2004 42 7 383 395 (Pubitemid 38969649)
120. Biering-Srensen F., Nielsen J. B., Klinge K., Spasticity-assessment: a review Spinal Cord 2006 44 12 708 722 (Pubitemid 44934977)
121. Maynard F. M., Karunas R. S., Waring W. P. III, Epidemiology of spasticity following traumatic spinal cord injury Archives of Physical Medicine and Rehabilitation 1990 71 8 566 569 (Pubitemid 20215961)
122. Boulenguez P., Vinay L., Strategies to restore motor functions after spinal cord injury Current Opinion in Neurobiology 2009 19 6 587 600
123. Li Y., Gorassini M. A., Bennett D. J., Role of persistent sodium and calcium currents in motoneuron firing and spasticity in chronic spinal rats Journal of Neurophysiology 2004 91 2 767 783 (Pubitemid 38168850)
124. Katz R., Presynaptic inhibition in humans: a comparison between normal and spastic patients Journal of Physiology 1999 93 4 379 385 (Pubitemid 29513260)
125. Boorman G. I., Lee R. G., Becker W. J., Windhorst U. R., Impaired "natural reciprocal inhibition" in patients with spasticity due to incomplete spinal cord injury Electroencephalography and Clinical Neurophysiology 1996 101 2 84 92
126. Edgley S. A., Aggelopoulos N. C., Short latency crossed inhibitory reflex actions evoked from cutaneous afferents Experimental Brain Research 2006 171 4 541 550 (Pubitemid 43829402)
127. Boulenguez P., Liabeuf S., Bos R., Bras H., Jean-Xavier C., Brocard C., Stil A., Darbon P., Cattaert D., Delpire E., Marsala M., Vinay L., Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury Nature Medicine 2010 16 3 302 307
128. Hou S., Duale H., Rabchevsky A. G., Intraspinal sprouting of unmyelinated pelvic afferents after complete spinal cord injury is correlated with autonomic dysreflexia induced by visceral pain Neuroscience 2009 159 1 369 379