-
2
-
-
33646162635
-
GRKs and beta-arrestins: Roles in receptor silencing, trafficking and signaling
-
Reiter E, Lefkowitz RJ (2006) GRKs and beta-arrestins: Roles in receptor silencing, trafficking and signaling. Trends Endocrinol Metab 17(4):159-165.
-
(2006)
Trends Endocrinol Metab
, vol.17
, Issue.4
, pp. 159-165
-
-
Reiter, E.1
Lefkowitz, R.J.2
-
3
-
-
0019982539
-
Decreased catecholamine sensitivity and β-adrenergic-receptor density in failing human hearts
-
Bristow MR, et al. (1982) Decreased catecholamine sensitivity and β-adrenergicreceptor density in failing human hearts. N Engl J Med 307:205-211. (Pubitemid 12079105)
-
(1982)
New England Journal of Medicine
, vol.307
, Issue.4
, pp. 205-211
-
-
Bristow, M.R.1
Ginsburg, R.2
Minobe, W.3
-
4
-
-
0024562830
-
2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium
-
Bristow MR, Hershberger RE, Port JD, Minobe W, Rasmussen R (1989) β1- and β2- adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium. Mol Pharmacol 35:295-303. (Pubitemid 19090345)
-
(1989)
Molecular Pharmacology
, vol.35
, Issue.3
, pp. 295-303
-
-
Bristow, M.R.1
Hershberger, R.E.2
Port, J.D.3
Minobe, W.4
Rasmussen, R.5
-
5
-
-
0028894951
-
Human lung cell beta2-adrenergic receptors desensitize in response to in vivo administered beta-agonist
-
Turki J, Green SA, Newman KB, Meyers MA, Liggett SB (1995) Human lung cell β2- adrenergic receptors desensitize in response to in vivo administered β-agonist. Am J Physiol 269:L709-L714. (Pubitemid 3005949)
-
(1995)
The American journal of physiology
, vol.269
, Issue.51
-
-
Turku, J.1
Green, S.A.2
Newman, K.B.3
Meyers, M.A.4
Liggett, S.B.5
-
6
-
-
0034949839
-
2 agonists
-
DOI 10.1136/thorax.56.7.529
-
van der Woude HJ, Winter TH, Aalbers R (2001) Decreased bronchodilating effect of salbutamol in relieving methacholine induced moderate to severe bronchoconstriction during high dose treatment with long acting beta2 agonists. Thorax 56: 529-535. (Pubitemid 32588531)
-
(2001)
Thorax
, vol.56
, Issue.7
, pp. 529-535
-
-
Van der Woude, H.J.1
Winter, T.H.2
Aalbers, R.3
-
7
-
-
0028981907
-
Regulation of beta 2-adrenergic receptor mRNA and gene transcription in rat C6 glioma cells: Effects of agonist, forskolin, and protein synthesis inhibition
-
Hosoda K, et al. (1995) Regulation of beta 2-adrenergic receptor mRNA and gene transcription in rat C6 glioma cells: Effects of agonist, forskolin, and protein synthesis inhibition. Mol Pharmacol 48:206-211.
-
(1995)
Mol Pharmacol
, vol.48
, pp. 206-211
-
-
Hosoda, K.1
-
8
-
-
0242673247
-
Agonist-induced destabilization of β-adrenergic receptor mRNA. Attenuation of glucocorticoid induced upregulation of β-adrenergic receptors
-
Hadcock JR, Wang H, Malbon CC (1992) Agonist-induced destabilization of β-adrenergic receptor mRNA. Attenuation of glucocorticoid induced upregulation of β-adrenergic receptors. J Biol Chem 267:4740-4746.
-
(1992)
J Biol Chem
, vol.267
, pp. 4740-4746
-
-
Hadcock, J.R.1
Wang, H.2
Malbon, C.C.3
-
9
-
-
0028978002
-
The M(r) 35,000 β-adrenergic receptor mRNA-binding protein binds transcripts of G-protein-linked receptors which undergo agonist-induced destabilization
-
Tholanikunnel BG, Granneman JG, Malbon CC (1995) The M(r) 35,000 β-adrenergic receptor mRNA-binding protein binds transcripts of G-protein-linked receptors which undergo agonist-induced destabilization. J Biol Chem 270:12787-12793.
-
(1995)
J Biol Chem
, vol.270
, pp. 12787-12793
-
-
Tholanikunnel, B.G.1
Granneman, J.G.2
Malbon, C.C.3
-
10
-
-
0024461392
-
2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level
-
Bouvier M, et al. (1989) Two distinct pathways for cAMP-mediated down-regulation of the β2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level. J Biol Chem 264:16786-16792. (Pubitemid 19243577)
-
(1989)
Journal of Biological Chemistry
, vol.264
, Issue.28
, pp. 16786-16792
-
-
Bouvier, M.1
Collins, S.2
O'Dowd, B.F.3
Campbell, P.T.4
De Blasi, A.5
Kobilka, B.K.6
MacGregor, C.7
Irons, G.P.8
Caron, M.G.9
Lefkowitz, R.J.10
-
11
-
-
41149090339
-
Regulation of GPCRs by endocytic membrane trafficking and its potential implications
-
DOI 10.1146/annurev.pharmtox.48.113006.094830
-
Hanyaloglu AC, von Zastrow M (2008) Regulation of GPCRs by endocytic membrane trafficking and its potential implications. Annu Rev Pharmacol Toxicol 48:537-568. (Pubitemid 351738163)
-
(2008)
Annual Review of Pharmacology and Toxicology
, vol.48
, pp. 537-568
-
-
Hanyaloglu, A.C.1
Von Zastrow, M.2
-
12
-
-
34249880154
-
2-adrenergic receptor 5′ sequence
-
DOI 10.1165/rcmb.2006-0394OC
-
Panebra A, Schwarb MR, Glinka CB, Liggett SB (2007) Allele-specific binding of airway nuclear extracts to polymorphic β2-adrenergic receptor 5? sequence. Am J Respir Cell Mol Biol 36:654-660. (Pubitemid 46871419)
-
(2007)
American Journal of Respiratory Cell and Molecular Biology
, vol.36
, Issue.6
, pp. 654-660
-
-
Panebra, A.1
Schwarb, M.R.2
Glinka, C.B.3
Liggett, S.B.4
-
13
-
-
11844262661
-
Phylogenetic shadowing and computational identification of human microRNA genes
-
DOI 10.1016/j.cell.2004.12.031, PII S0092867404012565
-
Berezikov E, et al. (2005) Phylogenetic shadowing and computational identification of human microRNA genes. Cell 120(1):21-24. (Pubitemid 40094599)
-
(2005)
Cell
, vol.120
, Issue.1
, pp. 21-24
-
-
Berezikov, E.1
Guryev, V.2
Van De Belt, J.3
Wienholds, E.4
Plasterk, R.H.A.5
Cuppen, E.6
-
14
-
-
60149095444
-
Most mammalian mRNAs are conserved targets of microRNAs
-
Friedman RC, Farh KK, Burge CB, Bartel DP (2009) Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 19(1):92-105.
-
(2009)
Genome Res
, vol.19
, Issue.1
, pp. 92-105
-
-
Friedman, R.C.1
Farh, K.K.2
Burge, C.B.3
Bartel, D.P.4
-
15
-
-
78649378267
-
MicroRNA functions in stress responses
-
Leung AK, Sharp PA (2010) MicroRNA functions in stress responses. Mol Cell 40: 205-215.
-
(2010)
Mol Cell
, vol.40
, pp. 205-215
-
-
Leung, A.K.1
Sharp, P.A.2
-
16
-
-
77954146850
-
MicroRNAs in heart disease: Putative novel therapeutic targets?
-
Condorelli G, Latronico MV, Dorn GW, 2nd (2010) microRNAs in heart disease: Putative novel therapeutic targets? Eur Heart J 31:649-658.
-
Eur Heart J
, vol.31
, pp. 649-658
-
-
Condorelli, G.1
Latronico, M.V.2
Dorn II, G.W.3
-
17
-
-
38349169664
-
Mechanisms of posttranscriptional regulation by microRNAs: Are the answers in sight?
-
Filipowicz W, Bhattacharyya SN, Sonenberg N (2008) Mechanisms of posttranscriptional regulation by microRNAs: Are the answers in sight? Nat Rev Genet 9 (2):102-114.
-
(2008)
Nat Rev Genet
, vol.9
, Issue.2
, pp. 102-114
-
-
Filipowicz, W.1
Bhattacharyya, S.N.2
Sonenberg, N.3
-
18
-
-
61849137222
-
Many roads to maturity: MicroRNA biogenesis pathways and their regulation
-
Winter J, Jung S, Keller S, Gregory RI, Diederichs S (2009) Many roads to maturity: MicroRNA biogenesis pathways and their regulation. Nat Cell Biol 11:228-234.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 228-234
-
-
Winter, J.1
Jung, S.2
Keller, S.3
Gregory, R.I.4
Diederichs, S.5
-
19
-
-
22444437609
-
Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis
-
DOI 10.1038/nature03817
-
Zhao Y, Samal E, Srivastava D (2005) Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature 436:214-220. (Pubitemid 41021266)
-
(2005)
Nature
, vol.436
, Issue.7048
, pp. 214-220
-
-
Zhao, Y.1
Samal, E.2
Srivastava, D.3
-
20
-
-
10644234841
-
The Drosha-DGCR8 complex in primary microRNA processing
-
DOI 10.1101/gad.1262504
-
Han J, et al. (2004) The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev 18:3016-3027. (Pubitemid 39658171)
-
(2004)
Genes and Development
, vol.18
, Issue.24
, pp. 3016-3027
-
-
Han, J.1
Lee, Y.2
Yeom, K.-H.3
Kim, Y.-K.4
Jin, H.5
Kim, V.N.6
-
21
-
-
23644433363
-
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
-
DOI 10.1038/nature03868
-
Chendrimada TP, et al. (2005) TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 436:740-744. (Pubitemid 41117280)
-
(2005)
Nature
, vol.436
, Issue.7051
, pp. 740-744
-
-
Chendrimada, T.P.1
Gregory, R.I.2
Kumaraswamy, E.3
Norman, J.4
Cooch, N.5
Nishikura, K.6
Shiekhattar, R.7
-
22
-
-
33846925885
-
Pleiotropic β-agonist-promoted receptor conformations and signals independent of intrinsic activity
-
DOI 10.1165/rcmb.2006-0257OC
-
Swift SM, Schwarb MR, Mihlbachler KA, Liggett SB (2007) Pleiotropic β-agonistpromoted receptor conformations and signals independent of intrinsic activity. Am J Respir Cell Mol Biol 36:236-243. (Pubitemid 46233477)
-
(2007)
American Journal of Respiratory Cell and Molecular Biology
, vol.36
, Issue.2
, pp. 236-243
-
-
Swift, S.M.1
Schwarb, M.R.2
Mihlbachler, K.A.3
Liggett, S.B.4
-
23
-
-
0029115523
-
Protective effects of a glucocorticoid on downregulation of pulmonary beta 2-adrenergic receptors in vivo
-
Mak JC, Nishikawa M, Shirasaki H, Miyayasu K, Barnes PJ (1995) Protective effects of a glucocorticoid on downregulation of pulmonary beta 2-adrenergic receptors in vivo. J Clin Invest 96(1):99-106.
-
(1995)
J Clin Invest
, vol.96
, Issue.1
, pp. 99-106
-
-
Mak, J.C.1
Nishikawa, M.2
Shirasaki, H.3
Miyayasu, K.4
Barnes, P.J.5
-
24
-
-
0023864252
-
2-adrenergic receptor in Chinese hamster fibroblasts (CHW): Functionality and regulation of the expressed receptors
-
Bouvier M, et al. (1988) Expression of a human cDNA encoding the beta 2-adrenergic receptor in Chinese hamster fibroblasts (CHW): Functionality and regulation of the expressed receptors. Mol Pharmacol 33(2):133-139. (Pubitemid 18068118)
-
(1988)
Molecular Pharmacology
, vol.33
, Issue.2
, pp. 133-139
-
-
Bouvier, M.1
Hnatowich, M.2
Collins, S.3
Kobilka, B.K.4
Deblasi, A.5
Lefkowitz, R.J.6
Caron, M.G.7
-
25
-
-
0032888049
-
2-adrenergic receptor function
-
DOI 10.1016/S0091-6749(99)70272-1
-
Liggett SB (1999) Molecular and genetic basis of β2-adrenergic receptor function. J Allergy Clin Immunol 104(2 pt 2):S42-S46. (Pubitemid 29426708)
-
(1999)
Journal of Allergy and Clinical Immunology
, vol.104
, Issue.2
-
-
Liggett, S.B.1
-
26
-
-
0026270156
-
Structure and regulation of G protein-coupled receptors: The beta 2-adrenergic receptor as a model
-
Collins S, Lohse MJ, O'Dowd B, Caron MG, Lefkowitz RJ (1991) Structure and regulation of G protein-coupled receptors: The beta 2-adrenergic receptor as a model. Vitam Horm 46:1-39.
-
(1991)
Vitam Horm
, vol.46
, pp. 1-39
-
-
Collins, S.1
Lohse, M.J.2
O'Dowd, B.3
Caron, M.G.4
Lefkowitz, R.J.5
-
27
-
-
0028145741
-
The peptide product of a 5? leader cistron in the beta 2 adrenergic receptor mRNA inhibits receptor synthesis
-
Parola AL, Kobilka BK (1994) The peptide product of a 5? leader cistron in the beta 2 adrenergic receptor mRNA inhibits receptor synthesis. J Biol Chem 269:4497-4505.
-
(1994)
J Biol Chem
, vol.269
, pp. 4497-4505
-
-
Parola, A.L.1
Kobilka, B.K.2
-
28
-
-
33746603033
-
1-adrenergic receptor motif alters cardiac function and β-blocker response in human heart failure
-
DOI 10.1073/pnas.0509937103
-
Liggett SB, et al. (2006) A polymorphism within a conserved β(1)-adrenergic receptor motif alters cardiac function and β-blocker response in human heart failure. Proc Natl Acad Sci USA 103:11288-11293. (Pubitemid 44156511)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.30
, pp. 11288-11293
-
-
Liggett, S.B.1
Mialet-Perez, J.2
Thaneemit-Chen, S.3
Weber, S.A.4
Greene, S.M.5
Hodne, D.6
Nelson, B.7
Morrison, J.8
Domanski, M.J.9
Wagoner, L.E.10
Abraham, W.T.11
Anderson, J.L.12
Carlquist, J.F.13
Krause-Steinrauf, H.J.14
Lazzeroni, L.C.15
Port, J.D.16
Lavori, P.W.17
Bristow, M.R.18
-
29
-
-
0023882417
-
Characterization of β-adrenergic receptors of human skeletal muscle obtained by needle biopsy
-
Liggett SB, Shah SD, Cryer PE (1988) Characterization of β-adrenergic receptors of human skeletal muscle obtained by needle biopsy. Am J Physiol 254:E795-E798.
-
(1988)
Am J Physiol
, vol.254
-
-
Liggett, S.B.1
Shah, S.D.2
Cryer, P.E.3
-
30
-
-
0023739442
-
Direct relationship between mononuclear leukocyte and lung β-adrenergic receptors and apparent reciprocal regulation of extravascular, but not intravascular, α- and β-adrenergic receptors by the sympathochromaffin system in humans
-
Liggett SB, Marker JC, Shah SD, Roper CL, Cryer PE (1988) Direct relationship between mononuclear leukocyte and lung β-adrenergic receptors and apparent reciprocal regulation of extravascular, but not intravascular, α- and β-adrenergic receptors by the sympathochromaffin system in humans. J Clin Invest 82(1):48-56. (Pubitemid 18262497)
-
(1988)
Journal of Clinical Investigation
, vol.82
, Issue.1
, pp. 48-56
-
-
Liggett, S.B.1
Marker, J.C.2
Shah, S.D.3
Roper, C.L.4
Cryer, P.E.5
-
31
-
-
77954135412
-
MMP-9 gene ablation and TIMP-4 mitigate PAR-1-mediated cardiomyocyte dysfunction: A plausible role of dicer and miRNA
-
Mishra PK, Metreveli N, Tyagi SC (2010) MMP-9 gene ablation and TIMP-4 mitigate PAR-1-mediated cardiomyocyte dysfunction: A plausible role of dicer and miRNA. Cell Biochem Biophys 57(2-3):67-76.
-
(2010)
Cell Biochem Biophys
, vol.57
, Issue.2-3
, pp. 67-76
-
-
Mishra, P.K.1
Metreveli, N.2
Tyagi, S.C.3
-
32
-
-
70849115884
-
MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction: A new mechanism for ischaemic cardioprotection
-
Lu Y, et al. (2009) MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction: A new mechanism for ischaemic cardioprotection. Cardiovasc Res 84:434-441.
-
(2009)
Cardiovasc Res
, vol.84
, pp. 434-441
-
-
Lu, Y.1
-
33
-
-
33646386694
-
Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex
-
McGraw DW, et al. (2006) Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex. J Clin Invest 116:1400-1409.
-
(2006)
J Clin Invest
, vol.116
, pp. 1400-1409
-
-
McGraw, D.W.1
-
34
-
-
78149355561
-
Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction
-
Deshpande DA, et al. (2010) Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nat Med 16: 1299-1304.
-
(2010)
Nat Med
, vol.16
, pp. 1299-1304
-
-
Deshpande, D.A.1
-
35
-
-
33645902491
-
Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: The heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment
-
Small KM, et al. (2006) Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: The heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment. Biochemistry 45:4760-4767.
-
(2006)
Biochemistry
, vol.45
, pp. 4760-4767
-
-
Small, K.M.1
-
36
-
-
79955046713
-
Paradoxical attenuation of β2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase
-
Wang WCH, Schillinger RM, Malone MM, Liggett SB (2011) Paradoxical attenuation of β2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase. Am J Physiol Lung Cell Mol Physiol 300:L472-L478.
-
(2011)
Am J Physiol Lung Cell Mol Physiol
, vol.300
-
-
Wang, W.C.H.1
Schillinger, R.M.2
Malone, M.M.3
Liggett, S.B.4
-
37
-
-
77955608819
-
Common ADRB2 haplotypes derived from 26 polymorphic sites direct β2-adrenergic receptor expression and regulation phenotypes
-
Panebra A, et al. (2010) Common ADRB2 haplotypes derived from 26 polymorphic sites direct β2-adrenergic receptor expression and regulation phenotypes. PLoS ONE 5:e11819.
-
(2010)
PLoS ONE
, vol.5
-
-
Panebra, A.1
-
38
-
-
46749127695
-
UCSC genome browser tutorial
-
Zweig AS, Karolchik D, Kuhn RM, Haussler D, Kent WJ (2008) UCSC genome browser tutorial. Genomics 92(2):75-84.
-
(2008)
Genomics
, vol.92
, Issue.2
, pp. 75-84
-
-
Zweig, A.S.1
Karolchik, D.2
Kuhn, R.M.3
Haussler, D.4
Kent, W.J.5
-
39
-
-
34250805982
-
MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing
-
DOI 10.1016/j.molcel.2007.06.017, PII S1097276507004078
-
Grimson A, et al. (2007) MicroRNA targeting specificity in mammals: Determinants beyond seed pairing. Mol Cell 27(1):91-105. (Pubitemid 46991392)
-
(2007)
Molecular Cell
, vol.27
, Issue.1
, pp. 91-105
-
-
Grimson, A.1
Farh, K.K.-H.2
Johnston, W.K.3
Garrett-Engele, P.4
Lim, L.P.5
Bartel, D.P.6
-
40
-
-
38549124383
-
The microRNA.org resource: Targets and expression
-
DOI 10.1093/nar/gkm995
-
Betel D, Wilson M, Gabow A, Marks DS, Sander C (2008) The microRNA.org resource: Targets and expression. Nucleic Acids Res 36(Database issue):D149-D153. (Pubitemid 351149712)
-
(2008)
Nucleic Acids Research
, vol.36
, Issue.SUPPL. 1
-
-
Betel, D.1
Wilson, M.2
Gabow, A.3
Marks, D.S.4
Sander, C.5
-
42
-
-
20944450160
-
Combinatorial microRNA target predictions
-
DOI 10.1038/ng1536
-
Krek A, et al. (2005) Combinatorial microRNA target predictions. Nat Genet 37: 495-500. (Pubitemid 40617277)
-
(2005)
Nature Genetics
, vol.37
, Issue.5
, pp. 495-500
-
-
Krek, A.1
Grun, D.2
Poy, M.N.3
Wolf, R.4
Rosenberg, L.5
Epstein, E.J.6
MacMenamin, P.7
Da Piedade, I.8
Gunsalus, K.C.9
Stoffel, M.10
Rajewsky, N.11
-
43
-
-
4644237189
-
Fast and effective prediction of microRNA/target duplexes
-
DOI 10.1261/rna.5248604
-
Rehmsmeier M, Steffen P, Hochsmann M, Giegerich R (2004) Fast and effective prediction of microRNA/target duplexes. RNA 10:1507-1517. (Pubitemid 39288185)
-
(2004)
RNA
, vol.10
, Issue.10
, pp. 1507-1517
-
-
Rehmsmeier, M.1
Steffen, P.2
Hochsmann, M.3
Giegerich, R.4
|