Conjugated and non-conjugated octadecaenoic acids affect differently intestinal acyl coenzyme A: Cholesterol acyltransferase activity

Atherosclerosis

Volumn 198, Issue 1, 2008, Pages 85-93

  Lam, Cheuk Kai ^a   Chen, Jingnan ^b   Cao, Ying ^b   Yang, Lin ^b   Wong, Yin Mei ^a   Yeung, Sai Ying Venus ^a   Yao, Xiaoqiang ^a   Huang, Yu ^a   Chen, Zhen Yu ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b HENAN NORMAL UNIVERSITY   (China)

Author keywords

Acyl coenzyme A: cholesterol acyltransferase; Alpha linonenic acid; Cholesterol; Conjugated linoleic acid; Conjugated linolenic acids; Linoleic acid

Indexed keywords

ACYL COENZYME A; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLESTEROL ACYLTRANSFERASE; CONJUGATED LINOLEIC ACID; CONJUGATED LINOLENIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LINOLEIC ACID; LINOLENIC ACID; LIVER X RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE MODEL; ENZYME ACTIVITY; ESTERIFICATION; FECES; HAMSTER; HYPERCHOLESTEROLEMIA; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ACYL COENZYME A; ANIMALS; BODY WEIGHT; CHOLESTEROL 7-ALPHA-HYDROXYLASE; CHOLESTEROL, HDL; CRICETINAE; DNA-BINDING PROTEINS; EATING; FATTY ACIDS, UNSATURATED; FECES; HYDROXYMETHYLGLUTARYL COA REDUCTASES; INTESTINES; LINOLEIC ACIDS, CONJUGATED; LIVER; MALE; MESOCRICETUS; ORGAN SIZE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, LDL; RNA, MESSENGER; STEROL O-ACYLTRANSFERASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; STEROLS;

EID: 40949136584     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2007.11.001     Document Type: Article

References (29)

1. Lee J.Y., Mitmesser S.H., and Car T.P. Regulation of cellular cholesterol. In: Zempleni J., and Daniel H. (Eds). Molecular nutrition (2002), CABI Publishing, London 309-320
2. Alegret M., Llaverias G., and Silverstre J.S. Acyl coenzyme A: cholesterol acyltransferase inhibitors as hypolipidemic and antiatherosclerotic drugs. Methods Find Exp Clin Pharmacol 26 (2004) 563-586
3. Takagi T., and Itabashi Y. Occurrence of mixtures of geometrical isomers of conjugated octadecatrienoic acids in some seed oils: Analysis by open tubular gas liquid chromatography and high performance liquid chromatography. Lipids 16 (1981) 546-551
4. Fernandez M.L., and West K.L. Mechanisms by which dietary fatty acids modulate plasma lipids. J Nutr 135 (2005) 2075-2078
5. Chan J.K., Bruce V.M., and McDonald B.E. Dietary alpha-linolenic acid is as effective as oleic acid and linoleic acid in lowering blood cholesterol in normolipidemic men. Am J Clin Nutr 53 (1991) 1230-1240
6. Yang L., Leung K.Y., Cao Y., et al. α-Linolenic acid but not conjugated linolenic acid is hypocholesterolemic in hamsters. Br J Nutr 93 (2005) 433-438
7. Salas-Salvado J., Maroquez F., and Bullo M. Conjugated linoleic acid intake in humans: a systematic review focusing on its effect on body composition, glucose, and lipid metabolism. Crit Rev Food Sci Nutr 46 (2007) 479-488
8. Dhar P., Ghosh S., and Bhattacharyya D.K. Dietary effects of conjugated octadecatrienoic fatty acid (9cis, 11trans, 13trans) levels on blood lipids and nonenzymatic in vitro lipid peroxidation in rats. Lipids 34 (1999) 109-114
9. Chan P.T., Fong W.P., Cheung Y.L., et al. Jasmine green epicatechins are hypolipidemic in hamsters fed a high fat diet. J Nutr 129 (1999) 1094-1101
10. Vaziri N.D., and Liang K.H. Down-regulation of hepatic LDL receptor expression in experimental nephrosis. Kidney Int 50 (1996) 887-893
11. Yeung T.C.H., Yang L., Huang Y., Wang J., and Chen Z.Y. Dietary conjugated linoleic acid mixture affects the activity of intestinal acyl coenzyme A: cholesterol acyltransferase in hamsters. Br J Nutr 84 (2000) 935-941
12. Wilson T.A., Nicolosi R.J., Saati A., Kotyla T., and Kritchevsky D. Conjugated linoleic acid isomers reduce blood cholesterols but not aortic cholesterol accumulation in hypercholesterolemic hamsters. Lipids 41 (2006) 41-48
13. Navarro V., Zabala A., Macarulla M.T., et al. Effects of conjugated lioleic acid on body fat accumulation and serum lipids in hamsters fed an atherogenic diet. J Physiol Biochem 59 (2003) 193-199
14. de Dechere E.A., van Amelsvoort J.M., McNeill G.P., and Jones P. Effects of conjugated linoleic acid (CLA) isomers on lipid level and peroxisome proliferation in the hamster. Br J Nutr 82 (1999) 309-317
15. Dhar P., and Bhattacharyya D.K. Nutritional characteristics of oil containing conjugated octadecatrienoic fatty acid. Ann Nutr Metab 42 (1998) 290-296
16. Navarro V., Macarulla M.T., Fernandez-Quintela A., et al. Effect of trans-10, cis-12 conjugated linoleic acid on cholesterol metabolism in hypercholesterolaemic hamsters. Eur J Nutr 46 (2007) 213-219
17. Zabala A., Churruca I., Macarulla M.T., et al. The trans-10,cis-12 isomer of conjugated linoleic acid reduces hepatic triacylglycerol content without affecting lipogenic enzymes in hamsters. Br J Nutr 92 (2004) 383-389
18. Yu-Poth S., Yin D., Zhao G., Kris-Etherton P.M., and Etherton T.D. Conjugated linoleic acid upregulates LDL receptor gene expression in HepG2 cells. J Nutr 134 (2004) 68-71
19. Ringseis R., Konig B., Leuner B., et al. LDL receptor gene transcription is selectively induced by t10c12-CLA but not by c9t11-CLA in the human hepatoma cell line HepG2. Biochim Biophys Acta 171 (2006) 1235-1243
20. Valeille K., Ferezou J., Amsler G., et al. A cis-9, trans-11 conjugated linoleic acid rich oil reduces the outcome of atherogenic process in hyperlipidemic hamster. Am J Physiol Heart Circ Physiol 289 (2005) H652-H659
21. Spady D.K. Regulatory effects of individual n - 6 and n - 3 polyunsaturated fatty acids on LDL transport in the rat. J Lipid Res 34 (1993) 1337-1346
22. Morise A., Serouge C., Gripois D., et al. Effects of dietary alpha linolenic acid on cholesterol metabolism in male and female hamsters of the LPN strain. J Nutr Biochem 15 (2004) 51-61
23. Yu-Poth S., Yin D., Kris-Etherton P.M., Zha G., and Etherton T.D. Long-chain polyunsaturated fatty acids upregulate LDL receptor protein expression in fibroblasts and HepG2 cell. J Nutr 135 (2005) 2541-2545
24. Tobin K.A.R., Steineger H.H., Aberti S., et al. Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-α. Mol Endocrinol 14 (2000) 741-752
25. Ribot J., Portillo M.P., Pico C., Macarulla M.T., and Palou A. Effects of trans-10,cis-12 conjugated linoleic acid on the expression of uncoupling proteins in hamsters fed an atherogenic diet. Br J Nutr 97 (2007) 1074-1082
26. Whigham L.D., Watras A.C., and Shoeller D.A. Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. Am J Clin Nutr 85 (2007) 1203-1211
27. Viswanadha S., McGilliard M.L., and Herbein J.H. Desaturation indices in liver, muscle, and bone growing male and female mice fed trans-10,cis-12 conjugated linoleic acid. Lipids 41 (2006) 763-770
28. Zabala A., Churruca I., Fernandez-Quintela A., Rodriguez V.M., Macarulla M.T., Martinez J.A., et al. Trans-10,cis-12 conjugated linoleic acid inhibits lipoprotein lipase but increases the activity of lipogenic enzymes in adipose tissue from hasmters fed an atherogenic diet. Br J Nutr 95 (2006) 1112-1119
29. Abdullah M.M., Xu Z., Pierece G.N., and Moghadasian M.H. The Effects of simultaneous administration of dietary conjugated linoleic acid and telmisartan on cardiovascular risks in rats. Lipids (2007) August 2 [Epub ahead of print]