Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables

Blood Coagulation and Fibrinolysis

Volumn 22, Issue 3, 2011, Pages 197-205

  Torres Urrutia, Constanza ^a   Guzmán, Luis ^a   Schmeda Hirschmann, Guillermo ^b   Moore Carrasco, Rodrigo ^a   Alarcón, Marcelo ^a   Astudillo, Luís ^b   Gutierrez, Margarita ^b   Carrasco, Gilda ^a   Yuri, José A ^a   Aranda, Eduardo ^c   Palomo, Iván ^a  

^a UNIVERSIDAD DE TALCA   (Chile)

^b Instituto de Química de Recursos Naturales   (Chile)

^c PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

Anticoagulant activity; antiplatelet activity; antithrombotic activity; fibrinolytic activity; fruits; vegetables

Indexed keywords

ADENOSINE DIPHOSPHATE; ANTICOAGULANT AGENT; ARACHIDONIC ACID; FIBRIN; FIBRINOLYTIC AGENT; FRUIT EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG; VEGETABLE EXTRACT;

ADULT; ANTICOAGULATION; APPLE; ARTICLE; AUBERGINE; BEET; CABBAGE; CARROT; CAULIFLOWER; CONTROLLED STUDY; CUCUMBER; DILUTED PROTHROMBIN TIME; FEMALE; FIBRINOLYSIS; FRUIT; FRUIT JUICE; GARLIC; GRAPE; HUMAN; KAOLIN CLOTTING TIME; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MELON; NONHUMAN; NORMAL HUMAN; ONION; PARTIAL THROMBOPLASTIN TIME; PEAR; PEAR MELON; PHASEOLUS VULGARIS; PLUM; PRIORITY JOURNAL; PROTHROMBIN TIME; QUINCE; RASPBERRY; SCALLION; SPINACH; SWEET PEPPER; SWISS CHARD; THROMBIN TIME; THROMBOCYTE AGGREGATION INHIBITION; TOMATO; VEGETABLE; WATERMELON;

ANTICOAGULANTS; BLOOD COAGULATION; BLOOD COAGULATION TESTS; BLOOD PLATELETS; CHILE; FIBRINOLYTIC AGENTS; FRUIT; HUMANS; PLANT EXTRACTS; PLATELET AGGREGATION INHIBITORS; THROMBOSIS; VEGETABLES;

EID: 79955057133     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/MBC.0b013e328343f7da     Document Type: Article

References (48)

1. Rimm EB. Fruit and vegetables: building a solid foundation. Am J Clin Nutr 2002; 76:1-2. (Pubitemid 34686546)
2. OMS: Estrategia Mundial sobre Régimen Alimentaria, Actividad Física y Salud. 57 Asamblea Mundial de Salud; 2004 (Geneva).
3. WHO. Diet, nutrition and the prevention of chronic disease. Report of a joint WHO/FAO expert consultation. Geneva: WHO; 2003.
4. Bazzano LA, He J, Ogden LG, Loria CM, Vupputuri S, Myers L, Whelton PK. Fruit and vegetable intake and risk of cardiovascular disease in US adults: the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. Am J Clin Nutr 2002; 76:93-99. (Pubitemid 34686554)
5. Villalobos P, Rojas A, Leporati M. Chile as an agricultural and food power: commitment to nutrition and population health. Rev Chil Nutr 2006; 33:232-237.
6. Liu S, Manson JE, Lee IM, Cole SR, Hennekens CH, WillettWC, Buring JE. Fruit and vegetable intake and risk of cardiovascular disease: the Women's Health Study. Am J Clin Nutr 2000; 72:922-928.
7. Fletcher B, Lamendola C. Insulin resistance syndrome. J Cardiovasc Nurs 2004; 19:339-345.
8. Lansbury AJ, Grant PJ, Catto AJ. Atherothrombotic risk factors in subjects with a family history of stroke. Cerebrovasc Dis 2002; 14:153-160. (Pubitemid 36151414)
9. Mills JD, Mansfield MW, Grant PJ. Factor XIII-circulating levels and the Val34Leu polymorphism in the healthy male relatives of patients with severe coronary artery disease. Thromb Haemost 2002; 87:409-414. (Pubitemid 34232480)
10. De Angelis RC. New concepts in nutrition: considerations on the connection diet-health. Arquivos de Gastroenterologia 2001; 38:269-271. (Pubitemid 33755866)
11. Palomo GI, Gutié rrez CM, Astudillo SL, Rivera SC, Torres UC, Guzmán JL, et al. Antioxidant effect of fruits and vegetables of central region of Chile. Revista Chilena de Nutrición 2009; 36:152-158.
12. Yuri JA, Neira A, Quilodran A, Motomura Y, Palomo I. Antioxidant activity and total phenolics concentration in apple peel and flesh is determined by cultivar and agroclimatic growing regions in Chile. J Food Agri Environ 2009; 7:3-4.
13. Torres C, Guzmán L, Moore-Carrasco R, Palomo I. Antithrombotic effect, a not well known characteristic of fruits and vegetables. Revista Chilena de Nutrición 2008; 35:10-17. (Pubitemid 351934210)
14. Palomo I. Efectos antitrobó ticos de las frutas y hortalizas. Dieta Mediterrá nea. Prevenció n de las Enfermedades Cardiovasculares. In: Palomo I, Leiva E, Vásquez M, editors. Editorial Universidad de Talca, Talca; 2007. p. 173.
15. Keevil JG, Osman HE, Reed JD, Folts JD. Grape juice, but not orange juice or grapefruit juice, inhibits human platelet aggregation. J Nutr 2000; 130:53-56. (Pubitemid 30032829)
16. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006; 17:37-41. (Pubitemid 41759239)
17. Naemura A, Mitani T, Ijiri Y, Tamura Y, Yamashita T, Okimura M, Yamamoto J. Antithrombotic effect of strawberries. Blood Coagul Fibrinolysis 2005; 16:501-509.
18. Duttaroy AK, Jorgensen A. Effects of kiwi fruit consumption on platelet aggregation and plasma lipids in healthy human volunteers. Platelets 2004; 15:287-292. (Pubitemid 39037130)
19. Cavagnaro PF, Camargo A, Galmarini CR, Simon PW. Effect of cooking on garlic (Allium sativum L.) antiplatelet activity and thiosulfinates content. J Agric Food Chem 2007; 55:1280-1288.
20. Ali M, Bordia T, Mustafa T. Effect of raw versus boiled aqueous extract of garlic and onion on platelet aggregation. Prostaglandins Leukot Essent Fatty Acids 1999; 60:43-47. (Pubitemid 29182164)
21. Chen JH, Chen HI, Tsai SJ, Jen CJ. Chronic consumption of raw but not boiled Welsh onion juice inhibits rat platelet function. J Nutr 2000; 130:34-37. (Pubitemid 30032826)
22. Dutta-Roy AK, Crosbie L, Gordon MJ. Effects of tomato extract on human platelet aggregation in vitro. Platelets 2001; 12:218-227. (Pubitemid 32578873)
23. Altman R, Rouvier J, Weisenberger H. Identification of platelet inhibitor present in the melon (Cucurbitacea cucumis melo). Thromb Haemost 1985; 53:312-313. (Pubitemid 15055620)
24. Hawkey C, Howell M. Orally induced fibrinolysis: a critical assessment of pineapple protease. Thromb Diath Haemorrh 1964; 12:382-390.
25. Kim GN, Lee MK, Park I. Acid and heat stability of the anticoagulative activity of an onion extract. Biosci Biotechnol Biochem 2002; 66:859-861. (Pubitemid 39251351)
26. Jung KA, Song TC, Han D, Kim IH, Kim YE, Lee CH. Cardiovascular protective properties of kiwifruit extracts in vitro. Biol Pharm Bull 2005; 28:1782-1785. (Pubitemid 41324154)
27. Born GV. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 1962; 194:927-929.
28. Palomo I, Muñoz B, Retamales E, Hidalgo P, Panes O, Artigas C, et al. Estudio de Laboratorio de las Enfermedades Hemorragíparas. Hematología, Fisiopatología y Diagnó stico. In: Palomo I, Pereira J, Palma J, editors. Editorial Universidad de Talca; 2005.
29. Lafan M, Manning R. Investigation of haemostasis. In Dacie and Lewis practical haemostasis. Elsevier, Churchill Livingstone. Chapter 16; 2006.
30. Boudjeltia KZ, Cauchie P, Remacle C, Guillaume M, Brohee D, Hubert JL, et al. A new device for measurement of fibrin clot lysis: application to the euglobulin clot lysis time. BMC Biotechnol 2002; 2:8.
31. Raftery AT. Method for measuring fibrinolytic activity in a single layer of cells. J Clin Pathol 1981; 34:625-629. (Pubitemid 12197116)
32. O'Donnell CJ, Elosua R. Cardiovascular risk factors. Insights from Framingham Heart Study. Rev Esp Cardiol 2008; 61:299-310. (Pubitemid 351934113)
33. Araya H, Lutz M. Functional and healthy foods. Rev Chil Nutr 2003; 30:8-14.
34. Avello M, Suwalsky M. Free radicals, natural antioxidants and protection mechanisms. Atenea (Concepc) 2006; 494:161-172.
35. de Angelis RC. New concepts in nutrition: considerations on the connection diet-health. Arq Gastroenterol 2001; 38:269-271. (Pubitemid 33755866)
36. Hannum SM. Potential impact of strawberries on human health: a review of the science. Crit Rev Food Sci Nutr 2004; 44:1-17. (Pubitemid 38552288)
37. Silva J, Riguld J, Cheynier V, Cheminat A,Moutounet M. Procyanidin dimmers and trimers from grape seeds. Phytochemistry 1991; 30:1259-1264.
38. Laughton MJ, Evans PJ, Moroney MA, Hoult JR, Halliwell B. Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives. Relationship to antioxidant activity and to iron ion-reducing ability. Biochem Pharmacol 1991; 42:1673-1681.
39. Folts JD. Potential health benefits from the flavonoids in grape products on vascular disease. Adv Exp Med Biol 2002; 505:95-111. (Pubitemid 34526427)
40. Freedman JE, Parker C, Li L, Perlman JA, Frei B, Ivanov V, et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 2001; 103:2792-2798. (Pubitemid 32550066)
41. Augusti K. Therapeutic and medicinal values of onions and garlic. In Rabinowitch HD, Brewster JL editors. Onions and allied crops. Boca Raton FL: CRC Press; 1990. vol 3, pp. 94-108.
42. Lawson LD, Ransom DK, Hughes BG. Inhibition of whole blood plateletaggregation by compounds in garlic clove extracts and commercia garlic products. Thromb Res 1992; 65:141-156.
43. Lancaster J, Collin H. Presence of alliinase in isolated vacuoles and of alkylcysteine sulphoxides in the cytoplasm of bulbs of onion (Allium cepa). Plant Sci Lett 1981; 22:169-176.
44. Lazarus SA, Garg ML. Tomato extract inhibits human platelet aggregation in vitro without increasing basal cAMP levels. Int J Food Sci Nutr 2004; 55:249-256. (Pubitemid 38996837)
45. O'Kennedy N, Crosbie L, Whelan S, Luther V, Horgan G, Broom JI, et al. Effects of tomato extract on platelet function: a double-blinded crossover study in healthy humans. Am J Clin Nutr 2006; 84:561-569. (Pubitemid 44713406)
46. Goldman IL, Kopelberg M, Debaene JE, Schwartz BS. Antiplatelet activity in onion (Allium cepa) is sulfur dependent. Thromb Haemost 1996; 76:450-452. (Pubitemid 26373542)
47. Yamada K, Naemura A, Sawashita N, Noguchi Y, Yamamoto J. An onion variety has natural antithrombotic effect as assessed by thrombosis/ thrombolysis models in rodents. Thromb Res 2004; 114:213-220. (Pubitemid 39165572)
48. Yamamoto J, Naemura A, Ura M, Ijiri Y, Yamashita T, Kurioka A, Koyama A. Testing various fruits for antithrombotic effect: i. Mulberries. Platelets 2006; 17:555-564. (Pubitemid 44837725)