Role and classification of cholesterol-lowering functional foods

Journal of Functional Foods

Volumn 3, Issue 2, 2011, Pages 61-69

  Chen, Zhen Yu ^a   Ma, Ka Ying ^a   Liang, Yintong ^a   Peng, Cheng ^a   Zuo, Yuanyuan ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

ACAT; CETP; Cholesterol; HDL; HMG CoA reductase; LDL; Lipoproteins; NPC1L1; Nutraceuticals

Indexed keywords

EID: 79955033730     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2011.02.003     Document Type: Review

References (67)

1. Andersson S.W., Skinner J., Ellegård L., Welch A.A., Bingham S., Mulligan A., Andersson H., Khaw K.T. Intake of dietary plant sterols is inversely related to serum cholesterol concentration in men and women in the EPIC Norfolk population: A cross-sectional study. European Journal of Clinical Nutrition 2004, 58(10):1378-1385.
2. Atzel A., Wetterau J.R. Mechanism of microsomal triglyceride transfer protein catalyzed lipid transport. Biochemistry 1993, 32:10444-10450.
3. Berge K.E., Tian H., Graf G.A., Yu L., Grishin N.V., Schultz J., Kwiterovich P., Shan B., Barnes R., Hobbs H.H. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science 2000, 290:1771-1775.
4. Borradaile N.M., de Dreu L.E., Wilcox L.J., Edwards J.Y., Huff M.W. Soya phytoestrogens, genistein and daidzein, decrease apolipoprotein B secretion from HepG2 cells through multiple mechanisms. Biochemical Journal 2002, 366:531-539.
5. Brown L., Rosner B., Willett W.W., Sacks F.M. Cholesterol-lowering effects of dietary fiber. A meta-analysis. American Journal of Clinical Nutrition 1999, 69:30-42.
6. Bursill C.A., Abbey M., Roach P.D. A green tea extract lowers plasma cholesterol by inhibiting cholesterol synthesis and upregulating the LDL receptor in the cholesterol-fed rabbit. Atherosclerosis 2007, 193(1):86-93.
7. Bursill C.A., Roach P.D. A green tea catechin extract upregulates the hepatic low-density lipoprotein receptor in rats. Lipids 2007, 42(7):621-627.
8. Caruso M.G., Messa C., Orlando A., D'Attoma B., Notarnicola M. Early induction of LDL receptor gene expression by genistein in DLD-1 colon cancer cell line. Fitoterapia 2008, 79(7-8):524-528.
9. Chen Z.Y., Jiao R., Ma K.Y. Cholesterol-lowering nutraceuticals and functional foods. Journal of Agricultural and Food Chemistry 2008, 56:8761-8773.
10. Cho I.J., Ahn J.Y., Kim S., Choi M.S., Ha T.Y. Resveratrol attenuates the expression of HMG-CoA reductase mRNA in hamsters. Biochemical and Biophysical Research Communications 2008, 367(1):190-194.
11. Cho S.J., Juillerat M.A., Lee C.H. Identification of LDL-receptor transcription stimulating peptides from soybean hydrolysate in human hepatocytes. Journal of Agricultural and Food Chemistry 2008, 56(12):4372-4376.
12. Das S., Nesaretnam K., Das D.K. Tocotrienols in cardioprotection. Vitamins and Hormones 2007, 76:419-433.
13. Dávalos A., Fernández-Hernando C., Cerrato F., Martínez-Botas J., Gómez-Coronado D., Gómez-Cordovés C., Lasunción M.A. Red grape juice polyphenols alter cholesterol homeostasis and increase LDL-receptor activity in human cells in vitro. Journal of Nutrition 2006, 136:1766-1773.
14. Davis H.R., Zhu L.J., Hoos L.M., Tetzloff G., Maguire M., Liu J., Yao X., Iyer S.P., Lam M.H., Lund E.G., Detmers P.A., Graziano M.P., Altmann S.W. Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis. Journal of Biological Chemistry 2004, 279:33586-33592.
15. Ellegård L., Andersson H. Oat bran rapidly increases bile acid excretion and bile acid synthesis: An ileostomy study. European Journal of Clinical Nutrition 2007, 61(8):938-945.
16. Erkkilä A.T., Lichtenstein A.H. Fiber and cardiovascular disease risk: How strong is the evidence?. Journal of Cardiovascular Nursing 2006, 21:3-8.
17. Estévez-González M.D., Saavedra-Santana P., López-Ríos L., Chirino R., Cebrero-García E., Peña-Quintana L., Betancor-León P. HDL cholesterol levels in children with mild hypercholesterolemia: Effect of consuming skim milk enriched with olive oil and modulation by the TAQ 1B polymorphism in the CETP gene. Annuals of Nutrition and Metabolism 2010, 56(4):288-293.
18. Gebhardt R., Beck H., Wagner K.G. Inhibition of cholesterol biosynthesis by allicin and ajoene in rat hepatocytes and HepG2 cells. Biochimica et Biophysica Acta 1994, 1213(1):57-62.
19. Graf G.A., Li W.P., Gerard R.D., Gelissen I., White A., Cohen J.C., Hobbs H.H. Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface. Journal of Clinical Investigation 2002, 110:659-669.
20. Grundy S.M. Absorption and metabolism of dietary cholesterol. Annual Review of Nutrition 1983, 3:71-96.
21. Grundy S.M., Metzger A.L. A physiological method for estimation of hepatic secretion of biliary lipids in man. Gastroenterology 1972, 62:1200-1217.
22. Han K.H., Iijuka M., Shimada K., Sekikawa M., Kuramochi K., Ohba K., Ruvini L., Chiji H., Fukushima M. Adzuki resistant starch lowered serum cholesterol and hepatic 3-hydroxy-3-methylglutaryl-CoA mRNA levels and increased hepatic LDL-receptor and cholesterol 7alpha-hydroxylase mRNA levels in rats fed a cholesterol diet. British Journal of Nutrition 2005, 94(6):902-908.
23. Jesch E.D., Seo J.M., Carr T.P., Lee J.Y. Sitosterol reduces messenger RNA and protein expression levels of Niemann-Pick C1-like 1 in FHs 74 Int cells. Nutrition Research 2009, 29(12):859-866.
24. Jiao R., Zhang Z., Yu H., Huang Y., Chen Z.Y. Hypocholesterolemic activity of grape seed proanthocyanidin is mediated by enhancement of bile acid excretion and up-regulation of CYP7A1. Journal of Nutritional Biochemistry 2010, 21:1134-1139.
25. Jones P.J., MacDougall D.E., Ntanios F., Vanstone C.A. Dietary phytosterols as cholesterol-lowering agents in humans. Canadian Journal of Physiology and Pharmacology 1997, 75:217-227.
26. Katan M.B., Grundy S.M., Jones P., Law M., Miettinen T., Paoletti R. Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clinic Proceedings 2003, 78:965-978.
27. Kawase M., Hashimoto H., Hosoda M., Morita H., Hosono A. Effect of administration of fermented milk containing whey protein concentrate to rats and healthy men on serum lipids and blood cholesterol. Journal of Dairy Science 2000, 83:255-263.
28. Kayashita J., Shimaoka I., Nakajoh M., Yamazaki M., Kato N. Consumption of buckwheat protein lowers plasma cholesterol and raises fecal neutral sterols in cholesterol-fed rats because of its low digestibility. Journal of Nutrition 1997, 127:1395-1400.
29. Kerckhoffs D.A.J.M., Brouns F., Hornstra G., Mensink R.P. Effects on the human serum lipoprotein profile of β-glucan, soy protein and isoflavones, plant sterols and stanols, garlic and tocotrienols. Journal of Nutrition 2002, 132:2494-2505.
30. Kim M., Kim Y. Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet. Nutrition Research and Practice 2010, 4(3):191-195.
31. Kim H.J., White P.J. In vitro bile-acid binding and fermentation of high, medium, and low molecular weight beta-glucan. Journal of Agricultural and Food Chemistry 2010, 58:628-634.
32. Kirk E.A., Sutherland P., Wang S.A., Chait A., LeBoeuf R.C. Dietary isoflavones reduce plasma cholesterol and atherosclerosis in C57BL/6 mice but not LDL receptor-deficient mice. Journal of Nutrition 1998, 128(6):954-959.
33. Kuhn D.J., Burns A.C., Kazi A., Dou Q.P. Direct inhibition of the ubiquitin-proteasome pathway by ester bond-containing green tea polyphenols is associated with increased expression of sterol regulatory element-binding protein 2 and LDL receptor. Biochimica et Biophysica Acta 2004, 1682:1-10.
34. Kuwabara T., Han K.H., Hashimoto N., Yamauchi H., Shimada K., Sekikawa M., Fukushima M. Tartary buckwheat sprout powder lowers plasma cholesterol level in rats. Journal of Nutritional Science and Vitaminology 2007, 53(6):501-507.
35. Kwon M.J., Song Y.S., Choi M.S., Park S.J., Jeong K.S., Song Y.O. Cholesteryl ester transfer protein activity and atherogenic parameters in rabbits supplemented with cholesterol and garlic powder. Life Sciences 2003, 72(26):2953-2964.
36. Kwon M.J., Song Y.S., Choi M.S., Song Y.O. Red pepper attenuates cholesteryl ester transfer protein activity and atherosclerosis in cholesterol-fed rabbits. Clinica Chimica Acta 2003, 332(1-2):37-44.
37. Lam C.K., Chen J., Cao Y., Yang L., Wong Y.M., Yeung S.Y.V., Yao Y., Huang Y., Chen Z.Y. Conjugated and non-conjugated octadecaenoic acids affect differently intestinal acyl coenzyme A:cholesterol acyltransferase activity. Atherosclerosis 2008, 198:85-93.
38. Largis E.E., Wang C.H., DeVries V.G., Schaffer S.A. CL 277,082: A novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption. Journal of Lipid Research 1989, 30:681-690.
39. Law M. Plant sterols and stanol margarine and health. Western Journal of Medicine 2000, 173:43-47.
40. Lee J.H., Cho K.H., Lee K.T., Kim M.R. Antiatherogenic effects of structured lipids containing conjugated linoleic acid in C57BL/6J mice. Journal of Agricultural and Food Chemistry 2005, 2005(53):7295-7301.
41. Lee M.H., Lu K., Hazard S., Yu H., Shulenin S., Hidaka H., Kojima H., Allikmets R., Sakuma N. Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption. Nature Genetics 2001, 27:79-83.
42. Lee S.H., Park Y.B., Bae K.H., Bok S.H., Kwon Y.K., Lee E.S., Choi M.S. Cholesterol-lowering activity of naringenin vial inhibition of 2-hydroxy-3-methylglutaryl coenzymes A reductase and acyl coenzyme A:cholesterol acyltransferase in rats. Annuals of Nutrition and Metabolism 1999, 43(3):173-180.
43. Lee M.S., Park J.Y., Freake H., Kwun I.S., Kim Y. Green tea catechin enhances cholesterol 7alpha-hydroxylase gene expression in HepG2 cells. British Journal of Nutrition 2008, 99(6):1182-1185.
44. Lin, Y., Vermeer, M. A., & Trautwein, E. (2009). Triterpenic acids present in hawthorn lower plasma cholesterol by inhibiting intestinal ACAT activity in hamsters. Evidence Based Complementary Alternative Medicine, PMID19228775 (Epub ahead of print).
45. Liu L., Yeh Y.Y. S-Alk(en)yl cysteines of garlic inhibit cholesterol synthesis by deactivating HMG-CoA reductase in cultured rat hepatocyte. Journal of Nutrition 2002, 132:1129-1134.
46. Liu J., Zhang J., Shi Y., Grimsgaard S., Alraek T., Pønnebø V. Chinese red yeast rice (Monascus purpureus) for primary hyperlipidemia: A meta-analysis of randomized controlled trials. Chinese Medicine 2006, 23:1-4.
47. Ma, K. Y., Yang, N., Jiao, R., Peng, C., Guan, L., Huang, Y., & Chen, Z. Y. (in press). Dietary calcium decreases plasma cholesterol by down-regulation of intestinal NPC1L1 and MTP and up-regulation of CYP7A1 and ABCG 5/8 in hamsters. Molecular Nutrition and Food Research.
48. Man R.Y., Lynn E.G., Cheung F., Tsang P.S. Cholestin inhibits cholesterol synthesis and secretion in hepatic cells (HepG2). Molecular and Cellular Biochemistry 2002, 233(1-2):153-158.
49. Marinangeli C.P., Jones P.J., Kassis A.N., Eskin M.N. Policosanols as nutraceuticals: Fact or fiction. Critical Review in Food Science and Nutrition 2010, 50(3):259-267.
50. Menendéz R., Amor A.M., Rodeiro I., González R.M., González P.C., Alfonso J.L., Más R. Policosanol modulates HMG-CoA reductase activity in cultured fibroblasts. Archives of Medical Research 2001, 32:8-12.
51. Oliaro-Bosso S., Calcio Gaudino E., Mantenga S., Giraudo E., Meda C., Viola F., Cravotto G. Regulation of HMGCoA reductase activity by policosanol and octacosadienol, a new synthetic analogue of octacosanol. Lipids 2009, 44(10):907-916.
52. Pal S., Ho N., Santos C., Dubois P., Mamo J., Croft K., Allister E. Red wine polyphenolics increase LDL receptor expression and activity and suppress the secretion of ApoB100 from human HepG2 cells. Journal of Nutrition 2003, 133(3):700-706.
53. Plat J., Mensink R.P. Plant stanol and sterol esters in the control of blood cholesterol levels: Mechanism and safety aspects. American Journal of Cardiology 2005, 96:15-22.
54. Qin Y., Xia M., Ma J., Hao Y., Liu J., Mou H., Cao L., Ling W. Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects. American Journal of Clinical Nutrition 2009, 90(3):485-492.
55. Rai S.K., Sharma M., Tiwari M. Inhibitory effect of novel diallyldisulfide analogs on HMG-CoA reductase expression in hypercholesterolemic rats: CREB as a potential upstream target. Life Sciences 2009, 85(5-6):211-219.
56. Rajendran S., Deepalakshmi P.D., Parasakthy K., Devaraj H., Devaraj S.N. Effect of tincture of Crataegus on the LDL-receptor activity of hepatic plasma membrane of rats fed an atherogenic diet. Atherosclerosis 1996, 123(1-2):235-241.
57. Repa J.J., Buhman K.K., Farese R.V., Dietschy J.M., Turley S.D. ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: Impact on hepatic cholesterol homeostasis. Hepatology 2004, 40:1088-1097.
58. Ringseis R., König B., Leuner B., Schubert S., Nass N., Stangl G., Eder K. LDL receptor gene transcription is selectively induced by t10c12-CLA but not by c9t11-CLA in the human hepatoma cell line HepG2. Biochimica et Biophysica Acta 2006, 1761(10):1235-1243.
59. Rukmini C., Raghuram T.C. Nutritional and biochemical aspects of the hypolipidemic action of rice bran oil: A review. Journal of American College of Nutrition 1991, 10(6):593-601.
60. Sung J.H., Choi S.J., Lee S.W., Park K.H., Moon T.W. Isoflavones found in Korean soybean paste as 3-hydroxy-3-methylglutaryl Coenzyme A reductase inhibitors. Bioscience, Biotechnology and Biochemistry 2004, 68(5):1051-1058.
61. Temel R.E., Gebre A.K., Parks J.S., Rudel L.L. Compared with acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol. Journal of Biological Chemistry 2003, 278:47594-47601.
62. Vidyashankar S., Sambaiah K., Srinivasan K. Dietary garlic and onion reduce the incidence of atherogenic diet-induced cholesterol gallstones in experimental mice. British Journal of Nutrition 2009, 101(11):621-629.
63. Walker R. Hyperlipidaemia. Clinical pharmacy and therapeutics 1994, 309-325. Churchill Livingstone, New York, USA. R. Walter, C. Edwards (Eds.).
64. Wong J.M., de Souza R., Kendall C.W., Emam A., Jenkins D.J. Colonic health: Fermentation and short chain fatty acids. Journal of Clinical Gastroenterology 2006, 40:235-243.
65. Yu-Poth S., Yin D., Zhao G., Kris-Etherton P.M., Etherton T.D. Conjugated linoleic acid upregulates LDL receptor gene expression in HepG2 cells. Journal of Nutrition 2004, 34(1):68-71.
66. Zhang Z., Ho W.K.K., Huang Y., Chen Z.Y. Hypocholesterolemic activity of hawthorn fruits mediated by regulation of cholesterol-7α-hydroxylase and acyl CoA:cholesterol acyltransferase. Food Research International 2002, 35:885-891.
67. Zhang Z., Ho W.K.K., Huang Y., James A.E., Lam L.W., Chen Z.Y. Hawthorn fruit is hypolipidemic in rabbits fed a high cholesterol diet. Journal of Nutrition 2002, 132:5-10.