Solid dispersion formulations of megestrol acetate with copovidone for enhanced dissolution and oral bioavailability

Archives of Pharmacal Research

Volumn 34, Issue 1, 2011, Pages 127-135

  Hong, Soon Wook ^a   Lee, Bong Sang ^a   Park, Su Jun ^b   Jeon, Hong Ryeol ^b   Moon, Ki Young ^a   Kang, Mean Hyung ^a   Park, Sang Han ^a   Choi, Sung Up ^a   Song, Woo Heon ^a   Lee, Jaehwi ^a   Choi, Young Wook ^a  

^a Chung Ang University   (South Korea)

^b CTC Bio Inc   (South Korea)

Author keywords

Bioavailability; Copovidone; Dissolution; Fluidized bed coating; Megestrol acetate; Solid dispersion

Indexed keywords

COPOVIDONE; MEGESTROL ACETATE; POVIDONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG SOLUBILITY; EVAPORATION; MALE; NONHUMAN; PARTICLE SIZE; PROCESS OPTIMIZATION; RAT; X RAY DIFFRACTION;

ADMINISTRATION, ORAL; ANIMALS; ANTHRAQUINONES; ANTINEOPLASTIC AGENTS, HORMONAL; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; CRYSTALLIZATION; EXCIPIENTS; MALE; MEGESTROL ACETATE; PARTICLE SIZE; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SUCROSE; VINYL COMPOUNDS; X-RAY DIFFRACTION;

EID: 79955057859     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-011-0115-2     Document Type: Article

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