Small structural changes of pentacyclic lupane type triterpenoid derivatives lead to significant differences in their anticancer properties

European Journal of Medicinal Chemistry

Volumn 45, Issue 8, 2010, Pages 3346-3353

  Kommera, Harish ^a   Kaluderović, Goran N ^a,b   Kalbitz, Jutta ^c   Dräger, Birgit ^a   Paschke, Reinhard ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b UNIVERSITY OF BELGRADE   (Serbia)

^c BioSolutions Halle GmbH   (Germany)

Author keywords

Antitumoral activity; Apoptosis; Betulinic acid; Betulonic acid; Cell cycle

Indexed keywords

2 AMINO 3 HYDROXY 2 (HYDROXYMETHYL)PROPYL (3 O ACETYL)BETULINATE; 2 AMINO 3 HYDROXY 2 (HYDROXYMETHYL)PROPYL(3 O ACETYL)BETULINATE; 2 AMINO 3 HYDROXY 2 (HYDROXYMETHYL)PROPYLBETULINATE; 2 AMINO 3 HYDROXY 2 (HYDROXYMETHYL)PROPYLBETULONATE; 3 HYDROXY 2 (HYDROXYMETHYL)PROPYLBETULINATE; ANTINEOPLASTIC AGENT; BETULIC ACID; BETULONIC ACID DERIVATIVE; N (2,3 HYDROXY 2 (HYDROXYMETHYL)PROPYL) (3 O ACETYL)BETULINAMIDE; N (2,3 HYDROXY 2 (HYDROXYMETHYL)PROPYL)BETULINAMIDE; TRITERPENOID; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG STRUCTURE; DRUG SYNTHESIS; INFRARED SPECTROSCOPY;

EID: 77954315717     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.04.018     Document Type: Article

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