Blood-derived iron mediates free radical production and neuronal death in the hippocampal CA1 area following transient forebrain ischemia in rat

Acta Neuropathologica

Volumn 121, Issue 4, 2011, Pages 459-473

  Park, Ui Jin ^a,b   Lee, Young Ae ^b   Won, Sun Mi ^a   Lee, Jin Hwan ^a,b   Kang, Seung Hee ^c   Springer, Joe E ^d   Lee, Yong Beom ^a   Gwag, Byoung Joo ^a,b  

^a Ajou University School of Medicine   (South Korea)

^b Ajou University Medical Center   (South Korea)

^c Inje University College of Medicine   (South Korea)

^d UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Blood brain barrier; CA1 pyramidal neurons; Free radicals; Iron; Transferrin receptor; Transient forebrain ischemia

Indexed keywords

DEFEROXAMINE; FREE RADICAL; IRON; TRANSFERRIN RECEPTOR; TROLOX C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN ISCHEMIA; CELL INFILTRATION; CONTROLLED STUDY; FOREBRAIN; HIPPOCAMPAL CA1 REGION; IRON BALANCE; IRON OVERLOAD; IRON TRANSPORT; MALE; MITOCHONDRION; NERVE CELL NECROSIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; X IRRADIATION;

ANALYSIS OF VARIANCE; ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; AUTOANTIGENS; CELL DEATH; CELLS, CULTURED; DEOXYGUANOSINE; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; EVANS BLUE; GLYCOPHORIN; HIPPOCAMPUS; IRON; ISCHEMIC ATTACK, TRANSIENT; L-LACTATE DEHYDROGENASE; MALE; MICE; MICE, INBRED ICR; NEURONS; PEROXIDASE; PHOSPHOPYRUVATE HYDRATASE; PROSENCEPHALON; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CELL SURFACE; TIME FACTORS; TRANSFERRIN; ZINC;

EID: 79954613019     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-010-0785-8     Document Type: Article

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